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The map label for this gene is nqo12 [H]

Identifier: 225852329

GI number: 225852329

Start: 810634

End: 812619

Strand: Direct

Name: nqo12 [H]

Synonym: BMEA_A0855

Alternate gene names: 225852329

Gene position: 810634-812619 (Clockwise)

Preceding gene: 225852328

Following gene: 225852330

Centisome position: 38.13

GC content: 57.2

Gene sequence:

>1986_bases
ATGCTCTACTACGCGATCGTCTTCCTTCCGCTTATCGGCTTTCTTGTTGCCGGCCTGTTCGGCAATAAGATCGGAGCCAA
AGCGAGTGAATACATCACATCCGGCCTGATGGTTTTCGTGGCAATCCTGTCCTGGATTGTCTTCTTCAAGATACCGCTTG
GCCATGATGCCGAAACTGTCCGCATCCCGGTTCTCCATTGGGTGAATTCGGGCGCGCTGACCTTTGACTGGGCGCTGCGT
GTCGATACGCTCACCGGCGTCATGCTGGTTGTGGTCAACTCGGTGTCGGCCCTCGTGCATATCTATTCGATCGGATATAT
GCACCACGATCCGCATCGTCCGCGCTTCTTCGCCTATCTCTCGCTCTTCACTTTCGCCATGCTCATGCTGGTGACGTCGG
ACAATCTGATCCAGATGTTCTTCGGCTGGGAAGGCGTGGGTCTGGCTTCCTATCTTCTGATCGGTTTCTGGTTCAAGAAG
CCTTCGGCCAATGCCGCCGCAATGAAAGCTTTCGTTGTCAACCGCGTTGGCGATTTTGGCTTCCTGCTCGGTATTTTCAG
TGTGTTCGCGCTGTTCCAGTCGGTCGATTACAACACGATCTTTGCTGCCGCAGCCAACGCCCTTCCGGGTGGCGATGCCA
ATCAGGTGGTGCTGGATTTCCTCGGCTACCAGCTCGACAGACAGGGCGCGATCACGATCGCCTGCCTGCTGCTGTTCATG
GGCGCTATGGGTAAATCGGCCCAGTTCCTGCTTCACACCTGGCTGCCGGACGCCATGGAAGGCCCGACGCCGGTTTCCGC
ACTCATTCACGCGGCAACGATGGTGACTGCGGGCGTGTTCATGGTTGCGCGCATGTCGCCGATCTTTGAACTGTCGCAGA
CCGCTCTTCTGGTTGTAACCATCATCGGCGCCACGACTGCCTTCTTCGCGGCCACCGTTGCTCTCGTCCAGAACGATATC
AAGCGCGTCATCGCTTATTCGACCTGTTCGCAGCTGGGTTACATGTTTGCGGCTCTCGGCGTTGGCGCTTATGGCGCTGC
CGTGTTCCATCTCTTCACGCACGCTTTCTTCAAGGCGCTTCTGTTCCTCTGCGCTGGTTCGGTCATTCACGCCGTTTCCG
ACGAGCAGGATATGCGTCGCATGGGTGGCCTGCGCAAACTGATCCCCGTTACCTACTGGATGATGATTATCGGTACGGTC
GCCATCACGGGCCTCGGCATTCCGGGCACCGTTATCGGTACGGCCGGTTTCTTCTCCAAGGATGCGATCATCGAAGCCGT
GTTTGCTTCGCATAATCTCGCAAGCGGTTATGCCTCGACACTGCTCATCGTGGCGGCTCTCTTCACGAGCTTCTATTCCT
GGCGTCTGATTTTCATGACCTTCTTCGGCAAGCCGCGCGCTTCGGCGGAAGTCATGCATCACGTCCATGAATCGCCGCCC
GTCATGCTCGTGCCGCTTTTGATCCTCGGCATCGGCGCCATTCTTGCAGGCGTTCTGTTCAAGGAACTGTTCTTCGGCCA
CGAATATGTCGAGTTCTGGAAGGGTTCGTTGTTCACTTCGACCGCCAACCAGCTTCTTGAGGAACATCACCACGTTCCGC
TGTGGGTCAAGCTGTCGCCTTTCGTTGCAATGGTCATCGGCTTCGTCGTCGCCTGGATATTCTATATCCGCGCGCCGGAA
ATGCCGAAGGCGCTGGCGGCCCGCCATCGCGGTCTCTACCAGTTCCTGCTGAACAAGTGGTATTTCGACGAACTCTATGA
CTTCCTGTTCGTTCGTCCAGCTCGCTGGCTCGGCCGCCTGTTCTGGAAGGGTGGTGATGGCTGGCTCATTGACGGCTTCG
GCCCGAATGGCGTGTCGGCCCGTGTGCTGGATGTCACCAACCGCGTCGTCAAGATGCAGTCCGGATACCTTTATCATTAC
GCATTCGCGATGCTGATCGGCGTCGCCGCGCTCGTCACCTGGATGATGCTCGGGAGCTCTTTCTGA

Upstream 100 bases:

>100_bases
GCCGAAGCTGCGATCGGTCTGGCAATTCTCGTTGTTTTCTTCCGTAATCGCGGCTCCATCGCGGTGGAAGACGTCAATGT
TATGAAAGGTTGACGGGCAA

Downstream 100 bases:

>100_bases
TGACCGACTGGCCAATTCTCTCAACGGTCACGTTTCTGCCGCTTGTCGGCGCGTTACTGATCCTTCTGATCAAGGACGAC
AGCGAGGCTTCGCGTCGCAA

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 12; NDH-1, chain 12 [H]

Number of amino acids: Translated: 661; Mature: 661

Protein sequence:

>661_residues
MLYYAIVFLPLIGFLVAGLFGNKIGAKASEYITSGLMVFVAILSWIVFFKIPLGHDAETVRIPVLHWVNSGALTFDWALR
VDTLTGVMLVVVNSVSALVHIYSIGYMHHDPHRPRFFAYLSLFTFAMLMLVTSDNLIQMFFGWEGVGLASYLLIGFWFKK
PSANAAAMKAFVVNRVGDFGFLLGIFSVFALFQSVDYNTIFAAAANALPGGDANQVVLDFLGYQLDRQGAITIACLLLFM
GAMGKSAQFLLHTWLPDAMEGPTPVSALIHAATMVTAGVFMVARMSPIFELSQTALLVVTIIGATTAFFAATVALVQNDI
KRVIAYSTCSQLGYMFAALGVGAYGAAVFHLFTHAFFKALLFLCAGSVIHAVSDEQDMRRMGGLRKLIPVTYWMMIIGTV
AITGLGIPGTVIGTAGFFSKDAIIEAVFASHNLASGYASTLLIVAALFTSFYSWRLIFMTFFGKPRASAEVMHHVHESPP
VMLVPLLILGIGAILAGVLFKELFFGHEYVEFWKGSLFTSTANQLLEEHHHVPLWVKLSPFVAMVIGFVVAWIFYIRAPE
MPKALAARHRGLYQFLLNKWYFDELYDFLFVRPARWLGRLFWKGGDGWLIDGFGPNGVSARVLDVTNRVVKMQSGYLYHY
AFAMLIGVAALVTWMMLGSSF

Sequences:

>Translated_661_residues
MLYYAIVFLPLIGFLVAGLFGNKIGAKASEYITSGLMVFVAILSWIVFFKIPLGHDAETVRIPVLHWVNSGALTFDWALR
VDTLTGVMLVVVNSVSALVHIYSIGYMHHDPHRPRFFAYLSLFTFAMLMLVTSDNLIQMFFGWEGVGLASYLLIGFWFKK
PSANAAAMKAFVVNRVGDFGFLLGIFSVFALFQSVDYNTIFAAAANALPGGDANQVVLDFLGYQLDRQGAITIACLLLFM
GAMGKSAQFLLHTWLPDAMEGPTPVSALIHAATMVTAGVFMVARMSPIFELSQTALLVVTIIGATTAFFAATVALVQNDI
KRVIAYSTCSQLGYMFAALGVGAYGAAVFHLFTHAFFKALLFLCAGSVIHAVSDEQDMRRMGGLRKLIPVTYWMMIIGTV
AITGLGIPGTVIGTAGFFSKDAIIEAVFASHNLASGYASTLLIVAALFTSFYSWRLIFMTFFGKPRASAEVMHHVHESPP
VMLVPLLILGIGAILAGVLFKELFFGHEYVEFWKGSLFTSTANQLLEEHHHVPLWVKLSPFVAMVIGFVVAWIFYIRAPE
MPKALAARHRGLYQFLLNKWYFDELYDFLFVRPARWLGRLFWKGGDGWLIDGFGPNGVSARVLDVTNRVVKMQSGYLYHY
AFAMLIGVAALVTWMMLGSSF
>Mature_661_residues
MLYYAIVFLPLIGFLVAGLFGNKIGAKASEYITSGLMVFVAILSWIVFFKIPLGHDAETVRIPVLHWVNSGALTFDWALR
VDTLTGVMLVVVNSVSALVHIYSIGYMHHDPHRPRFFAYLSLFTFAMLMLVTSDNLIQMFFGWEGVGLASYLLIGFWFKK
PSANAAAMKAFVVNRVGDFGFLLGIFSVFALFQSVDYNTIFAAAANALPGGDANQVVLDFLGYQLDRQGAITIACLLLFM
GAMGKSAQFLLHTWLPDAMEGPTPVSALIHAATMVTAGVFMVARMSPIFELSQTALLVVTIIGATTAFFAATVALVQNDI
KRVIAYSTCSQLGYMFAALGVGAYGAAVFHLFTHAFFKALLFLCAGSVIHAVSDEQDMRRMGGLRKLIPVTYWMMIIGTV
AITGLGIPGTVIGTAGFFSKDAIIEAVFASHNLASGYASTLLIVAALFTSFYSWRLIFMTFFGKPRASAEVMHHVHESPP
VMLVPLLILGIGAILAGVLFKELFFGHEYVEFWKGSLFTSTANQLLEEHHHVPLWVKLSPFVAMVIGFVVAWIFYIRAPE
MPKALAARHRGLYQFLLNKWYFDELYDFLFVRPARWLGRLFWKGGDGWLIDGFGPNGVSARVLDVTNRVVKMQSGYLYHY
AFAMLIGVAALVTWMMLGSSF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=496, Percent_Identity=37.0967741935484, Blast_Score=305, Evalue=7e-83,
Organism=Escherichia coli, GI1788614, Length=594, Percent_Identity=41.2457912457912, Blast_Score=355, Evalue=4e-99,
Organism=Escherichia coli, GI1788829, Length=515, Percent_Identity=29.3203883495146, Blast_Score=142, Evalue=1e-34,
Organism=Escherichia coli, GI1788831, Length=347, Percent_Identity=30.2593659942363, Blast_Score=122, Evalue=1e-28,
Organism=Escherichia coli, GI1788827, Length=449, Percent_Identity=27.6169265033408, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI2367154, Length=218, Percent_Identity=29.3577981651376, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788613, Length=340, Percent_Identity=26.4705882352941, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI145693160, Length=277, Percent_Identity=25.6317689530686, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 72854; Mature: 72854

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYYAIVFLPLIGFLVAGLFGNKIGAKASEYITSGLMVFVAILSWIVFFKIPLGHDAETV
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
RIPVLHWVNSGALTFDWALRVDTLTGVMLVVVNSVSALVHIYSIGYMHHDPHRPRFFAYL
EEEHEEEECCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCCHHHHHH
SLFTFAMLMLVTSDNLIQMFFGWEGVGLASYLLIGFWFKKPSANAAAMKAFVVNRVGDFG
HHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHH
FLLGIFSVFALFQSVDYNTIFAAAANALPGGDANQVVLDFLGYQLDRQGAITIACLLLFM
HHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHH
GAMGKSAQFLLHTWLPDAMEGPTPVSALIHAATMVTAGVFMVARMSPIFELSQTALLVVT
HCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
IIGATTAFFAATVALVQNDIKRVIAYSTCSQLGYMFAALGVGAYGAAVFHLFTHAFFKAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFLCAGSVIHAVSDEQDMRRMGGLRKLIPVTYWMMIIGTVAITGLGIPGTVIGTAGFFSK
HHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHH
DAIIEAVFASHNLASGYASTLLIVAALFTSFYSWRLIFMTFFGKPRASAEVMHHVHESPP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
VMLVPLLILGIGAILAGVLFKELFFGHEYVEFWKGSLFTSTANQLLEEHHHVPLWVKLSP
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEHHH
FVAMVIGFVVAWIFYIRAPEMPKALAARHRGLYQFLLNKWYFDELYDFLFVRPARWLGRL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FWKGGDGWLIDGFGPNGVSARVLDVTNRVVKMQSGYLYHYAFAMLIGVAALVTWMMLGSS
HEECCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
F
C
>Mature Secondary Structure
MLYYAIVFLPLIGFLVAGLFGNKIGAKASEYITSGLMVFVAILSWIVFFKIPLGHDAETV
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
RIPVLHWVNSGALTFDWALRVDTLTGVMLVVVNSVSALVHIYSIGYMHHDPHRPRFFAYL
EEEHEEEECCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCCHHHHHH
SLFTFAMLMLVTSDNLIQMFFGWEGVGLASYLLIGFWFKKPSANAAAMKAFVVNRVGDFG
HHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHH
FLLGIFSVFALFQSVDYNTIFAAAANALPGGDANQVVLDFLGYQLDRQGAITIACLLLFM
HHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHH
GAMGKSAQFLLHTWLPDAMEGPTPVSALIHAATMVTAGVFMVARMSPIFELSQTALLVVT
HCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
IIGATTAFFAATVALVQNDIKRVIAYSTCSQLGYMFAALGVGAYGAAVFHLFTHAFFKAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFLCAGSVIHAVSDEQDMRRMGGLRKLIPVTYWMMIIGTVAITGLGIPGTVIGTAGFFSK
HHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHH
DAIIEAVFASHNLASGYASTLLIVAALFTSFYSWRLIFMTFFGKPRASAEVMHHVHESPP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
VMLVPLLILGIGAILAGVLFKELFFGHEYVEFWKGSLFTSTANQLLEEHHHVPLWVKLSP
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEHHH
FVAMVIGFVVAWIFYIRAPEMPKALAARHRGLYQFLLNKWYFDELYDFLFVRPARWLGRL
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FWKGGDGWLIDGFGPNGVSARVLDVTNRVVKMQSGYLYHYAFAMLIGVAALVTWMMLGSS
HEECCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
F
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]