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The map label for this gene is trxB

Identifier: 226225026

GI number: 226225026

Start: 2526152

End: 2527111

Strand: Reverse

Name: trxB

Synonym: Lm4b_02447

Alternate gene names: 226225026

Gene position: 2527111-2526152 (Counterclockwise)

Preceding gene: 226225027

Following gene: 226225025

Centisome position: 86.76

GC content: 41.67

Gene sequence:

>960_bases
ATGGCTAGTGAAGAAAAAATTTATGATGTGATTATTATTGGAGCGGGACCAGCTGGAATGACAGCTGCTTTATATACTTC
CCGTGCAGATTTAGATACGTTAATGATTGAACGCGGTGTACCTGGTGGACAAATGGTTAACACAGCTGAGGTTGAAAATT
ACCCTGGATTTGATAGTATTTTAGGACCCGATTTATCCGATAAGATGCTTAGCGGTGCGAAACAATTTGGCGCTGAGTAT
GCTTATGGGGACATTAAAGAAGTCGTTGATGGCAAAGAATTTAAAACTGTAACGGCTGGATCGAAAACCTATAAAGCTCG
GGCGATTATTATTGCGACTGGTGCTGAACACCGGAAACTTGGTGCAGCTGGCGAAGAAGAGCTTAGTGGACGCGGCGTTT
CTTATTGTGCTGTTTGTGATGGAGCGTTCTTCAAAAATCGCGAATTAATCGTGGTTGGCGGCGGAGACTCTGCAGTGGAA
GAAGGAACTTATTTGACTCGTTATGCAGATAAAGTAACGATAGTACACCGTCGTGATAAATTGCGCGCACAACAAATTTT
ACAAGATCGTGCTTTCAAAGATGAAAAAGTTGATTTCATTTGGAATAGTACAGTAGAAGAAATTGTTGGCGATGGCAAAA
AAGTAACTGGAGCAAAACTTGTTTCCACAGTGGATGGTTCCGAATCTATTATGCCAGTGGATGGTGTTTTCATCTATGTT
GGACTTGTTCCACTTACGAAAGCATTCTTAAATTTAGGTATTACAGATGATGAAGGATACATCGTAACGGACGAGGAAAT
GCGTACAAACCTTCCTGGTATTTTTGCAGCTGGTGATGTTCGTGCGAAAAGCTTACGCCAAATTGTAACAGCAACAGGCG
ATGGCGGACTTGCTGGACAAAACGCTCAAAAATATGTAGAAGAATTAAAAGAGTCGCTAGAAGCAGAGGCAGCTAAATAA

Upstream 100 bases:

>100_bases
TGAGCGAGTTCTGAGCAGATAAATAGACCTTTTTGCTATTCCGTATTAGGATTAATTTAGGCTAACTATTGTATACACAT
AAACGAGGAGGGCAAAAAGA

Downstream 100 bases:

>100_bases
CAGTAAAGAAAACTCGAATGGGTCTGAGATTATTTATCTTAGACCCATTTTTGCGTGACTATATAGACTTGAGTAGTGTA
AAATGGAAGACAAAGACTAT

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MASEEKIYDVIIIGAGPAGMTAALYTSRADLDTLMIERGVPGGQMVNTAEVENYPGFDSILGPDLSDKMLSGAKQFGAEY
AYGDIKEVVDGKEFKTVTAGSKTYKARAIIIATGAEHRKLGAAGEEELSGRGVSYCAVCDGAFFKNRELIVVGGGDSAVE
EGTYLTRYADKVTIVHRRDKLRAQQILQDRAFKDEKVDFIWNSTVEEIVGDGKKVTGAKLVSTVDGSESIMPVDGVFIYV
GLVPLTKAFLNLGITDDEGYIVTDEEMRTNLPGIFAAGDVRAKSLRQIVTATGDGGLAGQNAQKYVEELKESLEAEAAK

Sequences:

