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The map label for this gene is ccpA

Identifier: 226224200

GI number: 226224200

Start: 1626571

End: 1627578

Strand: Reverse

Name: ccpA

Synonym: Lm4b_01610

Alternate gene names: 226224200

Gene position: 1627578-1626571 (Counterclockwise)

Preceding gene: 226224201

Following gene: 226224199

Centisome position: 55.88

GC content: 37.5

Gene sequence:

>1008_bases
ATGAATGTAACAATTTATGATGTTGCAAGAGAAGCGAATGTTTCTATGGCAACGGTATCTCGGGTAGTGAACGGCAATCC
GAATGTTAAACCAGTAACAAGAAAAAAAGTACTAGATGTTATTAATCAATTAGGGTATCGTCCTAATGCTGTAGCTAGAG
GTCTAGCGAGCAAACGTACAACTACAGTTGGTGTTATTATTCCAGATATTTCTAACGTGTTTTATGCAGAGCTTGCTCGT
GGGATTGAAGATATTGCGACAATGTATAAATACAACATTATCCTCAGCAATTCGGACGAAAATGAGGATAAAGAACTTCA
AGTACTTAACACGCTTCTTGGTAAACAAGTGGACGGAATTATTTACATGGGCGAACGTATTTCAGAACAATTACAAGAAG
AATTTGACCGTTCTCCAGCACCAGTAGTTTTAGCAGGAGCCGTTGATATGGAAAATAAATTTGCTTCTGTAAACATCGAT
TACAAACAAGCAACAAAAGAAGCGGTGAAACGTTTTGTAGATAATGGTCATAAGCAAATCGCTTTTGTAAGTGGTTCTCT
AAACGAGCCGGTCAATCGCGAAATGAAATTAGCTGGTTACAAAGAAGCATTAGAAGAAGCTGGAATTTCTTATCAAGAAG
ACTACATTATTGAAGCGAAATATAACTACAATGCAGGTGTAAAAGTTTGGGCAGAATTAAGTGCCTTGTCTAAAAAACCA
AATGCAGTGGTAGTTGCAGATGATGAACTAGCTATTGGTATTTTGAATGCCGCGCTTGATGTTGGAATCAAAGTCCCAGA
AGACTTAGAAGTAATGACAAGCAACAATACGAAATTAACATTAATGTCACGCCCGCAACTTTCGACAATCGTACAACCTT
TATACGATATCGGCGCCGTGGCTATGCGTCTACTAACAAAGTTGATGACGAGTGAAGAAGTAGATGAAAAAACAGTTATC
TTACCACATAGTGAAAAACTACGTGGTACGACTAAAGAAAAAAAATAA

Upstream 100 bases:

>100_bases
ATCGAAAAAAGTTATCGTATTATTAAAGGAAGGCTAGTTTGTTTACGTTTACAATGGTAGGTAGAGCCATTAAAATAATG
AATATGGAGAGTGAATAGAG

Downstream 100 bases:

>100_bases
GTTGACAGCATTTTTAACGGTATGTTATAAATGTATGTATACTTTTCATAACGAAAATGACTATGAACGGACGAAGTAGT
TGCTTATTCTTATTCCTAGA

Product: catabolite control protein A

Products: NA

Alternate protein names: Glucose-resistance amylase regulator [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MNVTIYDVAREANVSMATVSRVVNGNPNVKPVTRKKVLDVINQLGYRPNAVARGLASKRTTTVGVIIPDISNVFYAELAR
GIEDIATMYKYNIILSNSDENEDKELQVLNTLLGKQVDGIIYMGERISEQLQEEFDRSPAPVVLAGAVDMENKFASVNID
YKQATKEAVKRFVDNGHKQIAFVSGSLNEPVNREMKLAGYKEALEEAGISYQEDYIIEAKYNYNAGVKVWAELSALSKKP
NAVVVADDELAIGILNAALDVGIKVPEDLEVMTSNNTKLTLMSRPQLSTIVQPLYDIGAVAMRLLTKLMTSEEVDEKTVI
LPHSEKLRGTTKEKK

Sequences:

>Translated_335_residues
MNVTIYDVAREANVSMATVSRVVNGNPNVKPVTRKKVLDVINQLGYRPNAVARGLASKRTTTVGVIIPDISNVFYAELAR
GIEDIATMYKYNIILSNSDENEDKELQVLNTLLGKQVDGIIYMGERISEQLQEEFDRSPAPVVLAGAVDMENKFASVNID
YKQATKEAVKRFVDNGHKQIAFVSGSLNEPVNREMKLAGYKEALEEAGISYQEDYIIEAKYNYNAGVKVWAELSALSKKP
NAVVVADDELAIGILNAALDVGIKVPEDLEVMTSNNTKLTLMSRPQLSTIVQPLYDIGAVAMRLLTKLMTSEEVDEKTVI
LPHSEKLRGTTKEKK
>Mature_335_residues
MNVTIYDVAREANVSMATVSRVVNGNPNVKPVTRKKVLDVINQLGYRPNAVARGLASKRTTTVGVIIPDISNVFYAELAR
GIEDIATMYKYNIILSNSDENEDKELQVLNTLLGKQVDGIIYMGERISEQLQEEFDRSPAPVVLAGAVDMENKFASVNID
YKQATKEAVKRFVDNGHKQIAFVSGSLNEPVNREMKLAGYKEALEEAGISYQEDYIIEAKYNYNAGVKVWAELSALSKKP
NAVVVADDELAIGILNAALDVGIKVPEDLEVMTSNNTKLTLMSRPQLSTIVQPLYDIGAVAMRLLTKLMTSEEVDEKTVI
LPHSEKLRGTTKEKK

Specific function: Transcriptional regulator involved in both the repression of carbohydrate utilization genes such as the alpha- amylase (AmyE) and the acetyl-coenzyme A synthetase (AcsA); and in the positive regulation of genes involved in excretion of excess carbon such

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=329, Percent_Identity=33.1306990881459, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1790194, Length=319, Percent_Identity=29.4670846394984, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789068, Length=300, Percent_Identity=30.3333333333333, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1787948, Length=306, Percent_Identity=30.718954248366, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788474, Length=303, Percent_Identity=29.7029702970297, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1787580, Length=332, Percent_Identity=29.2168674698795, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1789202, Length=296, Percent_Identity=28.7162162162162, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI48994940, Length=309, Percent_Identity=24.5954692556634, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787906, Length=333, Percent_Identity=25.8258258258258, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1786540, Length=341, Percent_Identity=27.5659824046921, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786268, Length=290, Percent_Identity=27.2413793103448, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1789456, Length=350, Percent_Identity=26, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1790715, Length=326, Percent_Identity=24.5398773006135, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790689, Length=182, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006377
- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37012; Mature: 37012

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVTIYDVAREANVSMATVSRVVNGNPNVKPVTRKKVLDVINQLGYRPNAVARGLASKRT
CCEEEEEHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCC
TTVGVIIPDISNVFYAELARGIEDIATMYKYNIILSNSDENEDKELQVLNTLLGKQVDGI
EEEEEEECCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCCCE
IYMGERISEQLQEEFDRSPAPVVLAGAVDMENKFASVNIDYKQATKEAVKRFVDNGHKQI
EEECHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCEE
AFVSGSLNEPVNREMKLAGYKEALEEAGISYQEDYIIEAKYNYNAGVKVWAELSALSKKP
EEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCC
NAVVVADDELAIGILNAALDVGIKVPEDLEVMTSNNTKLTLMSRPQLSTIVQPLYDIGAV
CEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHH
AMRLLTKLMTSEEVDEKTVILPHSEKLRGTTKEKK
HHHHHHHHHHHCCCCCCEEECCCCHHHCCCCCCCC
>Mature Secondary Structure
MNVTIYDVAREANVSMATVSRVVNGNPNVKPVTRKKVLDVINQLGYRPNAVARGLASKRT
CCEEEEEHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCC
TTVGVIIPDISNVFYAELARGIEDIATMYKYNIILSNSDENEDKELQVLNTLLGKQVDGI
EEEEEEECCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCCCE
IYMGERISEQLQEEFDRSPAPVVLAGAVDMENKFASVNIDYKQATKEAVKRFVDNGHKQI
EEECHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCEE
AFVSGSLNEPVNREMKLAGYKEALEEAGISYQEDYIIEAKYNYNAGVKVWAELSALSKKP
EEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCC
NAVVVADDELAIGILNAALDVGIKVPEDLEVMTSNNTKLTLMSRPQLSTIVQPLYDIGAV
CEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHH
AMRLLTKLMTSEEVDEKTVILPHSEKLRGTTKEKK
HHHHHHHHHHHCCCCCCEEECCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1904524; 9387221; 9384377 [H]