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The map label for this gene is galE [H]

Identifier: 222525536

GI number: 222525536

Start: 2891139

End: 2892179

Strand: Direct

Name: galE [H]

Synonym: Chy400_2285

Alternate gene names: 222525536

Gene position: 2891139-2892179 (Clockwise)

Preceding gene: 222525535

Following gene: 222525537

Centisome position: 54.87

GC content: 55.81

Gene sequence:

>1041_bases
ATGACGAGTGCGAAGACGCCTCATGCCTTGATTACCGGTGGCGCAGGGTATATTGGTTCTTTACTAACCGGCGTGCTCTT
GAATCAGGGCTGGTCGGTAACCGTGGTAGACGACCTTCTCTTCGGGGGCGCGTCTCTGTTAGGCTACTGGCATCATCCGC
GCTTCCGTTTTGCAAAAGGCGATATTTGCGATCCGGCGACCCTGCGTGCCACCGGTGATGGTATTGCCGTCGGTGATTTG
CCACCTGCATCGTTCGATGCGGTCATTCATTTGGCAGCAATTGTCGGTTTTCCAGCCTGTCAGATGGTAGGGCCGCAGGT
CGCCTGGCGCTATAACTTTGAAGGAACCAAACGGGTTTTCGCCGCCGCTGAGGCTGGACGGGTTGGGCGTTTCGTCTTTG
CTTCCACCTACAGCAATTACGGTCTCTCTCCTGATGGCAAGCCGGTCACCGAAGAGTCGCCGCTGAACCCGCAATCACTC
TACGCCGAGACGAAGATTGCGGCCGAGCAGTTCCTGCGCGAAAACACGGCCGGGGCAGCGACTATGCCGATTCTCTTCCG
TTTCGCCACGCTGTTTGGGGTGTCGCCCCGCACACGTTTTGATCTCATCATTAACCAGTTCGTCCTCGAAGCGATCACAC
GCCGCAAACTGATCATCTATCAGCGCGGCTATGCGCGTTCGTTCGTGCACGTGCGCGATGTATGTGATGCAATCTTGCTG
GGTCTGGAAGCTCCGGAGGCGGTTGTCAATCGCGAGATTTTTAATGTGGGGAGTGATGAGGGGAATTACACCAAGGATGA
AATTGTGGCCCTGGTGCAACGACACGTCGAGGGAACTGTGGTCGAGTACAAAGACTTGACCTTCGGTGGTGATATGCGCG
ATATTCGCGTTTCGTTTGCCAAAATCCGGGAACGCCTCGGTTTCCGACCGCGGATTAGCGTCGAACAGGGCATTCGCGAG
GTGGCCAGTGTCTTGACGAACGGTGTGATCAAAGACGCACTTGATAGCCAGTACCGCAACGCTCAGTTCATCGTCCAGTA
A

Upstream 100 bases:

>100_bases
GCGCATTATTCCCGATAGCTGGGATCAGCGGCTGCGCTGGAATATGAATGCGCAAGTCGTCTTTTCGGCAGGTCAGTAAC
CATCCTGGAGGAGGAAGCAA

Downstream 100 bases:

>100_bases
GCCCTGCTCTGTGAGGTTTCTATGCATCTCAACAATCATCACTGGCCTGATAGCTATGAGTTCTGGCAGGACAAATCTGT
TGTAGTGACGGGTGGTGCCG

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MTSAKTPHALITGGAGYIGSLLTGVLLNQGWSVTVVDDLLFGGASLLGYWHHPRFRFAKGDICDPATLRATGDGIAVGDL
PPASFDAVIHLAAIVGFPACQMVGPQVAWRYNFEGTKRVFAAAEAGRVGRFVFASTYSNYGLSPDGKPVTEESPLNPQSL
YAETKIAAEQFLRENTAGAATMPILFRFATLFGVSPRTRFDLIINQFVLEAITRRKLIIYQRGYARSFVHVRDVCDAILL
GLEAPEAVVNREIFNVGSDEGNYTKDEIVALVQRHVEGTVVEYKDLTFGGDMRDIRVSFAKIRERLGFRPRISVEQGIRE
VASVLTNGVIKDALDSQYRNAQFIVQ

Sequences:

>Translated_346_residues
MTSAKTPHALITGGAGYIGSLLTGVLLNQGWSVTVVDDLLFGGASLLGYWHHPRFRFAKGDICDPATLRATGDGIAVGDL
PPASFDAVIHLAAIVGFPACQMVGPQVAWRYNFEGTKRVFAAAEAGRVGRFVFASTYSNYGLSPDGKPVTEESPLNPQSL
YAETKIAAEQFLRENTAGAATMPILFRFATLFGVSPRTRFDLIINQFVLEAITRRKLIIYQRGYARSFVHVRDVCDAILL
GLEAPEAVVNREIFNVGSDEGNYTKDEIVALVQRHVEGTVVEYKDLTFGGDMRDIRVSFAKIRERLGFRPRISVEQGIRE
VASVLTNGVIKDALDSQYRNAQFIVQ
>Mature_345_residues
TSAKTPHALITGGAGYIGSLLTGVLLNQGWSVTVVDDLLFGGASLLGYWHHPRFRFAKGDICDPATLRATGDGIAVGDLP
PASFDAVIHLAAIVGFPACQMVGPQVAWRYNFEGTKRVFAAAEAGRVGRFVFASTYSNYGLSPDGKPVTEESPLNPQSLY
AETKIAAEQFLRENTAGAATMPILFRFATLFGVSPRTRFDLIINQFVLEAITRRKLIIYQRGYARSFVHVRDVCDAILLG
LEAPEAVVNREIFNVGSDEGNYTKDEIVALVQRHVEGTVVEYKDLTFGGDMRDIRVSFAKIRERLGFRPRISVEQGIREV
ASVLTNGVIKDALDSQYRNAQFIVQ

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=325, Percent_Identity=27.3846153846154, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI7657641, Length=321, Percent_Identity=25.5451713395639, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1786974, Length=285, Percent_Identity=27.719298245614, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI48994969, Length=337, Percent_Identity=27.5964391691395, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17539532, Length=320, Percent_Identity=24.0625, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319493, Length=341, Percent_Identity=24.3401759530792, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 37938; Mature: 37807

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAKTPHALITGGAGYIGSLLTGVLLNQGWSVTVVDDLLFGGASLLGYWHHPRFRFAKG
CCCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEHHHHHHCCHHHHHHHCCCCEEECCC
DICDPATLRATGDGIAVGDLPPASFDAVIHLAAIVGFPACQMVGPQVAWRYNFEGTKRVF
CCCCCCEEEECCCCEEECCCCCCHHHHHHHHHHHHCCCHHHHCCCCEEEEECCCCHHHHH
AAAEAGRVGRFVFASTYSNYGLSPDGKPVTEESPLNPQSLYAETKIAAEQFLRENTAGAA
HHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
TMPILFRFATLFGVSPRTRFDLIINQFVLEAITRRKLIIYQRGYARSFVHVRDVCDAILL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHH
GLEAPEAVVNREIFNVGSDEGNYTKDEIVALVQRHVEGTVVEYKDLTFGGDMRDIRVSFA
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHH
KIRERLGFRPRISVEQGIREVASVLTNGVIKDALDSQYRNAQFIVQ
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
>Mature Secondary Structure 
TSAKTPHALITGGAGYIGSLLTGVLLNQGWSVTVVDDLLFGGASLLGYWHHPRFRFAKG
CCCCCCCEEEECCHHHHHHHHHHHHHCCCCEEEEHHHHHHCCHHHHHHHCCCCEEECCC
DICDPATLRATGDGIAVGDLPPASFDAVIHLAAIVGFPACQMVGPQVAWRYNFEGTKRVF
CCCCCCEEEECCCCEEECCCCCCHHHHHHHHHHHHCCCHHHHCCCCEEEEECCCCHHHHH
AAAEAGRVGRFVFASTYSNYGLSPDGKPVTEESPLNPQSLYAETKIAAEQFLRENTAGAA
HHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
TMPILFRFATLFGVSPRTRFDLIINQFVLEAITRRKLIIYQRGYARSFVHVRDVCDAILL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHH
GLEAPEAVVNREIFNVGSDEGNYTKDEIVALVQRHVEGTVVEYKDLTFGGDMRDIRVSFA
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHH
KIRERLGFRPRISVEQGIREVASVLTNGVIKDALDSQYRNAQFIVQ
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2116013; 14602910 [H]