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The map label for this gene is gltC

Identifier: 226224338

GI number: 226224338

Start: 1791470

End: 1792357

Strand: Direct

Name: gltC

Synonym: Lm4b_01749

Alternate gene names: 226224338

Gene position: 1791470-1792357 (Clockwise)

Preceding gene: 226224335

Following gene: 226224352

Centisome position: 61.51

GC content: 40.43

Gene sequence:

>888_bases
ATGGAACTACGACAATTAAAGTATTTTATGGAAGTAGCCCGTGTCGAGCATATGACCAAAGCTAGTGAGAATTTACACGT
AGCCCAATCTGCCGTTAGTAGACAGATAACGAAACTCGAAGAAGAACTCGGCGTACATTTATTTGACCGTGTTGGAAGAA
ATATGCAACTCACCAGCGTTGGTCAAGATTTCTTAAAACAAGCAGCAATCGCCTTAAACGAGCTACAAAAAGCCGAAGCA
CTCGTGACCGAATATACCGATCCCGCAAAAGGAACTGTTCGCGTCGGCTTACCGAACTCCCTGTCTACCAAAGTGTTGCC
ATCCGTTATTTCGACCTTTCGGGAAAAATATCCGCAAATTACCTACCAGTTTATGGAAGGCACCAATGAAGAACTTACCG
AGATGCTCTTAAGCGGCGTCCTTGATATGACTTTTTTATCGCCCGTCCCAGAATCTAGCGAACAAATTGAAGCCATTCGT
TTTTTTGATGAAAAATTGAAGCTAATTGTCCCTAAAACCCATCCACTTGCTGAAAACTTCACCGTTTCACTAAAAGAGCT
CGCTTCCGAAAAGTTCGTACTTTATCCAGAAGACTTTGATTTATATAAAATCGTAACAAAAGCTGCCAATAAAAAAGGAT
TTGAGCCACAAATAGCATTTCAAAGTAGAGATTTTTATACAATTCAAGGACTTGTCGGAGCAGGTCTTGGTATTAGCATT
TTGCCAGAAATGATTTTAGATGGAGCGATTTTTAAGGAAACGAAAAGTATCGCTTTGCGTGATAAAGAATTGCGGCGTTC
GGTCGGGATTATTACGACAAAAAAACGGAACCTATCCCCTTCCGAGAATTTGTTCCGTTCGTTTATTATTTCGTTCTTTT
CGAATTAA

Upstream 100 bases:

>100_bases
TACATTTCTTGTAGTATCTATTTTATTCCTTTTCATTTATCGAAACAATATATATAATAGAATAAAACAATCTCATTTCG
AGAACAATTGGAGGTAAGAA

Downstream 100 bases:

>100_bases
TTATTTTCAGAAAATGCAGCTGGATAATGGATAGTTCCAGCTAAATTTTCTAAACTACCATCATATAATTCTAATAACAT
AAAGTATTCAGCAGGCACAT

Product: HTH-type transcriptional regulator gltC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MELRQLKYFMEVARVEHMTKASENLHVAQSAVSRQITKLEEELGVHLFDRVGRNMQLTSVGQDFLKQAAIALNELQKAEA
LVTEYTDPAKGTVRVGLPNSLSTKVLPSVISTFREKYPQITYQFMEGTNEELTEMLLSGVLDMTFLSPVPESSEQIEAIR
FFDEKLKLIVPKTHPLAENFTVSLKELASEKFVLYPEDFDLYKIVTKAANKKGFEPQIAFQSRDFYTIQGLVGAGLGISI
LPEMILDGAIFKETKSIALRDKELRRSVGIITTKKRNLSPSENLFRSFIISFFSN

Sequences:

