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The map label for this gene is mdmC [H]

Identifier: 225630791

GI number: 225630791

Start: 1184813

End: 1185460

Strand: Direct

Name: mdmC [H]

Synonym: WRi_010940

Alternate gene names: 225630791

Gene position: 1184813-1185460 (Clockwise)

Preceding gene: 225630789

Following gene: 225630794

Centisome position: 81.94

GC content: 29.48

Gene sequence:

>648_bases
ATGCGTAATAATTTTAGTATAAAATTGTCATACATAAGAAATCTATTTGCAAAAGAATATAAAACAATAGAAGAATATTG
TATTCTTGAAAAAAAGCAACATATTCAGATTAGCCCTGAAGAAGGAAAGCTATTAAGTTTATTTATAAAAATCCATAAAA
TCAAAAGTATTGTTGAGATTGGCACGTTATACGGTTATTCGTCGATTTGCATGGCAAAAGCTCTACTGGAAGATGGTCAC
ATATATACAATAGAAAATAACCCTCAATACTCAAGAATAGCAAAAAAAAATTTTAGTGCTTTTAATCTGAGTGATAAAAT
TACTCTAATAGAAGGCAATGCATTGGAAAAACTTAATGAATTATCAGCAAAAGCACCATTTGACATGATATTTATCGATG
CTGATAAAGGTGGTTATCCTAAATATTTAGATTGGGCAGAGTCATACATTAAACAAGATGGGCTAATCGTTGCAGATAAC
ACTCTATTGTTTAACACAGTATTTTTAGAATCGCCTCCAAAAGAAGTATCAGAAAAATCATGGCATGCTATGAGGGAGTT
TAATAATAGATTATCAGATGAAAAAAAATATTTCTCTATATTGATTCCAACTGATGAAGGAATGACTGTAGCTTTAAAGC
TAACATAA

Upstream 100 bases:

>100_bases
ACTATGAAATAATAACTTAAAATAAATATTTTTATTATTTCAAACTATATTATTATATTTATAAATTGTGTATGAATTAA
GCCTCCCTAATTTATAATAT

Downstream 100 bases:

>100_bases
GTTAAAAATCAAGGTCAGCGTAATGTTTAGGAGGGATTAAACCGGAAACTCTCTCTAATAATATCTCACGAAAACAAGGC
TTTGATTTAACAATGGAGTA

Product: O-methyltransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MRNNFSIKLSYIRNLFAKEYKTIEEYCILEKKQHIQISPEEGKLLSLFIKIHKIKSIVEIGTLYGYSSICMAKALLEDGH
IYTIENNPQYSRIAKKNFSAFNLSDKITLIEGNALEKLNELSAKAPFDMIFIDADKGGYPKYLDWAESYIKQDGLIVADN
TLLFNTVFLESPPKEVSEKSWHAMREFNNRLSDEKKYFSILIPTDEGMTVALKLT

Sequences:

>Translated_215_residues
MRNNFSIKLSYIRNLFAKEYKTIEEYCILEKKQHIQISPEEGKLLSLFIKIHKIKSIVEIGTLYGYSSICMAKALLEDGH
IYTIENNPQYSRIAKKNFSAFNLSDKITLIEGNALEKLNELSAKAPFDMIFIDADKGGYPKYLDWAESYIKQDGLIVADN
TLLFNTVFLESPPKEVSEKSWHAMREFNNRLSDEKKYFSILIPTDEGMTVALKLT
>Mature_215_residues
MRNNFSIKLSYIRNLFAKEYKTIEEYCILEKKQHIQISPEEGKLLSLFIKIHKIKSIVEIGTLYGYSSICMAKALLEDGH
IYTIENNPQYSRIAKKNFSAFNLSDKITLIEGNALEKLNELSAKAPFDMIFIDADKGGYPKYLDWAESYIKQDGLIVADN
TLLFNTVFLESPPKEVSEKSWHAMREFNNRLSDEKKYFSILIPTDEGMTVALKLT

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=178, Percent_Identity=27.5280898876405, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI72001127, Length=188, Percent_Identity=29.2553191489362, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25148771, Length=171, Percent_Identity=29.8245614035088, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17565612, Length=171, Percent_Identity=28.6549707602339, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI72001028, Length=222, Percent_Identity=29.7297297297297, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24753; Mature: 24753

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNNFSIKLSYIRNLFAKEYKTIEEYCILEKKQHIQISPEEGKLLSLFIKIHKIKSIVEI
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
GTLYGYSSICMAKALLEDGHIYTIENNPQYSRIAKKNFSAFNLSDKITLIEGNALEKLNE
HHHHCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHCCCCEEECCCEEEEEECCHHHHHHH
LSAKAPFDMIFIDADKGGYPKYLDWAESYIKQDGLIVADNTLLFNTVFLESPPKEVSEKS
HHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCEEEEEEEEECCCCHHHHHHH
WHAMREFNNRLSDEKKYFSILIPTDEGMTVALKLT
HHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEC
>Mature Secondary Structure
MRNNFSIKLSYIRNLFAKEYKTIEEYCILEKKQHIQISPEEGKLLSLFIKIHKIKSIVEI
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHH
GTLYGYSSICMAKALLEDGHIYTIENNPQYSRIAKKNFSAFNLSDKITLIEGNALEKLNE
HHHHCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHCCCCEEECCCEEEEEECCHHHHHHH
LSAKAPFDMIFIDADKGGYPKYLDWAESYIKQDGLIVADNTLLFNTVFLESPPKEVSEKS
HHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCEEEEEEEEECCCCHHHHHHH
WHAMREFNNRLSDEKKYFSILIPTDEGMTVALKLT
HHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]