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The map label for this gene is nqo13 [H]

Identifier: 225852330

GI number: 225852330

Start: 812619

End: 814127

Strand: Direct

Name: nqo13 [H]

Synonym: BMEA_A0856

Alternate gene names: 225852330

Gene position: 812619-814127 (Clockwise)

Preceding gene: 225852329

Following gene: 225852331

Centisome position: 38.23

GC content: 57.65

Gene sequence:

>1509_bases
ATGACCGACTGGCCAATTCTCTCAACGGTCACGTTTCTGCCGCTTGTCGGCGCGTTACTGATCCTTCTGATCAAGGACGA
CAGCGAGGCTTCGCGTCGCAACATCCGCAACGTGGCTTTGCTCACGACGGTGTTCGTCTTTATCCTGTCGCTTGTCGTCT
GGGCGGGGTTCGATAATTCAAACCCCGGCTTCCAGATGGTCGAGGAACTCGACTGGATGGGCAGCGGCATCAGCTACCAC
ATGGGCGTGGACGGCATCTCCGTCCTGTTCGTGGTGCTGTCCGCTTTCCTCATGCCCTTCTGCATTCTCGCAAGCTGGGT
GTCGGTGGAAAAGCGCGTCAAGGAATATATGATCGCGTTCCTCATCCTGGAAACGCTCATGATCGGCGTGTTCTGCGCGC
TCGACCTGTTCCTGTTCTACGTGTTCTTTGAAGCAAGCCTTATCCCGATGTTCATCATCATCGGCGTGTGGGGCGGCAAG
CGCCGCGTCTATGCGAGCCTGAAGTTCTTCCTCTATACGCTTTTGGGCTCCGTGCTGATGCTCATCGCCATCATGGCCAT
GTACTGGCAGGCTGGCACGATGAATATCGTCGAGCTGTTGCAGTATAACTTCCCGGCAAGTATGCAGACATGGCTATGGC
TCGCCTTCTTCGCGTCCTTCGCGGTGAAGATGCCGATGTGGCCGGTCCACACCTGGTTGCCGGATGCACACGTGGAAGCG
CCGACGGCAGGCTCGGTCATTCTGGCCGGTATTCTCCTGAAGCTCGGCGGCTATGGCTTCATCCGCTTCTCGCTGCCGAT
GTTCCCGCTGGCTTCCGCTGATTTCGCGCCCTTCATCTTCACCCTGTCGGTCGTTGCGATCATCTATACGTCGCTCGTCG
CCATGGTTCAGGAGGACATGAAGAAGCTGATCGCCTATTCGTCGGTTGCCCACATGGCCTATGTGACGATGGGTATCTTT
GCGGCAAACGAGCAGGGCCTGCAGGGCGCCATCTTCCAGATGCTGTCGCACGGTATAGTGTCGGGTGCGCTCTTCCTTTG
CGTCGGCGTGATCTATGACCGTATGCATACCCGTGAGATCGCTGCTTTCGGCGGCCTTGTGAACAATATGCCGAAATATG
CGGTGGCCTTCCTCATCTTCACGATGGCGAATGTCGGCCTGCCGGGTACTTCAGGCTTCATCGGTGAATTCCTGACGCTG
TTCGGTGTGTTCCGGGTCAATACCTGGGTGGCGCTGTTCGCGACCACGGGCGTCATTCTCTCGGCTGCCTATGCGCTCTG
GCTCTACCGCAAGGTGATCTTCGGCGCGCTGGACAAGGAAAGCCTCAAGGCGCTCCTCGACCTCAGCCCGCGTGAAAAGC
TGATCCTTTATCCGCTTGTGGCACTCACCATCTTCTTTGGCGTCTATCCAACCCCGGTCTTCAATGCGACCGCCGGTGCC
GTGAACGCCTTGATCCAACATTACGATGCAGCTCTCGCGGCCAACGCGAGCGCCATGCTGGTCCAATAA

Upstream 100 bases:

>100_bases
TCGTCAAGATGCAGTCCGGATACCTTTATCATTACGCATTCGCGATGCTGATCGGCGTCGCCGCGCTCGTCACCTGGATG
ATGCTCGGGAGCTCTTTCTG

Downstream 100 bases:

