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The map label for this gene is accA1 [H]

Identifier: 225851563

GI number: 225851563

Start: 19214

End: 21181

Strand: Reverse

Name: accA1 [H]

Synonym: BMEA_A0018

Alternate gene names: 225851563

Gene position: 21181-19214 (Counterclockwise)

Preceding gene: 225851564

Following gene: 225851562

Centisome position: 1.0

GC content: 62.3

Gene sequence:

>1968_bases
ATGTTTCAGAAAATACTGATTGCCAATCGCGGAGAAATCGCCTGCCGGGTCATTCGCACGGCGCGCAAGCTTGGCATTGC
CACGGTGGCGATTTATTCCGATGCGGATGCACGGGCGTTGCATGTGGAAATGGCCGACGAGGCGGTGCGTGTCGGCCCGG
CTGCATCCGCGCAAAGCTATCTGAACGTCGATGCGATCATCAAGGCCGCGAAGGAAACAGGCGCGGAGGCGATCCATCCG
GGCTATGGCTTCCTTTCGGAAAACCCGGCTTTCGTGGATGCGGTCGAAGAAGCGGGCCTCATCTTCATCGGCCCATCGGC
CAAGGCCATCCGCGCCATGGGGCTGAAGGATGCCGCCAAGGCGCTGATGGAAAAGGCAGGCGTGCCGGTCGTGCCGGGCT
ATCACGGCGACAATCAGGATGGCGCCTTTCTCAAAAGCGAGGCGGACCGGATCACCTATCCCGTCCTCATCAAGGCGCGG
GCTGGCGGCGGCGGCAAGGGCATGCGCCGGGTCGATAGCGCTGCCGATTTTGCTGCGGCGCTGGAAAGTGCCCGGCGCGA
GGCGGAAGCCTCGTTCGGCGATGGCGCGGTGCTGGTCGAAAAATATATGGCGAAACCGCGCCATATCGAAGTGCAGGTCT
TTGGCGATAATCACGGCAATGCCGTGCATCTGTTCGAGCGCGATTGCTCACTGCAACGCCGCCACCAGAAGGTGATCGAA
GAAGCGCCAGCGCCCGGCATGACGGAAGAAATGCGCGCCGCCATGGGCGAAGCGGCGGTGAAGGCGGCCTTGACCATTGG
CTATTCCGGCGCGGGCACGGTGGAATTCATCGCCGATGTGTCGGAGGGCCTCAGGCCCGACCGCTTCTTCTTCATGGAAA
TGAACACGCGCTTGCAGGTGGAACATCCGGTGACGGAAGCAATCACCGGCCTCGACCTTGTCGAATGGCAATTGCGTGTG
GCCTCCGGCGAAGCGCTGCCGAAGCGTCAGGACGAACTGTCCATAAACGGCTGGGCTTTCGAGGCGCGGCTTTATGCGGA
AGACCCGGCGCGCGATTTCCTGCCCGCGACCGGCAAGCTTGCGCTCTTTGTCCCGCCTGAAAATGCGCGTGTCGATTCCG
GCGTGCGCACCGGCGATACGATCACGCCGTTCTACGATCCCATGATCGCCAAGATCATCACGCATGGAGCCACGCGCGAC
GAGGCGCTGAACCGGCTGGACGCGGCCCTGAACAAGACCCGCATTGCCGGGCTTGTCACCAATCGTCAGTTCCTGTCGGC
GCTCTGTAATCTCGAAGCTTTCCGCACCGGCGATGTCGATACCGGGCTGATCGGGCGCGAGACGGCGGCGCTTTTCACCG
ATGCACAGCCTTCGGACATCGCCTTTGCGCTGGCCGCACTTGGCGCACTCGATCTTCTGGATGCGCCAGAAAAAAGCGAT
CCATGGTCGGGCCTGCGTGGGTTCCGCCTGTGGGGCGAGGCATCGCGCTCGGTTCTCATCGAGCATCATGGCGAGCGCCG
CACGGTCAGCTTCACGGCCAGGGGCGACAGGCATTTCGGCTTTGCTTTCGGCACCATGGACATTCGCGCGCACAAGAACG
GACTGGTTCGCTTTGCCATTGATGGTCGCGTGTCGGAAGCATCGGTCTCACGCATCGGGCATGATGTGACGGTGCAAATC
GAAGGGCACGACACCATATTCCATCATGTGCTGGCGACAGGCGCGGAGGAGGATGCCTCCAGCGAAAGCCGCATCCTGTC
GCCGATGCCGGGGCTGGTGCGGCTGGTTTCCGTCGTGGAAGGTGCGAGCGTCGCCAAGGGCGATCCGCTGGTGACGATGG
AAGCCATGAAGATGGAACTGTCACTGACCGCGCCGCGCGATGGCAAGGTTGCCTCCGTGACAGTTGCGGCAGGCGATCAG
GTCAATGAAGGCGCATTGCTAGTCGAGCTGGAGGAGCAACATGGCTGA

