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The map label for this gene is hisD [H]

Identifier: 222526154

GI number: 222526154

Start: 3599498

End: 3600805

Strand: Direct

Name: hisD [H]

Synonym: Chy400_2911

Alternate gene names: 222526154

Gene position: 3599498-3600805 (Clockwise)

Preceding gene: 222526153

Following gene: 222526155

Centisome position: 68.32

GC content: 60.55

Gene sequence:

>1308_bases
ATGACGGTTCCTATCATCCGCGACATTGATACTGCCCGTGCCGGTATTCTGCGGCGTATGCCACTCGATGACGATGCTGC
GACGACTACTGCCGTTGCCGGGATTATTGCTGGCGTGCGCCAACGGGGCGATGCCGCATTACGCGAGTATACGCAACGCT
TCGATGGGGTAGATCGGGCAACGCTTGAAATTCCGCGTGAGCGGTGGGCTGCGGCGGCAGCCGATCTTGATCCGGCGTTA
CGTCATGCCCTCTTGCTGGCAATCGGCGAGATTCGGCGTTTTCATGAACGGCAACTGCGCAACTCCTGGGTTGAATTTAG
CGTCGAAGGAGCACTGGGGCAGTTGGTGCGGCCCCTGGATCGAGTTGGGCTTTACGTTCCCGGTGGAGCAGCCCCGCTCC
CGTCATCGTTGATCCACGCTGCGGTACCCGCACGGGTCGCCGGTGTGCGCGAGATTGTGGTCTGCTCGCCACCACAACGC
TCGACCGGTGAACCGGCTGAGGTGGTGATGGCAGCGGCGCATCTGGCCGGAGTTGATCGCTTGTTTGCGGTTGGTGGCGC
CCAGGCCATTGCCGCGCTGGCCTATGGCACCGAGAGCGTTCCACGGGTGGAGACGATAGCCGGGCCAGGGAATCGGTATG
TCATTCAGGCGATGCGCCTGGTGTACGGTACGGTAGGAATCGTCAGTCTGCCAGGGCCAACCGAGACCCTGATCATCGCC
GATCACACAGCCAGCCCGCGGGCGGTTGCGGCTGATCTGCTGGCACAGGCCGAACATGTCGAGGCAAGTGCCATTTTATT
GACCCCTGATCCGGTGCTGGCCGAACAGGTGCAGGTTGAAGTCGAACGACAGCTTGCCACATTACCGTCACCAAATGCAC
AGGCTGCCCGTGACGCAGTGACCCGGCGTGGTGGCATCGTGATTGTGCCCGACCTGGCAACAGCCTTCATGCTGGCCAAT
GACTACGGGCCAGAGCATCTCTGCCTGTTGGTCGCCGACCCGTGGTCGTATGTCGGAATGGTGCGCAACGCAGGCGGTAT
TTTCCTGGGCGAAGAGTCGTTTGAAGTACTGGGTGATTATGTTGCCGGGCCATCACACATCATGCCAACCGAGGGCACGG
CGCGCTATGCTTCACCGGTCAACGTTGATAGTTTTCGCAAGATCATCTCGCTGGTTGGCCTGAATCGAAGTGGTCTCAAT
CGGATTGGGCCAGCAGCGATGCGGTTAGCAGAAGCAGAGGGTCTCGTTGCGCACGCTGCTGCCGTCAAAGTTCGCTTCGA
GTCGGCAGATACCGATGGGAGGGAGTAG

Upstream 100 bases:

>100_bases
GTTACCAGGATGCGGTAGAATGACGGAAAGGATTGGTTTCAGAGCTGCATGACTATCAGCGTGATGGATGCAGCTAAGTA
GCGTATGAGAGCGATACAGC

Downstream 100 bases:

>100_bases
TATGTCAGGCTTTCTGGTTAGTTTTGTCAGTATTCTCTTCACTGTCCTGTTTTATGCCATTTTGGGACGTGTGCTGGCGT
CATGGATCGACCCACAGGGT

Product: Histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MTVPIIRDIDTARAGILRRMPLDDDAATTTAVAGIIAGVRQRGDAALREYTQRFDGVDRATLEIPRERWAAAAADLDPAL
RHALLLAIGEIRRFHERQLRNSWVEFSVEGALGQLVRPLDRVGLYVPGGAAPLPSSLIHAAVPARVAGVREIVVCSPPQR
STGEPAEVVMAAAHLAGVDRLFAVGGAQAIAALAYGTESVPRVETIAGPGNRYVIQAMRLVYGTVGIVSLPGPTETLIIA
DHTASPRAVAADLLAQAEHVEASAILLTPDPVLAEQVQVEVERQLATLPSPNAQAARDAVTRRGGIVIVPDLATAFMLAN
DYGPEHLCLLVADPWSYVGMVRNAGGIFLGEESFEVLGDYVAGPSHIMPTEGTARYASPVNVDSFRKIISLVGLNRSGLN
RIGPAAMRLAEAEGLVAHAAAVKVRFESADTDGRE

