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The map label for this gene is mutX

Identifier: 225858954

GI number: 225858954

Start: 1131927

End: 1132391

Strand: Reverse

Name: mutX

Synonym: SP70585_1219

Alternate gene names: 225858954

Gene position: 1132391-1131927 (Counterclockwise)

Preceding gene: 225858955

Following gene: 225858953

Centisome position: 51.83

GC content: 44.73

Gene sequence:

>465_bases
ATGCCTCAGTTAGCGACGATTTGCTACATTGATAATGGGAAAGAACTGCTCATGCTCCATCGTAATAAGAAACCCAATGA
TGTCCATGAAGGGAAATGGATTGGTGTGGGTGGTAAGCTAGAGAGAGGAGAGACGCCCCAGGAATGCGCGGCGCGTGAAA
TCCTTGAAGAAACAGGGCTCAAAGCCAAGCCAGTTCTAAAAGGTGTCATCACTTTTCCTGAATTTACACCAGATTTAGAC
TGGTACACCTATGTTTTTAAGGTGACGGAGTTTGAGGGCGACTTGATTGACTGCAATGAGGGGACGCTAGAATGGGTTCC
CTATGACGAGGTTTTGAGCAAGCCGACTTGGGAAGGTGACCACACCTTTGTTGAGTGGCTTTTAGAGGATAAACCCTTCT
TTTCAGCTAAGTTTGTTTATGATGGGGATAAATTGTTGGATACCCAAGTTGATTTCTATGAATAA

Upstream 100 bases:

>100_bases
TTATAGAGGATTTTGGGGTTCCAAGCCCTTTTCCAAGGCCAATGCATTCTTAAAAGAGACAGGACAAGAGCCAATCGATT
GGCTTAGATAAGGAGAAAAT

Downstream 100 bases:

>100_bases
AGGAGAAAGCAGATGCTACTAATCAAAAATGGTCGTGTAATGGATCCTAAGTCTGGTTTGGATCAAGTTTGTGATGTCTT
AGTTCAAGATGGGAAAATTA

Product: mutator MutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (dGTP pyrophosphohydrolase)

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MPQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGETPQECAAREILEETGLKAKPVLKGVITFPEFTPDLD
WYTYVFKVTEFEGDLIDCNEGTLEWVPYDEVLSKPTWEGDHTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE

Sequences:

>Translated_154_residues
MPQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGETPQECAAREILEETGLKAKPVLKGVITFPEFTPDLD
WYTYVFKVTEFEGDLIDCNEGTLEWVPYDEVLSKPTWEGDHTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE
>Mature_153_residues
PQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGETPQECAAREILEETGLKAKPVLKGVITFPEFTPDLDW
YTYVFKVTEFEGDLIDCNEGTLEWVPYDEVLSKPTWEGDHTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE

Specific function: Involved in the DNA repair system to avoid A.T to G.C transversions. Degrades 8-oxo-dGTP to the monophosphate, but is also active on all of the nucleoside triphosphates

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTX_STRPN (P41354)

Other databases:

- EMBL:   Z21702
- EMBL:   AE005672
- PIR:   D95135
- PIR:   F98003
- PIR:   S41532
- RefSeq:   NP_345637.1
- ProteinModelPortal:   P41354
- SMR:   P41354
- IntAct:   P41354
- EnsemblBacteria:   EBSTRT00000026182
- GeneID:   931682
- GenomeReviews:   AE005672_GR
- KEGG:   spn:SP_1168
- TIGR:   SP_1168
- GeneTree:   EBGT00050000027101
- HOGENOM:   HBG404367
- OMA:   PYTPIVA
- ProtClustDB:   CLSK877140
- BioCyc:   SPNE170187-1:SP_1168-MONOMER
- InterPro:   IPR003562
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR01402
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: NA

Molecular weight: Translated: 17812; Mature: 17681

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGETPQECAAREILEETGL
CCCEEEEEEEECCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCC
KAKPVLKGVITFPEFTPDLDWYTYVFKVTEFEGDLIDCNEGTLEWVPYDEVLSKPTWEGD
CCCCHHEEEEECCCCCCCCCEEEEEEEEEECCCCEEECCCCEEEEECHHHHHCCCCCCCC
HTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE
HHHEEEECCCCCCEEEEEEECCCEEECCCCCCCC
>Mature Secondary Structure 
PQLATICYIDNGKELLMLHRNKKPNDVHEGKWIGVGGKLERGETPQECAAREILEETGL
CCEEEEEEEECCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCC
KAKPVLKGVITFPEFTPDLDWYTYVFKVTEFEGDLIDCNEGTLEWVPYDEVLSKPTWEGD
CCCCHHEEEEECCCCCCCCCEEEEEEEEEECCCCEEECCCCEEEEECHHHHHCCCCCCCC
HTFVEWLLEDKPFFSAKFVYDGDKLLDTQVDFYE
HHHEEEECCCCCCEEEEEEECCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8170394; 11463916; 8163538