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The map label for this gene is treR [H]

Identifier: 226949287

GI number: 226949287

Start: 2273474

End: 2274184

Strand: Direct

Name: treR [H]

Synonym: CLM_2206

Alternate gene names: 226949287

Gene position: 2273474-2274184 (Clockwise)

Preceding gene: 226949286

Following gene: 226949294

Centisome position: 54.71

GC content: 25.74

Gene sequence:

>711_bases
ATGGAAAGCAAATATTTGACTATTTATAATGAGATTTCAAATAAAATAGAAAATAATAAAATTCAATCCGGCGAAAAACT
TTCTTCTGAAAATGAAATGATGAAAGAATATAATGTATCTAGAGATACCATAAGAAAAGCATTAAATTTACTGGAAAGTA
ATGGTTATATTCAAAAAGTGAAAGGTAAAGGTTCCTTTGTACTAGATATTAATAAATTTGATTTTCCTGTTTCAGGACTT
ACAAGCTTTAAAGAATTATCTACTAGAATGGGAGTAGAATCTAATACCCTAGTTAAAGAATTAAAGTTAATAAAGTCAGA
TAACTTTTTAATGAAACAACTAAACCTGTCAAAAAACGATGACGTGTGGAAAGTTATAAGAGTAAGAGAAATAGATAATA
AAAAAATTATCTTAGATAAAGACTTTTTTAATAAGAAATATGTTCCTTTATTAACTAAAGATATTTGTGAAAATTCTATA
TATGAATATCTTGAAAATGAACTAGGACTTAAAATTAGCTTTGCTAAAAAGGAAATTACAGTGCAACAAGCTACACAGGA
AGACAAATCATATTTAGATTTTGAAAATTATAGTATGATAGTGGTGGTAAAAAACTATATATATCTAGATGATATGAGTC
TATTTCAGTACACTGAATCTAGACATAGGCCGGATAGATTTAAATTTGTAGAATTTGCAAGAAGAAAATAG

Upstream 100 bases:

>100_bases
CTATAGACTTTAGAAAAATTAATTTAAGACCTTATGAGTCTATAGTTTACCATCTTGAGAGAAAATAAAAAAAATGTTAA
AATGTTTCTGGTGATAAGAT

Downstream 100 bases:

>100_bases
TAATGCTTTTAATTTTATACTAATAGTTCAGAAAAGAAATTGCTTCATTAAGATAGGTTTATATTTGCGCCTTTAAAATA
AAATTAAATCATTTTATTTT

Product: trehalose operon repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MESKYLTIYNEISNKIENNKIQSGEKLSSENEMMKEYNVSRDTIRKALNLLESNGYIQKVKGKGSFVLDINKFDFPVSGL
TSFKELSTRMGVESNTLVKELKLIKSDNFLMKQLNLSKNDDVWKVIRVREIDNKKIILDKDFFNKKYVPLLTKDICENSI
YEYLENELGLKISFAKKEITVQQATQEDKSYLDFENYSMIVVVKNYIYLDDMSLFQYTESRHRPDRFKFVEFARRK

Sequences:

>Translated_236_residues
MESKYLTIYNEISNKIENNKIQSGEKLSSENEMMKEYNVSRDTIRKALNLLESNGYIQKVKGKGSFVLDINKFDFPVSGL
TSFKELSTRMGVESNTLVKELKLIKSDNFLMKQLNLSKNDDVWKVIRVREIDNKKIILDKDFFNKKYVPLLTKDICENSI
YEYLENELGLKISFAKKEITVQQATQEDKSYLDFENYSMIVVVKNYIYLDDMSLFQYTESRHRPDRFKFVEFARRK
>Mature_236_residues
MESKYLTIYNEISNKIENNKIQSGEKLSSENEMMKEYNVSRDTIRKALNLLESNGYIQKVKGKGSFVLDINKFDFPVSGL
TSFKELSTRMGVESNTLVKELKLIKSDNFLMKQLNLSKNDDVWKVIRVREIDNKKIILDKDFFNKKYVPLLTKDICENSI
YEYLENELGLKISFAKKEITVQQATQEDKSYLDFENYSMIVVVKNYIYLDDMSLFQYTESRHRPDRFKFVEFARRK

Specific function: Repressor for the trehalose operon (treP and treA). Binds trehalose-6-phosphate, which probably acts as an inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=232, Percent_Identity=28.8793103448276, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI87082252, Length=192, Percent_Identity=26.5625, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790540, Length=235, Percent_Identity=23.4042553191489, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790118, Length=147, Percent_Identity=27.891156462585, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788418, Length=226, Percent_Identity=19.9115044247788, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR012770
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27897; Mature: 27897

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESKYLTIYNEISNKIENNKIQSGEKLSSENEMMKEYNVSRDTIRKALNLLESNGYIQKV
CCCCEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEE
KGKGSFVLDINKFDFPVSGLTSFKELSTRMGVESNTLVKELKLIKSDNFLMKQLNLSKND
CCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCC
DVWKVIRVREIDNKKIILDKDFFNKKYVPLLTKDICENSIYEYLENELGLKISFAKKEIT
CCEEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHH
VQQATQEDKSYLDFENYSMIVVVKNYIYLDDMSLFQYTESRHRPDRFKFVEFARRK
HHHHHHHHHCCCCCCCCEEEEEEEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MESKYLTIYNEISNKIENNKIQSGEKLSSENEMMKEYNVSRDTIRKALNLLESNGYIQKV
CCCCEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEE
KGKGSFVLDINKFDFPVSGLTSFKELSTRMGVESNTLVKELKLIKSDNFLMKQLNLSKND
CCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCC
DVWKVIRVREIDNKKIILDKDFFNKKYVPLLTKDICENSIYEYLENELGLKISFAKKEIT
CCEEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHH
VQQATQEDKSYLDFENYSMIVVVKNYIYLDDMSLFQYTESRHRPDRFKFVEFARRK
HHHHHHHHHCCCCCCCCEEEEEEEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8917076; 8969503; 9384377; 7651129; 8755887 [H]