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The map label for this gene is asd [H]

Identifier: 226224038

GI number: 226224038

Start: 1453136

End: 1454179

Strand: Reverse

Name: asd [H]

Synonym: Lm4b_01447

Alternate gene names: 226224038

Gene position: 1454179-1453136 (Counterclockwise)

Preceding gene: 226224039

Following gene: 226224037

Centisome position: 49.93

GC content: 38.89

Gene sequence:

>1044_bases
ATGACAAAAAGCTATCATGTCGCAGTTGTAGGTGCAACTGGTGCAGTTGGTACCCAAATGATTGAATTACTAGAAGAGGC
GGCGACTTTTAAGATAAAGCAAGTTTCATTCTTGTCTTCTATTCGTTCTGCTGGAAAAAAACTATCCTTCCGTGGTGAAG
AAGTAACTATTCAAGAAGCCACACCTGAAAGTTTTGAAGGCGTAGATATCGCTTTATTTAGCGCTGGTGGTTCTGTATCG
AAAGCACTTGCGAAAGAAGCAGTTAAACGTGGAGCTATCGTTATTGATAACACGAGTGCATATCGTATGGATCCAACAGT
TCCTTTAGTCGTTCCAGAAGTGAATGAAAAAGCACTTTTCTCACATAAGGGTATTATTGCTAATCCTAACTGTTCCACTA
TTCAGATGGTAGCAGCCCTCGAACCGATTCGAGAAGCATTCGGCTTAAATCGTATTATTGTTTCCACTTATCAAGCTGTT
TCTGGCTCTGGTGTAAGCGCGATTCAAGAATTAAAAGATGGTAGCAGAGCAGTTTTAGATAACAAAGAATTCACTCCACA
AATCATGCCCGTTAAAGGGGACAAAAAACATTATCCAATTGCTTTTAATGCATTGCCACAAATTGACGTTTTCACAGAGA
ATGACTATACATACGAAGAAATGAAAATGATCAATGAAACAAAAAAAATCATGGAAGACAACACAATAAAAGTTTCTGCT
ACGTGCGTTCGTATCCCAGTAGTTAGCGGACACTCTGAAAGTGTTTATATCGAAGTGGATAAAGAAGGCATAACTGCTAA
AGAAATCCAAAATGAACTAAAAAACGCACCTGGTATTGTCCTAGAAGATGACCCAGCAAATCAAGTTTACCCACAAGCTG
TTCAAGCTGCAGGTAAGAAGGAAGTCTTCGTTGGTCGTATTCGTGCTGACATTGACGATCCTAAAGGTTTTCATATGTGG
ATTGTTTCTGACAACTTACTAAAAGGTGCCGCATGGAATTCGATTCAAATAGCTGAAAGTTTAGTTAAACTAGCGATTAT
TTAG

Upstream 100 bases:

>100_bases
AAGGCTTTGTTTATGGTATGATAAAGTAAGTGTAAAATTAACCAGATTTCTGTTTTTAGGCAGGAATACGAGGATTAAAT
TGAAGGAGGAATTGTAAACT

Downstream 100 bases:

>100_bases
AGGTGTAAGTAATGAAAATTATTGTCCAAAAATTTGGCGGAACATCCGTACAAAATGAAAAATCACGTTTGATGGCATTC
AATCATATCAAACAAGTACT

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTKSYHVAVVGATGAVGTQMIELLEEAATFKIKQVSFLSSIRSAGKKLSFRGEEVTIQEATPESFEGVDIALFSAGGSVS
KALAKEAVKRGAIVIDNTSAYRMDPTVPLVVPEVNEKALFSHKGIIANPNCSTIQMVAALEPIREAFGLNRIIVSTYQAV
SGSGVSAIQELKDGSRAVLDNKEFTPQIMPVKGDKKHYPIAFNALPQIDVFTENDYTYEEMKMINETKKIMEDNTIKVSA
TCVRIPVVSGHSESVYIEVDKEGITAKEIQNELKNAPGIVLEDDPANQVYPQAVQAAGKKEVFVGRIRADIDDPKGFHMW
IVSDNLLKGAAWNSIQIAESLVKLAII

Sequences:

>Translated_347_residues
MTKSYHVAVVGATGAVGTQMIELLEEAATFKIKQVSFLSSIRSAGKKLSFRGEEVTIQEATPESFEGVDIALFSAGGSVS
KALAKEAVKRGAIVIDNTSAYRMDPTVPLVVPEVNEKALFSHKGIIANPNCSTIQMVAALEPIREAFGLNRIIVSTYQAV
SGSGVSAIQELKDGSRAVLDNKEFTPQIMPVKGDKKHYPIAFNALPQIDVFTENDYTYEEMKMINETKKIMEDNTIKVSA
TCVRIPVVSGHSESVYIEVDKEGITAKEIQNELKNAPGIVLEDDPANQVYPQAVQAAGKKEVFVGRIRADIDDPKGFHMW
IVSDNLLKGAAWNSIQIAESLVKLAII
>Mature_346_residues
TKSYHVAVVGATGAVGTQMIELLEEAATFKIKQVSFLSSIRSAGKKLSFRGEEVTIQEATPESFEGVDIALFSAGGSVSK
ALAKEAVKRGAIVIDNTSAYRMDPTVPLVVPEVNEKALFSHKGIIANPNCSTIQMVAALEPIREAFGLNRIIVSTYQAVS
GSGVSAIQELKDGSRAVLDNKEFTPQIMPVKGDKKHYPIAFNALPQIDVFTENDYTYEEMKMINETKKIMEDNTIKVSAT
CVRIPVVSGHSESVYIEVDKEGITAKEIQNELKNAPGIVLEDDPANQVYPQAVQAAGKKEVFVGRIRADIDDPKGFHMWI
VSDNLLKGAAWNSIQIAESLVKLAII

Specific function: Unknown

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788658, Length=348, Percent_Identity=32.4712643678161, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1789841, Length=359, Percent_Identity=25.9052924791086, Blast_Score=83, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320362, Length=401, Percent_Identity=28.927680798005, Blast_Score=105, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR012080
- InterPro:   IPR005986
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 37700; Mature: 37568

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSYHVAVVGATGAVGTQMIELLEEAATFKIKQVSFLSSIRSAGKKLSFRGEEVTIQEA
CCCCEEEEEEECCCHHHHHHHHHHHHHHHEEHHHHHHHHHHHHCCCEEECCCCEEEEECC
TPESFEGVDIALFSAGGSVSKALAKEAVKRGAIVIDNTSAYRMDPTVPLVVPEVNEKALF
CCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCEEECCCCEEEECCCCCHHHH
SHKGIIANPNCSTIQMVAALEPIREAFGLNRIIVSTYQAVSGSGVSAIQELKDGSRAVLD
HCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHCCCCHHHHHHHCCCCEEEEC
NKEFTPQIMPVKGDKKHYPIAFNALPQIDVFTENDYTYEEMKMINETKKIMEDNTIKVSA
CCCCCCEEEECCCCCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEE
TCVRIPVVSGHSESVYIEVDKEGITAKEIQNELKNAPGIVLEDDPANQVYPQAVQAAGKK
EEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHCCCC
EVFVGRIRADIDDPKGFHMWIVSDNLLKGAAWNSIQIAESLVKLAII
CEEEEEEECCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKSYHVAVVGATGAVGTQMIELLEEAATFKIKQVSFLSSIRSAGKKLSFRGEEVTIQEA
CCCEEEEEEECCCHHHHHHHHHHHHHHHEEHHHHHHHHHHHHCCCEEECCCCEEEEECC
TPESFEGVDIALFSAGGSVSKALAKEAVKRGAIVIDNTSAYRMDPTVPLVVPEVNEKALF
CCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCEEECCCCEEEECCCCCHHHH
SHKGIIANPNCSTIQMVAALEPIREAFGLNRIIVSTYQAVSGSGVSAIQELKDGSRAVLD
HCCCEEECCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHCCCCHHHHHHHCCCCEEEEC
NKEFTPQIMPVKGDKKHYPIAFNALPQIDVFTENDYTYEEMKMINETKKIMEDNTIKVSA
CCCCCCEEEECCCCCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEE
TCVRIPVVSGHSESVYIEVDKEGITAKEIQNELKNAPGIVLEDDPANQVYPQAVQAAGKK
EEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHCCCC
EVFVGRIRADIDDPKGFHMWIVSDNLLKGAAWNSIQIAESLVKLAII
CEEEEEEECCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8098035; 9384377; 8345520 [H]