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The map label for this gene is tcyM [H]

Identifier: 226224892

GI number: 226224892

Start: 2379415

End: 2380122

Strand: Reverse

Name: tcyM [H]

Synonym: Lm4b_02311

Alternate gene names: 226224892

Gene position: 2380122-2379415 (Counterclockwise)

Preceding gene: 226224893

Following gene: 226224891

Centisome position: 81.72

GC content: 41.38

Gene sequence:

>708_bases
ATGCCGCTTGATGTGACTTTTATTGGAACCGCCGTAATGGCAATGTTAAAAACGATCCCGTTAACACTTGCGATGACTTT
CTTTCCGATATTGTTCGGTTTCATTATCGCTATAGGTATGACGTTGATTCGGATGTATCATGTCCGATTTTTAGAACCGA
TAGCGAAGTTTTACGTTTCTTTTTTTCGAAGCACCCCAGCGATTCTGCATATTATGCTGATTTACCTAGGCATTCCCCTA
TTGGTGGATTTTTTGAGCAAATCATTCGGATTAGGCATTTCTGCAAACAAAATACCGGTCGTTATTTTTGTCATTATCGC
GCTGTCTTTCACGGCAGGAGCTTACTTAACCGAGATTTTGCGCTCCGGTATTATTGCGGTTGATATCGGACAAATGGAAG
CGGCTTACTCTGTGGGATATACGCATGGCCAAGCGATTCGAAAAGTGCTCTTACCGCAAGCCTTCATGATTGCCCTACCG
AATTTCACGAATTTGTGCATCGGATTTTTACATACCACATCCATCGCTGCCATCGTTGCAGTCCCAGAAATCACTGGAAT
GGCAACAATAGTAGCTTCCGACAATTACGCGTTTCTCGAAGCATTTATCGGTGCCGCACTCATTTATTGGTTTTTAACTA
TTTTGATTGAAGCGATTAATTATATTTTGGAAAAAAATATCGCTAAATATCGAGGAGGAACAGTATGA

Upstream 100 bases:

>100_bases
TTACTGGAATATTCCTTCAAATGGATTGAAAAACGAGTTAAAAAAGAAAACACCAGATTCACGAGTATTTTCGATATCGA
GTTATAAAGGAGAGATAATG

Downstream 100 bases:

>100_bases
TTACAATTAAAAATATTCAAAAAAGCTTTGGTGAAAACAAGGTTTTAAAAGGAATTGATTTAACGGTGAAAAAGGGTGAA
GTAGTAACAATACTTGGCCC

Product: amino acid ABC transporter (permease)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MPLDVTFIGTAVMAMLKTIPLTLAMTFFPILFGFIIAIGMTLIRMYHVRFLEPIAKFYVSFFRSTPAILHIMLIYLGIPL
LVDFLSKSFGLGISANKIPVVIFVIIALSFTAGAYLTEILRSGIIAVDIGQMEAAYSVGYTHGQAIRKVLLPQAFMIALP
NFTNLCIGFLHTTSIAAIVAVPEITGMATIVASDNYAFLEAFIGAALIYWFLTILIEAINYILEKNIAKYRGGTV

Sequences:

>Translated_235_residues
MPLDVTFIGTAVMAMLKTIPLTLAMTFFPILFGFIIAIGMTLIRMYHVRFLEPIAKFYVSFFRSTPAILHIMLIYLGIPL
LVDFLSKSFGLGISANKIPVVIFVIIALSFTAGAYLTEILRSGIIAVDIGQMEAAYSVGYTHGQAIRKVLLPQAFMIALP
NFTNLCIGFLHTTSIAAIVAVPEITGMATIVASDNYAFLEAFIGAALIYWFLTILIEAINYILEKNIAKYRGGTV
>Mature_234_residues
PLDVTFIGTAVMAMLKTIPLTLAMTFFPILFGFIIAIGMTLIRMYHVRFLEPIAKFYVSFFRSTPAILHIMLIYLGIPLL
VDFLSKSFGLGISANKIPVVIFVIIALSFTAGAYLTEILRSGIIAVDIGQMEAAYSVGYTHGQAIRKVLLPQAFMIALPN
FTNLCIGFLHTTSIAAIVAVPEITGMATIVASDNYAFLEAFIGAALIYWFLTILIEAINYILEKNIAKYRGGTV

Specific function: Part of the ABC transporter complex tcyJKLMN involved in L-cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable). Is also involved in cystathionine, djenkolate, and S-methylcysteine transport [H]

COG id: COG0765

COG function: function code E; ABC-type amino acid transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788226, Length=212, Percent_Identity=35.377358490566, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786873, Length=214, Percent_Identity=26.1682242990654, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1788645, Length=196, Percent_Identity=27.0408163265306, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788646, Length=220, Percent_Identity=24.5454545454545, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1787030, Length=227, Percent_Identity=23.3480176211454, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1786874, Length=210, Percent_Identity=24.7619047619048, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787087, Length=178, Percent_Identity=27.5280898876405, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI87082239, Length=206, Percent_Identity=27.1844660194175, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI48994930, Length=132, Percent_Identity=29.5454545454545, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 25759; Mature: 25628

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLDVTFIGTAVMAMLKTIPLTLAMTFFPILFGFIIAIGMTLIRMYHVRFLEPIAKFYVS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFRSTPAILHIMLIYLGIPLLVDFLSKSFGLGISANKIPVVIFVIIALSFTAGAYLTEIL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RSGIIAVDIGQMEAAYSVGYTHGQAIRKVLLPQAFMIALPNFTNLCIGFLHTTSIAAIVA
HCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VPEITGMATIVASDNYAFLEAFIGAALIYWFLTILIEAINYILEKNIAKYRGGTV
HHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PLDVTFIGTAVMAMLKTIPLTLAMTFFPILFGFIIAIGMTLIRMYHVRFLEPIAKFYVS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFRSTPAILHIMLIYLGIPLLVDFLSKSFGLGISANKIPVVIFVIIALSFTAGAYLTEIL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RSGIIAVDIGQMEAAYSVGYTHGQAIRKVLLPQAFMIALPNFTNLCIGFLHTTSIAAIVA
HCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VPEITGMATIVASDNYAFLEAFIGAALIYWFLTILIEAINYILEKNIAKYRGGTV
HHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]