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The map label for this gene is iolR [H]

Identifier: 226223007

GI number: 226223007

Start: 407091

End: 407852

Strand: Reverse

Name: iolR [H]

Synonym: Lm4b_00400

Alternate gene names: 226223007

Gene position: 407852-407091 (Counterclockwise)

Preceding gene: 226223014

Following gene: 226223003

Centisome position: 14.0

GC content: 40.81

Gene sequence:

>762_bases
ATGAAAGTACAACGCATTCAAGCGATTGAGAATTTAATTCACGAAAAAGGCAGTATTAGCCTCGACGATTTATGCGAACA
ATTCAATGTTTCCAAAAATACCGTTCGCCGAGACATTGCCAAACTTCTCCAAAAAAACACCATCCAAAAAGTCTATGGTG
GCGTCGTTTCTGTTTATAATAATCCCGAAGAAATTCGGCCGTTCGAAAATCGTGATACAGAAAATCACACAGAAAAACAG
CTTATCGGAAAAGCGGCGGCTGATTTTATTGAAGAAAATGATTTGATTTTTATTGATTCCGGCACAACGACTAGCTGTCT
CGCTGCGGCTCTGCCAACGGATAAGGATATTACTATTATTACGAACAGCCTAGATGTGATTAATTTTGCGAGTGAAATGG
ATAATGTGAAATTGATTGTTATTGGCTCGACTTTTAAAACGAGTACTAAATCATTTGTTGGCGTGGAGAATTGGGGATTT
TTTGAGAAATATAATATTACGAAAGCTTTTATGGCCGCAACTGCGCTGTCTACTACGCACGGGGTGATGAATTCGGATAT
TTTGGAGTATGAGATTAAGCGCCATATGATGGAAAAAGCGACGGAGAAATTTTTGCTGGTGGATCATACGAAGGTGGATA
AGTCGGCTTTGCTTACATACGGGGAGTTGGCGGAATTTGATTGGTTGGTTACGTCGAAGGACATGGCTGGTGGGTGTTTG
GGGTATTGTGAGGATGTTGGGGTTTTGGTGAGGTTGGTTTAG

Upstream 100 bases:

>100_bases
TTGTCACTAACTTCACCATAAAAAATCATAGTTGATTACCTTTTGAGCATGTGTTATAAATAGTGTAATTAAAATAATTT
TGCCAAAGGATGAATTTAAA

Downstream 100 bases:

>100_bases
TTTGTGTGATGAAAGAAGCCCCATTTGATGAAATGGGACTTCTTTTTATATTCACAAACTCTGAACTTTATTTTAATAAT
TTTTCCAAAAAAACGAATTT

Product: transcription repressor of myo-inositol catabolism operon IolR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MKVQRIQAIENLIHEKGSISLDDLCEQFNVSKNTVRRDIAKLLQKNTIQKVYGGVVSVYNNPEEIRPFENRDTENHTEKQ
LIGKAAADFIEENDLIFIDSGTTTSCLAAALPTDKDITIITNSLDVINFASEMDNVKLIVIGSTFKTSTKSFVGVENWGF
FEKYNITKAFMAATALSTTHGVMNSDILEYEIKRHMMEKATEKFLLVDHTKVDKSALLTYGELAEFDWLVTSKDMAGGCL
GYCEDVGVLVRLV

Sequences:

>Translated_253_residues
MKVQRIQAIENLIHEKGSISLDDLCEQFNVSKNTVRRDIAKLLQKNTIQKVYGGVVSVYNNPEEIRPFENRDTENHTEKQ
LIGKAAADFIEENDLIFIDSGTTTSCLAAALPTDKDITIITNSLDVINFASEMDNVKLIVIGSTFKTSTKSFVGVENWGF
FEKYNITKAFMAATALSTTHGVMNSDILEYEIKRHMMEKATEKFLLVDHTKVDKSALLTYGELAEFDWLVTSKDMAGGCL
GYCEDVGVLVRLV
>Mature_253_residues
MKVQRIQAIENLIHEKGSISLDDLCEQFNVSKNTVRRDIAKLLQKNTIQKVYGGVVSVYNNPEEIRPFENRDTENHTEKQ
LIGKAAADFIEENDLIFIDSGTTTSCLAAALPTDKDITIITNSLDVINFASEMDNVKLIVIGSTFKTSTKSFVGVENWGF
FEKYNITKAFMAATALSTTHGVMNSDILEYEIKRHMMEKATEKFLLVDHTKVDKSALLTYGELAEFDWLVTSKDMAGGCL
GYCEDVGVLVRLV

Specific function: Iol operon repressor [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788069, Length=241, Percent_Identity=28.6307053941909, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789059, Length=229, Percent_Identity=31.0043668122271, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1789829, Length=233, Percent_Identity=26.6094420600858, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI87082344, Length=223, Percent_Identity=31.8385650224215, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI226510968, Length=234, Percent_Identity=29.0598290598291, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1789519, Length=251, Percent_Identity=26.2948207171315, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790635, Length=250, Percent_Identity=25.6, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1789170, Length=232, Percent_Identity=25.8620689655172, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1787540, Length=250, Percent_Identity=23.2, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790753, Length=217, Percent_Identity=24.4239631336406, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787063, Length=234, Percent_Identity=23.9316239316239, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28292; Mature: 28292

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVQRIQAIENLIHEKGSISLDDLCEQFNVSKNTVRRDIAKLLQKNTIQKVYGGVVSVYN
CCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECC
NPEEIRPFENRDTENHTEKQLIGKAAADFIEENDLIFIDSGTTTSCLAAALPTDKDITII
CHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCCEEEE
TNSLDVINFASEMDNVKLIVIGSTFKTSTKSFVGVENWGFFEKYNITKAFMAATALSTTH
ECCCHHHHHHHHCCCEEEEEEECCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHH
GVMNSDILEYEIKRHMMEKATEKFLLVDHTKVDKSALLTYGELAEFDWLVTSKDMAGGCL
CCCCCHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHEEEEECCCCCCHHH
GYCEDVGVLVRLV
HHHHHHHHHHCCC
>Mature Secondary Structure
MKVQRIQAIENLIHEKGSISLDDLCEQFNVSKNTVRRDIAKLLQKNTIQKVYGGVVSVYN
CCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECC
NPEEIRPFENRDTENHTEKQLIGKAAADFIEENDLIFIDSGTTTSCLAAALPTDKDITII
CHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCCEEEE
TNSLDVINFASEMDNVKLIVIGSTFKTSTKSFVGVENWGFFEKYNITKAFMAATALSTTH
ECCCHHHHHHHHCCCEEEEEEECCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHH
GVMNSDILEYEIKRHMMEKATEKFLLVDHTKVDKSALLTYGELAEFDWLVTSKDMAGGCL
CCCCCHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHEEEEECCCCCCHHH
GYCEDVGVLVRLV
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377 [H]