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The map label for this gene is yfmO [H]

Identifier: 226224010

GI number: 226224010

Start: 1423131

End: 1424324

Strand: Direct

Name: yfmO [H]

Synonym: Lm4b_01418

Alternate gene names: 226224010

Gene position: 1423131-1424324 (Clockwise)

Preceding gene: 226224008

Following gene: 226224011

Centisome position: 48.86

GC content: 36.6

Gene sequence:

>1194_bases
ATGATGACAGACAAGGAAATGAATACGGGGAAATGGATAACAGCAGCAGCTAGTTTGCTTGCGTTTATGGGAATAGGGGT
TGTTGATCCACTTTTACCTTCTATTGCAGAAAGTATTGGGGCATCTCACTCGCAAGTAGAAATGTTATTCACCGCTTATA
TTTTTACTATGGCGATTATGATGATTCCGATTGGTATTGTTGCCGGAAAGCTTGGAGATAAAAAGTTAATCGTTATCGGA
CTATTTATTGTTACTATTTTTGCATTATTATGTGGTTTATCTGATACAATTGGTGCTTTATCTATTTTTCGGGCTGGTTG
GGGTTTTGGTAACTCTATGTTCATGGCTACTGCGATGACAATGCTTATTGCTTTATCAGAGACACCAGGACATGCAATTG
GGATTTACGAAGCTTCCATGGGCCTTGGGATGGCATTTGGACCACTACTAGGAGGTATTCTAGGTAATATTTCTTGGCGC
TATCCATTTTTTGCGACAGCTTGTCTAATTTTTATCGCATTTTTACTTATTTTATTTAAAGTAAAAGAACCGAAGAAAGT
CGCACCAGCACCTACAGAGAAAAATGAGGTTGCTATCAAGCAAATGCTCCATTTATTCAAATATCGACCATTTTTACAAA
TCGCTTTTAGTGGAATGTTTTATTATTATTGTTTCTTTACAATTTTAGCTTATTCGCCACTTATTCTTGGATTATCAGCA
ATTCAAATTGGTTTTGTATTTTTTGCTTGGGGATTATGTTTGGCGTTGGGTTCGGCAAAAATTTCACATGCGTTGGAGTT
TCGTTTTAATAGCAAACAAATCTTAAAAGGATCTTTACTGGCATGTGCTGTTATCTTAGCATTACTTGGATTTATTGATA
ATATAGCTGTAGATATAGGTTTGATTGTTATTTCTGGCTTGATTTTAGGAATCAATAACGCACTATTTACAACCACTGTT
ATGGAACATTCACCGTATGCAAGAAGTGTGACTAGTGGAGCATATAATTTTGTGCGTTGGTTAGGTGCTGCGTTTGCGCC
ACTTTGTTCTGGGTTACTCAGCGAAGCGCTTGGTATGAAAATGCCATTTATCGTAGCGAGCGTCATTTGTTTGGCAGGCA
TGGGATTACTATTTATTAAACTAAAACCATCACATTTTACCTTACAACAATCTACTTCTATAGAAAGTGAATAA

Upstream 100 bases:

>100_bases
TATATATGTAATAAATTATATATGTAAATATTGACATTAGTATTTATCAAGCGTAATATAATAATTGAGTTTTATTTAGA
AAGGGAAGTGTAGTTGTATT

Downstream 100 bases:

>100_bases
AATAATAAAGAGACTGAGTAATCCGGCTCAGTCTTTTTTTATGCTAAAAGTTAATTATTTAATGATTATCGTTAAAAATT
ATTGACATTTTATCTTTCTT

Product: multidrug-efflux transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MMTDKEMNTGKWITAAASLLAFMGIGVVDPLLPSIAESIGASHSQVEMLFTAYIFTMAIMMIPIGIVAGKLGDKKLIVIG
LFIVTIFALLCGLSDTIGALSIFRAGWGFGNSMFMATAMTMLIALSETPGHAIGIYEASMGLGMAFGPLLGGILGNISWR
YPFFATACLIFIAFLLILFKVKEPKKVAPAPTEKNEVAIKQMLHLFKYRPFLQIAFSGMFYYYCFFTILAYSPLILGLSA
IQIGFVFFAWGLCLALGSAKISHALEFRFNSKQILKGSLLACAVILALLGFIDNIAVDIGLIVISGLILGINNALFTTTV
MEHSPYARSVTSGAYNFVRWLGAAFAPLCSGLLSEALGMKMPFIVASVICLAGMGLLFIKLKPSHFTLQQSTSIESE

