Click here to switch to the map view.

The map label for this gene is degU [H]

Identifier: 226225063

GI number: 226225063

Start: 2566579

End: 2567265

Strand: Reverse

Name: degU [H]

Synonym: Lm4b_02484

Alternate gene names: 226225063

Gene position: 2567265-2566579 (Counterclockwise)

Preceding gene: 226225067

Following gene: 226225062

Centisome position: 88.14

GC content: 37.99

Gene sequence:

>687_bases
ATGGCACTCAAAATCATGATTGTAGATGATCATCAGTTGTTTCGCGAAGGTATCAAGCGAATTTTAGAGTTGGAAGATTC
TTTTGAGGTCGTAGCGGAAGCTGAAAATGGTAAAAATATCGTAGCAAAAGTTCGCGAATATAAACCAGATATTGTTTTAA
TGGATATTAATATGCCAACTGTCAACGGACTAGATGCAACTGAAATGCTAGTACGTCAATTTCCTAGCATCAAAGTAATC
GTCTTGACTATTCATGATACAGATGAATATGTAACAGAAGCGCTTAGAGCTGGAGCAGTCGGTTATTTATTAAAAGAAAT
GGATGCCCATGAACTTGTAGAAGCTGTAAAAATTGTTGATAATGGAGGCGCGTATATTCATCCACGTGTAGCGATTAAAT
TAATTCGTGAATACCGCCATTTAGCAAGCACTAACACTTCTCAAGGTGTTTATGGCTACCAACAACCTGAAGTCAAAATG
CCACTACACATCTTAACGCATAGAGAGTGCGAGGTATTGCAACTTCTTACCGATGGAAAAAGTAACCGCGGAATTGGGGA
GACACTTTTCATTAGTGAAAAAACAGTAAAAAACCATGTAAGTAGTATTTTACAAAAAATGAAAGTGAATGATAGGACTC
AAGCGGTGGTAACGGCAATCAAGCACGGCTGGGTATATATTCGCTAA

Upstream 100 bases:

>100_bases
GGGATTATAAGGTTAAGCGGTTTTGCTACTTAAAAAGGATGATGTTTTCGATTGCAAAGAGGCTTGGTGAAATTAGATAA
GTGAAGGAGGAGTAGTCATT

Downstream 100 bases:

>100_bases
AGAAATATCAGGGGGACTATATGAACGAAAAAATAGCAGTGGTTACTGACAGCACAACTTATTTGCCAAATGAAGTGAAA
GAGCAGCTACGAATTAATGT

Product: two-component response regulator DegU

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MALKIMIVDDHQLFREGIKRILELEDSFEVVAEAENGKNIVAKVREYKPDIVLMDINMPTVNGLDATEMLVRQFPSIKVI
VLTIHDTDEYVTEALRAGAVGYLLKEMDAHELVEAVKIVDNGGAYIHPRVAIKLIREYRHLASTNTSQGVYGYQQPEVKM
PLHILTHRECEVLQLLTDGKSNRGIGETLFISEKTVKNHVSSILQKMKVNDRTQAVVTAIKHGWVYIR

Sequences:

>Translated_228_residues
MALKIMIVDDHQLFREGIKRILELEDSFEVVAEAENGKNIVAKVREYKPDIVLMDINMPTVNGLDATEMLVRQFPSIKVI
VLTIHDTDEYVTEALRAGAVGYLLKEMDAHELVEAVKIVDNGGAYIHPRVAIKLIREYRHLASTNTSQGVYGYQQPEVKM
PLHILTHRECEVLQLLTDGKSNRGIGETLFISEKTVKNHVSSILQKMKVNDRTQAVVTAIKHGWVYIR
>Mature_227_residues
ALKIMIVDDHQLFREGIKRILELEDSFEVVAEAENGKNIVAKVREYKPDIVLMDINMPTVNGLDATEMLVRQFPSIKVIV
LTIHDTDEYVTEALRAGAVGYLLKEMDAHELVEAVKIVDNGGAYIHPRVAIKLIREYRHLASTNTSQGVYGYQQPEVKMP
LHILTHRECEVLQLLTDGKSNRGIGETLFISEKTVKNHVSSILQKMKVNDRTQAVVTAIKHGWVYIR

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=220, Percent_Identity=35, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1788222, Length=222, Percent_Identity=32.4324324324324, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790102, Length=223, Percent_Identity=31.390134529148, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1787473, Length=226, Percent_Identity=32.3008849557522, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788712, Length=208, Percent_Identity=28.8461538461538, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786747, Length=222, Percent_Identity=24.7747747747748, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI87082052, Length=110, Percent_Identity=32.7272727272727, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1787277, Length=152, Percent_Identity=32.2368421052632, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788546, Length=213, Percent_Identity=25.3521126760563, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1786599, Length=236, Percent_Identity=27.1186440677966, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 25816; Mature: 25685

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2 ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKIMIVDDHQLFREGIKRILELEDSFEVVAEAENGKNIVAKVREYKPDIVLMDINMPT
CEEEEEEECCHHHHHHHHHHHHHCCCCHHEEEECCCCCHHHHHHHHCCCCEEEEECCCCC
VNGLDATEMLVRQFPSIKVIVLTIHDTDEYVTEALRAGAVGYLLKEMDAHELVEAVKIVD
CCCCCHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
NGGAYIHPRVAIKLIREYRHLASTNTSQGVYGYQQPEVKMPLHILTHRECEVLQLLTDGK
CCCCEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHEECCCCHHHHHHHHCCC
SNRGIGETLFISEKTVKNHVSSILQKMKVNDRTQAVVTAIKHGWVYIR
CCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEC
>Mature Secondary Structure 
ALKIMIVDDHQLFREGIKRILELEDSFEVVAEAENGKNIVAKVREYKPDIVLMDINMPT
EEEEEEECCHHHHHHHHHHHHHCCCCHHEEEECCCCCHHHHHHHHCCCCEEEEECCCCC
VNGLDATEMLVRQFPSIKVIVLTIHDTDEYVTEALRAGAVGYLLKEMDAHELVEAVKIVD
CCCCCHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
NGGAYIHPRVAIKLIREYRHLASTNTSQGVYGYQQPEVKMPLHILTHRECEVLQLLTDGK
CCCCEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHEECCCCHHHHHHHHCCC
SNRGIGETLFISEKTVKNHVSSILQKMKVNDRTQAVVTAIKHGWVYIR
CCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]