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The map label for this gene is ilvC

Identifier: 226224584

GI number: 226224584

Start: 2047255

End: 2048250

Strand: Direct

Name: ilvC

Synonym: Lm4b_01998

Alternate gene names: 226224584

Gene position: 2047255-2048250 (Clockwise)

Preceding gene: 226224583

Following gene: 226224585

Centisome position: 70.29

GC content: 41.16

Gene sequence:

>996_bases
ATGACAAAAGTTTATTATGAAGATGCAGTAAAAAACAACGCACTAGAAGGTAAAACAGTAGCAGTAATCGGGTACGGCTC
GCAAGGTCACGCACATTCTCAAAATCTACGTGACAATGGCAATAACGTTATTATCGGCATTCGCGAAGGAAAATCTGCCG
AATCTGCTAGAAACGATGGCTTTGATGTTTATTCTGTTAGCGAAGCCGCTGAAAAAGCAGACGTTATCATGATTCTTTTG
CCAGATGAAACGCAAGGTGAAACATACGAAAACGAAATTAAACCTAACCTAAAAGCTGGCAATGCGCTTGTTTTCGCACA
TGGTTTCAACATTCATTTTGACGTAATTAATCCTCCAAGCGATGTGGATGTTTTCCTAGTAGCTCCAAAAGGTCCTGGTC
ACTTAGTTCGCCGCACATTTGTTGAAGGTGGCGCGGTTCCTTCCCTATTCGCTATCTATCAAGATGCCACTGGAAACGCA
CGCGACACAGCCCTTTCCTATGCAAAAGGTATTGGCGCAACTCGTGCTGGCGTTATCGAAACCACTTTCAAAGAAGAAAC
CGAAACCGATCTATTTGGCGAACAAGCAGTTCTTTGTGGGGGTGCAACTCACCTTATCCAAGCTGGTTTTGAAACACTTG
TAGAGGCTGGCTACCAACCAGAACTTGCTTATTTTGAAGTATTACACGAAATGAAACTAATTGTTGATTTGATGTATGAA
GGCGGCATGGAAAAAATGCGCCACTCGATCTCCAATACAGCAGAATATGGTGATTATGTTTCCGGTCCTCGTGTTGTTAC
AGCTGATACGAAAAAAGCAATGAAAGAAGTACTTACCGACATTCAAAATGGTAACTTTGCTAAATCATTCATTGACGACA
ATAAAAATGGTTTTAAAGAATTCCATAGAATGCGCAAAGAACAACAAGGTCATCAAATCGAAAAAGTTGGTGCTGAACTT
CGTGAAATGATGCCGTTTGTTAAACCACAACATTAA

Upstream 100 bases:

>100_bases
AAAAATCATTTACTACAGAGCAGTCTCTTGCTTTGCTAGCATCAGAACAGCACATCGCTATTCTGAAATATAAAAAGAAA
TTAGTTGGAGGTTAGGAAAA

Downstream 100 bases:

>100_bases
TACTTAATTCGGATTGCTAGGTGAGATTTCTTGCCTAGCAACCGTTTATCCTTTTTCAATATGAGTTTAAGGAAGAACCT
CTTTCTTTCCTAAACTGATA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTKVYYEDAVKNNALEGKTVAVIGYGSQGHAHSQNLRDNGNNVIIGIREGKSAESARNDGFDVYSVSEAAEKADVIMILL
PDETQGETYENEIKPNLKAGNALVFAHGFNIHFDVINPPSDVDVFLVAPKGPGHLVRRTFVEGGAVPSLFAIYQDATGNA
RDTALSYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGGATHLIQAGFETLVEAGYQPELAYFEVLHEMKLIVDLMYE
GGMEKMRHSISNTAEYGDYVSGPRVVTADTKKAMKEVLTDIQNGNFAKSFIDDNKNGFKEFHRMRKEQQGHQIEKVGAEL
REMMPFVKPQH

Sequences:

