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The map label for this gene is icd [H]

Identifier: 225630402

GI number: 225630402

Start: 683169

End: 684605

Strand: Reverse

Name: icd [H]

Synonym: WRi_006330

Alternate gene names: 225630402

Gene position: 684605-683169 (Counterclockwise)

Preceding gene: 225630405

Following gene: 225630401

Centisome position: 47.35

GC content: 38.9

Gene sequence:

>1437_bases
ATGTCAACACCAATCACAGTTGCGTATGGCGACGGTATCGGACCAGAGATTATGGAGGCGGTGCTGTCGATATTGCGCGG
AGCGGAAGCGAAGATCTCAATAGATATTATTGAAATAGGGGAACGTGTTTATAGTAAGGAATGGTCTCACGGAATTTCTC
CAAGTGGTTGGGAGTCTATTGAAAGGACAAAGATATTACTTAAGTCTCCGACAACAACTCCGCAAGGTAAAGGCCACAAA
AGCTTAAACGTTGCACTCAGAAAAAATCTAGGGTTGTATGCAAATATCAGACCATGCATTTCATATCATCCTGTGATAGA
AAATAAATTCGGTAAGTTTGATATCGTAGTGATACGCGAAAATGAAGAGGACGTTTACACCGGAATAGAGCATAGGCTCA
CTGGTGACTCTTACCAATGCACTAAAATTATTACTAGGTCTGGCTCAGAGAAGATATGCAGGTACGCTTTTGAATACGCG
AAAAAACACAACAGAAAAAAAGTAACTTGCCTGACTAAAGATAACATAATGAAAATGACTGACGGCACTTTCCATGCAGC
GTTTGATCGCATTGCAAAGGAATACCAGGACATAAAGGCAGAACATTATATAGTTGATATTGGAATGGCACGTGTTGCAA
CAGAACCCGAGAATTTCGATGTTATAGTAACCGAGAACTTATATGGCGACATATTATCAGACATTGTGGCACAAACCTCT
GGATCTGTGGGGCTTGCTGGAAGTAGCAACATCGGAAATGAATACGCAATGTTTGAAGCAGTGCACGGTTCTGCCCCTGA
TATTGCAGGAAAAAACATAGCTAATCCTTCTGGTCTTTTAAATGCTGCAGTGCATATGCTAATTTACATAGGTCAAGTGG
GTACTGCAAAATTAATCTACGATGCATGGCTCAAGACTTTGGAGGGTGGAATACACACTGCCGATTTGTATAAGGAGAAA
AGAAGTAAACAGAAAGTTGGTACAAAAGAATTTGCAGAAGCTGTTATAGATAATTTAGGAAAGAAACCTGCTGAGCTTAC
AATTGGCAGTGGTTCGGATAGTAAAATAAATTTGGATAGTAAAATAAATAAAGTACAAGACAATTACGAACAAGATTACA
AAGTTAAAAAGCTAGTGGGTAGTGATATAACTCTCGCTTGGGACAAATCCAGTAATGTTGATCAAATAGTAGGATTATTT
GAATCAAGTAATCCGCAGATTATAGCAATATATTCGAAAGGCCTTGCGATTTGGCCAGGAAGTTCAAAGTCTTCAAGTGA
CCAAATAACCTGTAGGTTTATCGCGAATAGCGAAAAAAAACCTATCACAAATAGTGACGTAAACGACCTACTAATCAAAC
TCGAAGAAAATACCTTTGACGTAGTAAGAATGGATAAGTTGTATTTGTATGATGGGAAAGAGGGGTTTTTCTCTTAA

Upstream 100 bases:

>100_bases
GTTATTAAATAACCGTAAATATACTAATTTGGGTAATATTAGCTACTTGTGTCACTCTATTATTTGAATTAACATTAAAT
CATTTACAGTTAGGGAAGTT

Downstream 100 bases:

>100_bases
TGATCGTTTGACATTCTTATGATTGCATAAAACATTTAAATAGATTATACTAGAGATATAATTTATTTATGTGAGATGTA
GTAATGGGTCAACATTTCAA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MSTPITVAYGDGIGPEIMEAVLSILRGAEAKISIDIIEIGERVYSKEWSHGISPSGWESIERTKILLKSPTTTPQGKGHK
SLNVALRKNLGLYANIRPCISYHPVIENKFGKFDIVVIRENEEDVYTGIEHRLTGDSYQCTKIITRSGSEKICRYAFEYA
KKHNRKKVTCLTKDNIMKMTDGTFHAAFDRIAKEYQDIKAEHYIVDIGMARVATEPENFDVIVTENLYGDILSDIVAQTS
GSVGLAGSSNIGNEYAMFEAVHGSAPDIAGKNIANPSGLLNAAVHMLIYIGQVGTAKLIYDAWLKTLEGGIHTADLYKEK
RSKQKVGTKEFAEAVIDNLGKKPAELTIGSGSDSKINLDSKINKVQDNYEQDYKVKKLVGSDITLAWDKSSNVDQIVGLF
ESSNPQIIAIYSKGLAIWPGSSKSSSDQITCRFIANSEKKPITNSDVNDLLIKLEENTFDVVRMDKLYLYDGKEGFFS

Sequences:

>Translated_478_residues
MSTPITVAYGDGIGPEIMEAVLSILRGAEAKISIDIIEIGERVYSKEWSHGISPSGWESIERTKILLKSPTTTPQGKGHK
SLNVALRKNLGLYANIRPCISYHPVIENKFGKFDIVVIRENEEDVYTGIEHRLTGDSYQCTKIITRSGSEKICRYAFEYA
KKHNRKKVTCLTKDNIMKMTDGTFHAAFDRIAKEYQDIKAEHYIVDIGMARVATEPENFDVIVTENLYGDILSDIVAQTS
GSVGLAGSSNIGNEYAMFEAVHGSAPDIAGKNIANPSGLLNAAVHMLIYIGQVGTAKLIYDAWLKTLEGGIHTADLYKEK
RSKQKVGTKEFAEAVIDNLGKKPAELTIGSGSDSKINLDSKINKVQDNYEQDYKVKKLVGSDITLAWDKSSNVDQIVGLF
ESSNPQIIAIYSKGLAIWPGSSKSSSDQITCRFIANSEKKPITNSDVNDLLIKLEENTFDVVRMDKLYLYDGKEGFFS
>Mature_477_residues
STPITVAYGDGIGPEIMEAVLSILRGAEAKISIDIIEIGERVYSKEWSHGISPSGWESIERTKILLKSPTTTPQGKGHKS
LNVALRKNLGLYANIRPCISYHPVIENKFGKFDIVVIRENEEDVYTGIEHRLTGDSYQCTKIITRSGSEKICRYAFEYAK
KHNRKKVTCLTKDNIMKMTDGTFHAAFDRIAKEYQDIKAEHYIVDIGMARVATEPENFDVIVTENLYGDILSDIVAQTSG
SVGLAGSSNIGNEYAMFEAVHGSAPDIAGKNIANPSGLLNAAVHMLIYIGQVGTAKLIYDAWLKTLEGGIHTADLYKEKR
SKQKVGTKEFAEAVIDNLGKKPAELTIGSGSDSKINLDSKINKVQDNYEQDYKVKKLVGSDITLAWDKSSNVDQIVGLFE
SSNPQIIAIYSKGLAIWPGSSKSSSDQITCRFIANSEKKPITNSDVNDLLIKLEENTFDVVRMDKLYLYDGKEGFFS

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=311, Percent_Identity=42.1221864951768, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI4758582, Length=316, Percent_Identity=35.4430379746835, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI28178838, Length=307, Percent_Identity=35.5048859934853, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI28178816, Length=307, Percent_Identity=34.2019543973941, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI28178821, Length=307, Percent_Identity=34.2019543973941, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI28178819, Length=166, Percent_Identity=39.1566265060241, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1787381, Length=394, Percent_Identity=31.9796954314721, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI1788101, Length=309, Percent_Identity=33.6569579288026, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI87081683, Length=357, Percent_Identity=31.0924369747899, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71986051, Length=315, Percent_Identity=41.5873015873016, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17505779, Length=313, Percent_Identity=38.6581469648562, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI25144293, Length=346, Percent_Identity=36.4161849710983, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17550882, Length=348, Percent_Identity=33.6206896551724, Blast_Score=175, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6324709, Length=345, Percent_Identity=40.5797101449275, Blast_Score=230, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6324291, Length=314, Percent_Identity=38.2165605095541, Blast_Score=189, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6322097, Length=353, Percent_Identity=35.1274787535411, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319830, Length=249, Percent_Identity=30.5220883534137, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24661184, Length=342, Percent_Identity=41.5204678362573, Blast_Score=245, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24643270, Length=313, Percent_Identity=43.4504792332268, Blast_Score=245, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24643268, Length=313, Percent_Identity=43.4504792332268, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI161078635, Length=316, Percent_Identity=35.4430379746835, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI161078633, Length=316, Percent_Identity=35.4430379746835, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24650122, Length=316, Percent_Identity=35.4430379746835, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI161078637, Length=316, Percent_Identity=35.4430379746835, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI161078639, Length=311, Percent_Identity=35.6913183279743, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI281362242, Length=345, Percent_Identity=32.1739130434783, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24648872, Length=345, Percent_Identity=32.1739130434783, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI20130355, Length=340, Percent_Identity=29.1176470588235, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI45550436, Length=307, Percent_Identity=24.1042345276873, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR014273 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 52819; Mature: 52687

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPITVAYGDGIGPEIMEAVLSILRGAEAKISIDIIEIGERVYSKEWSHGISPSGWESI
CCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCHHHH
ERTKILLKSPTTTPQGKGHKSLNVALRKNLGLYANIRPCISYHPVIENKFGKFDIVVIRE
HHCEEEEECCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCHHCCCCCCEEEEEEEC
NEEDVYTGIEHRLTGDSYQCTKIITRSGSEKICRYAFEYAKKHNRKKVTCLTKDNIMKMT
CCCHHHHCHHHEECCCCCEEHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEC
DGTFHAAFDRIAKEYQDIKAEHYIVDIGMARVATEPENFDVIVTENLYGDILSDIVAQTS
CCHHHHHHHHHHHHHHHCCCCEEEEEECHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCC
GSVGLAGSSNIGNEYAMFEAVHGSAPDIAGKNIANPSGLLNAAVHMLIYIGQVGTAKLIY
CCEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
DAWLKTLEGGIHTADLYKEKRSKQKVGTKEFAEAVIDNLGKKPAELTIGSGSDSKINLDS
HHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEECHH
KINKVQDNYEQDYKVKKLVGSDITLAWDKSSNVDQIVGLFESSNPQIIAIYSKGLAIWPG
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCEEEECC
SSKSSSDQITCRFIANSEKKPITNSDVNDLLIKLEENTFDVVRMDKLYLYDGKEGFFS
CCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCEEEEEEEEEEEEECCCCCCC
>Mature Secondary Structure 
STPITVAYGDGIGPEIMEAVLSILRGAEAKISIDIIEIGERVYSKEWSHGISPSGWESI
CCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCHHHH
ERTKILLKSPTTTPQGKGHKSLNVALRKNLGLYANIRPCISYHPVIENKFGKFDIVVIRE
HHCEEEEECCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCHHCCCCCCEEEEEEEC
NEEDVYTGIEHRLTGDSYQCTKIITRSGSEKICRYAFEYAKKHNRKKVTCLTKDNIMKMT
CCCHHHHCHHHEECCCCCEEHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEC
DGTFHAAFDRIAKEYQDIKAEHYIVDIGMARVATEPENFDVIVTENLYGDILSDIVAQTS
CCHHHHHHHHHHHHHHHCCCCEEEEEECHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCC
GSVGLAGSSNIGNEYAMFEAVHGSAPDIAGKNIANPSGLLNAAVHMLIYIGQVGTAKLIY
CCEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
DAWLKTLEGGIHTADLYKEKRSKQKVGTKEFAEAVIDNLGKKPAELTIGSGSDSKINLDS
HHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEECHH
KINKVQDNYEQDYKVKKLVGSDITLAWDKSSNVDQIVGLFESSNPQIIAIYSKGLAIWPG
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCEEEECC
SSKSSSDQITCRFIANSEKKPITNSDVNDLLIKLEENTFDVVRMDKLYLYDGKEGFFS
CCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCEEEEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA