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The map label for this gene is uvrA [H]

Identifier: 226224656

GI number: 226224656

Start: 2132047

End: 2134287

Strand: Direct

Name: uvrA [H]

Synonym: Lm4b_02071

Alternate gene names: 226224656

Gene position: 2132047-2134287 (Clockwise)

Preceding gene: 226224655

Following gene: 226224664

Centisome position: 73.2

GC content: 40.21

Gene sequence:

>2241_bases
ATGGTACAAGAATATATTCGATTAAGAGGAGCGCGTGAAAACAATCTCCAAAATATTTCCCTAGATATCCCCAAACGAAA
AATCACTATTTTTACTGGTGTATCTGGTTCCGGGAAATCTTCTATTGTATTTGAAACTATTGCCACGGAATCGCAAAGAC
AGTTAAACGAAACATACAGCGCCTATCTTCGTAATTTCCTTCCGAAGTATACGCAGCCGGACGCAGATTCAATTGAAAAC
CTCTCCACCTCTGTTATTATTGATCAAAAACGACTTGGCGGTAATTCCCGCTCCACCCTTGGTACCATCACGGATATTAA
TTCGATTTTGCGATTACTTTTCTCGCGTGTCGGCAAGCCTAGTATCGGGACAGCAAATTTATTTTCTTTTAACGACCCTG
CTGGTATGTGCCCTGATTGCCATGGTGTTGGACAAAAAGTTTCGGTTGATTTAGTCAAATTACTTGATCCAAATAAATCG
CTCAAAGAAGGCGCCATCTTATTTCCGACGTTTTCGGTAGATTCATGGTACTGGAATTCCTATGCTTATTCCGGCTTTTT
TGATGTGAATAAAAAAATAAAAGATTATACTGACGAAGAATACGATATGTTGTTACATGGGAAAGATATTAAAGTTTTCC
TAGAAACACCCATGGGAAGCATGAACGCTACATATGAAGGGTTGATTCCAAAATTCAATCGTTTGTATATTCAAAAAGAA
GGCGAAATGTCCGCCTCTACTAAAAAACGTGTCGATAAATTCACCCATATTGCGCCTTGTACAACTTGCGAAGGCACGAG
ACTCTCCGCGCAAGCATTATCTTGTACAATAAATGGTGCAAATATCGCCGACTTCACAGCGATGCAATTAGATGAATTAA
AAGCAACGATTGCGAGTATTGATGACCCTATCGCTGCTCCAATGGTCAAAAGTGTCACAGAGCGATTGCAACATTTGATT
GATATTGGTCTTGGTTATATGACACTTGACCGCCAAACTGCTTCTCTTTCTGGTGGTGAATCACAACGCGTCAAAATGAT
TCGTCATTTGAATAGTAGCTTAACTGACTTGCTTTATATTTTCGATGAACCAAGTATCGGTCTTCATCCACGAGATGTTC
ATCGACTCAATGAATTACTCGTGAAATTGCGCGACAAAGGAAATACGATTCTCGTGGTGGAACATGACCCAGATGTGATC
AAAATTGCCGACCATATTGTCGATGTCGGTCCGCACGCAGGAAAACATGGCGGTGAGATTCAGTTTGTCGGAAGTTACAC
CGATTTGCTGAAATCAGACACACTAACTGGCAAGTTCCTCAATCGCCATTTACCAATTAATAGCAAACCGAGACAACCAA
AAGGCTTTTTAACAACTGAAAAAAGTAGTCGCTTTAACCTAAAAGATATTCAGGCCAACATTCCAAAAGAAATTCTTACT
GTAGTAACTGGCGTGGCTGGTTCGGGTAAGAGTACCTTGATTCATTCTGTTTTCCTAAAAGAATATCCAGATGCGATAGT
GATCGACCAATCAGCCGCTCATGCCAATATTCGCTCTAATCCTGCCACCTATACTGGGATAATGGACCCGATTCGAAAAG
CATTTGGAAAAGAAAATGATGTCAGTCCATCACTCTTTAGTTACAATTCCAAAGGCGCCTGCGAAAACTGTAAAGGACTT
GGTTTCACAACTATGGATTTAGCTTTTATGGATTCGATTCGCACACCTTGCGAAGTATGTCACGGCAAGCGATTCCAAGA
TTCTGTTTTGCAATATAAGCTAAATGGTAAATCCATTAGCGATGTGTTAGAACTAACTGTCTCAGAAGCACTCGATTTCT
TTACGGATAAAAAAATCTTGAAGAAAATTGAGGCAATGGAAGAGGTTGGAATTGGTTATGTCACGCTTGGCCAAGCACTT
AGCACCTTATCAGGCGGTGAGTGCCAACGTTTAAAACTCGCCAATGAGCTTCATAAAAAAGGGTCGATTTATATTATGGA
TGAACCAACAACTGGTCTACACATGTCAGACATCGAACATATTTTGACGATTATCCACTCACTTGTAAATAAAGGAAATA
CCGTTATTGTAATTGAACATAATGTCGATATTATTCGTAACGCAGACTGGATTATCGACCTTGGCCCAGAAGGCGGAAGT
GCTGGCGGACAAATTATCTTCGAAGGCGCTCCCCTTGATTTACTTGAAAATAAACAATCATTAACTGCCAAATATCTTTA
A

