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The map label for this gene is galE

Identifier: 226225025

GI number: 226225025

Start: 2525049

End: 2526032

Strand: Reverse

Name: galE

Synonym: Lm4b_02446

Alternate gene names: 226225025

Gene position: 2526032-2525049 (Counterclockwise)

Preceding gene: 226225026

Following gene: 226225024

Centisome position: 86.73

GC content: 39.13

Gene sequence:

>984_bases
ATGAGTATTGTTGTACTTGGTGGCGCTGGCTATATCGGTTCACATGCAGTAGATGAGTTAATTACTCGCGGATATGAAGT
AGTAGTTATTGATAATTTAAGAACAGGGCACAAGGAATCCATTCATACAAAGGCAAAATTTTATGAAGGAGATATTCGAG
ATAAGGCATTTTTAAGTTCAGTTTTTGAAAAAGAAAAGGTAGATGGTGTGATTCACTTTGCTGCTAGTTCACTTGTAGGA
GAATCGATGGAAGTACCGCTTGTTTATTTAAATAATAATGTTTATGGTACGCAAATTGTCTTAGAAGTGATGGAGCAATT
TGGTGTGAAGCATATTGTCTTTTCTTCTAGCGCTGCAACATATGGTGAGCCAGAACGAGTACCGATTACGGAAGATATGC
CAACAAATCCGGAAAGTACTTACGGCGAAACGAAGCTAATCATGGAAAAAATGATGAAATGGTGCGATAAAGCGTATGAT
ATGAAATATGTTGCACTCCGGTATTTTAATGTTGCTGGCGCCAAAGCGGATGGTTCAATTGGGGAAGATCACAAACCAGA
ATCACACTTAGTCCCAATTATTTTACAAGTTGCGCTTGGTCAACGAGAAAAATTAGCGATTTACGGTGACGACTACAATA
CGCCTGATGGTACTTGTATTCGTGATTATGTACAAGTAGAAGATTTAATTGACGCGCATATTAAAGCGCTAGAATACTTG
AAAAATGGCGGGGAAAGTAATATTTTCAACCTTGGTAGCAGTAACGGTTTTTCAGTGAAAGAAATGCTTGAAGCAGCTCG
TACTGTAACAGGTAAAGAAATTCCAGCTGAAGTTGTACCACGCCGTGCAGGAGATCCAGGAACGTTAATTGCTTCAAGTG
ATAAAGCGCGTGAAATTCTTGGTTGGGAGCCAACTTATACAGACGTAAAAGATATTATCGCCACTGCTTGGAAATGGCAC
GTATCTCATCCAAATGGCTATTAA

Upstream 100 bases:

>100_bases
GGGTCTGAGATTATTTATCTTAGACCCATTTTTGCGTGACTATATAGACTTGAGTAGTGTAAAATGGAAGACAAAGACTA
TTGTTAGGAGAGAGATAATA

Downstream 100 bases:

>100_bases
TAACTTATGAAGGAATGTGATTTTTATCGAAGTAATGAAGGAGCGATTTGGGGAGTTTGAGGGAGAAACTGTTTGGAAGT
GGACGATGGTAAATGATCAT

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MSIVVLGGAGYIGSHAVDELITRGYEVVVIDNLRTGHKESIHTKAKFYEGDIRDKAFLSSVFEKEKVDGVIHFAASSLVG
ESMEVPLVYLNNNVYGTQIVLEVMEQFGVKHIVFSSSAATYGEPERVPITEDMPTNPESTYGETKLIMEKMMKWCDKAYD
MKYVALRYFNVAGAKADGSIGEDHKPESHLVPIILQVALGQREKLAIYGDDYNTPDGTCIRDYVQVEDLIDAHIKALEYL
KNGGESNIFNLGSSNGFSVKEMLEAARTVTGKEIPAEVVPRRAGDPGTLIASSDKAREILGWEPTYTDVKDIIATAWKWH
VSHPNGY

Sequences:

>Translated_327_residues
MSIVVLGGAGYIGSHAVDELITRGYEVVVIDNLRTGHKESIHTKAKFYEGDIRDKAFLSSVFEKEKVDGVIHFAASSLVG
ESMEVPLVYLNNNVYGTQIVLEVMEQFGVKHIVFSSSAATYGEPERVPITEDMPTNPESTYGETKLIMEKMMKWCDKAYD
MKYVALRYFNVAGAKADGSIGEDHKPESHLVPIILQVALGQREKLAIYGDDYNTPDGTCIRDYVQVEDLIDAHIKALEYL
KNGGESNIFNLGSSNGFSVKEMLEAARTVTGKEIPAEVVPRRAGDPGTLIASSDKAREILGWEPTYTDVKDIIATAWKWH
VSHPNGY
>Mature_326_residues
SIVVLGGAGYIGSHAVDELITRGYEVVVIDNLRTGHKESIHTKAKFYEGDIRDKAFLSSVFEKEKVDGVIHFAASSLVGE
SMEVPLVYLNNNVYGTQIVLEVMEQFGVKHIVFSSSAATYGEPERVPITEDMPTNPESTYGETKLIMEKMMKWCDKAYDM
KYVALRYFNVAGAKADGSIGEDHKPESHLVPIILQVALGQREKLAIYGDDYNTPDGTCIRDYVQVEDLIDAHIKALEYLK
NGGESNIFNLGSSNGFSVKEMLEAARTVTGKEIPAEVVPRRAGDPGTLIASSDKAREILGWEPTYTDVKDIIATAWKWHV
SHPNGY

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=344, Percent_Identity=41.5697674418605, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI56118217, Length=344, Percent_Identity=41.5697674418605, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI189083684, Length=344, Percent_Identity=41.5697674418605, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI42516563, Length=312, Percent_Identity=27.2435897435897, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI7657641, Length=316, Percent_Identity=26.5822784810127, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI193211614, Length=240, Percent_Identity=27.0833333333333, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI8393516, Length=240, Percent_Identity=27.0833333333333, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786974, Length=337, Percent_Identity=39.7626112759644, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1788353, Length=366, Percent_Identity=26.775956284153, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI48994969, Length=345, Percent_Identity=28.4057971014493, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790049, Length=268, Percent_Identity=28.7313432835821, Blast_Score=74, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71982035, Length=346, Percent_Identity=39.5953757225434, Blast_Score=239, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71982038, Length=348, Percent_Identity=39.367816091954, Blast_Score=238, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17539532, Length=313, Percent_Identity=26.1980830670927, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI115532424, Length=349, Percent_Identity=25.214899713467, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17568069, Length=329, Percent_Identity=24.9240121580547, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6319493, Length=343, Percent_Identity=44.0233236151604, Blast_Score=261, Evalue=8e-71,
Organism=Saccharomyces cerevisiae, GI6321437, Length=341, Percent_Identity=25.8064516129032, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19923002, Length=344, Percent_Identity=41.5697674418605, Blast_Score=262, Evalue=2e-70,
Organism=Drosophila melanogaster, GI21356223, Length=314, Percent_Identity=26.4331210191083, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 36172; Mature: 36041

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIVVLGGAGYIGSHAVDELITRGYEVVVIDNLRTGHKESIHTKAKFYEGDIRDKAFLSS
CEEEEEECCCCCCHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHH
VFEKEKVDGVIHFAASSLVGESMEVPLVYLNNNVYGTQIVLEVMEQFGVKHIVFSSSAAT
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCEEEEEECCCCC
YGEPERVPITEDMPTNPESTYGETKLIMEKMMKWCDKAYDMKYVALRYFNVAGAKADGSI
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEHHCCCCCCCCC
GEDHKPESHLVPIILQVALGQREKLAIYGDDYNTPDGTCIRDYVQVEDLIDAHIKALEYL
CCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KNGGESNIFNLGSSNGFSVKEMLEAARTVTGKEIPAEVVPRRAGDPGTLIASSDKAREIL
HCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEEECCCCHHHHC
GWEPTYTDVKDIIATAWKWHVSHPNGY
CCCCCHHHHHHHHHHHHEEEECCCCCC
>Mature Secondary Structure 
SIVVLGGAGYIGSHAVDELITRGYEVVVIDNLRTGHKESIHTKAKFYEGDIRDKAFLSS
EEEEEECCCCCCHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHH
VFEKEKVDGVIHFAASSLVGESMEVPLVYLNNNVYGTQIVLEVMEQFGVKHIVFSSSAAT
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCEEEEEECCCCC
YGEPERVPITEDMPTNPESTYGETKLIMEKMMKWCDKAYDMKYVALRYFNVAGAKADGSI
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEHHCCCCCCCCC
GEDHKPESHLVPIILQVALGQREKLAIYGDDYNTPDGTCIRDYVQVEDLIDAHIKALEYL
CCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KNGGESNIFNLGSSNGFSVKEMLEAARTVTGKEIPAEVVPRRAGDPGTLIASSDKAREIL
HCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEEECCCCHHHHC
GWEPTYTDVKDIIATAWKWHVSHPNGY
CCCCCHHHHHHHHHHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9603808 [H]