Upstream 100 bases:

>100_bases
TCGAGCCGACGCGTTTTGGCATCTTCAGAATGTGAGGAAGCGCGGGATGAGGAAAAGTGTGAAGCGGTTTTCCGCCCGCA
TCCCGCGAGGAAAAAATGTG

Downstream 100 bases:

>100_bases
ACACGTGGAAATCGTTGAAATGGCTGCGCGTGATGGCCTGCAAAACGAAAAGCGTTTTGTGCCGACAGCCGACAAGATCG
CGCTGATCAACCGCCTTTCG

Product: carbamoyl-phosphate synthase subunit L

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 655; Mature: 655

Protein sequence:

>655_residues
MFQKILIANRGEIACRVIRTARKLGIATVAIYSDADARALHVEMADEAVRVGPAASAQSYLNVDAIIKAAKETGAEAIHP
GYGFLSENPAFVDAVEEAGLIFIGPSAKAIRAMGLKDAAKALMEKAGVPVVPGYHGDNQDGAFLKSEADRITYPVLIKAR
AGGGGKGMRRVDSAADFAAALESARREAEASFGDGAVLVEKYMAKPRHIEVQVFGDNHGNAVHLFERDCSLQRRHQKVIE
EAPAPGMTEEMRAAMGEAAVKAALTIGYSGAGTVEFIADVSEGLRPDRFFFMEMNTRLQVEHPVTEAITGLDLVEWQLRV
ASGEALPKRQDELSINGWAFEARLYAEDPARDFLPATGKLALFVPPENARVDSGVRTGDTITPFYDPMIAKIITHGATRD
EALNRLDAALNKTRIAGLVTNRQFLSALCNLEAFRTGDVDTGLIGRETAALFTDAQPSDIAFALAALGALDLLDAPEKSD
PWSGLRGFRLWGEASRSVLIEHHGERRTVSFTARGDRHFGFAFGTMDIRAHKNGLVRFAIDGRVSEASVSRIGHDVTVQI
EGHDTIFHHVLATGAEEDASSESRILSPMPGLVRLVSVVEGASVAKGDPLVTMEAMKMELSLTAPRDGKVASVTVAAGDQ
VNEGALLVELEEQHG

Sequences:

>Translated_655_residues
MFQKILIANRGEIACRVIRTARKLGIATVAIYSDADARALHVEMADEAVRVGPAASAQSYLNVDAIIKAAKETGAEAIHP
GYGFLSENPAFVDAVEEAGLIFIGPSAKAIRAMGLKDAAKALMEKAGVPVVPGYHGDNQDGAFLKSEADRITYPVLIKAR
AGGGGKGMRRVDSAADFAAALESARREAEASFGDGAVLVEKYMAKPRHIEVQVFGDNHGNAVHLFERDCSLQRRHQKVIE
EAPAPGMTEEMRAAMGEAAVKAALTIGYSGAGTVEFIADVSEGLRPDRFFFMEMNTRLQVEHPVTEAITGLDLVEWQLRV
ASGEALPKRQDELSINGWAFEARLYAEDPARDFLPATGKLALFVPPENARVDSGVRTGDTITPFYDPMIAKIITHGATRD
EALNRLDAALNKTRIAGLVTNRQFLSALCNLEAFRTGDVDTGLIGRETAALFTDAQPSDIAFALAALGALDLLDAPEKSD
PWSGLRGFRLWGEASRSVLIEHHGERRTVSFTARGDRHFGFAFGTMDIRAHKNGLVRFAIDGRVSEASVSRIGHDVTVQI
EGHDTIFHHVLATGAEEDASSESRILSPMPGLVRLVSVVEGASVAKGDPLVTMEAMKMELSLTAPRDGKVASVTVAAGDQ
VNEGALLVELEEQHG
>Mature_655_residues
MFQKILIANRGEIACRVIRTARKLGIATVAIYSDADARALHVEMADEAVRVGPAASAQSYLNVDAIIKAAKETGAEAIHP
GYGFLSENPAFVDAVEEAGLIFIGPSAKAIRAMGLKDAAKALMEKAGVPVVPGYHGDNQDGAFLKSEADRITYPVLIKAR
AGGGGKGMRRVDSAADFAAALESARREAEASFGDGAVLVEKYMAKPRHIEVQVFGDNHGNAVHLFERDCSLQRRHQKVIE
EAPAPGMTEEMRAAMGEAAVKAALTIGYSGAGTVEFIADVSEGLRPDRFFFMEMNTRLQVEHPVTEAITGLDLVEWQLRV
ASGEALPKRQDELSINGWAFEARLYAEDPARDFLPATGKLALFVPPENARVDSGVRTGDTITPFYDPMIAKIITHGATRD
EALNRLDAALNKTRIAGLVTNRQFLSALCNLEAFRTGDVDTGLIGRETAALFTDAQPSDIAFALAALGALDLLDAPEKSD
PWSGLRGFRLWGEASRSVLIEHHGERRTVSFTARGDRHFGFAFGTMDIRAHKNGLVRFAIDGRVSEASVSRIGHDVTVQI
EGHDTIFHHVLATGAEEDASSESRILSPMPGLVRLVSVVEGASVAKGDPLVTMEAMKMELSLTAPRDGKVASVTVAAGDQ
VNEGALLVELEEQHG