>Translated_319_residues
MASEEKIYDVIIIGAGPAGMTAALYTSRADLDTLMIERGVPGGQMVNTAEVENYPGFDSILGPDLSDKMLSGAKQFGAEY
AYGDIKEVVDGKEFKTVTAGSKTYKARAIIIATGAEHRKLGAAGEEELSGRGVSYCAVCDGAFFKNRELIVVGGGDSAVE
EGTYLTRYADKVTIVHRRDKLRAQQILQDRAFKDEKVDFIWNSTVEEIVGDGKKVTGAKLVSTVDGSESIMPVDGVFIYV
GLVPLTKAFLNLGITDDEGYIVTDEEMRTNLPGIFAAGDVRAKSLRQIVTATGDGGLAGQNAQKYVEELKESLEAEAAK
>Mature_318_residues
ASEEKIYDVIIIGAGPAGMTAALYTSRADLDTLMIERGVPGGQMVNTAEVENYPGFDSILGPDLSDKMLSGAKQFGAEYA
YGDIKEVVDGKEFKTVTAGSKTYKARAIIIATGAEHRKLGAAGEEELSGRGVSYCAVCDGAFFKNRELIVVGGGDSAVEE
GTYLTRYADKVTIVHRRDKLRAQQILQDRAFKDEKVDFIWNSTVEEIVGDGKKVTGAKLVSTVDGSESIMPVDGVFIYVG
LVPLTKAFLNLGITDDEGYIVTDEEMRTNLPGIFAAGDVRAKSLRQIVTATGDGGLAGQNAQKYVEELKESLEAEAAK

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=331, Percent_Identity=24.4712990936556, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI226437568, Length=331, Percent_Identity=24.4712990936556, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI65787454, Length=331, Percent_Identity=24.4712990936556, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787114, Length=318, Percent_Identity=39.622641509434, Blast_Score=207, Evalue=6e-55,
Organism=Escherichia coli, GI87081763, Length=305, Percent_Identity=35.4098360655738, Blast_Score=164, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6320560, Length=314, Percent_Identity=40.4458598726115, Blast_Score=223, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6321898, Length=314, Percent_Identity=38.5350318471338, Blast_Score=194, Evalue=1e-50,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 34174; Mature: 34043

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASEEKIYDVIIIGAGPAGMTAALYTSRADLDTLMIERGVPGGQMVNTAEVENYPGFDSI
CCCCCCEEEEEEECCCCCCCEEHHHHCCCCHHHHHHHCCCCCCCEEEHHHCCCCCCCHHH
LGPDLSDKMLSGAKQFGAEYAYGDIKEVVDGKEFKTVTAGSKTYKARAIIIATGAEHRKL
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEECCCCCEEEEEEEEEECCCCCCC
GAAGEEELSGRGVSYCAVCDGAFFKNRELIVVGGGDSAVEEGTYLTRYADKVTIVHRRDK
CCCCCHHHCCCCCEEEEEECCCEECCCEEEEEECCCCHHHCCCEEEEECCEEEEEECHHH
LRAQQILQDRAFKDEKVDFIWNSTVEEIVGDGKKVTGAKLVSTVDGSESIMPVDGVFIYV
HHHHHHHHHHCCCCCCEEEEECCHHHHHHCCCCEECCHHHEEECCCCCCEECCCCEEEEH
GLVPLTKAFLNLGITDDEGYIVTDEEMRTNLPGIFAAGDVRAKSLRQIVTATGDGGLAGQ
HHHHHHHHHHHCCCCCCCCEEEECHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCC
NAQKYVEELKESLEAEAAK
CHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ASEEKIYDVIIIGAGPAGMTAALYTSRADLDTLMIERGVPGGQMVNTAEVENYPGFDSI
CCCCCEEEEEEECCCCCCCEEHHHHCCCCHHHHHHHCCCCCCCEEEHHHCCCCCCCHHH
LGPDLSDKMLSGAKQFGAEYAYGDIKEVVDGKEFKTVTAGSKTYKARAIIIATGAEHRKL
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEECCCCCEEEEEEEEEECCCCCCC
GAAGEEELSGRGVSYCAVCDGAFFKNRELIVVGGGDSAVEEGTYLTRYADKVTIVHRRDK
CCCCCHHHCCCCCEEEEEECCCEECCCEEEEEECCCCHHHCCCEEEEECCEEEEEECHHH
LRAQQILQDRAFKDEKVDFIWNSTVEEIVGDGKKVTGAKLVSTVDGSESIMPVDGVFIYV
HHHHHHHHHHCCCCCCEEEEECCHHHHHHCCCCEECCHHHEEECCCCCCEECCCCEEEEH
GLVPLTKAFLNLGITDDEGYIVTDEEMRTNLPGIFAAGDVRAKSLRQIVTATGDGGLAGQ
HHHHHHHHHHHCCCCCCCCEEEECHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCC
NAQKYVEELKESLEAEAAK
CHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]