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The map label for this gene is purE

Identifier: 225853196

GI number: 225853196

Start: 1698206

End: 1698694

Strand: Direct

Name: purE

Synonym: BMEA_A1796

Alternate gene names: 225853196

Gene position: 1698206-1698694 (Clockwise)

Preceding gene: 225853195

Following gene: 225853197

Centisome position: 79.89

GC content: 62.78

Gene sequence:

>489_bases
ATGAGCGTTGATGTCGCCATTATCATGGGAAGCCAGTCCGATTGGGAAACCATGCACCATGCAGCCGACACATTGGAGGC
GCTCGGCATCTCCTTCGACGCACGGATCGTTTCCGCCCATCGCACCCCTGACAGGCTGGTCGCCTTCGCCAAGGGGGCGA
AAGCGGAAGGCTTCAAGGTCATCATCGCAGGCGCCGGCGGCGCGGCCCACCTGCCCGGCATGGCCGCTGCCATGACACCG
CTTCCCGTCTTTGGCGTTCCAGTTCAATCCAAGGCGCTTTCGGGCCAGGATTCGCTACTCTCCATCGTACAGATGCCAGC
GGGTATTCCCGTCGGCACTCTCGCCATCGGCCGTGCAGGCGCGGTCAATGCCGCCCTTCTCGCCGCCGCCGTTCTGGCGC
TATATGATGAAGCACTTGCCGCCCGTCTTGATGAATGGCGCAAGGCGCAGACCGAAAGCGTTGCAGAACGCCCCTCGAAC
GAAGCCTGA

Upstream 100 bases:

>100_bases
TGAACATTCAAGAACACTATAGGGAAGAGCCGGGGTTCGCCCGGCTTTGTCTTTTCAAGACCTTCCTCATGCCAACCGAA
AAGCCAAGCAGGAAAGACCG

Downstream 100 bases:

>100_bases
TCCGGCGAGGTAGAAAATGGACAAGACATCTCTCAAGCCCGGCTCCACCATCGGCATTATCGGCGGGGGCCAGCTTGGCC
GTATGCTCGCCATGGCAGCG

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MSVDVAIIMGSQSDWETMHHAADTLEALGISFDARIVSAHRTPDRLVAFAKGAKAEGFKVIIAGAGGAAHLPGMAAAMTP
LPVFGVPVQSKALSGQDSLLSIVQMPAGIPVGTLAIGRAGAVNAALLAAAVLALYDEALAARLDEWRKAQTESVAERPSN
EA

Sequences:

>Translated_162_residues
MSVDVAIIMGSQSDWETMHHAADTLEALGISFDARIVSAHRTPDRLVAFAKGAKAEGFKVIIAGAGGAAHLPGMAAAMTP
LPVFGVPVQSKALSGQDSLLSIVQMPAGIPVGTLAIGRAGAVNAALLAAAVLALYDEALAARLDEWRKAQTESVAERPSN
EA
>Mature_161_residues
SVDVAIIMGSQSDWETMHHAADTLEALGISFDARIVSAHRTPDRLVAFAKGAKAEGFKVIIAGAGGAAHLPGMAAAMTPL
PVFGVPVQSKALSGQDSLLSIVQMPAGIPVGTLAIGRAGAVNAALLAAAVLALYDEALAARLDEWRKAQTESVAERPSNE
A

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family

Homologues:

Organism=Escherichia coli, GI1786734, Length=154, Percent_Identity=66.2337662337662, Blast_Score=174, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324702, Length=150, Percent_Identity=54.6666666666667, Blast_Score=154, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURE_BRUME (P52558)

Other databases:

- EMBL:   U10241
- EMBL:   AE008917
- PIR:   AB3289
- RefSeq:   NP_539213.1
- ProteinModelPortal:   P52558
- SMR:   P52558
- GeneID:   1196007
- GenomeReviews:   AE008917_GR
- KEGG:   bme:BMEI0296
- HOGENOM:   HBG301965
- OMA:   GVVMGSS
- PhylomeDB:   P52558
- ProtClustDB:   CLSK898071
- BioCyc:   BMEL224914:BMEI0296-MONOMER
- BRENDA:   4.1.1.21
- InterPro:   IPR000031
- Gene3D:   G3DSA:3.40.50.7700
- PANTHER:   PTHR23046
- TIGRFAMs:   TIGR01162

Pfam domain/function: PF00731 AIRC; SSF52255 AIR_carboxyl

EC number: =5.4.99.18

Molecular weight: Translated: 16596; Mature: 16465

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: BINDING 11-11 BINDING 14-14 BINDING 41-41

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVDVAIIMGSQSDWETMHHAADTLEALGISFDARIVSAHRTPDRLVAFAKGAKAEGFKV
CCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCCCCCEEE
IIAGAGGAAHLPGMAAAMTPLPVFGVPVQSKALSGQDSLLSIVQMPAGIPVGTLAIGRAG
EEEECCCCCCCCCHHHHHCCCCEECCCCCCHHCCCHHHHHHHHHCCCCCCCHHHCCCCCC
AVNAALLAAAVLALYDEALAARLDEWRKAQTESVAERPSNEA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SVDVAIIMGSQSDWETMHHAADTLEALGISFDARIVSAHRTPDRLVAFAKGAKAEGFKV
CCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCCCCCEEE
IIAGAGGAAHLPGMAAAMTPLPVFGVPVQSKALSGQDSLLSIVQMPAGIPVGTLAIGRAG
EEEECCCCCCCCCHHHHHCCCCEECCCCCCHHCCCHHHHHHHHHCCCCCCCHHHCCCCCC
AVNAALLAAAVLALYDEALAARLDEWRKAQTESVAERPSNEA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688