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=675, Percent_Identity=45.7777777777778, Blast_Score=572, Evalue=1e-163,
Organism=Homo sapiens, GI65506442, Length=683, Percent_Identity=43.7774524158126, Blast_Score=481, Evalue=1e-135,
Organism=Homo sapiens, GI189095269, Length=683, Percent_Identity=43.7774524158126, Blast_Score=481, Evalue=1e-135,
Organism=Homo sapiens, GI295821183, Length=447, Percent_Identity=51.9015659955257, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI106049528, Length=458, Percent_Identity=45.4148471615721, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI106049295, Length=458, Percent_Identity=45.4148471615721, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI106049292, Length=458, Percent_Identity=45.4148471615721, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI38679960, Length=725, Percent_Identity=28.2758620689655, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI38679974, Length=725, Percent_Identity=28.2758620689655, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI38679971, Length=725, Percent_Identity=28.2758620689655, Blast_Score=249, Evalue=6e-66,
Organism=Homo sapiens, GI38679977, Length=725, Percent_Identity=28.2758620689655, Blast_Score=249, Evalue=6e-66,
Organism=Homo sapiens, GI38679967, Length=725, Percent_Identity=28.2758620689655, Blast_Score=249, Evalue=6e-66,
Organism=Homo sapiens, GI134142062, Length=725, Percent_Identity=27.448275862069, Blast_Score=237, Evalue=2e-62,
Organism=Escherichia coli, GI1789654, Length=442, Percent_Identity=51.8099547511312, Blast_Score=418, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71987519, Length=663, Percent_Identity=47.0588235294118, Blast_Score=545, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17567343, Length=687, Percent_Identity=43.3770014556041, Blast_Score=498, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17562816, Length=482, Percent_Identity=42.1161825726141, Blast_Score=333, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI133931226, Length=708, Percent_Identity=28.6723163841808, Blast_Score=237, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=29.7455968688845, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=29.7455968688845, Blast_Score=211, Evalue=9e-55,
Organism=Saccharomyces cerevisiae, GI6319685, Length=452, Percent_Identity=46.6814159292035, Blast_Score=424, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319695, Length=459, Percent_Identity=43.1372549019608, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6321376, Length=459, Percent_Identity=44.0087145969499, Blast_Score=331, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6324343, Length=722, Percent_Identity=28.5318559556787, Blast_Score=247, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6323863, Length=464, Percent_Identity=32.3275862068966, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24651757, Length=671, Percent_Identity=47.5409836065574, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24651759, Length=635, Percent_Identity=45.9842519685039, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24652212, Length=480, Percent_Identity=43.9583333333333, Blast_Score=364, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652210, Length=480, Percent_Identity=43.9583333333333, Blast_Score=364, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652214, Length=480, Percent_Identity=43.9583333333333, Blast_Score=364, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19921944, Length=480, Percent_Identity=43.9583333333333, Blast_Score=364, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652216, Length=480, Percent_Identity=43.9583333333333, Blast_Score=364, Evalue=1e-100,
Organism=Drosophila melanogaster, GI281363050, Length=480, Percent_Identity=43.9583333333333, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652224, Length=480, Percent_Identity=43.9583333333333, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652222, Length=480, Percent_Identity=43.9583333333333, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652220, Length=480, Percent_Identity=43.9583333333333, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652218, Length=480, Percent_Identity=43.9583333333333, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI161076407, Length=721, Percent_Identity=28.4327323162275, Blast_Score=244, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24586460, Length=721, Percent_Identity=28.4327323162275, Blast_Score=244, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24586458, Length=721, Percent_Identity=28.4327323162275, Blast_Score=244, Evalue=2e-64,
Organism=Drosophila melanogaster, GI161076409, Length=721, Percent_Identity=28.4327323162275, Blast_Score=244, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 70295; Mature: 70295