Sequences:

>Translated_435_residues
MTVPIIRDIDTARAGILRRMPLDDDAATTTAVAGIIAGVRQRGDAALREYTQRFDGVDRATLEIPRERWAAAAADLDPAL
RHALLLAIGEIRRFHERQLRNSWVEFSVEGALGQLVRPLDRVGLYVPGGAAPLPSSLIHAAVPARVAGVREIVVCSPPQR
STGEPAEVVMAAAHLAGVDRLFAVGGAQAIAALAYGTESVPRVETIAGPGNRYVIQAMRLVYGTVGIVSLPGPTETLIIA
DHTASPRAVAADLLAQAEHVEASAILLTPDPVLAEQVQVEVERQLATLPSPNAQAARDAVTRRGGIVIVPDLATAFMLAN
DYGPEHLCLLVADPWSYVGMVRNAGGIFLGEESFEVLGDYVAGPSHIMPTEGTARYASPVNVDSFRKIISLVGLNRSGLN
RIGPAAMRLAEAEGLVAHAAAVKVRFESADTDGRE
>Mature_434_residues
TVPIIRDIDTARAGILRRMPLDDDAATTTAVAGIIAGVRQRGDAALREYTQRFDGVDRATLEIPRERWAAAAADLDPALR
HALLLAIGEIRRFHERQLRNSWVEFSVEGALGQLVRPLDRVGLYVPGGAAPLPSSLIHAAVPARVAGVREIVVCSPPQRS
TGEPAEVVMAAAHLAGVDRLFAVGGAQAIAALAYGTESVPRVETIAGPGNRYVIQAMRLVYGTVGIVSLPGPTETLIIAD
HTASPRAVAADLLAQAEHVEASAILLTPDPVLAEQVQVEVERQLATLPSPNAQAARDAVTRRGGIVIVPDLATAFMLAND
YGPEHLCLLVADPWSYVGMVRNAGGIFLGEESFEVLGDYVAGPSHIMPTEGTARYASPVNVDSFRKIISLVGLNRSGLNR
IGPAAMRLAEAEGLVAHAAAVKVRFESADTDGRE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=434, Percent_Identity=39.8617511520737, Blast_Score=279, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6319819, Length=443, Percent_Identity=37.4717832957111, Blast_Score=265, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46049; Mature: 45918

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVPIIRDIDTARAGILRRMPLDDDAATTTAVAGIIAGVRQRGDAALREYTQRFDGVDRA
CCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHH
TLEIPRERWAAAAADLDPALRHALLLAIGEIRRFHERQLRNSWVEFSVEGALGQLVRPLD
HHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHH
RVGLYVPGGAAPLPSSLIHAAVPARVAGVREIVVCSPPQRSTGEPAEVVMAAAHLAGVDR
HCCEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
LFAVGGAQAIAALAYGTESVPRVETIAGPGNRYVIQAMRLVYGTVGIVSLPGPTETLIIA
HHHHCCHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCEEECCCCCEEEEEE
DHTASPRAVAADLLAQAEHVEASAILLTPDPVLAEQVQVEVERQLATLPSPNAQAARDAV
ECCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
TRRGGIVIVPDLATAFMLANDYGPEHLCLLVADPWSYVGMVRNAGGIFLGEESFEVLGDY
HHCCCEEEECCHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHCCCCEEECCHHHHHHHHH
VAGPSHIMPTEGTARYASPVNVDSFRKIISLVGLNRSGLNRIGPAAMRLAEAEGLVAHAA
HCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHCHHHHHHHHHCCHHEEEE
AVKVRFESADTDGRE
EEEEEEECCCCCCCC
>Mature Secondary Structure 
TVPIIRDIDTARAGILRRMPLDDDAATTTAVAGIIAGVRQRGDAALREYTQRFDGVDRA
CCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHH
TLEIPRERWAAAAADLDPALRHALLLAIGEIRRFHERQLRNSWVEFSVEGALGQLVRPLD
HHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHH
RVGLYVPGGAAPLPSSLIHAAVPARVAGVREIVVCSPPQRSTGEPAEVVMAAAHLAGVDR
HCCEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
LFAVGGAQAIAALAYGTESVPRVETIAGPGNRYVIQAMRLVYGTVGIVSLPGPTETLIIA
HHHHCCHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCEEECCCCCEEEEEE
DHTASPRAVAADLLAQAEHVEASAILLTPDPVLAEQVQVEVERQLATLPSPNAQAARDAV
ECCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
TRRGGIVIVPDLATAFMLANDYGPEHLCLLVADPWSYVGMVRNAGGIFLGEESFEVLGDY
HHCCCEEEECCHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHCCCCEEECCHHHHHHHHH
VAGPSHIMPTEGTARYASPVNVDSFRKIISLVGLNRSGLNRIGPAAMRLAEAEGLVAHAA
HCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHCHHHHHHHHHCCHHEEEE
AVKVRFESADTDGRE
EEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]