>Translated_295_residues
MELRQLKYFMEVARVEHMTKASENLHVAQSAVSRQITKLEEELGVHLFDRVGRNMQLTSVGQDFLKQAAIALNELQKAEA
LVTEYTDPAKGTVRVGLPNSLSTKVLPSVISTFREKYPQITYQFMEGTNEELTEMLLSGVLDMTFLSPVPESSEQIEAIR
FFDEKLKLIVPKTHPLAENFTVSLKELASEKFVLYPEDFDLYKIVTKAANKKGFEPQIAFQSRDFYTIQGLVGAGLGISI
LPEMILDGAIFKETKSIALRDKELRRSVGIITTKKRNLSPSENLFRSFIISFFSN
>Mature_295_residues
MELRQLKYFMEVARVEHMTKASENLHVAQSAVSRQITKLEEELGVHLFDRVGRNMQLTSVGQDFLKQAAIALNELQKAEA
LVTEYTDPAKGTVRVGLPNSLSTKVLPSVISTFREKYPQITYQFMEGTNEELTEMLLSGVLDMTFLSPVPESSEQIEAIR
FFDEKLKLIVPKTHPLAENFTVSLKELASEKFVLYPEDFDLYKIVTKAANKKGFEPQIAFQSRDFYTIQGLVGAGLGISI
LPEMILDGAIFKETKSIALRDKELRRSVGIITTKKRNLSPSENLFRSFIISFFSN

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=275, Percent_Identity=31.6363636363636, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1787879, Length=301, Percent_Identity=30.8970099667774, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790399, Length=277, Percent_Identity=28.158844765343, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1787530, Length=251, Percent_Identity=27.8884462151394, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1788296, Length=243, Percent_Identity=29.6296296296296, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1788887, Length=244, Percent_Identity=29.5081967213115, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI145693105, Length=304, Percent_Identity=27.9605263157895, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788481, Length=288, Percent_Identity=28.8194444444444, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1787601, Length=247, Percent_Identity=26.3157894736842, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790262, Length=285, Percent_Identity=25.2631578947368, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788297, Length=303, Percent_Identity=25.0825082508251, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788748, Length=245, Percent_Identity=28.9795918367347, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1787806, Length=249, Percent_Identity=24.4979919678715, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI2367136, Length=258, Percent_Identity=23.6434108527132, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790208, Length=285, Percent_Identity=23.1578947368421, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87081904, Length=199, Percent_Identity=30.1507537688442, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1786401, Length=248, Percent_Identity=24.1935483870968, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI145693193, Length=299, Percent_Identity=22.742474916388, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789639, Length=248, Percent_Identity=21.7741935483871, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI48994962, Length=78, Percent_Identity=42.3076923076923, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789204, Length=252, Percent_Identity=21.031746031746, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33353; Mature: 33353

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRQLKYFMEVARVEHMTKASENLHVAQSAVSRQITKLEEELGVHLFDRVGRNMQLTSV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCEEHHH
GQDFLKQAAIALNELQKAEALVTEYTDPAKGTVRVGLPNSLSTKVLPSVISTFREKYPQI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
TYQFMEGTNEELTEMLLSGVLDMTFLSPVPESSEQIEAIRFFDEKLKLIVPKTHPLAENF
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEECCCCCCCHHHH
TVSLKELASEKFVLYPEDFDLYKIVTKAANKKGFEPQIAFQSRDFYTIQGLVGAGLGISI
HHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCCCEEECCCCCEEEHHHHHCCCCHHH
LPEMILDGAIFKETKSIALRDKELRRSVGIITTKKRNLSPSENLFRSFIISFFSN
HHHHHHCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELRQLKYFMEVARVEHMTKASENLHVAQSAVSRQITKLEEELGVHLFDRVGRNMQLTSV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCEEHHH
GQDFLKQAAIALNELQKAEALVTEYTDPAKGTVRVGLPNSLSTKVLPSVISTFREKYPQI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
TYQFMEGTNEELTEMLLSGVLDMTFLSPVPESSEQIEAIRFFDEKLKLIVPKTHPLAENF
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEECCCCCCCHHHH
TVSLKELASEKFVLYPEDFDLYKIVTKAANKKGFEPQIAFQSRDFYTIQGLVGAGLGISI
HHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCCCEEECCCCCEEEHHHHHCCCCHHH
LPEMILDGAIFKETKSIALRDKELRRSVGIITTKKRNLSPSENLFRSFIISFFSN
HHHHHHCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]