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The map label for this gene is purM [H]

Identifier: 225630687

GI number: 225630687

Start: 1053266

End: 1054303

Strand: Reverse

Name: purM [H]

Synonym: WRi_009800

Alternate gene names: 225630687

Gene position: 1054303-1053266 (Counterclockwise)

Preceding gene: 225630690

Following gene: 225630685

Centisome position: 72.92

GC content: 35.26

Gene sequence:

>1038_bases
ATGAATACTTATACCAGATCAGGAATAGATATTGAACTATATAATAAGTTAATAAAAGAAGTCAAGCCTATTGCTCAAGA
AACTACTAGAGAAGAAGTAATCAGCGAAATAGGTTCATTTTCTGCGTTATTTGATTTTGCTGCACTAAGTAAGAAGTATG
ACCATCCAGTACTCGTTTCCTCAACTGATGGAGTAGGTACGAAACTGTTGATAGCTCAAGAAGTGAATAAACATGATACT
ATAGGTATAGATTTAGTTGCAATGTGTGTAAATGACTTACTTGCACAAGGAGCAACGCCTTTGTTTTTCCTTGATTACTT
TGCAACAGGCGTTTTGACCAAAGATGTTTTATTATCTGTGGTTAAGGGCATTGCAGAGGGGTGCAAGCAAGCTAAAATAG
CATTGGTTGGTGGGGAAACTGCAGAAATGCCTGGAATGTATGGTAATAATCACTATGACCTTGCAGGGTTTGTGGTTGGT
GTAGTTGATCGAAAGCAAATTCTTCCAAACTGTAGTATGATGAAAGCAGGTGATTATATAGTTGGCTTAGAGTCAAGTGG
AATTCACTCAAATGGGTTTTCTTTAGTGCGCCATGTTTTCAAAAGCTTAGGTATAAATTATAACGATACATCTCTATGGA
ATAATAAATCTTGGAGTGAAATACTACTTGAACCAACAAAAATATATGTTGATTCTTTGCTGCCTATCATGTCACAAGTA
AAAGGTATTGCGCACATCACGGGTGGTGGTTTGGTAGACAATATTCCGCGAATTCTTCCAAAAAACTTATTTGCAAACAT
AGACATTAATTCCTGGAAATGGCCAGATATATTTTTATGGCTAACAAAGGAGGGTAAAATAGAGAAGAAAGAAATGCTAA
AAACATTTAATTGTGGTATTGGTATGGTATTGATCGTAAGTTCTGAGAATATGCAAAACGTGAAAAATCATTTCCAAAAA
CGTGGAGAAAAAATTGAAATTATTGGAAAACTTGATGAGGCATGTAACCCTCCACTTGATAGAGTAGTATTTAGTTAA

Upstream 100 bases:

>100_bases
TTGGTAAGTATATAATAGTCAATTAAGAGAAAGTTTCGTTGCACTTTTTATATCAAGGCATTAATATAGTATTAACAATT
TTAAAATTTATAAAAGGATT

Downstream 100 bases:

>100_bases
CCTAACTTTACTGACAGTCTTTTTGCAACTTCTAGGTATGCTTCCTTTAAATCTCCTAAATTCAAACGAAAGACATCTTT
ATCTAGCTTTTTATAAGTAT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MNTYTRSGIDIELYNKLIKEVKPIAQETTREEVISEIGSFSALFDFAALSKKYDHPVLVSSTDGVGTKLLIAQEVNKHDT
IGIDLVAMCVNDLLAQGATPLFFLDYFATGVLTKDVLLSVVKGIAEGCKQAKIALVGGETAEMPGMYGNNHYDLAGFVVG
VVDRKQILPNCSMMKAGDYIVGLESSGIHSNGFSLVRHVFKSLGINYNDTSLWNNKSWSEILLEPTKIYVDSLLPIMSQV
KGIAHITGGGLVDNIPRILPKNLFANIDINSWKWPDIFLWLTKEGKIEKKEMLKTFNCGIGMVLIVSSENMQNVKNHFQK
RGEKIEIIGKLDEACNPPLDRVVFS

Sequences:

>Translated_345_residues
MNTYTRSGIDIELYNKLIKEVKPIAQETTREEVISEIGSFSALFDFAALSKKYDHPVLVSSTDGVGTKLLIAQEVNKHDT
IGIDLVAMCVNDLLAQGATPLFFLDYFATGVLTKDVLLSVVKGIAEGCKQAKIALVGGETAEMPGMYGNNHYDLAGFVVG
VVDRKQILPNCSMMKAGDYIVGLESSGIHSNGFSLVRHVFKSLGINYNDTSLWNNKSWSEILLEPTKIYVDSLLPIMSQV
KGIAHITGGGLVDNIPRILPKNLFANIDINSWKWPDIFLWLTKEGKIEKKEMLKTFNCGIGMVLIVSSENMQNVKNHFQK
RGEKIEIIGKLDEACNPPLDRVVFS
>Mature_345_residues
MNTYTRSGIDIELYNKLIKEVKPIAQETTREEVISEIGSFSALFDFAALSKKYDHPVLVSSTDGVGTKLLIAQEVNKHDT
IGIDLVAMCVNDLLAQGATPLFFLDYFATGVLTKDVLLSVVKGIAEGCKQAKIALVGGETAEMPGMYGNNHYDLAGFVVG
VVDRKQILPNCSMMKAGDYIVGLESSGIHSNGFSLVRHVFKSLGINYNDTSLWNNKSWSEILLEPTKIYVDSLLPIMSQV
KGIAHITGGGLVDNIPRILPKNLFANIDINSWKWPDIFLWLTKEGKIEKKEMLKTFNCGIGMVLIVSSENMQNVKNHFQK
RGEKIEIIGKLDEACNPPLDRVVFS

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=333, Percent_Identity=49.5495495495495, Blast_Score=341, Evalue=5e-94,
Organism=Homo sapiens, GI209869995, Length=333, Percent_Identity=49.5495495495495, Blast_Score=341, Evalue=5e-94,
Organism=Homo sapiens, GI209869993, Length=333, Percent_Identity=49.5495495495495, Blast_Score=341, Evalue=5e-94,
Organism=Escherichia coli, GI1788845, Length=329, Percent_Identity=49.5440729483283, Blast_Score=322, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI17567511, Length=340, Percent_Identity=42.6470588235294, Blast_Score=270, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6321203, Length=335, Percent_Identity=49.8507462686567, Blast_Score=328, Evalue=7e-91,
Organism=Drosophila melanogaster, GI24582400, Length=295, Percent_Identity=41.6949152542373, Blast_Score=254, Evalue=8e-68,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38103; Mature: 38103

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTYTRSGIDIELYNKLIKEVKPIAQETTREEVISEIGSFSALFDFAALSKKYDHPVLVS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
STDGVGTKLLIAQEVNKHDTIGIDLVAMCVNDLLAQGATPLFFLDYFATGVLTKDVLLSV
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VKGIAEGCKQAKIALVGGETAEMPGMYGNNHYDLAGFVVGVVDRKQILPNCSMMKAGDYI
HHHHHHHHHHCEEEEECCCHHHCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCEECCCEE
VGLESSGIHSNGFSLVRHVFKSLGINYNDTSLWNNKSWSEILLEPTKIYVDSLLPIMSQV
EEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHHHH
KGIAHITGGGLVDNIPRILPKNLFANIDINSWKWPDIFLWLTKEGKIEKKEMLKTFNCGI
HHHEEECCCCHHHHHHHHCCHHHEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCC
GMVLIVSSENMQNVKNHFQKRGEKIEIIGKLDEACNPPLDRVVFS
EEEEEEECCCHHHHHHHHHHCCCEEEEEECHHHHCCCCHHHHCCC
>Mature Secondary Structure
MNTYTRSGIDIELYNKLIKEVKPIAQETTREEVISEIGSFSALFDFAALSKKYDHPVLVS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
STDGVGTKLLIAQEVNKHDTIGIDLVAMCVNDLLAQGATPLFFLDYFATGVLTKDVLLSV
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VKGIAEGCKQAKIALVGGETAEMPGMYGNNHYDLAGFVVGVVDRKQILPNCSMMKAGDYI
HHHHHHHHHHCEEEEECCCHHHCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCEECCCEE
VGLESSGIHSNGFSLVRHVFKSLGINYNDTSLWNNKSWSEILLEPTKIYVDSLLPIMSQV
EEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHHHH
KGIAHITGGGLVDNIPRILPKNLFANIDINSWKWPDIFLWLTKEGKIEKKEMLKTFNCGI
HHHEEECCCCHHHHHHHHCCHHHEEECCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCC
GMVLIVSSENMQNVKNHFQKRGEKIEIIGKLDEACNPPLDRVVFS
EEEEEEECCCHHHHHHHHHHCCCEEEEEECHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA