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The map label for this gene is yngE [H]

Identifier: 225851564

GI number: 225851564

Start: 21247

End: 22854

Strand: Reverse

Name: yngE [H]

Synonym: BMEA_A0019

Alternate gene names: 225851564

Gene position: 22854-21247 (Counterclockwise)

Preceding gene: 225851565

Following gene: 225851563

Centisome position: 1.08

GC content: 61.94

Gene sequence:

>1608_bases
ATGCCGGTTCTGAAATCTGAAATCTCGACGCGCAGCACAAGCTTCGAGGCCAACCGCAAGGCCATGCTGGCGGCAATCGA
CGTGGTGGCGGAAGCCTCGCGCATTGCCATTGACGGCGGCGGCGAGAAAGCGCGCGACCGCCATGTTTCGCGCGGAAAAC
TTCTGCCCCGTGAGCGCGTGGCGCAATTGCTCGATCCGGGTTCCCCCTTTCTGGAACTGGGGCTGACGGCAGCGCATGGC
ATGTATGGCGGGCCAGCGCCCGCCGCTGGCTTCATCACCGGCATCGGGCGCGTATCGGGCCGCGAATGCATGATCGTCTG
CAATGATGCGACGGTAAAGGGTGGCACCTATTATCCGATGACGGTGAAAAAGCATCTGCGCGCGCAGGAGATTGCAGGCG
AAAATCGCCTGCCCTGCATTTATCTGGTCGATTCCGGCGGCGCGAACCTGCCCAATCAGGATGAGGTTTTCCCGGATCGC
GACCATTTCGGACGCATTTTCTACAATCAGGCGCAGATGTCGGCGGCAGGCATTCCGCAGGTGGCCGTGGTCATGGGATC
ATGCACGGCAGGCGGCGCTTACGTACCCGCCATGAGCGACGAGACGGTGATCGTGCGGGGCCAAGGCACGATCTTTCTGG
CAGGCCCCCCTCTGGTCAAGGCTGCAACCGGCGAAGTGGTGAGCGCGGAAGATCTTGGCGGTGGCGATGTACACACCCGG
CTTTCCGGCGTGGCGGATCATCTTGCCAATGACGATGCACACGCCTTGCAGATCGCACGCGCCATTGCCGCTAATCTGGC
TAGCGAGAAGCGCTCGTTCATTCCAAGAGGCGACGGCGCTGCCCCGCTTTACGACCCGGAAGAACTGCTCGGCGTCGTTT
CCGCCGATACGCGCATTCCCTATGATGTGCGCGAGGTGATCGCGCGGCTGGTCGATGGCTCCGATTTCGATGAGTTCAAG
GCGCGCTACGGCACAACTTTGGTCTGCAGTTTTGCCAGCGTCTACGGCATGCCGGTCGGCATTATTACCAATAATGGCGT
GCTGTTTTCCGAAGCAGCACTCAAGGGCGCGCATTTCATCGAGCTTTGCTGCCAGCGCAATATTCCGCTGGTGTTTTTGC
AAAATATCACCGGCTTTATGGTCGGGCGCAAATATGAGGCCGAAGGCATTGCCAAGCACGGCGCCAAACTGGTGACGGCG
GTGGCGACCGCCAATGTGCCGAAGATCACCATGCTGATCGGCGCGTCCTATGGCGCGGGCAATTACGGCATGGCGGGACG
GGCCTATTCGCCGCGCTTCCAGTGGACCTGGCCGAACAGCCGCATTGCGGTGATGGGCGGCGAGCAGGCGGCAGGCGTGC
TGGCAACCGTCAAGCGCGACGGGATCGAGCGCACCGGCGGCACATGGTCGGCGGAAGAGGAAGCGGAGTTCAAGCGCCCG
ACGCTCGAAATGTTCGAGCGCCAGAGCCACCCGCTCTATGCCTCGGCGCGGCTTTGGGATGACGGCATCGTCGATCCGCG
CAAGAGCCGCGAAGTGCTTGGCCTGTCGCTTTCCGCCACGCTGAACGCGCCGGTCGAGCCGACGCGTTTTGGCATCTTCA
GAATGTGA

Upstream 100 bases:

>100_bases
GCCGCCTTTTGCGCGATGCCAAGCTTTATGAAATCGGCGCGGGCACGTCGGAAATCCGGCGTATGCTGATCGGACGGGAA
CTCTTTCAGGAGACCCGTTG

Downstream 100 bases:

>100_bases
GGAAGCGCGGGATGAGGAAAAGTGTGAAGCGGTTTTCCGCCCGCATCCCGCGAGGAAAAAATGTGATGTTTCAGAAAATA
CTGATTGCCAATCGCGGAGA

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MPVLKSEISTRSTSFEANRKAMLAAIDVVAEASRIAIDGGGEKARDRHVSRGKLLPRERVAQLLDPGSPFLELGLTAAHG
MYGGPAPAAGFITGIGRVSGRECMIVCNDATVKGGTYYPMTVKKHLRAQEIAGENRLPCIYLVDSGGANLPNQDEVFPDR
DHFGRIFYNQAQMSAAGIPQVAVVMGSCTAGGAYVPAMSDETVIVRGQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTR
LSGVADHLANDDAHALQIARAIAANLASEKRSFIPRGDGAAPLYDPEELLGVVSADTRIPYDVREVIARLVDGSDFDEFK
ARYGTTLVCSFASVYGMPVGIITNNGVLFSEAALKGAHFIELCCQRNIPLVFLQNITGFMVGRKYEAEGIAKHGAKLVTA
VATANVPKITMLIGASYGAGNYGMAGRAYSPRFQWTWPNSRIAVMGGEQAAGVLATVKRDGIERTGGTWSAEEEAEFKRP
TLEMFERQSHPLYASARLWDDGIVDPRKSREVLGLSLSATLNAPVEPTRFGIFRM

Sequences:

>Translated_535_residues
MPVLKSEISTRSTSFEANRKAMLAAIDVVAEASRIAIDGGGEKARDRHVSRGKLLPRERVAQLLDPGSPFLELGLTAAHG
MYGGPAPAAGFITGIGRVSGRECMIVCNDATVKGGTYYPMTVKKHLRAQEIAGENRLPCIYLVDSGGANLPNQDEVFPDR
DHFGRIFYNQAQMSAAGIPQVAVVMGSCTAGGAYVPAMSDETVIVRGQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTR
LSGVADHLANDDAHALQIARAIAANLASEKRSFIPRGDGAAPLYDPEELLGVVSADTRIPYDVREVIARLVDGSDFDEFK
ARYGTTLVCSFASVYGMPVGIITNNGVLFSEAALKGAHFIELCCQRNIPLVFLQNITGFMVGRKYEAEGIAKHGAKLVTA
VATANVPKITMLIGASYGAGNYGMAGRAYSPRFQWTWPNSRIAVMGGEQAAGVLATVKRDGIERTGGTWSAEEEAEFKRP
TLEMFERQSHPLYASARLWDDGIVDPRKSREVLGLSLSATLNAPVEPTRFGIFRM
>Mature_534_residues
PVLKSEISTRSTSFEANRKAMLAAIDVVAEASRIAIDGGGEKARDRHVSRGKLLPRERVAQLLDPGSPFLELGLTAAHGM
YGGPAPAAGFITGIGRVSGRECMIVCNDATVKGGTYYPMTVKKHLRAQEIAGENRLPCIYLVDSGGANLPNQDEVFPDRD
HFGRIFYNQAQMSAAGIPQVAVVMGSCTAGGAYVPAMSDETVIVRGQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTRL
SGVADHLANDDAHALQIARAIAANLASEKRSFIPRGDGAAPLYDPEELLGVVSADTRIPYDVREVIARLVDGSDFDEFKA
RYGTTLVCSFASVYGMPVGIITNNGVLFSEAALKGAHFIELCCQRNIPLVFLQNITGFMVGRKYEAEGIAKHGAKLVTAV
ATANVPKITMLIGASYGAGNYGMAGRAYSPRFQWTWPNSRIAVMGGEQAAGVLATVKRDGIERTGGTWSAEEEAEFKRPT
LEMFERQSHPLYASARLWDDGIVDPRKSREVLGLSLSATLNAPVEPTRFGIFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=525, Percent_Identity=65.5238095238095, Blast_Score=690, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=511, Percent_Identity=31.5068493150685, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI295821216, Length=531, Percent_Identity=30.3201506591337, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI310133460, Length=135, Percent_Identity=60.7407407407407, Blast_Score=146, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17552936, Length=536, Percent_Identity=61.9402985074627, Blast_Score=687, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=544, Percent_Identity=33.6397058823529, Blast_Score=245, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI25147359, Length=548, Percent_Identity=33.2116788321168, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24586065, Length=550, Percent_Identity=62.5454545454545, Blast_Score=700, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 57135; Mature: 57004

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVLKSEISTRSTSFEANRKAMLAAIDVVAEASRIAIDGGGEKARDRHVSRGKLLPRERV
CCCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCCCCCCHHHH
AQLLDPGSPFLELGLTAAHGMYGGPAPAAGFITGIGRVSGRECMIVCNDATVKGGTYYPM
HHHHCCCCCHHHHCCHHHCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCEECCCEECCH
TVKKHLRAQEIAGENRLPCIYLVDSGGANLPNQDEVFPDRDHFGRIFYNQAQMSAAGIPQ
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHCCEEEEEHHHHHHCCCCE
VAVVMGSCTAGGAYVPAMSDETVIVRGQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTR
EEEEEECCCCCCEEECCCCCCEEEEEECCEEEEECCCEEEECCCCEEECCCCCCCHHHHH
LSGVADHLANDDAHALQIARAIAANLASEKRSFIPRGDGAAPLYDPEELLGVVSADTRIP
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHEEHCCCCCCC
YDVREVIARLVDGSDFDEFKARYGTTLVCSFASVYGMPVGIITNNGVLFSEAALKGAHFI
HHHHHHHHHHHCCCCHHHHHHHHCCEEEEEHHHHHCCEEEEEECCCEEEEHHHHCCHHHH
ELCCQRNIPLVFLQNITGFMVGRKYEAEGIAKHGAKLVTAVATANVPKITMLIGASYGAG
HHHHCCCCCEEEECCCCHHHCCCEECCCHHHHCCHHEEEHHHHCCCCEEEEEEECCCCCC
NYGMAGRAYSPRFQWTWPNSRIAVMGGEQAAGVLATVKRDGIERTGGTWSAEEEAEFKRP
CCCCCCCCCCCCEEEECCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHCCC
TLEMFERQSHPLYASARLWDDGIVDPRKSREVLGLSLSATLNAPVEPTRFGIFRM
HHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCEECC
>Mature Secondary Structure 
PVLKSEISTRSTSFEANRKAMLAAIDVVAEASRIAIDGGGEKARDRHVSRGKLLPRERV
CCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCCCCCCHHHH
AQLLDPGSPFLELGLTAAHGMYGGPAPAAGFITGIGRVSGRECMIVCNDATVKGGTYYPM
HHHHCCCCCHHHHCCHHHCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCEECCCEECCH
TVKKHLRAQEIAGENRLPCIYLVDSGGANLPNQDEVFPDRDHFGRIFYNQAQMSAAGIPQ
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHCCEEEEEHHHHHHCCCCE
VAVVMGSCTAGGAYVPAMSDETVIVRGQGTIFLAGPPLVKAATGEVVSAEDLGGGDVHTR
EEEEEECCCCCCEEECCCCCCEEEEEECCEEEEECCCEEEECCCCEEECCCCCCCHHHHH
LSGVADHLANDDAHALQIARAIAANLASEKRSFIPRGDGAAPLYDPEELLGVVSADTRIP
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHEEHCCCCCCC
YDVREVIARLVDGSDFDEFKARYGTTLVCSFASVYGMPVGIITNNGVLFSEAALKGAHFI
HHHHHHHHHHHCCCCHHHHHHHHCCEEEEEHHHHHCCEEEEEECCCEEEEHHHHCCHHHH
ELCCQRNIPLVFLQNITGFMVGRKYEAEGIAKHGAKLVTAVATANVPKITMLIGASYGAG
HHHHCCCCCEEEECCCCHHHCCCEECCCHHHHCCHHEEEHHHHCCCCEEEEEEECCCCCC
NYGMAGRAYSPRFQWTWPNSRIAVMGGEQAAGVLATVKRDGIERTGGTWSAEEEAEFKRP
CCCCCCCCCCCCEEEECCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHCCC
TLEMFERQSHPLYASARLWDDGIVDPRKSREVLGLSLSATLNAPVEPTRFGIFRM
HHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]