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The map label for this gene is adk [H]

Identifier: 222525824

GI number: 222525824

Start: 3218633

End: 3219301

Strand: Direct

Name: adk [H]

Synonym: Chy400_2577

Alternate gene names: 222525824

Gene position: 3218633-3219301 (Clockwise)

Preceding gene: 222525823

Following gene: 222525825

Centisome position: 61.09

GC content: 55.9

Gene sequence:

>669_bases
ATGACCAACGTTATCTTACTAGGACCACCCGGTGCCGGCAAAGGCACCCAGGCCAAAACCCTTGCCGATCGCACGGGACT
TACGCATGTAGCGAGTGGCGATCTCTTCCGTGCAGCCCTACGCGAAGGGACTGAATTGGGTATGCTGGCTAAGTCCTACA
TGGATCGGGGGGAATTGGTACCTGATGAAGTCGTGATTCGGATGATCCTTGAACGCATTCAACAACCTGATTGCGCGTCA
GGGGTTATCTTTGACGGTTTTCCGCGCACGCAAGAGCAGGCGCGGGCACTGGAAGTGGCGCTCGCCGACCACAACGCACG
TATCGATGCTGTTCTCTTTCTGGCCGTACCACAAGATGTCTTGCTGCGCCGCATTGCCGGTCGGCAGACGTGCCGCACCT
GTGGTGCGATCTTCAATATCTATTACTTCCCGTCGCATCGGCCAGGTATCTGCGACGCCTGCGGCGGCAAACTCTATCAA
CGGAGCGATGACTCGATCGAGACGGCGCAGCACCGATTAGATGTCTATTTTGCTCAGACAATGCCGCTGATTGAATACTA
TCAGCGACAGGGTATTCTGCACGAAATCGATGGTCAACGTGAGATCGCGCTCGTGACAGAGGCAATGCTAAAAGCGCTCA
GCCCATATCTGGCTCCAGCGCAGCCGTAG

Upstream 100 bases:

>100_bases
CGCCGGCATGCCGGTTGGGCAGCGTCTTTGTGAGACAGGCAGATGGTCATACCGTGCAACAGATAATGTGCGGTTTTTGA
AGTTGAGCGAGCGCCGAGTC

Downstream 100 bases:

>100_bases
GTTAGGAGACATATGTCAAAGAAGAAAGACGTCATCGAGATGGAGGGTACCATCACGGAACCATTGCCAAACGCAATGTT
CCGGGTACAGCTCGATAATG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MTNVILLGPPGAGKGTQAKTLADRTGLTHVASGDLFRAALREGTELGMLAKSYMDRGELVPDEVVIRMILERIQQPDCAS
GVIFDGFPRTQEQARALEVALADHNARIDAVLFLAVPQDVLLRRIAGRQTCRTCGAIFNIYYFPSHRPGICDACGGKLYQ
RSDDSIETAQHRLDVYFAQTMPLIEYYQRQGILHEIDGQREIALVTEAMLKALSPYLAPAQP

Sequences:

>Translated_222_residues
MTNVILLGPPGAGKGTQAKTLADRTGLTHVASGDLFRAALREGTELGMLAKSYMDRGELVPDEVVIRMILERIQQPDCAS
GVIFDGFPRTQEQARALEVALADHNARIDAVLFLAVPQDVLLRRIAGRQTCRTCGAIFNIYYFPSHRPGICDACGGKLYQ
RSDDSIETAQHRLDVYFAQTMPLIEYYQRQGILHEIDGQREIALVTEAMLKALSPYLAPAQP
>Mature_221_residues
TNVILLGPPGAGKGTQAKTLADRTGLTHVASGDLFRAALREGTELGMLAKSYMDRGELVPDEVVIRMILERIQQPDCASG
VIFDGFPRTQEQARALEVALADHNARIDAVLFLAVPQDVLLRRIAGRQTCRTCGAIFNIYYFPSHRPGICDACGGKLYQR
SDDSIETAQHRLDVYFAQTMPLIEYYQRQGILHEIDGQREIALVTEAMLKALSPYLAPAQP