>100_bases
GAGAATAGAGGCGTAAAGGTCATGCAGACTGATCTGTTAGCTCATCTGACCCTGGCAGCACCGGAGGTTCTCCTTGCTGT
AGGCGCCTTGGCACGGCTCA

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 13; NDH-1, chain 13 [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MTDWPILSTVTFLPLVGALLILLIKDDSEASRRNIRNVALLTTVFVFILSLVVWAGFDNSNPGFQMVEELDWMGSGISYH
MGVDGISVLFVVLSAFLMPFCILASWVSVEKRVKEYMIAFLILETLMIGVFCALDLFLFYVFFEASLIPMFIIIGVWGGK
RRVYASLKFFLYTLLGSVLMLIAIMAMYWQAGTMNIVELLQYNFPASMQTWLWLAFFASFAVKMPMWPVHTWLPDAHVEA
PTAGSVILAGILLKLGGYGFIRFSLPMFPLASADFAPFIFTLSVVAIIYTSLVAMVQEDMKKLIAYSSVAHMAYVTMGIF
AANEQGLQGAIFQMLSHGIVSGALFLCVGVIYDRMHTREIAAFGGLVNNMPKYAVAFLIFTMANVGLPGTSGFIGEFLTL
FGVFRVNTWVALFATTGVILSAAYALWLYRKVIFGALDKESLKALLDLSPREKLILYPLVALTIFFGVYPTPVFNATAGA
VNALIQHYDAALAANASAMLVQ

Sequences:

>Translated_502_residues
MTDWPILSTVTFLPLVGALLILLIKDDSEASRRNIRNVALLTTVFVFILSLVVWAGFDNSNPGFQMVEELDWMGSGISYH
MGVDGISVLFVVLSAFLMPFCILASWVSVEKRVKEYMIAFLILETLMIGVFCALDLFLFYVFFEASLIPMFIIIGVWGGK
RRVYASLKFFLYTLLGSVLMLIAIMAMYWQAGTMNIVELLQYNFPASMQTWLWLAFFASFAVKMPMWPVHTWLPDAHVEA
PTAGSVILAGILLKLGGYGFIRFSLPMFPLASADFAPFIFTLSVVAIIYTSLVAMVQEDMKKLIAYSSVAHMAYVTMGIF
AANEQGLQGAIFQMLSHGIVSGALFLCVGVIYDRMHTREIAAFGGLVNNMPKYAVAFLIFTMANVGLPGTSGFIGEFLTL
FGVFRVNTWVALFATTGVILSAAYALWLYRKVIFGALDKESLKALLDLSPREKLILYPLVALTIFFGVYPTPVFNATAGA
VNALIQHYDAALAANASAMLVQ
>Mature_501_residues
TDWPILSTVTFLPLVGALLILLIKDDSEASRRNIRNVALLTTVFVFILSLVVWAGFDNSNPGFQMVEELDWMGSGISYHM
GVDGISVLFVVLSAFLMPFCILASWVSVEKRVKEYMIAFLILETLMIGVFCALDLFLFYVFFEASLIPMFIIIGVWGGKR
RVYASLKFFLYTLLGSVLMLIAIMAMYWQAGTMNIVELLQYNFPASMQTWLWLAFFASFAVKMPMWPVHTWLPDAHVEAP
TAGSVILAGILLKLGGYGFIRFSLPMFPLASADFAPFIFTLSVVAIIYTSLVAMVQEDMKKLIAYSSVAHMAYVTMGIFA
ANEQGLQGAIFQMLSHGIVSGALFLCVGVIYDRMHTREIAAFGGLVNNMPKYAVAFLIFTMANVGLPGTSGFIGEFLTLF
GVFRVNTWVALFATTGVILSAAYALWLYRKVIFGALDKESLKALLDLSPREKLILYPLVALTIFFGVYPTPVFNATAGAV
NALIQHYDAALAANASAMLVQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=335, Percent_Identity=37.3134328358209, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI251831117, Length=403, Percent_Identity=22.5806451612903, Blast_Score=83, Evalue=7e-16,
Organism=Escherichia coli, GI1788613, Length=470, Percent_Identity=39.7872340425532, Blast_Score=325, Evalue=5e-90,
Organism=Escherichia coli, GI1788827, Length=298, Percent_Identity=29.1946308724832, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1788831, Length=293, Percent_Identity=26.962457337884, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788614, Length=492, Percent_Identity=25, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788829, Length=298, Percent_Identity=24.8322147651007, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI145693160, Length=372, Percent_Identity=25, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI2367154, Length=258, Percent_Identity=24.031007751938, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55419; Mature: 55288

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHCCCCCEECC
>Mature Secondary Structure 
TDWPILSTVTFLPLVGALLILLIKDDSEASRRNIRNVALLTTVFVFILSLVVWAGFDNS
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC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HHHHHHHHHHHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]