Upstream 100 bases:

>100_bases
ACCAATTTTAACCTTGTAATCTTTACAAGGTTTTTGGTTGACTTTTATGGGGCTATTTTGCTAAGATGTTTGTCCGACTC
AAAAAACAGGAGGTATGTGT

Downstream 100 bases:

>100_bases
TGAAAAAAGCCGTTTTGTCTATAGCAGACAAAATGGCTTTTTTTATTGTAGTTTTTCTAAATAATCCACAGCATCTTGGA
AAGTTTTAACTGGAACGATT

Product: excinuclease ABC (subunit A)

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 746; Mature: 746

Protein sequence:

>746_residues
MVQEYIRLRGARENNLQNISLDIPKRKITIFTGVSGSGKSSIVFETIATESQRQLNETYSAYLRNFLPKYTQPDADSIEN
LSTSVIIDQKRLGGNSRSTLGTITDINSILRLLFSRVGKPSIGTANLFSFNDPAGMCPDCHGVGQKVSVDLVKLLDPNKS
LKEGAILFPTFSVDSWYWNSYAYSGFFDVNKKIKDYTDEEYDMLLHGKDIKVFLETPMGSMNATYEGLIPKFNRLYIQKE
GEMSASTKKRVDKFTHIAPCTTCEGTRLSAQALSCTINGANIADFTAMQLDELKATIASIDDPIAAPMVKSVTERLQHLI
DIGLGYMTLDRQTASLSGGESQRVKMIRHLNSSLTDLLYIFDEPSIGLHPRDVHRLNELLVKLRDKGNTILVVEHDPDVI
KIADHIVDVGPHAGKHGGEIQFVGSYTDLLKSDTLTGKFLNRHLPINSKPRQPKGFLTTEKSSRFNLKDIQANIPKEILT
VVTGVAGSGKSTLIHSVFLKEYPDAIVIDQSAAHANIRSNPATYTGIMDPIRKAFGKENDVSPSLFSYNSKGACENCKGL
GFTTMDLAFMDSIRTPCEVCHGKRFQDSVLQYKLNGKSISDVLELTVSEALDFFTDKKILKKIEAMEEVGIGYVTLGQAL
STLSGGECQRLKLANELHKKGSIYIMDEPTTGLHMSDIEHILTIIHSLVNKGNTVIVIEHNVDIIRNADWIIDLGPEGGS
AGGQIIFEGAPLDLLENKQSLTAKYL

Sequences:

>Translated_746_residues
MVQEYIRLRGARENNLQNISLDIPKRKITIFTGVSGSGKSSIVFETIATESQRQLNETYSAYLRNFLPKYTQPDADSIEN
LSTSVIIDQKRLGGNSRSTLGTITDINSILRLLFSRVGKPSIGTANLFSFNDPAGMCPDCHGVGQKVSVDLVKLLDPNKS
LKEGAILFPTFSVDSWYWNSYAYSGFFDVNKKIKDYTDEEYDMLLHGKDIKVFLETPMGSMNATYEGLIPKFNRLYIQKE
GEMSASTKKRVDKFTHIAPCTTCEGTRLSAQALSCTINGANIADFTAMQLDELKATIASIDDPIAAPMVKSVTERLQHLI
DIGLGYMTLDRQTASLSGGESQRVKMIRHLNSSLTDLLYIFDEPSIGLHPRDVHRLNELLVKLRDKGNTILVVEHDPDVI
KIADHIVDVGPHAGKHGGEIQFVGSYTDLLKSDTLTGKFLNRHLPINSKPRQPKGFLTTEKSSRFNLKDIQANIPKEILT
VVTGVAGSGKSTLIHSVFLKEYPDAIVIDQSAAHANIRSNPATYTGIMDPIRKAFGKENDVSPSLFSYNSKGACENCKGL
GFTTMDLAFMDSIRTPCEVCHGKRFQDSVLQYKLNGKSISDVLELTVSEALDFFTDKKILKKIEAMEEVGIGYVTLGQAL
STLSGGECQRLKLANELHKKGSIYIMDEPTTGLHMSDIEHILTIIHSLVNKGNTVIVIEHNVDIIRNADWIIDLGPEGGS
AGGQIIFEGAPLDLLENKQSLTAKYL
>Mature_746_residues
MVQEYIRLRGARENNLQNISLDIPKRKITIFTGVSGSGKSSIVFETIATESQRQLNETYSAYLRNFLPKYTQPDADSIEN
LSTSVIIDQKRLGGNSRSTLGTITDINSILRLLFSRVGKPSIGTANLFSFNDPAGMCPDCHGVGQKVSVDLVKLLDPNKS
LKEGAILFPTFSVDSWYWNSYAYSGFFDVNKKIKDYTDEEYDMLLHGKDIKVFLETPMGSMNATYEGLIPKFNRLYIQKE
GEMSASTKKRVDKFTHIAPCTTCEGTRLSAQALSCTINGANIADFTAMQLDELKATIASIDDPIAAPMVKSVTERLQHLI
DIGLGYMTLDRQTASLSGGESQRVKMIRHLNSSLTDLLYIFDEPSIGLHPRDVHRLNELLVKLRDKGNTILVVEHDPDVI
KIADHIVDVGPHAGKHGGEIQFVGSYTDLLKSDTLTGKFLNRHLPINSKPRQPKGFLTTEKSSRFNLKDIQANIPKEILT
VVTGVAGSGKSTLIHSVFLKEYPDAIVIDQSAAHANIRSNPATYTGIMDPIRKAFGKENDVSPSLFSYNSKGACENCKGL
GFTTMDLAFMDSIRTPCEVCHGKRFQDSVLQYKLNGKSISDVLELTVSEALDFFTDKKILKKIEAMEEVGIGYVTLGQAL
STLSGGECQRLKLANELHKKGSIYIMDEPTTGLHMSDIEHILTIIHSLVNKGNTVIVIEHNVDIIRNADWIIDLGPEGGS
AGGQIIFEGAPLDLLENKQSLTAKYL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=677, Percent_Identity=37.370753323486, Blast_Score=430, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 82337; Mature: 82337

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQEYIRLRGARENNLQNISLDIPKRKITIFTGVSGSGKSSIVFETIATESQRQLNETYS
CCCHHHHHCCCCCCCCCEEEEECCCEEEEEEECCCCCCCCCEEEEEHHCHHHHHHHHHHH
AYLRNFLPKYTQPDADSIENLSTSVIIDQKRLGGNSRSTLGTITDINSILRLLFSRVGKP
HHHHHHCCCCCCCCHHHHHCCCCEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
SIGTANLFSFNDPAGMCPDCHGVGQKVSVDLVKLLDPNKSLKEGAILFPTFSVDSWYWNS
CCCCCEEEECCCCCCCCCCCCCCCCCHHEHHHHHCCCCCCHHCCEEEEEEECCCCEEECC
YAYSGFFDVNKKIKDYTDEEYDMLLHGKDIKVFLETPMGSMNATYEGLIPKFNRLYIQKE
EEECCEEECCCHHHCCCCCCCEEEEECCCEEEEEECCCCCCCCCHHHCCCCCEEEEEEEC
GEMSASTKKRVDKFTHIAPCTTCEGTRLSAQALSCTINGANIADFTAMQLDELKATIASI
CCCCHHHHHHHHHHHCCCCCCCCCCCCEECEEEEEEECCCCCCHHHHHHHHHHHHHHHHC
DDPIAAPMVKSVTERLQHLIDIGLGYMTLDRQTASLSGGESQRVKMIRHLNSSLTDLLYI
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEEEE
FDEPSIGLHPRDVHRLNELLVKLRDKGNTILVVEHDPDVIKIADHIVDVGPHAGKHGGEI
ECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHHHCCCCCCCCCCEE
QFVGSYTDLLKSDTLTGKFLNRHLPINSKPRQPKGFLTTEKSSRFNLKDIQANIPKEILT
EEEECHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHCCHHHHHH
VVTGVAGSGKSTLIHSVFLKEYPDAIVIDQSAAHANIRSNPATYTGIMDPIRKAFGKEND
HHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
VSPSLFSYNSKGACENCKGLGFTTMDLAFMDSIRTPCEVCHGKRFQDSVLQYKLNGKSIS
CCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCHHCCHHEEEECCCCHH
DVLELTVSEALDFFTDKKILKKIEAMEEVGIGYVTLGQALSTLSGGECQRLKLANELHKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCCHHHHHHHHHHHHC
GSIYIMDEPTTGLHMSDIEHILTIIHSLVNKGNTVIVIEHNVDIIRNADWIIDLGPEGGS
CCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCEEEEECCCCCC
AGGQIIFEGAPLDLLENKQSLTAKYL
CCCEEEECCCCHHHHCCCHHHHCCCC
>Mature Secondary Structure
MVQEYIRLRGARENNLQNISLDIPKRKITIFTGVSGSGKSSIVFETIATESQRQLNETYS
CCCHHHHHCCCCCCCCCEEEEECCCEEEEEEECCCCCCCCCEEEEEHHCHHHHHHHHHHH
AYLRNFLPKYTQPDADSIENLSTSVIIDQKRLGGNSRSTLGTITDINSILRLLFSRVGKP
HHHHHHCCCCCCCCHHHHHCCCCEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
SIGTANLFSFNDPAGMCPDCHGVGQKVSVDLVKLLDPNKSLKEGAILFPTFSVDSWYWNS
CCCCCEEEECCCCCCCCCCCCCCCCCHHEHHHHHCCCCCCHHCCEEEEEEECCCCEEECC
YAYSGFFDVNKKIKDYTDEEYDMLLHGKDIKVFLETPMGSMNATYEGLIPKFNRLYIQKE
EEECCEEECCCHHHCCCCCCCEEEEECCCEEEEEECCCCCCCCCHHHCCCCCEEEEEEEC
GEMSASTKKRVDKFTHIAPCTTCEGTRLSAQALSCTINGANIADFTAMQLDELKATIASI
CCCCHHHHHHHHHHHCCCCCCCCCCCCEECEEEEEEECCCCCCHHHHHHHHHHHHHHHHC
DDPIAAPMVKSVTERLQHLIDIGLGYMTLDRQTASLSGGESQRVKMIRHLNSSLTDLLYI
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEEEE
FDEPSIGLHPRDVHRLNELLVKLRDKGNTILVVEHDPDVIKIADHIVDVGPHAGKHGGEI
ECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEHHHHHHHHCCCCCCCCCCEE
QFVGSYTDLLKSDTLTGKFLNRHLPINSKPRQPKGFLTTEKSSRFNLKDIQANIPKEILT
EEEECHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHCCHHHHHH
VVTGVAGSGKSTLIHSVFLKEYPDAIVIDQSAAHANIRSNPATYTGIMDPIRKAFGKEND
HHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
VSPSLFSYNSKGACENCKGLGFTTMDLAFMDSIRTPCEVCHGKRFQDSVLQYKLNGKSIS
CCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCHHCCHHEEEECCCCHH
DVLELTVSEALDFFTDKKILKKIEAMEEVGIGYVTLGQALSTLSGGECQRLKLANELHKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCCHHHHHHHHHHHHC
GSIYIMDEPTTGLHMSDIEHILTIIHSLVNKGNTVIVIEHNVDIIRNADWIIDLGPEGGS
CCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCEEEEECCCCCC
AGGQIIFEGAPLDLLENKQSLTAKYL
CCCEEEECCCCHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8675016 [H]