Click here to switch to the map view.

The map label for this gene is pyrC

Identifier: 225858953

GI number: 225858953

Start: 1130646

End: 1131914

Strand: Reverse

Name: pyrC

Synonym: SP70585_1218

Alternate gene names: 225858953

Gene position: 1131914-1130646 (Counterclockwise)

Preceding gene: 225858954

Following gene: 225858952

Centisome position: 51.81

GC content: 43.5

Gene sequence:

>1269_bases
ATGCTACTAATCAAAAATGGTCGTGTAATGGATCCTAAGTCTGGTTTGGATCAAGTTTGTGATGTCTTAGTTCAAGATGG
GAAAATTATCAAAATTGCGCCTGAGATCACGGAAGAAGGAGCAGAAACGATTGATGCTACTGGTCTTGTGGTTGCTCCTG
GTTTGGTCGATATTCATGTGCATTTCCGTGAACCTGGTCAAACACATAAAGAAGACATTCATACTGGTACCCTGGCAGCC
GCTGCAGGTGGTTTTACTACTGTCGTCATGATGGCTAATACCAGTCCAACCATTTCAGACGTGGAGACTTTGCAAGCAGT
TCTCCAGTCAGCTGCCAAAGAGAAGATTAATGTCAAGACAGTTGCGACCATTACTAAAAACTTTAATGGTAAAAACTTGA
CTGACTTTAAGGCGCTCTTAGAAGCTGGTGCGGTTGGTTTCTCTGATGACGGTATTCCGCTTGAGAGCAGTAAGATTGTC
AAGGAAGCCATGGAGGAAGCCAAAAAACTCAATACCTTTATCAGCCTTCATGAGGAAGATCCAGGTTTGAACGGTGTTCT
TGGCTTTAATGAAAATATTGCTAGAGAACATTTCCATATCTGCGGTGCTACTGGAGTGGCTGAGTACGCTATGATGGCGC
GTGATGTCATGATTGCCTATGCAACTAAAGCCCATGTTCACATCCAGCATTTGTCTAAGGAAGAAAGTGTTAAAGTAGTG
GAGTTTGCTCAGGGGTTAGGTGCAGAAGTCACAGCAGAAGTAGCACCACAGCATTTCTCTAAGACAGAAGCACTTCTTTT
AACACAAGGTAGCAATGCTAAGATGAATCCACCGCTTCGTTTGGAATCAGACCGTCGTGCCGTTATCGAAGGTCTCAAAT
CAGGTGTCATCACAGTTATTGCGACTGACCACGCGCCTCATCATGTAGATGAAAAAAATGTTGAAGATATTACCAAAGCG
CCATCTGGTATGACTGGCTTAGAAACATCCCTGTCTCTCGGCTTGACCTATTTGGTAGAAGCTGGTGAGTTGAGCTTGAT
GGAATTACTTGAAAAAATGACATACAACCCAGCCAAGCTTTACAACTTTAAAGCAGGTTACTTGGCTGAGAATGGTCCAG
CAGATATCACTATTTTTGATGCCAAGGCTGACCGCCTTGTGGACTCCCATTTTGCTTCCAAAGCAGCTAATTCACCATTC
ATCGGTGAAACCTTAAAAGGGCAGGTTAAATATACCATCTGTAAGGGACAAATCGTCTATCAAGCTTGA

Upstream 100 bases:

>100_bases
GCTTTTAGAGGATAAACCCTTCTTTTCAGCTAAGTTTGTTTATGATGGGGATAAATTGTTGGATACCCAAGTTGATTTCT
ATGAATAAAGGAGAAAGCAG

Downstream 100 bases:

>100_bases
TAGGAGTTAGAATATGAATTATTTTCGAAAACGTAGGGAGAGACAAGCGAAATCTAATAGTGGAATTTACTGTCCCGCAG
CTAATCGTTCCAAAATTCAA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MLLIKNGRVMDPKSGLDQVCDVLVQDGKIIKIAPEITEEGAETIDATGLVVAPGLVDIHVHFREPGQTHKEDIHTGTLAA
AAGGFTTVVMMANTSPTISDVETLQAVLQSAAKEKINVKTVATITKNFNGKNLTDFKALLEAGAVGFSDDGIPLESSKIV
KEAMEEAKKLNTFISLHEEDPGLNGVLGFNENIAREHFHICGATGVAEYAMMARDVMIAYATKAHVHIQHLSKEESVKVV
EFAQGLGAEVTAEVAPQHFSKTEALLLTQGSNAKMNPPLRLESDRRAVIEGLKSGVITVIATDHAPHHVDEKNVEDITKA
PSGMTGLETSLSLGLTYLVEAGELSLMELLEKMTYNPAKLYNFKAGYLAENGPADITIFDAKADRLVDSHFASKAANSPF
IGETLKGQVKYTICKGQIVYQA

Sequences:

>Translated_422_residues
MLLIKNGRVMDPKSGLDQVCDVLVQDGKIIKIAPEITEEGAETIDATGLVVAPGLVDIHVHFREPGQTHKEDIHTGTLAA
AAGGFTTVVMMANTSPTISDVETLQAVLQSAAKEKINVKTVATITKNFNGKNLTDFKALLEAGAVGFSDDGIPLESSKIV
KEAMEEAKKLNTFISLHEEDPGLNGVLGFNENIAREHFHICGATGVAEYAMMARDVMIAYATKAHVHIQHLSKEESVKVV
EFAQGLGAEVTAEVAPQHFSKTEALLLTQGSNAKMNPPLRLESDRRAVIEGLKSGVITVIATDHAPHHVDEKNVEDITKA
PSGMTGLETSLSLGLTYLVEAGELSLMELLEKMTYNPAKLYNFKAGYLAENGPADITIFDAKADRLVDSHFASKAANSPF
IGETLKGQVKYTICKGQIVYQA
>Mature_422_residues
MLLIKNGRVMDPKSGLDQVCDVLVQDGKIIKIAPEITEEGAETIDATGLVVAPGLVDIHVHFREPGQTHKEDIHTGTLAA
AAGGFTTVVMMANTSPTISDVETLQAVLQSAAKEKINVKTVATITKNFNGKNLTDFKALLEAGAVGFSDDGIPLESSKIV
KEAMEEAKKLNTFISLHEEDPGLNGVLGFNENIAREHFHICGATGVAEYAMMARDVMIAYATKAHVHIQHLSKEESVKVV
EFAQGLGAEVTAEVAPQHFSKTEALLLTQGSNAKMNPPLRLESDRRAVIEGLKSGVITVIATDHAPHHVDEKNVEDITKA
PSGMTGLETSLSLGLTYLVEAGELSLMELLEKMTYNPAKLYNFKAGYLAENGPADITIFDAKADRLVDSHFASKAANSPF
IGETLKGQVKYTICKGQIVYQA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=376, Percent_Identity=32.9787234042553, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI4503375, Length=455, Percent_Identity=25.7142857142857, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4503051, Length=462, Percent_Identity=24.2424242424242, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI62422571, Length=464, Percent_Identity=24.5689655172414, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1786722, Length=438, Percent_Identity=28.7671232876712, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI87082175, Length=455, Percent_Identity=26.3736263736264, Blast_Score=118, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI193204318, Length=380, Percent_Identity=30.7894736842105, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI86575075, Length=444, Percent_Identity=25.6756756756757, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17539558, Length=464, Percent_Identity=27.1551724137931, Blast_Score=105, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6322218, Length=428, Percent_Identity=29.4392523364486, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24642586, Length=388, Percent_Identity=29.3814432989691, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17137462, Length=441, Percent_Identity=24.9433106575964, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI18859883, Length=418, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI221377917, Length=456, Percent_Identity=25.219298245614, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45330; Mature: 45330

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIKNGRVMDPKSGLDQVCDVLVQDGKIIKIAPEITEEGAETIDATGLVVAPGLVDIHV
CEEECCCCEECCCCCHHHHHHHHHCCCCEEEECCHHHHCCHHHCCCCCEEEECCEEEEEE
HFREPGQTHKEDIHTGTLAAAAGGFTTVVMMANTSPTISDVETLQAVLQSAAKEKINVKT
EECCCCCCHHHHCCCCHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEE
VATITKNFNGKNLTDFKALLEAGAVGFSDDGIPLESSKIVKEAMEEAKKLNTFISLHEED
EEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCC
PGLNGVLGFNENIAREHFHICGATGVAEYAMMARDVMIAYATKAHVHIQHLSKEESVKVV
CCCCEEECCCCCHHHHHHEEECCHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCCCHHH
EFAQGLGAEVTAEVAPQHFSKTEALLLTQGSNAKMNPPLRLESDRRAVIEGLKSGVITVI
HHHCCCCCCEEHHHCHHHCCCCCEEEEECCCCCCCCCCEEECCCHHHHHHHHCCCEEEEE
ATDHAPHHVDEKNVEDITKAPSGMTGLETSLSLGLTYLVEAGELSLMELLEKMTYNPAKL
EECCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHCEEEEEECCCHHHHHHHHHHCCCCHHE
YNFKAGYLAENGPADITIFDAKADRLVDSHFASKAANSPFIGETLKGQVKYTICKGQIVY
EEECCCCEECCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECEEEE
QA
EC
>Mature Secondary Structure
MLLIKNGRVMDPKSGLDQVCDVLVQDGKIIKIAPEITEEGAETIDATGLVVAPGLVDIHV
CEEECCCCEECCCCCHHHHHHHHHCCCCEEEECCHHHHCCHHHCCCCCEEEECCEEEEEE
HFREPGQTHKEDIHTGTLAAAAGGFTTVVMMANTSPTISDVETLQAVLQSAAKEKINVKT
EECCCCCCHHHHCCCCHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEE
VATITKNFNGKNLTDFKALLEAGAVGFSDDGIPLESSKIVKEAMEEAKKLNTFISLHEED
EEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCC
PGLNGVLGFNENIAREHFHICGATGVAEYAMMARDVMIAYATKAHVHIQHLSKEESVKVV
CCCCEEECCCCCHHHHHHEEECCHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCCCHHH
EFAQGLGAEVTAEVAPQHFSKTEALLLTQGSNAKMNPPLRLESDRRAVIEGLKSGVITVI
HHHCCCCCCEEHHHCHHHCCCCCEEEEECCCCCCCCCCEEECCCHHHHHHHHCCCEEEEE
ATDHAPHHVDEKNVEDITKAPSGMTGLETSLSLGLTYLVEAGELSLMELLEKMTYNPAKL
EECCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHCEEEEEECCCHHHHHHHHHHCCCCHHE
YNFKAGYLAENGPADITIFDAKADRLVDSHFASKAANSPFIGETLKGQVKYTICKGQIVY
EEECCCCEECCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECEEEE
QA
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]