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=210, Percent_Identity=40.4761904761905, Blast_Score=167, Evalue=7e-42,
Organism=Homo sapiens, GI4502013, Length=210, Percent_Identity=40.4761904761905, Blast_Score=167, Evalue=8e-42,
Organism=Homo sapiens, GI19923437, Length=194, Percent_Identity=40.2061855670103, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI310110345, Length=194, Percent_Identity=36.0824742268041, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI53832003, Length=194, Percent_Identity=36.0824742268041, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI8051579, Length=194, Percent_Identity=36.0824742268041, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI53832001, Length=194, Percent_Identity=36.0824742268041, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI7706497, Length=213, Percent_Identity=26.7605633802817, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI4502011, Length=197, Percent_Identity=25.3807106598985, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI28144897, Length=203, Percent_Identity=28.0788177339901, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI28144899, Length=203, Percent_Identity=28.0788177339901, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI22749187, Length=185, Percent_Identity=28.6486486486486, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI237858799, Length=126, Percent_Identity=31.7460317460317, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786680, Length=215, Percent_Identity=40, Blast_Score=158, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17552384, Length=201, Percent_Identity=39.3034825870647, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17537943, Length=219, Percent_Identity=31.0502283105023, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=207, Percent_Identity=29.4685990338164, Blast_Score=107, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17550688, Length=216, Percent_Identity=28.2407407407407, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17567503, Length=216, Percent_Identity=29.1666666666667, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320432, Length=211, Percent_Identity=37.4407582938389, Blast_Score=154, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=35.3535353535354, Blast_Score=132, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6322828, Length=217, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI22026816, Length=203, Percent_Identity=38.9162561576355, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI17737899, Length=208, Percent_Identity=35.0961538461538, Blast_Score=130, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24645822, Length=208, Percent_Identity=35.0961538461538, Blast_Score=130, Evalue=6e-31,
Organism=Drosophila melanogaster, GI221459597, Length=195, Percent_Identity=30.2564102564103, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21356893, Length=195, Percent_Identity=30.2564102564103, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24663208, Length=219, Percent_Identity=24.6575342465753, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17647141, Length=219, Percent_Identity=24.6575342465753, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- InterPro:   IPR001878 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24487; Mature: 24355

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNVILLGPPGAGKGTQAKTLADRTGLTHVASGDLFRAALREGTELGMLAKSYMDRGELV
CCCEEEECCCCCCCCCCHHHHHHHCCCCCHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCC
PDEVVIRMILERIQQPDCASGVIFDGFPRTQEQARALEVALADHNARIDAVLFLAVPQDV
HHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCHHH
LLRRIAGRQTCRTCGAIFNIYYFPSHRPGICDACGGKLYQRSDDSIETAQHRLDVYFAQT
HHHHHHCHHHHHHHHHHHEEEECCCCCCCCCHHHCCHHCCCCCCHHHHHHHHHHHHHHHH
MPLIEYYQRQGILHEIDGQREIALVTEAMLKALSPYLAPAQP
HHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TNVILLGPPGAGKGTQAKTLADRTGLTHVASGDLFRAALREGTELGMLAKSYMDRGELV
CCEEEECCCCCCCCCCHHHHHHHCCCCCHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCC
PDEVVIRMILERIQQPDCASGVIFDGFPRTQEQARALEVALADHNARIDAVLFLAVPQDV
HHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCHHH
LLRRIAGRQTCRTCGAIFNIYYFPSHRPGICDACGGKLYQRSDDSIETAQHRLDVYFAQT
HHHHHHCHHHHHHHHHHHEEEECCCCCCCCCHHHCCHHCCCCCCHHHHHHHHHHHHHHHH
MPLIEYYQRQGILHEIDGQREIALVTEAMLKALSPYLAPAQP
HHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA