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The map label for this gene is acdA [H]

Identifier: 225851565

GI number: 225851565

Start: 22854

End: 24032

Strand: Reverse

Name: acdA [H]

Synonym: BMEA_A0020

Alternate gene names: 225851565

Gene position: 24032-22854 (Counterclockwise)

Preceding gene: 225851566

Following gene: 225851564

Centisome position: 1.13

GC content: 58.69

Gene sequence:

>1179_bases
ATGTTTGCTTTGGGTCAAAATGGAGGGGGTATGAACTTCGGTCTTGGCGAGGAGATCGAAGCCCTTCGTGACACTGTGCG
CCGTTTCGCCGAAAGCCGCATTGCGCCGCTTGCCGCTGAAACCGACCGCAATAATCAATTTCCCATGCATCTTTGGCGTG
AATTTGGTGAGCTTGGCGTACTCGGCATTACGGCGCCGGAAGACTATGGTGGCGCAGGCATGGGCTATCTCGCCCATTGC
ATCGCCATGGAGGAGATCAGCCGTGCTTCCGCCTCCATCGGCCTTAGCTACGGCGCCCATTCCAATCTCTGCGTCAACCA
GATCACCCGCAACGGTTCGCCCGAACAGCGCGCGAAATATCTGCCGAAACTCATTTCCGGTGAGCATGTCGGCGCGCTGG
CCATGTCTGAGCCGGGCGCGGGGTCCGATGTTGTTTTCATGAAGCTTGCCGCCGAAAAGCGCGGGGACCGTTACGTCCTC
AACGGCAACAAGATGTGGATCACCAATGGCCCGGATGCCGATGTGCTGGTGGTCTATGCCAAGACAGACCTGTCGGCTGG
CCCGCGCGGGATCAGCGCCTTTATCATTGAAAAAGGGTTCAAGGGTTTTTCGACCGCGCAAAAGCTCGACAAACTCGGTA
TGCGCGGTTCCAACACCTGCGAACTGGTGTTCGAGGATTGCGAAGTGCCAGCCGAAAACCTGCTCGGAACCGAGGGCAAG
GGCGTCAATGTGCTGATGTCCGGCCTCGATTATGAGCGCGTGGTGCTGGCGGGTGGGCCGCTCGGCATCATGGCGGCCTG
CCTCGATGTCGTGGTGCCCTATGTGCATGAGCGCAAGCAGTTCGACCAGCCAATCGGTGAATTCCAGCTCATGCAGTGCA
AGCTTGCCGACATGTATGTGACCTTCAACGCTTCACGCGCTTATGTCTATGCCGTGGCCGCAGCCTGCGACCGGGGTGAG
ACGACGCGCAAGGATGCGGCGGGCTGCATTCTTTACTCTGCGGAAAATGCCACGCAGATGGCCTTGCAGGCGATCCAGTC
TCTCGGCGGCAACGGCTATATCAACGATTATCCGACGGGCCGCCTTTTGCGCGATGCCAAGCTTTATGAAATCGGCGCGG
GCACGTCGGAAATCCGGCGTATGCTGATCGGACGGGAACTCTTTCAGGAGACCCGTTGA

Upstream 100 bases:

>100_bases
CACGCAAAACCATTGCGTATTTGGCCGCTACGGGACACTCTGGCCGGGACATAGCTGTTCTCGAAAAACAGCAGCCGGGC
AGAACTTGTGGAGGACGAGT

Downstream 100 bases:

>100_bases
TGCCGGTTCTGAAATCTGAAATCTCGACGCGCAGCACAAGCTTCGAGGCCAACCGCAAGGCCATGCTGGCGGCAATCGAC
GTGGTGGCGGAAGCCTCGCG

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MFALGQNGGGMNFGLGEEIEALRDTVRRFAESRIAPLAAETDRNNQFPMHLWREFGELGVLGITAPEDYGGAGMGYLAHC
IAMEEISRASASIGLSYGAHSNLCVNQITRNGSPEQRAKYLPKLISGEHVGALAMSEPGAGSDVVFMKLAAEKRGDRYVL
NGNKMWITNGPDADVLVVYAKTDLSAGPRGISAFIIEKGFKGFSTAQKLDKLGMRGSNTCELVFEDCEVPAENLLGTEGK
GVNVLMSGLDYERVVLAGGPLGIMAACLDVVVPYVHERKQFDQPIGEFQLMQCKLADMYVTFNASRAYVYAVAAACDRGE
TTRKDAAGCILYSAENATQMALQAIQSLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFQETR

Sequences:

>Translated_392_residues
MFALGQNGGGMNFGLGEEIEALRDTVRRFAESRIAPLAAETDRNNQFPMHLWREFGELGVLGITAPEDYGGAGMGYLAHC
IAMEEISRASASIGLSYGAHSNLCVNQITRNGSPEQRAKYLPKLISGEHVGALAMSEPGAGSDVVFMKLAAEKRGDRYVL
NGNKMWITNGPDADVLVVYAKTDLSAGPRGISAFIIEKGFKGFSTAQKLDKLGMRGSNTCELVFEDCEVPAENLLGTEGK
GVNVLMSGLDYERVVLAGGPLGIMAACLDVVVPYVHERKQFDQPIGEFQLMQCKLADMYVTFNASRAYVYAVAAACDRGE
TTRKDAAGCILYSAENATQMALQAIQSLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFQETR
>Mature_392_residues
MFALGQNGGGMNFGLGEEIEALRDTVRRFAESRIAPLAAETDRNNQFPMHLWREFGELGVLGITAPEDYGGAGMGYLAHC
IAMEEISRASASIGLSYGAHSNLCVNQITRNGSPEQRAKYLPKLISGEHVGALAMSEPGAGSDVVFMKLAAEKRGDRYVL
NGNKMWITNGPDADVLVVYAKTDLSAGPRGISAFIIEKGFKGFSTAQKLDKLGMRGSNTCELVFEDCEVPAENLLGTEGK
GVNVLMSGLDYERVVLAGGPLGIMAACLDVVVPYVHERKQFDQPIGEFQLMQCKLADMYVTFNASRAYVYAVAAACDRGE
TTRKDAAGCILYSAENATQMALQAIQSLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFQETR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=68.3510638297872, Blast_Score=535, Evalue=1e-152,
Organism=Homo sapiens, GI226958414, Length=370, Percent_Identity=67.027027027027, Blast_Score=507, Evalue=1e-144,
Organism=Homo sapiens, GI4557233, Length=378, Percent_Identity=41.005291005291, Blast_Score=291, Evalue=6e-79,
Organism=Homo sapiens, GI4501859, Length=366, Percent_Identity=34.4262295081967, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI187960098, Length=382, Percent_Identity=35.6020942408377, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI4557231, Length=382, Percent_Identity=35.6020942408377, Blast_Score=239, Evalue=5e-63,
Organism=Homo sapiens, GI21361497, Length=358, Percent_Identity=37.4301675977654, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI7656849, Length=383, Percent_Identity=33.9425587467363, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=34.1333333333333, Blast_Score=225, Evalue=7e-59,
Organism=Homo sapiens, GI76496475, Length=373, Percent_Identity=33.2439678284182, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4557235, Length=373, Percent_Identity=33.2439678284182, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI4503943, Length=377, Percent_Identity=32.8912466843501, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI7669494, Length=373, Percent_Identity=33.5120643431635, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI48976061, Length=286, Percent_Identity=25.1748251748252, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI211971008, Length=286, Percent_Identity=25.1748251748252, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI38505218, Length=278, Percent_Identity=23.021582733813, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI218563752, Length=227, Percent_Identity=26.431718061674, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786223, Length=383, Percent_Identity=28.9817232375979, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=28.9817232375979, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87082384, Length=259, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI87081702, Length=335, Percent_Identity=24.1791044776119, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=65.2631578947368, Blast_Score=517, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17506239, Length=369, Percent_Identity=33.8753387533875, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=35.9580052493438, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=34.2318059299191, Blast_Score=240, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=34.8167539267016, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17570075, Length=382, Percent_Identity=34.2931937172775, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17533517, Length=381, Percent_Identity=32.2834645669291, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71990804, Length=278, Percent_Identity=38.8489208633094, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71985184, Length=352, Percent_Identity=33.8068181818182, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17551932, Length=368, Percent_Identity=31.25, Blast_Score=185, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17505929, Length=367, Percent_Identity=31.8801089918256, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17534353, Length=376, Percent_Identity=30.3191489361702, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=36.3636363636364, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71985192, Length=288, Percent_Identity=33.6805555555556, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=33.2116788321168, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17531909, Length=246, Percent_Identity=28.0487804878049, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI86563383, Length=279, Percent_Identity=28.3154121863799, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI86563381, Length=279, Percent_Identity=28.3154121863799, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21355753, Length=384, Percent_Identity=64.0625, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI21356377, Length=376, Percent_Identity=41.7553191489362, Blast_Score=298, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24646207, Length=390, Percent_Identity=37.9487179487179, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24660351, Length=386, Percent_Identity=36.0103626943005, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24666513, Length=371, Percent_Identity=33.6927223719677, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI281363737, Length=359, Percent_Identity=33.7047353760446, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI19920834, Length=377, Percent_Identity=29.7082228116711, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 42416; Mature: 42416

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFALGQNGGGMNFGLGEEIEALRDTVRRFAESRIAPLAAETDRNNQFPMHLWREFGELGV
CCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHCCCCE
LGITAPEDYGGAGMGYLAHCIAMEEISRASASIGLSYGAHSNLCVNQITRNGSPEQRAKY
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHCCCCHHHHHHH
LPKLISGEHVGALAMSEPGAGSDVVFMKLAAEKRGDRYVLNGNKMWITNGPDADVLVVYA
HHHHHCCCCCCEEEECCCCCCCCEEEEEEEHHCCCCEEEECCCEEEEECCCCCCEEEEEE
KTDLSAGPRGISAFIIEKGFKGFSTAQKLDKLGMRGSNTCELVFEDCEVPAENLLGTEGK
ECCCCCCCCCCEEEEEHHCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHCCCCCC
GVNVLMSGLDYERVVLAGGPLGIMAACLDVVVPYVHERKQFDQPIGEFQLMQCKLADMYV
CCEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEEEEEE
TFNASRAYVYAVAAACDRGETTRKDAAGCILYSAENATQMALQAIQSLGGNGYINDYPTG
EEECCCEEEEEEEHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCC
RLLRDAKLYEIGAGTSEIRRMLIGRELFQETR
CEECCCEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFALGQNGGGMNFGLGEEIEALRDTVRRFAESRIAPLAAETDRNNQFPMHLWREFGELGV
CCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHCCCCE
LGITAPEDYGGAGMGYLAHCIAMEEISRASASIGLSYGAHSNLCVNQITRNGSPEQRAKY
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHCCCCHHHHHHH
LPKLISGEHVGALAMSEPGAGSDVVFMKLAAEKRGDRYVLNGNKMWITNGPDADVLVVYA
HHHHHCCCCCCEEEECCCCCCCCEEEEEEEHHCCCCEEEECCCEEEEECCCCCCEEEEEE
KTDLSAGPRGISAFIIEKGFKGFSTAQKLDKLGMRGSNTCELVFEDCEVPAENLLGTEGK
ECCCCCCCCCCEEEEEHHCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHCCCCCC
GVNVLMSGLDYERVVLAGGPLGIMAACLDVVVPYVHERKQFDQPIGEFQLMQCKLADMYV
CCEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEEEEEEEE
TFNASRAYVYAVAAACDRGETTRKDAAGCILYSAENATQMALQAIQSLGGNGYINDYPTG
EEECCCEEEEEEEHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCC
RLLRDAKLYEIGAGTSEIRRMLIGRELFQETR
CEECCCEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]