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The map label for this gene is bcc [H]

Identifier: 222526917

GI number: 222526917

Start: 4608082

End: 4608543

Strand: Reverse

Name: bcc [H]

Synonym: Chy400_3695

Alternate gene names: 222526917

Gene position: 4608543-4608082 (Counterclockwise)

Preceding gene: 222526918

Following gene: 222526916

Centisome position: 87.47

GC content: 56.06

Gene sequence:

>462_bases
ATGCGCCGTTATCAATTAACAGTTAACGGTAAATCCTACACGGTGGCTGTCACCGAGACGGGAAGTGACCGCTTTATCGT
CCAGATCGATGGCCGCGAATTCGAGGTGCAACTGACCGAGAGTGGTGAGGTAAGTGAACCCATACCCCGTTCGGCACCGC
TACCGGCTGTATCACCACCGGTACCAAACACTCCAACACCGCCGCCCGCATCGCCCGCACCGTCCATTCCGCCACCAACG
ACCGTTAGCGATCAGCTTATTCGAGCACCGATGCCGGGCACAATCTTGCAGATCGTAGTCACCCCTGGTACACGGGTCAA
ACGCGGTCAACCGGTCATCGTCCTGGAAGCCATGAAGATGAATAACAGCATCGGTGCGCCACGTGATGGCGTCATTTCTG
CCATCCTGGTCAAAACCGGGCAAAGTGTCGGATACGGTGAACCGCTGGCTCAGATTGAATAA

Upstream 100 bases:

>100_bases
TCGCAGTTACTGGCCGGGGAGTCTGCTCTTTGCCAGTCGTTGGGTTGCCGCCGGTCGCACGCGCCAGAATCAGAGCTGGC
AGCGAAGGAGATAGAACGCT

Downstream 100 bases:

>100_bases
CAGAGAATGGAACGATCTATGAGTGAATTGATCGCCAGCATCTTCGCCGGCATTGGTGCGCTTTCCTGGCAATCTCTGGT
GATGATAGGGATTGCCGCCC

Product: biotin/lipoyl attachment domain-containing protein

Products: propanoyl-CoA; CO2

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MRRYQLTVNGKSYTVAVTETGSDRFIVQIDGREFEVQLTESGEVSEPIPRSAPLPAVSPPVPNTPTPPPASPAPSIPPPT
TVSDQLIRAPMPGTILQIVVTPGTRVKRGQPVIVLEAMKMNNSIGAPRDGVISAILVKTGQSVGYGEPLAQIE

Sequences:

>Translated_153_residues
MRRYQLTVNGKSYTVAVTETGSDRFIVQIDGREFEVQLTESGEVSEPIPRSAPLPAVSPPVPNTPTPPPASPAPSIPPPT
TVSDQLIRAPMPGTILQIVVTPGTRVKRGQPVIVLEAMKMNNSIGAPRDGVISAILVKTGQSVGYGEPLAQIE
>Mature_153_residues
MRRYQLTVNGKSYTVAVTETGSDRFIVQIDGREFEVQLTESGEVSEPIPRSAPLPAVSPPVPNTPTPPPASPAPSIPPPT
TVSDQLIRAPMPGTILQIVVTPGTRVKRGQPVIVLEAMKMNNSIGAPRDGVISAILVKTGQSVGYGEPLAQIE

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=68, Percent_Identity=39.7058823529412, Blast_Score=64, Evalue=5e-11,
Organism=Homo sapiens, GI65506442, Length=68, Percent_Identity=39.7058823529412, Blast_Score=64, Evalue=5e-11,
Organism=Escherichia coli, GI1789653, Length=138, Percent_Identity=31.8840579710145, Blast_Score=65, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17567343, Length=68, Percent_Identity=44.1176470588235, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: 4.1.1.41

Molecular weight: Translated: 16189; Mature: 16189

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRYQLTVNGKSYTVAVTETGSDRFIVQIDGREFEVQLTESGEVSEPIPRSAPLPAVSPP
CCEEEEEECCCEEEEEEEECCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCC
VPNTPTPPPASPAPSIPPPTTVSDQLIRAPMPGTILQIVVTPGTRVKRGQPVIVLEAMKM
CCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCEEEEEEEEC
NNSIGAPRDGVISAILVKTGQSVGYGEPLAQIE
CCCCCCCCCHHEEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRYQLTVNGKSYTVAVTETGSDRFIVQIDGREFEVQLTESGEVSEPIPRSAPLPAVSPP
CCEEEEEECCCEEEEEEEECCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCC
VPNTPTPPPASPAPSIPPPTTVSDQLIRAPMPGTILQIVVTPGTRVKRGQPVIVLEAMKM
CCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCEEEEEEEEC
NNSIGAPRDGVISAILVKTGQSVGYGEPLAQIE
CCCCCCCCCHHEEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-methylmalonyl-CoA

Specific reaction: (S)-methylmalonyl-CoA = propanoyl-CoA + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8431283; 12397186 [H]