Sequences:

>Translated_397_residues
MMTDKEMNTGKWITAAASLLAFMGIGVVDPLLPSIAESIGASHSQVEMLFTAYIFTMAIMMIPIGIVAGKLGDKKLIVIG
LFIVTIFALLCGLSDTIGALSIFRAGWGFGNSMFMATAMTMLIALSETPGHAIGIYEASMGLGMAFGPLLGGILGNISWR
YPFFATACLIFIAFLLILFKVKEPKKVAPAPTEKNEVAIKQMLHLFKYRPFLQIAFSGMFYYYCFFTILAYSPLILGLSA
IQIGFVFFAWGLCLALGSAKISHALEFRFNSKQILKGSLLACAVILALLGFIDNIAVDIGLIVISGLILGINNALFTTTV
MEHSPYARSVTSGAYNFVRWLGAAFAPLCSGLLSEALGMKMPFIVASVICLAGMGLLFIKLKPSHFTLQQSTSIESE
>Mature_397_residues
MMTDKEMNTGKWITAAASLLAFMGIGVVDPLLPSIAESIGASHSQVEMLFTAYIFTMAIMMIPIGIVAGKLGDKKLIVIG
LFIVTIFALLCGLSDTIGALSIFRAGWGFGNSMFMATAMTMLIALSETPGHAIGIYEASMGLGMAFGPLLGGILGNISWR
YPFFATACLIFIAFLLILFKVKEPKKVAPAPTEKNEVAIKQMLHLFKYRPFLQIAFSGMFYYYCFFTILAYSPLILGLSA
IQIGFVFFAWGLCLALGSAKISHALEFRFNSKQILKGSLLACAVILALLGFIDNIAVDIGLIVISGLILGINNALFTTTV
MEHSPYARSVTSGAYNFVRWLGAAFAPLCSGLLSEALGMKMPFIVASVICLAGMGLLFIKLKPSHFTLQQSTSIESE

Specific function: Acts to efflux copper or a copper complex. It is possible that yfmO could contribute to copper resistance [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42786; Mature: 42786

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTDKEMNTGKWITAAASLLAFMGIGVVDPLLPSIAESIGASHSQVEMLFTAYIFTMAIM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
MIPIGIVAGKLGDKKLIVIGLFIVTIFALLCGLSDTIGALSIFRAGWGFGNSMFMATAMT
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
MLIALSETPGHAIGIYEASMGLGMAFGPLLGGILGNISWRYPFFATACLIFIAFLLILFK
HHHHHCCCCCCEEEEEEHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
VKEPKKVAPAPTEKNEVAIKQMLHLFKYRPFLQIAFSGMFYYYCFFTILAYSPLILGLSA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQIGFVFFAWGLCLALGSAKISHALEFRFNSKQILKGSLLACAVILALLGFIDNIAVDIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIVISGLILGINNALFTTTVMEHSPYARSVTSGAYNFVRWLGAAFAPLCSGLLSEALGMK
HHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MPFIVASVICLAGMGLLFIKLKPSHFTLQQSTSIESE
CHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCCCCC
>Mature Secondary Structure
MMTDKEMNTGKWITAAASLLAFMGIGVVDPLLPSIAESIGASHSQVEMLFTAYIFTMAIM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
MIPIGIVAGKLGDKKLIVIGLFIVTIFALLCGLSDTIGALSIFRAGWGFGNSMFMATAMT
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
MLIALSETPGHAIGIYEASMGLGMAFGPLLGGILGNISWRYPFFATACLIFIAFLLILFK
HHHHHCCCCCCEEEEEEHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
VKEPKKVAPAPTEKNEVAIKQMLHLFKYRPFLQIAFSGMFYYYCFFTILAYSPLILGLSA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQIGFVFFAWGLCLALGSAKISHALEFRFNSKQILKGSLLACAVILALLGFIDNIAVDIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIVISGLILGINNALFTTTVMEHSPYARSVTSGAYNFVRWLGAAFAPLCSGLLSEALGMK
HHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MPFIVASVICLAGMGLLFIKLKPSHFTLQQSTSIESE
CHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]