>Translated_331_residues
MTKVYYEDAVKNNALEGKTVAVIGYGSQGHAHSQNLRDNGNNVIIGIREGKSAESARNDGFDVYSVSEAAEKADVIMILL
PDETQGETYENEIKPNLKAGNALVFAHGFNIHFDVINPPSDVDVFLVAPKGPGHLVRRTFVEGGAVPSLFAIYQDATGNA
RDTALSYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGGATHLIQAGFETLVEAGYQPELAYFEVLHEMKLIVDLMYE
GGMEKMRHSISNTAEYGDYVSGPRVVTADTKKAMKEVLTDIQNGNFAKSFIDDNKNGFKEFHRMRKEQQGHQIEKVGAEL
REMMPFVKPQH
>Mature_330_residues
TKVYYEDAVKNNALEGKTVAVIGYGSQGHAHSQNLRDNGNNVIIGIREGKSAESARNDGFDVYSVSEAAEKADVIMILLP
DETQGETYENEIKPNLKAGNALVFAHGFNIHFDVINPPSDVDVFLVAPKGPGHLVRRTFVEGGAVPSLFAIYQDATGNAR
DTALSYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGGATHLIQAGFETLVEAGYQPELAYFEVLHEMKLIVDLMYEG
GMEKMRHSISNTAEYGDYVSGPRVVTADTKKAMKEVLTDIQNGNFAKSFIDDNKNGFKEFHRMRKEQQGHQIEKVGAELR
EMMPFVKPQH

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=309, Percent_Identity=32.0388349514563, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323387, Length=324, Percent_Identity=37.6543209876543, Blast_Score=163, Evalue=4e-41,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_LISIN (Q92A29)

Other databases:

- EMBL:   AL596171
- PIR:   AC1694
- RefSeq:   NP_471427.1
- ProteinModelPortal:   Q92A29
- SMR:   Q92A29
- GeneID:   1130813
- GenomeReviews:   AL592022_GR
- KEGG:   lin:lin2093
- GenoList:   LIN2093
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   LINN272626:LIN2093-MONOMER
- BRENDA:   1.1.1.86
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36383; Mature: 36252

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVYYEDAVKNNALEGKTVAVIGYGSQGHAHSQNLRDNGNNVIIGIREGKSAESARNDG
CCEEEEHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCHHCCCC
FDVYSVSEAAEKADVIMILLPDETQGETYENEIKPNLKAGNALVFAHGFNIHFDVINPPS
CCEEEHHHHHCCCCEEEEEECCCCCCCCCHHHCCCCCCCCCEEEEEECCEEEEEECCCCC
DVDVFLVAPKGPGHLVRRTFVEGGAVPSLFAIYQDATGNARDTALSYAKGIGATRAGVIE
CCEEEEECCCCCCHHHHHHHHCCCCCHHHHHHEECCCCCHHHHHHHHHHCCCCCCCCCEE
TTFKEETETDLFGEQAVLCGGATHLIQAGFETLVEAGYQPELAYFEVLHEMKLIVDLMYE
HHHHHCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGMEKMRHSISNTAEYGDYVSGPRVVTADTKKAMKEVLTDIQNGNFAKSFIDDNKNGFKE
CCHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCCCEEHHHHCCCCHHHHH
FHRMRKEQQGHQIEKVGAELREMMPFVKPQH
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TKVYYEDAVKNNALEGKTVAVIGYGSQGHAHSQNLRDNGNNVIIGIREGKSAESARNDG
CEEEEHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCHHCCCC
FDVYSVSEAAEKADVIMILLPDETQGETYENEIKPNLKAGNALVFAHGFNIHFDVINPPS
CCEEEHHHHHCCCCEEEEEECCCCCCCCCHHHCCCCCCCCCEEEEEECCEEEEEECCCCC
DVDVFLVAPKGPGHLVRRTFVEGGAVPSLFAIYQDATGNARDTALSYAKGIGATRAGVIE
CCEEEEECCCCCCHHHHHHHHCCCCCHHHHHHEECCCCCHHHHHHHHHHCCCCCCCCCEE
TTFKEETETDLFGEQAVLCGGATHLIQAGFETLVEAGYQPELAYFEVLHEMKLIVDLMYE
HHHHHCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGMEKMRHSISNTAEYGDYVSGPRVVTADTKKAMKEVLTDIQNGNFAKSFIDDNKNGFKE
CCHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCCCEEHHHHCCCCHHHHH
FHRMRKEQQGHQIEKVGAELREMMPFVKPQH
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669