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKILIANRGEIACRVIRTARKLGIATVAIYSDADARALHVEMADEAVRVGPAASAQSY
CCCEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCCHHCCCCCCCHHHH
LNVDAIIKAAKETGAEAIHPGYGFLSENPAFVDAVEEAGLIFIGPSAKAIRAMGLKDAAK
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHCCHHHHHH
ALMEKAGVPVVPGYHGDNQDGAFLKSEADRITYPVLIKARAGGGGKGMRRVDSAADFAAA
HHHHHCCCCEECCCCCCCCCCCEEECCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHH
LESARREAEASFGDGAVLVEKYMAKPRHIEVQVFGDNHGNAVHLFERDCSLQRRHQKVIE
HHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCHHHHHHHHHHH
EAPAPGMTEEMRAAMGEAAVKAALTIGYSGAGTVEFIADVSEGLRPDRFFFMEMNTRLQV
HCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCEEEE
EHPVTEAITGLDLVEWQLRVASGEALPKRQDELSINGWAFEARLYAEDPARDFLPATGKL
CCCHHHHHCCCEEEEEEEEEECCCCCCCCCCCCEECCEEEEEEEEECCCCHHCCCCCCCE
ALFVPPENARVDSGVRTGDTITPFYDPMIAKIITHGATRDEALNRLDAALNKTRIAGLVT
EEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEE
NRQFLSALCNLEAFRTGDVDTGLIGRETAALFTDAQPSDIAFALAALGALDLLDAPEKSD
CHHHHHHHHCCHHEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCC
PWSGLRGFRLWGEASRSVLIEHHGERRTVSFTARGDRHFGFAFGTMDIRAHKNGLVRFAI
CCCCCCCEEEECCCCCEEEEEECCCEEEEEEEECCCCEEEEEEEEEEEEECCCCEEEEEE
DGRVSEASVSRIGHDVTVQIEGHDTIFHHVLATGAEEDASSESRILSPMPGLVRLVSVVE
CCCCCHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHC
GASVAKGDPLVTMEAMKMELSLTAPRDGKVASVTVAAGDQVNEGALLVELEEQHG
CCCCCCCCCEEEEEEEEEEEEEECCCCCCEEEEEEECCCCCCCCEEEEEEECCCC
>Mature Secondary Structure
MFQKILIANRGEIACRVIRTARKLGIATVAIYSDADARALHVEMADEAVRVGPAASAQSY
CCCEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEECCCHHCCCCCCCHHHH
LNVDAIIKAAKETGAEAIHPGYGFLSENPAFVDAVEEAGLIFIGPSAKAIRAMGLKDAAK
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHCCHHHHHH
ALMEKAGVPVVPGYHGDNQDGAFLKSEADRITYPVLIKARAGGGGKGMRRVDSAADFAAA
HHHHHCCCCEECCCCCCCCCCCEEECCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHH
LESARREAEASFGDGAVLVEKYMAKPRHIEVQVFGDNHGNAVHLFERDCSLQRRHQKVIE
HHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCHHHHHHHHHHH
EAPAPGMTEEMRAAMGEAAVKAALTIGYSGAGTVEFIADVSEGLRPDRFFFMEMNTRLQV
HCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCEEEE
EHPVTEAITGLDLVEWQLRVASGEALPKRQDELSINGWAFEARLYAEDPARDFLPATGKL
CCCHHHHHCCCEEEEEEEEEECCCCCCCCCCCCEECCEEEEEEEEECCCCHHCCCCCCCE
ALFVPPENARVDSGVRTGDTITPFYDPMIAKIITHGATRDEALNRLDAALNKTRIAGLVT
EEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEE
NRQFLSALCNLEAFRTGDVDTGLIGRETAALFTDAQPSDIAFALAALGALDLLDAPEKSD
CHHHHHHHHCCHHEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCC
PWSGLRGFRLWGEASRSVLIEHHGERRTVSFTARGDRHFGFAFGTMDIRAHKNGLVRFAI
CCCCCCCEEEECCCCCEEEEEECCCEEEEEEEECCCCEEEEEEEEEEEEECCCCEEEEEE
DGRVSEASVSRIGHDVTVQIEGHDTIFHHVLATGAEEDASSESRILSPMPGLVRLVSVVE
CCCCCHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHC
GASVAKGDPLVTMEAMKMELSLTAPRDGKVASVTVAAGDQVNEGALLVELEEQHG
CCCCCCCCCEEEEEEEEEEEEEECCCCCCEEEEEEECCCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]