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The map label for this gene is tcyL [H]

Identifier: 226224893

GI number: 226224893

Start: 2380136

End: 2380852

Strand: Reverse

Name: tcyL [H]

Synonym: Lm4b_02312

Alternate gene names: 226224893

Gene position: 2380852-2380136 (Counterclockwise)

Preceding gene: 226224894

Following gene: 226224892

Centisome position: 81.74

GC content: 39.19

Gene sequence:

>717_bases
ATGGATAAAGCGTTCGATGTAAAAATGATTGCTGATTTTATTCCAACGTTAGCTGGTTATTTACCGATTACGTTGTATAT
TTTGGCACTCTCGCTTATTTTTGGATTTATATTAGGCGTTCTACTATCTTTACCAAGAATTTATAAGATACCAGTTTTAG
ATCAATTGGTCAGAGTGTATATTTCGTTTTTCCGTGGGACGCCGATTATGGTTCAACTATTTATTGTTTTTTACGGAATC
CCGGCACTTTCAAGCATCGTTGGCATTGATTTATCACAAATGGATCCCCTTTATGCTGCGATTGCGACTTATGCGTTAAG
CAGTGCAGCGACCATTGCCGAAGTGATTCGCGCAGGCGTGAACAGCGTGGATGCCGGACAAGCAGAGGCGGCTTATAGTA
TTGGTCTGAGTAGTCGCCAAACGTTTTTACGAATCATCTTGCCACAAGCACTCTATCAAGCTCTACCGAATTTTGGCAAT
TTAGTCATTGGTTATTTGAAAGATACGTCGCTCGCTTTTTCGATTGGAGTAATGGATATGTCAGGAAGAGGTCAGACGCT
GATAACACTAAGTAATCACGCGCTAGAGGTCTATATTTCTTTATCTATTATTTACTATTTGACGGCCGTCTTACTGGAAT
ATTCCTTCAAATGGATTGAAAAACGAGTTAAAAAAGAAAACACCAGATTCACGAGTATTTTCGATATCGAGTTATAA

Upstream 100 bases:

>100_bases
ATCTATTATTGATGATGGAACACTAAAAAAATTAAGCGAAAAATGGCTTGGCGCAGATTATTCAAAAGAACAATATTAAA
CAAGGGAGGGTGCCATTAAA

Downstream 100 bases:

>100_bases
AGGAGAGATAATGATGCCGCTTGATGTGACTTTTATTGGAACCGCCGTAATGGCAATGTTAAAAACGATCCCGTTAACAC
TTGCGATGACTTTCTTTCCG

Product: amino acid ABC-transporter (permease)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MDKAFDVKMIADFIPTLAGYLPITLYILALSLIFGFILGVLLSLPRIYKIPVLDQLVRVYISFFRGTPIMVQLFIVFYGI
PALSSIVGIDLSQMDPLYAAIATYALSSAATIAEVIRAGVNSVDAGQAEAAYSIGLSSRQTFLRIILPQALYQALPNFGN
LVIGYLKDTSLAFSIGVMDMSGRGQTLITLSNHALEVYISLSIIYYLTAVLLEYSFKWIEKRVKKENTRFTSIFDIEL

Sequences:

>Translated_238_residues
MDKAFDVKMIADFIPTLAGYLPITLYILALSLIFGFILGVLLSLPRIYKIPVLDQLVRVYISFFRGTPIMVQLFIVFYGI
PALSSIVGIDLSQMDPLYAAIATYALSSAATIAEVIRAGVNSVDAGQAEAAYSIGLSSRQTFLRIILPQALYQALPNFGN
LVIGYLKDTSLAFSIGVMDMSGRGQTLITLSNHALEVYISLSIIYYLTAVLLEYSFKWIEKRVKKENTRFTSIFDIEL
>Mature_238_residues
MDKAFDVKMIADFIPTLAGYLPITLYILALSLIFGFILGVLLSLPRIYKIPVLDQLVRVYISFFRGTPIMVQLFIVFYGI
PALSSIVGIDLSQMDPLYAAIATYALSSAATIAEVIRAGVNSVDAGQAEAAYSIGLSSRQTFLRIILPQALYQALPNFGN
LVIGYLKDTSLAFSIGVMDMSGRGQTLITLSNHALEVYISLSIIYYLTAVLLEYSFKWIEKRVKKENTRFTSIFDIEL

Specific function: Part of the ABC transporter complex tcyJKLMN involved in L-cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable). Is also involved in cystathionine, djenkolate, and S-methylcysteine transport [H]

COG id: COG0765

COG function: function code E; ABC-type amino acid transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788226, Length=225, Percent_Identity=37.3333333333333, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1787030, Length=220, Percent_Identity=34.5454545454545, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1787086, Length=214, Percent_Identity=30.8411214953271, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87082239, Length=213, Percent_Identity=30.5164319248826, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786874, Length=210, Percent_Identity=26.6666666666667, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788645, Length=214, Percent_Identity=28.5046728971963, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1786873, Length=219, Percent_Identity=25.1141552511416, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1787087, Length=236, Percent_Identity=28.8135593220339, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788646, Length=162, Percent_Identity=28.3950617283951, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI48994930, Length=148, Percent_Identity=35.1351351351351, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26349; Mature: 26349

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKAFDVKMIADFIPTLAGYLPITLYILALSLIFGFILGVLLSLPRIYKIPVLDQLVRVY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECHHHHHHHHHH
ISFFRGTPIMVQLFIVFYGIPALSSIVGIDLSQMDPLYAAIATYALSSAATIAEVIRAGV
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
NSVDAGQAEAAYSIGLSSRQTFLRIILPQALYQALPNFGNLVIGYLKDTSLAFSIGVMDM
CCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEEEE
SGRGQTLITLSNHALEVYISLSIIYYLTAVLLEYSFKWIEKRVKKENTRFTSIFDIEL
CCCCCEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure
MDKAFDVKMIADFIPTLAGYLPITLYILALSLIFGFILGVLLSLPRIYKIPVLDQLVRVY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECHHHHHHHHHH
ISFFRGTPIMVQLFIVFYGIPALSSIVGIDLSQMDPLYAAIATYALSSAATIAEVIRAGV
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
NSVDAGQAEAAYSIGLSSRQTFLRIILPQALYQALPNFGNLVIGYLKDTSLAFSIGVMDM
CCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEEEE
SGRGQTLITLSNHALEVYISLSIIYYLTAVLLEYSFKWIEKRVKKENTRFTSIFDIEL
CCCCCEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]