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The map label for this gene is purK [H]

Identifier: 225853197

GI number: 225853197

Start: 1698711

End: 1699799

Strand: Direct

Name: purK [H]

Synonym: BMEA_A1797

Alternate gene names: 225853197

Gene position: 1698711-1699799 (Clockwise)

Preceding gene: 225853196

Following gene: 225853198

Centisome position: 79.91

GC content: 59.87

Gene sequence:

>1089_bases
ATGGACAAGACATCTCTCAAGCCCGGCTCCACCATCGGCATTATCGGCGGGGGCCAGCTTGGCCGTATGCTCGCCATGGC
AGCGGCGCGCTTCGGTTATGAAACCATAATCCTTGAGCCGCAGGCCGGTTGCCCGGCAGCACAGGTTGCCAATCGCCAGA
TTGTCGCCGCCTATGATGACCCGAAGGCGCTGGCCGAACTTGCCGCCGCTTCCGACGTCATCACCTATGAATTTGAAAAT
GTGCCAGTCAGCGCCGCCGACAAGCTGGCTGAAACGGCGCTTGTTCTGCCCCCGCCCGCCGCACTGGAAATCTCTCAGGA
CCGCTTCACAGAAAAGCAGTTTCTCAACGAAAGCGGCATTGAAACCGCGCCCTGGCGGCTCGTGGATGACGAGGAAACGC
TCATCGCCGCGCTCGGCGCACTGGGCGGGCGTGGCATCCTCAAGACACGGCGTCTGGGTTATGACGGCAAGGGGCAGGTG
CGCCTTGCCTCCCTCGATGAAACCCAGGCCTGCAACGCTTTTGCAGCCATCAACAAGGCGCCTGCGATTCTCGAAGGCTT
CGTGGAATTCGAGCGCGAAGTCTCCGTCATCGCCGCGCGCGATCGCAGCGGCAATGTCGCCATCTTCGATCTTGCGGAAA
ACGTCCACAAGGATGGCATTCTCGCCACGTCCACAGTGCCTGCCGCGATCAGCGTACAGACGGCAGAAGCCGCGCGCACA
GCCGCCGAAAAACTGTTGCACGCGCTGGACTATGTCGGTGTGCTGGGGCTTGAATTCTTCGTGCTGAAGGACGGCACGCT
GCTCGCCAATGAATTTGCCCCGCGTGTGCATAATTCGGGCCACTGGACGGAAGCAGCCTGCGCCATTTCCCAATTTGAGC
AGCATATCCGCGCTGTGGCGGGACTGCCGCTCGGCAATACGGATCGCCATAGCGACTGTGTGATGGAAAACCTGATTGGC
GACGATATCGAAAAGGTTCCGGCGATTCTCTGCGAGAAGAACGCCGTGCTGCATCTTTACGGTAAAAAGGAAGCTCGCGC
GGGCCGGAAAATAGGCCATGTGACCCGCATAAAGCCCCGCACAATTTAA

Upstream 100 bases:

>100_bases
GATGAAGCACTTGCCGCCCGTCTTGATGAATGGCGCAAGGCGCAGACCGAAAGCGTTGCAGAACGCCCCTCGAACGAAGC
CTGATCCGGCGAGGTAGAAA

Downstream 100 bases:

>100_bases
GCTGCGCCGGGAATCTGCACGATTCCCGGCCCTTCCTGGCCGCCCGCCAAGAAATTCGGGGCCTCGGACCCTGAATCTGC
GGCGCGGGAGTTGACATTTG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MDKTSLKPGSTIGIIGGGQLGRMLAMAAARFGYETIILEPQAGCPAAQVANRQIVAAYDDPKALAELAAASDVITYEFEN
VPVSAADKLAETALVLPPPAALEISQDRFTEKQFLNESGIETAPWRLVDDEETLIAALGALGGRGILKTRRLGYDGKGQV
RLASLDETQACNAFAAINKAPAILEGFVEFEREVSVIAARDRSGNVAIFDLAENVHKDGILATSTVPAAISVQTAEAART
AAEKLLHALDYVGVLGLEFFVLKDGTLLANEFAPRVHNSGHWTEAACAISQFEQHIRAVAGLPLGNTDRHSDCVMENLIG
DDIEKVPAILCEKNAVLHLYGKKEARAGRKIGHVTRIKPRTI

Sequences:

>Translated_362_residues
MDKTSLKPGSTIGIIGGGQLGRMLAMAAARFGYETIILEPQAGCPAAQVANRQIVAAYDDPKALAELAAASDVITYEFEN
VPVSAADKLAETALVLPPPAALEISQDRFTEKQFLNESGIETAPWRLVDDEETLIAALGALGGRGILKTRRLGYDGKGQV
RLASLDETQACNAFAAINKAPAILEGFVEFEREVSVIAARDRSGNVAIFDLAENVHKDGILATSTVPAAISVQTAEAART
AAEKLLHALDYVGVLGLEFFVLKDGTLLANEFAPRVHNSGHWTEAACAISQFEQHIRAVAGLPLGNTDRHSDCVMENLIG
DDIEKVPAILCEKNAVLHLYGKKEARAGRKIGHVTRIKPRTI
>Mature_362_residues
MDKTSLKPGSTIGIIGGGQLGRMLAMAAARFGYETIILEPQAGCPAAQVANRQIVAAYDDPKALAELAAASDVITYEFEN
VPVSAADKLAETALVLPPPAALEISQDRFTEKQFLNESGIETAPWRLVDDEETLIAALGALGGRGILKTRRLGYDGKGQV
RLASLDETQACNAFAAINKAPAILEGFVEFEREVSVIAARDRSGNVAIFDLAENVHKDGILATSTVPAAISVQTAEAART
AAEKLLHALDYVGVLGLEFFVLKDGTLLANEFAPRVHNSGHWTEAACAISQFEQHIRAVAGLPLGNTDRHSDCVMENLIG
DDIEKVPAILCEKNAVLHLYGKKEARAGRKIGHVTRIKPRTI

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=348, Percent_Identity=35.9195402298851, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1788155, Length=367, Percent_Identity=27.7929155313352, Blast_Score=102, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6324702, Length=365, Percent_Identity=32.3287671232877, Blast_Score=192, Evalue=6e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 38671; Mature: 38671

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKTSLKPGSTIGIIGGGQLGRMLAMAAARFGYETIILEPQAGCPAAQVANRQIVAAYDD
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCCEEEEEECC
PKALAELAAASDVITYEFENVPVSAADKLAETALVLPPPAALEISQDRFTEKQFLNESGI
HHHHHHHHHHCCEEEEEECCCCCHHHHHHHHCEEECCCCCCEEECHHHHHHHHHHCCCCC
ETAPWRLVDDEETLIAALGALGGRGILKTRRLGYDGKGQVRLASLDETQACNAFAAINKA
CCCCEEEECCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHCCC
PAILEGFVEFEREVSVIAARDRSGNVAIFDLAENVHKDGILATSTVPAAISVQTAEAART
HHHHHHHHHHHHCEEEEEEECCCCCEEEEECHHHHCCCCEEEECCCCCEEEEEHHHHHHH
AAEKLLHALDYVGVLGLEFFVLKDGTLLANEFAPRVHNSGHWTEAACAISQFEQHIRAVA
HHHHHHHHHHHHHHHHEEEEEEECCEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GLPLGNTDRHSDCVMENLIGDDIEKVPAILCEKNAVLHLYGKKEARAGRKIGHVTRIKPR
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCHHHHCCCHHCCEECCCCC
TI
CC
>Mature Secondary Structure
MDKTSLKPGSTIGIIGGGQLGRMLAMAAARFGYETIILEPQAGCPAAQVANRQIVAAYDD
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCCEEEEEECC
PKALAELAAASDVITYEFENVPVSAADKLAETALVLPPPAALEISQDRFTEKQFLNESGI
HHHHHHHHHHCCEEEEEECCCCCHHHHHHHHCEEECCCCCCEEECHHHHHHHHHHCCCCC
ETAPWRLVDDEETLIAALGALGGRGILKTRRLGYDGKGQVRLASLDETQACNAFAAINKA
CCCCEEEECCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHCCC
PAILEGFVEFEREVSVIAARDRSGNVAIFDLAENVHKDGILATSTVPAAISVQTAEAART
HHHHHHHHHHHHCEEEEEEECCCCCEEEEECHHHHCCCCEEEECCCCCEEEEEHHHHHHH
AAEKLLHALDYVGVLGLEFFVLKDGTLLANEFAPRVHNSGHWTEAACAISQFEQHIRAVA
HHHHHHHHHHHHHHHHEEEEEEECCEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GLPLGNTDRHSDCVMENLIGDDIEKVPAILCEKNAVLHLYGKKEARAGRKIGHVTRIKPR
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCHHHHCCCHHCCEECCCCC
TI
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]