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The map label for this gene is typA [H]

Identifier: 225630047

GI number: 225630047

Start: 219974

End: 221803

Strand: Reverse

Name: typA [H]

Synonym: WRi_002160

Alternate gene names: 225630047

Gene position: 221803-219974 (Counterclockwise)

Preceding gene: 225630048

Following gene: 225630046

Centisome position: 15.34

GC content: 40.22

Gene sequence:

>1830_bases
ATGAACGAATTTAAATCGATCCGTAATATAGCAATAATCGCACACGTTGACCACGGTAAAACTACTTTGCTTGATAACAT
GTTAAAACAAAGTGGCACGTTCCGCGAGAATCAAGAAGTTCAAGAGCGAGTGATGGATAGTGGTGATCAAGAGCGTGAAC
GAGGAATTACAATACTTGCAAAATGCACATCAATAATGTGGGGTGATGAAAAAATCAATATTATTGATACGCCAGGGCAC
GCAGACTTTGGTGGAGAAGTAGAAAGGGTATTGTGCATGGCAGATGGTGTGTTGCTGCTGGTTGATGCTGCAGAAGGTCC
AATGCCACAAACAAAATTTGTGCTCTCAAAAGCACTAAAAGCAAATTTGAAGCCAATTGTGATAATCAATAAGGTCGACC
GACCAGACAGCAGAATTGATGAAGTATTAAATGAAATATATGAGTTATTTTTTAACCTTGATGCAACCAACGAGCAGCTA
GATTTTCCAGTGTTGTATGCTTCAGGTAGAAATGGTTGGTGTGCTAAGGAGCTTTCCGATGAAAGAAAAGATTTAAGCCC
ATTATTTTCAACGGTTATAGATTATATAAAACCTTCTGTTTATGATCAAAATGCACCTTTTGCTATGTTGGTCACTCTAC
TTGAGTCTGATAAGTTTCTTGGCAGAATATTGACAGGAAAGGTTTATCAGGGCGTTGCAAAAGTCAATTCAGATCTTAAG
GTGCTTGACCTCGATGGTAAAGTAATTGAACGAGGGAGATTAACTAAATTGCTCTCATTTTCTGGCTTGAAACGCATTCC
AGTAGAACAAGCTGTAGCGGGAGACATAATTGCAATTGCAGGACTTGAGGAAGCTTCAGTTTCAGACACTATAGCAGCAC
CAGAGGTTACAACTGCAGTAAGCTCAACTCCAGTTGATCCGCCGACAATGGCGATTACTCTAAGCGTTAATGATTCGCCT
TTTGCTGGACAAGAAGGTACAAAGCTTACCTCAACTGCTATAAAGGATCGCTTATACGCGGAGGCAGAAACAAATGTTGC
AATTACTGTGACTTTGGCACCAAGCGGTGAAGCGTTTGAAGTAGGTGGACGTGGTGAGCTACAGCTTGGGGTGTTAATTG
AAAATATGAGAAGAGAAGGTTTTGAGCTTTCGGTATCACGCCCTCGAGTGCTATTTAAGGAAGAAGATGGCAAAAAACTT
GAACCTATAGAGGAAGTAGTAATTGATGTGGATGATGAATATAGTGGAATCATCATGGAAAAACTCAGCTTCCGAAAAGG
TGAAGTGACTGACATGAGACCTTCTGGCAATGGCAGGACAAGATTAACGTTTTTAGTGCCATCAAGAGGATTAATTGGTT
ATCAAGGAGAGTTTTTAACTGATTCTCGGGGTACGGGCATAATTAACCGTTTATTTCATAGTTATGCTCCACATAAAGGT
CCAATTTCTGGAAGGCGCAATGGAGTTTTAATTTCTACAGATAAGGGTGAGGCTGTGGCATATGCAATTTTCAATTTGCA
AGATAGGGGAATTATGTTTATCAAACCACAGGATAAGGTATATTGTGGCATGGTTGTCGGCCAGCATAGCCGTGACAATG
ATTTGGAGATAAATGTGCTAAAAGGTAAACAATTAACCAATGTAAGAGCTTCAGGTAGTGATGAAGCCATAAAACTCACT
CCTCCAAAGATAATGACCCTGGAGGATATGATAGCGTATATAGACGATGATGAATTGGTAGAAGTAACCCCAAAATCTAT
ACGTTTACGCAAGAAATTCCTCGATCCAAATGAACGCAAACGTGCAGGAAGGGCAAAAAATAAGGAGTAA

Upstream 100 bases:

>100_bases
TAATCCTATAATATCTTGGAAGCACAGCACAGCTTTAGTTATTTACTCTAAGTGTATTTTATGTATACTTATTACTAAAT
TAATTTTGAAATGATAGAAA

Downstream 100 bases:

>100_bases
TCAGAGGTTGAACATTTGCGAAAAATAGTGTATAATTATTCGTCTCCTAATTGTATTTAATTATGGCCTTTTCGAAATTT
CTCGATCCAAAAAACAATTT

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MNEFKSIRNIAIIAHVDHGKTTLLDNMLKQSGTFRENQEVQERVMDSGDQERERGITILAKCTSIMWGDEKINIIDTPGH
ADFGGEVERVLCMADGVLLLVDAAEGPMPQTKFVLSKALKANLKPIVIINKVDRPDSRIDEVLNEIYELFFNLDATNEQL
DFPVLYASGRNGWCAKELSDERKDLSPLFSTVIDYIKPSVYDQNAPFAMLVTLLESDKFLGRILTGKVYQGVAKVNSDLK
VLDLDGKVIERGRLTKLLSFSGLKRIPVEQAVAGDIIAIAGLEEASVSDTIAAPEVTTAVSSTPVDPPTMAITLSVNDSP
FAGQEGTKLTSTAIKDRLYAEAETNVAITVTLAPSGEAFEVGGRGELQLGVLIENMRREGFELSVSRPRVLFKEEDGKKL
EPIEEVVIDVDDEYSGIIMEKLSFRKGEVTDMRPSGNGRTRLTFLVPSRGLIGYQGEFLTDSRGTGIINRLFHSYAPHKG
PISGRRNGVLISTDKGEAVAYAIFNLQDRGIMFIKPQDKVYCGMVVGQHSRDNDLEINVLKGKQLTNVRASGSDEAIKLT
PPKIMTLEDMIAYIDDDELVEVTPKSIRLRKKFLDPNERKRAGRAKNKE

Sequences:

>Translated_609_residues
MNEFKSIRNIAIIAHVDHGKTTLLDNMLKQSGTFRENQEVQERVMDSGDQERERGITILAKCTSIMWGDEKINIIDTPGH
ADFGGEVERVLCMADGVLLLVDAAEGPMPQTKFVLSKALKANLKPIVIINKVDRPDSRIDEVLNEIYELFFNLDATNEQL
DFPVLYASGRNGWCAKELSDERKDLSPLFSTVIDYIKPSVYDQNAPFAMLVTLLESDKFLGRILTGKVYQGVAKVNSDLK
VLDLDGKVIERGRLTKLLSFSGLKRIPVEQAVAGDIIAIAGLEEASVSDTIAAPEVTTAVSSTPVDPPTMAITLSVNDSP
FAGQEGTKLTSTAIKDRLYAEAETNVAITVTLAPSGEAFEVGGRGELQLGVLIENMRREGFELSVSRPRVLFKEEDGKKL
EPIEEVVIDVDDEYSGIIMEKLSFRKGEVTDMRPSGNGRTRLTFLVPSRGLIGYQGEFLTDSRGTGIINRLFHSYAPHKG
PISGRRNGVLISTDKGEAVAYAIFNLQDRGIMFIKPQDKVYCGMVVGQHSRDNDLEINVLKGKQLTNVRASGSDEAIKLT
PPKIMTLEDMIAYIDDDELVEVTPKSIRLRKKFLDPNERKRAGRAKNKE
>Mature_609_residues
MNEFKSIRNIAIIAHVDHGKTTLLDNMLKQSGTFRENQEVQERVMDSGDQERERGITILAKCTSIMWGDEKINIIDTPGH
ADFGGEVERVLCMADGVLLLVDAAEGPMPQTKFVLSKALKANLKPIVIINKVDRPDSRIDEVLNEIYELFFNLDATNEQL
DFPVLYASGRNGWCAKELSDERKDLSPLFSTVIDYIKPSVYDQNAPFAMLVTLLESDKFLGRILTGKVYQGVAKVNSDLK
VLDLDGKVIERGRLTKLLSFSGLKRIPVEQAVAGDIIAIAGLEEASVSDTIAAPEVTTAVSSTPVDPPTMAITLSVNDSP
FAGQEGTKLTSTAIKDRLYAEAETNVAITVTLAPSGEAFEVGGRGELQLGVLIENMRREGFELSVSRPRVLFKEEDGKKL
EPIEEVVIDVDDEYSGIIMEKLSFRKGEVTDMRPSGNGRTRLTFLVPSRGLIGYQGEFLTDSRGTGIINRLFHSYAPHKG
PISGRRNGVLISTDKGEAVAYAIFNLQDRGIMFIKPQDKVYCGMVVGQHSRDNDLEINVLKGKQLTNVRASGSDEAIKLT
PPKIMTLEDMIAYIDDDELVEVTPKSIRLRKKFLDPNERKRAGRAKNKE

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=493, Percent_Identity=28.6004056795132, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=44.3609022556391, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI18390331, Length=147, Percent_Identity=43.5374149659864, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI4503483, Length=166, Percent_Identity=34.3373493975904, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI25306287, Length=144, Percent_Identity=40.2777777777778, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI19923640, Length=144, Percent_Identity=40.2777777777778, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI25306283, Length=144, Percent_Identity=40.2777777777778, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI34147630, Length=245, Percent_Identity=31.8367346938775, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=41.4414414414414, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=41.4414414414414, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=41.4414414414414, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI217272892, Length=140, Percent_Identity=35.7142857142857, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI217272894, Length=140, Percent_Identity=35.7142857142857, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=32.5581395348837, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI223555963, Length=306, Percent_Identity=26.1437908496732, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI5729864, Length=306, Percent_Identity=26.1437908496732, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI48994988, Length=603, Percent_Identity=52.5704809286899, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=541, Percent_Identity=25.8780036968577, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1789738, Length=148, Percent_Identity=39.8648648648649, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1790835, Length=156, Percent_Identity=31.4102564102564, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790412, Length=250, Percent_Identity=27.6, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789737, Length=250, Percent_Identity=27.6, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17557151, Length=237, Percent_Identity=34.5991561181435, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17556745, Length=336, Percent_Identity=27.9761904761905, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71988811, Length=144, Percent_Identity=36.1111111111111, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71988819, Length=144, Percent_Identity=36.1111111111111, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17506493, Length=178, Percent_Identity=32.5842696629214, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17533571, Length=133, Percent_Identity=42.8571428571429, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17552882, Length=194, Percent_Identity=33.5051546391753, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17556456, Length=284, Percent_Identity=27.4647887323944, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323320, Length=504, Percent_Identity=27.7777777777778, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324707, Length=166, Percent_Identity=37.9518072289157, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320593, Length=166, Percent_Identity=37.9518072289157, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323098, Length=137, Percent_Identity=42.3357664233577, Blast_Score=98, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6322359, Length=149, Percent_Identity=38.9261744966443, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324166, Length=174, Percent_Identity=35.0574712643678, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324761, Length=239, Percent_Identity=29.7071129707113, Blast_Score=90, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6322675, Length=140, Percent_Identity=30, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI78706572, Length=403, Percent_Identity=29.5285359801489, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24582462, Length=145, Percent_Identity=44.1379310344828, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI221458488, Length=160, Percent_Identity=41.25, Blast_Score=108, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24585709, Length=170, Percent_Identity=34.7058823529412, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24585711, Length=170, Percent_Identity=34.7058823529412, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24585713, Length=170, Percent_Identity=34.7058823529412, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI28574573, Length=166, Percent_Identity=36.144578313253, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21357743, Length=134, Percent_Identity=40.2985074626866, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281363316, Length=277, Percent_Identity=28.8808664259928, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17864358, Length=277, Percent_Identity=28.8808664259928, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19921738, Length=249, Percent_Identity=27.3092369477912, Blast_Score=76, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28572034, Length=146, Percent_Identity=32.1917808219178, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67280; Mature: 67280

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEFKSIRNIAIIAHVDHGKTTLLDNMLKQSGTFRENQEVQERVMDSGDQERERGITILA
CCCHHHHCEEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHCCCEEEE
KCTSIMWGDEKINIIDTPGHADFGGEVERVLCMADGVLLLVDAAEGPMPQTKFVLSKALK
EEHHHEECCCEEEEEECCCCCCCCCHHHHHEEEECCEEEEEECCCCCCCHHHHHHHHHHH
ANLKPIVIINKVDRPDSRIDEVLNEIYELFFNLDATNEQLDFPVLYASGRNGWCAKELSD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHH
ERKDLSPLFSTVIDYIKPSVYDQNAPFAMLVTLLESDKFLGRILTGKVYQGVAKVNSDLK
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCE
VLDLDGKVIERGRLTKLLSFSGLKRIPVEQAVAGDIIAIAGLEEASVSDTIAAPEVTTAV
EEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHH
SSTPVDPPTMAITLSVNDSPFAGQEGTKLTSTAIKDRLYAEAETNVAITVTLAPSGEAFE
CCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHEECCCCEEEEEEECCCCCEEE
VGGRGELQLGVLIENMRREGFELSVSRPRVLFKEEDGKKLEPIEEVVIDVDDEYSGIIME
ECCCCCEEEHHHHHHHHCCCCEEEECCCEEEEECCCCCCCCCHHHHEEECCCCCCCHHHH
KLSFRKGEVTDMRPSGNGRTRLTFLVPSRGLIGYQGEFLTDSRGTGIINRLFHSYAPHKG
HHCCCCCCCEECCCCCCCCEEEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHCCCCCC
PISGRRNGVLISTDKGEAVAYAIFNLQDRGIMFIKPQDKVYCGMVVGQHSRDNDLEINVL
CCCCCCCCEEEECCCCCEEEEEEEEECCCCEEEECCCCCEEEEEEEECCCCCCCEEEEEE
KGKQLTNVRASGSDEAIKLTPPKIMTLEDMIAYIDDDELVEVTPKSIRLRKKFLDPNERK
CCCEEEEEECCCCCCEEEECCCCEEEHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCHHH
RAGRAKNKE
HCCCCCCCC
>Mature Secondary Structure
MNEFKSIRNIAIIAHVDHGKTTLLDNMLKQSGTFRENQEVQERVMDSGDQERERGITILA
CCCHHHHCEEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHCCCEEEE
KCTSIMWGDEKINIIDTPGHADFGGEVERVLCMADGVLLLVDAAEGPMPQTKFVLSKALK
EEHHHEECCCEEEEEECCCCCCCCCHHHHHEEEECCEEEEEECCCCCCCHHHHHHHHHHH
ANLKPIVIINKVDRPDSRIDEVLNEIYELFFNLDATNEQLDFPVLYASGRNGWCAKELSD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHHH
ERKDLSPLFSTVIDYIKPSVYDQNAPFAMLVTLLESDKFLGRILTGKVYQGVAKVNSDLK
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCE
VLDLDGKVIERGRLTKLLSFSGLKRIPVEQAVAGDIIAIAGLEEASVSDTIAAPEVTTAV
EEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHH
SSTPVDPPTMAITLSVNDSPFAGQEGTKLTSTAIKDRLYAEAETNVAITVTLAPSGEAFE
CCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHEECCCCEEEEEEECCCCCEEE
VGGRGELQLGVLIENMRREGFELSVSRPRVLFKEEDGKKLEPIEEVVIDVDDEYSGIIME
ECCCCCEEEHHHHHHHHCCCCEEEECCCEEEEECCCCCCCCCHHHHEEECCCCCCCHHHH
KLSFRKGEVTDMRPSGNGRTRLTFLVPSRGLIGYQGEFLTDSRGTGIINRLFHSYAPHKG
HHCCCCCCCEECCCCCCCCEEEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHCCCCCC
PISGRRNGVLISTDKGEAVAYAIFNLQDRGIMFIKPQDKVYCGMVVGQHSRDNDLEINVL
CCCCCCCCEEEECCCCCEEEEEEEEECCCCEEEECCCCCEEEEEEEECCCCCCCEEEEEE
KGKQLTNVRASGSDEAIKLTPPKIMTLEDMIAYIDDDELVEVTPKSIRLRKKFLDPNERK
CCCEEEEEECCCCCCEEEECCCCEEEHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCHHH
RAGRAKNKE
HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]