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The map label for this gene is htrA [H]

Identifier: 222526153

GI number: 222526153

Start: 3598169

End: 3599398

Strand: Direct

Name: htrA [H]

Synonym: Chy400_2910

Alternate gene names: 222526153

Gene position: 3598169-3599398 (Clockwise)

Preceding gene: 222526152

Following gene: 222526154

Centisome position: 68.29

GC content: 57.8

Gene sequence:

>1230_bases
ATGCACCGGCTTTTGATTGTGTTTGCCATATTCATCGTGGCTGGTTGTACCTCTGCAAATGCGCCGCGTCCACAACTAAA
CGAGGTGCCGACGCCAGTTAGCCAGTTGCCGCGGCCCACAGCAACGATTGGCCCGTCGCCAACGACATTGCCGCCGCTGG
CGACGGTAAGTACGTTCGATGAAGCCGTGATAAGTACGGCTGGCTTGAATGAGATTGAGCAGCAATTGATCGCACTCTAC
CAGCGTGCTCATCTGGCGGTGGTCAGCCTCGATGTGGTTGTGGATCAGAGTGCGAATTTGCCCCCCGGTCATCCACCAGT
ATCTCCTGACGGCCTGGTTGGGCAGGGGTCTGGTTTTCTCTTCGATACGCAGGGCCATATAGTTACCAACCACCACGTGG
TAGCCGGTGCAACGAACATTCAGGTGCGGTTTGCCAATGGGGCGACGGTGCTGGCAGATCTGGTCGGTAGCGATCCCGAT
AGTGATCTGGCTGTGATCAGGTTAACTAATCTGCCGGAGGGCCTGGAACCACTGCCACTTGGTGACAGTGGCGCGTTGCA
GGTTGGTCAGACTGCGGTTGCGATTGGGAGTCCATTCGGCGAACAGAATACACTCACCGTTGGCGTGATCAGTGGTCTGG
GACGCACATTGCGTGCACCGGCCCGTAGTTTTGGCAGTTTCAGTATTCCCAATGTGATTCAGACCGATGCCGCAATCAAT
CCGGGCAATTCGGGTGGGCCGTTGTTGAACCTGCGCGGTGAGGTGATCGGGGTCAACACAGCGATTGCGGTTAGCCTGGG
TGGACGTGATTTCGAGGGGGTGGGTTATGCGGTGCCGGCGAGTACCGTGGCGCGGGTGGTGCCGGCGTTGATTAGCCAGG
GCCGTTACGATCATCCCTGGCTGGGGATCAGCATGACCACGGTTGATACCCTGTTTGCGCAGCGTTTTGGGTTGTCGATT
GATCGAGGCGTGTTGATCGGCGCGGTGCAACCAGGGAGTCCCGCAGCAGTAGCAGGGTTGCGTGGTGGGACGACATCTGC
CACGTACCGCGGATTACCGGTGCAGATCGGTGGTGATGTGATCATTGCCTGCAATGACGAAGCGGTCTTCTCGAGTGACC
AGCTCGTTGGGATTATTGACCGGTTTCAGGTTGGTGATCAGATTACGCTAACGATCTGGCGTGATAACGAGTCCGTAACC
GTCCCGGTGACGCTGGCGGCGCGTCCATAG

Upstream 100 bases:

>100_bases
CTGCCTCATCCCCACTGAGAGCGGTGGTTTCCTGGTATGATGAGAATAGTGTCGCTGATCTGCTTACTGTTTTTTGTTCT
ACATTAACGAGGATCCTGTT

Downstream 100 bases:

>100_bases
TTACCAGGATGCGGTAGAATGACGGAAAGGATTGGTTTCAGAGCTGCATGACTATCAGCGTGATGGATGCAGCTAAGTAG
CGTATGAGAGCGATACAGCA

Product: 2-alkenal reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MHRLLIVFAIFIVAGCTSANAPRPQLNEVPTPVSQLPRPTATIGPSPTTLPPLATVSTFDEAVISTAGLNEIEQQLIALY
QRAHLAVVSLDVVVDQSANLPPGHPPVSPDGLVGQGSGFLFDTQGHIVTNHHVVAGATNIQVRFANGATVLADLVGSDPD
SDLAVIRLTNLPEGLEPLPLGDSGALQVGQTAVAIGSPFGEQNTLTVGVISGLGRTLRAPARSFGSFSIPNVIQTDAAIN
PGNSGGPLLNLRGEVIGVNTAIAVSLGGRDFEGVGYAVPASTVARVVPALISQGRYDHPWLGISMTTVDTLFAQRFGLSI
DRGVLIGAVQPGSPAAVAGLRGGTTSATYRGLPVQIGGDVIIACNDEAVFSSDQLVGIIDRFQVGDQITLTIWRDNESVT
VPVTLAARP

Sequences:

>Translated_409_residues
MHRLLIVFAIFIVAGCTSANAPRPQLNEVPTPVSQLPRPTATIGPSPTTLPPLATVSTFDEAVISTAGLNEIEQQLIALY
QRAHLAVVSLDVVVDQSANLPPGHPPVSPDGLVGQGSGFLFDTQGHIVTNHHVVAGATNIQVRFANGATVLADLVGSDPD
SDLAVIRLTNLPEGLEPLPLGDSGALQVGQTAVAIGSPFGEQNTLTVGVISGLGRTLRAPARSFGSFSIPNVIQTDAAIN
PGNSGGPLLNLRGEVIGVNTAIAVSLGGRDFEGVGYAVPASTVARVVPALISQGRYDHPWLGISMTTVDTLFAQRFGLSI
DRGVLIGAVQPGSPAAVAGLRGGTTSATYRGLPVQIGGDVIIACNDEAVFSSDQLVGIIDRFQVGDQITLTIWRDNESVT
VPVTLAARP
>Mature_409_residues
MHRLLIVFAIFIVAGCTSANAPRPQLNEVPTPVSQLPRPTATIGPSPTTLPPLATVSTFDEAVISTAGLNEIEQQLIALY
QRAHLAVVSLDVVVDQSANLPPGHPPVSPDGLVGQGSGFLFDTQGHIVTNHHVVAGATNIQVRFANGATVLADLVGSDPD
SDLAVIRLTNLPEGLEPLPLGDSGALQVGQTAVAIGSPFGEQNTLTVGVISGLGRTLRAPARSFGSFSIPNVIQTDAAIN
PGNSGGPLLNLRGEVIGVNTAIAVSLGGRDFEGVGYAVPASTVARVVPALISQGRYDHPWLGISMTTVDTLFAQRFGLSI
DRGVLIGAVQPGSPAAVAGLRGGTTSATYRGLPVQIGGDVIIACNDEAVFSSDQLVGIIDRFQVGDQITLTIWRDNESVT
VPVTLAARP

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=307, Percent_Identity=32.8990228013029, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI7019477, Length=319, Percent_Identity=35.423197492163, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI22129776, Length=266, Percent_Identity=34.2105263157895, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI24308541, Length=269, Percent_Identity=32.7137546468402, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI1786356, Length=291, Percent_Identity=38.1443298969072, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1789629, Length=293, Percent_Identity=36.1774744027304, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI1789630, Length=295, Percent_Identity=33.2203389830508, Blast_Score=142, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646839, Length=272, Percent_Identity=35.2941176470588, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 42199; Mature: 42199

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRLLIVFAIFIVAGCTSANAPRPQLNEVPTPVSQLPRPTATIGPSPTTLPPLATVSTFD
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHH
EAVISTAGLNEIEQQLIALYQRAHLAVVSLDVVVDQSANLPPGHPPVSPDGLVGQGSGFL
HHHHHHCCHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCCCCCCCCCCCCEEECCCCEE
FDTQGHIVTNHHVVAGATNIQVRFANGATVLADLVGSDPDSDLAVIRLTNLPEGLEPLPL
EECCCCEEECCEEEEECEEEEEEECCCCEEEHHHHCCCCCCCEEEEEEECCCCCCCCCCC
GDSGALQVGQTAVAIGSPFGEQNTLTVGVISGLGRTLRAPARSFGSFSIPNVIQTDAAIN
CCCCCEEECCEEEEECCCCCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCCCCEECCCCCC
PGNSGGPLLNLRGEVIGVNTAIAVSLGGRDFEGVGYAVPASTVARVVPALISQGRYDHPW
CCCCCCCEEEECCCEEEECEEEEEEECCCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCE
LGISMTTVDTLFAQRFGLSIDRGVLIGAVQPGSPAAVAGLRGGTTSATYRGLPVQIGGDV
EEEEHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEECCCCCCCCEECCCEEEECCCE
IIACNDEAVFSSDQLVGIIDRFQVGDQITLTIWRDNESVTVPVTLAARP
EEEECCCCEECCCCEEEEEHHHCCCCEEEEEEEECCCEEEEEEEEECCC
>Mature Secondary Structure
MHRLLIVFAIFIVAGCTSANAPRPQLNEVPTPVSQLPRPTATIGPSPTTLPPLATVSTFD
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHH
EAVISTAGLNEIEQQLIALYQRAHLAVVSLDVVVDQSANLPPGHPPVSPDGLVGQGSGFL
HHHHHHCCHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCCCCCCCCCCCCEEECCCCEE
FDTQGHIVTNHHVVAGATNIQVRFANGATVLADLVGSDPDSDLAVIRLTNLPEGLEPLPL
EECCCCEEECCEEEEECEEEEEEECCCCEEEHHHHCCCCCCCEEEEEEECCCCCCCCCCC
GDSGALQVGQTAVAIGSPFGEQNTLTVGVISGLGRTLRAPARSFGSFSIPNVIQTDAAIN
CCCCCEEECCEEEEECCCCCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCCCCEECCCCCC
PGNSGGPLLNLRGEVIGVNTAIAVSLGGRDFEGVGYAVPASTVARVVPALISQGRYDHPW
CCCCCCCEEEECCCEEEECEEEEEEECCCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCE
LGISMTTVDTLFAQRFGLSIDRGVLIGAVQPGSPAAVAGLRGGTTSATYRGLPVQIGGDV
EEEEHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEECCCCCCCCEECCCEEEECCCE
IIACNDEAVFSSDQLVGIIDRFQVGDQITLTIWRDNESVTVPVTLAARP
EEEECCCCEECCCCEEEEEHHHCCCCEEEEEEEECCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]