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The map label for this gene is yngE [H]

Identifier: 222525446

GI number: 222525446

Start: 2779349

End: 2780956

Strand: Direct

Name: yngE [H]

Synonym: Chy400_2194

Alternate gene names: 222525446

Gene position: 2779349-2780956 (Clockwise)

Preceding gene: 222525445

Following gene: 222525447

Centisome position: 52.75

GC content: 57.59

Gene sequence:

>1608_bases
ATGTCAATTATCCATTCGCATATCCAACCCAACAGCCCCGATTTTCAGGCCAACTTTGCCTATCATCAGTCACTGGCTGC
CGATCTCCGCGAACGCCTGGCCCAGATTCGCCAGGGTGGCGGTGCTGAACAGCGTCGTCGGCACGAAGAACGCGGCAAGC
TCTTTGTGCGTGACCGGATTGATACATTGATCGATCCTGATAGTTCCTTTCTTGAGATCGGTGCGCTGGCTGCCTACAAC
GTCTACGATGAAGAGGTGCCTGCCGCCGGCATCGTTTGCGGGATTGGCCGCGTAGCCGGGCGCCCGGTGATGATTATCGC
CAATGATGCCACTGTGAAGGGCGGCACCTATTTCCCACTGACGGTGAAAAAGCACCTCCGGGCCCAGGAGATTGCCCGCG
AAAACCGCCTGCCCTGCATCTATCTGGTTGATAGTGGCGGAGCCTATCTCCCGCTGCAAAGCGAGGTCTTCCCCGACCGC
GACCATTTCGGTCGCATCTTTTACAACCAGGCCCAGATGTCAGCCGAAGGCATTCCCCAAATTGCCTGTGTGATGGGCAG
TTGTACCGCCGGTGGGGCTTACGTCCCGGCCATGAGTGATGAAGTCGTGATTGTGAAGGGCAATGGCACCATCTTTCTCG
GTGGGCCACCGCTGGTCAAGGCAGCTACCGGCGAAGAGGTAACTGCTGAAGAACTGGGTGGGGCCGATGTTCATACCCGT
ATCTCTGGGGTGGCCGACTATTTTGCCAACGATGATCGCGAGGCGTTGGCGATTGTCCGCGACATCGTTGCCCATTTGGG
GCCGCGCCAGCGAGCAAATTGGGAATTGCGTGATCCGGAGCCGCCGCGTTACGATCCACGGGAAATCTATGGCATCCTAC
CGCGCGATTTTCGCCAGAGCTACGATGTGCGCGAAGTAATTGCCCGGATTGTGGATGGCAGCCGCTTGCACGAATTCAAG
ACGCGCTACGGCACCACGCTGGTTTGCGGCTTTGCCCATATCGAGGGCTTCCCGGTTGGGATTCTCGCCAACAACGGCAT
TCTCTTCAGCGAAAGTGCTCTCAAGGGTGCTCATTTTATCGAGCTGTGTTGTGCGCGCAATATTCCACTTGTCTTCCTGC
AAAACATCACCGGCTTTATGGTCGGCAAGCAGTATGAGAATGGCGGTATCGCGAAAGATGGCGCTAAATTGGTGACGGCT
GTCAGTTGTGCGAATGTGCCAAAGTTTACCGTGATTATCGGCGGTAGCTTTGGTGCCGGTAATTATGGTATGTGCGGGCG
CGCTTATCAGCCCCGCCAGCTCTGGATGTGGCCGAACGCGCGCATTAGCGTGATGGGTGGAACGCAGGCTGCGAATGTCC
TCCTCACTATCCGACGTGACAATCTGCGTGCTCGTGGTCAGGACATGACCCCTGAAGAGCAAGAACGCTTCATGGCGCCG
ATTCTGGCTAAATATGAGCAGGAGGGGCATCCGTATTATGCCAGTGCCCGGCTCTGGGATGACGGAGTGATTGACCCGGT
AGAGACGCGGCGCGTGCTGGCGTTGGGACTGGCGGCTGCCGCCGAAGCGCCGGTGCAACCGACCCGTTTCGGCGTCTTTC
GCATGTAG

Upstream 100 bases:

>100_bases
ATTCGTCAGGCCAGTATCGATGAGCTTGCTGCCGTGCCGGGCATGACGCGCAAGGCTGCCGAAGAGCTGAAGAGTTTGCT
GTAGTTGTCGGAGAAGAGCA

Downstream 100 bases:

>100_bases
GTCTGCCATGACACCTTTACGCATCGTGACCGGAATTGCCGTGATCTGGCTGATATTTGATCCGCAGCCGGTCGTTGGCT
TTGTGGCCTACACCCTGATA

Product: Propionyl-CoA carboxylase

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MSIIHSHIQPNSPDFQANFAYHQSLAADLRERLAQIRQGGGAEQRRRHEERGKLFVRDRIDTLIDPDSSFLEIGALAAYN
VYDEEVPAAGIVCGIGRVAGRPVMIIANDATVKGGTYFPLTVKKHLRAQEIARENRLPCIYLVDSGGAYLPLQSEVFPDR
DHFGRIFYNQAQMSAEGIPQIACVMGSCTAGGAYVPAMSDEVVIVKGNGTIFLGGPPLVKAATGEEVTAEELGGADVHTR
ISGVADYFANDDREALAIVRDIVAHLGPRQRANWELRDPEPPRYDPREIYGILPRDFRQSYDVREVIARIVDGSRLHEFK
TRYGTTLVCGFAHIEGFPVGILANNGILFSESALKGAHFIELCCARNIPLVFLQNITGFMVGKQYENGGIAKDGAKLVTA
VSCANVPKFTVIIGGSFGAGNYGMCGRAYQPRQLWMWPNARISVMGGTQAANVLLTIRRDNLRARGQDMTPEEQERFMAP
ILAKYEQEGHPYYASARLWDDGVIDPVETRRVLALGLAAAAEAPVQPTRFGVFRM

Sequences:

>Translated_535_residues
MSIIHSHIQPNSPDFQANFAYHQSLAADLRERLAQIRQGGGAEQRRRHEERGKLFVRDRIDTLIDPDSSFLEIGALAAYN
VYDEEVPAAGIVCGIGRVAGRPVMIIANDATVKGGTYFPLTVKKHLRAQEIARENRLPCIYLVDSGGAYLPLQSEVFPDR
DHFGRIFYNQAQMSAEGIPQIACVMGSCTAGGAYVPAMSDEVVIVKGNGTIFLGGPPLVKAATGEEVTAEELGGADVHTR
ISGVADYFANDDREALAIVRDIVAHLGPRQRANWELRDPEPPRYDPREIYGILPRDFRQSYDVREVIARIVDGSRLHEFK
TRYGTTLVCGFAHIEGFPVGILANNGILFSESALKGAHFIELCCARNIPLVFLQNITGFMVGKQYENGGIAKDGAKLVTA
VSCANVPKFTVIIGGSFGAGNYGMCGRAYQPRQLWMWPNARISVMGGTQAANVLLTIRRDNLRARGQDMTPEEQERFMAP
ILAKYEQEGHPYYASARLWDDGVIDPVETRRVLALGLAAAAEAPVQPTRFGVFRM
>Mature_534_residues
SIIHSHIQPNSPDFQANFAYHQSLAADLRERLAQIRQGGGAEQRRRHEERGKLFVRDRIDTLIDPDSSFLEIGALAAYNV
YDEEVPAAGIVCGIGRVAGRPVMIIANDATVKGGTYFPLTVKKHLRAQEIARENRLPCIYLVDSGGAYLPLQSEVFPDRD
HFGRIFYNQAQMSAEGIPQIACVMGSCTAGGAYVPAMSDEVVIVKGNGTIFLGGPPLVKAATGEEVTAEELGGADVHTRI
SGVADYFANDDREALAIVRDIVAHLGPRQRANWELRDPEPPRYDPREIYGILPRDFRQSYDVREVIARIVDGSRLHEFKT
RYGTTLVCGFAHIEGFPVGILANNGILFSESALKGAHFIELCCARNIPLVFLQNITGFMVGKQYENGGIAKDGAKLVTAV
SCANVPKFTVIIGGSFGAGNYGMCGRAYQPRQLWMWPNARISVMGGTQAANVLLTIRRDNLRARGQDMTPEEQERFMAPI
LAKYEQEGHPYYASARLWDDGVIDPVETRRVLALGLAAAAEAPVQPTRFGVFRM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=537, Percent_Identity=62.1973929236499, Blast_Score=674, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=526, Percent_Identity=32.319391634981, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI295821216, Length=546, Percent_Identity=31.3186813186813, Blast_Score=227, Evalue=3e-59,
Organism=Homo sapiens, GI310133460, Length=140, Percent_Identity=57.8571428571429, Blast_Score=142, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=62.1013133208255, Blast_Score=696, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=511, Percent_Identity=33.4637964774951, Blast_Score=240, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI25147362, Length=511, Percent_Identity=33.4637964774951, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24586065, Length=551, Percent_Identity=61.524500907441, Blast_Score=700, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 58767; Mature: 58636

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIIHSHIQPNSPDFQANFAYHQSLAADLRERLAQIRQGGGAEQRRRHEERGKLFVRDRI
CCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEHH
DTLIDPDSSFLEIGALAAYNVYDEEVPAAGIVCGIGRVAGRPVMIIANDATVKGGTYFPL
HHHCCCCCCHHHHCCEEEECCCCCCCCCCHHEEEHHHHCCCEEEEEECCCEECCCEEEEE
TVKKHLRAQEIARENRLPCIYLVDSGGAYLPLQSEVFPDRDHFGRIFYNQAQMSAEGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCHHHCCEEEEEHHHHCCCCCCE
IACVMGSCTAGGAYVPAMSDEVVIVKGNGTIFLGGPPLVKAATGEEVTAEELGGADVHTR
EEHEEECCCCCCEECCCCCCCEEEEECCCEEEECCCCEEEECCCCCCCHHHCCCCCHHHH
ISGVADYFANDDREALAIVRDIVAHLGPRQRANWELRDPEPPRYDPREIYGILPRDFRQS
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHC
YDVREVIARIVDGSRLHEFKTRYGTTLVCGFAHIEGFPVGILANNGILFSESALKGAHFI
CCHHHHHHHHHCCHHHHHHHHHCCCEEEEEEHHCCCCEEEEEECCCEEEECHHCCCHHHH
ELCCARNIPLVFLQNITGFMVGKQYENGGIAKDGAKLVTAVSCANVPKFTVIIGGSFGAG
HHHHHCCCCEEEECCCCCEEEECEECCCCCCCCCHHHEEEEHHCCCCEEEEEEECCCCCC
NYGMCGRAYQPRQLWMWPNARISVMGGTQAANVLLTIRRDNLRARGQDMTPEEQERFMAP
CCCCCCCCCCCCEEEECCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHH
ILAKYEQEGHPYYASARLWDDGVIDPVETRRVLALGLAAAAEAPVQPTRFGVFRM
HHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECC
>Mature Secondary Structure 
SIIHSHIQPNSPDFQANFAYHQSLAADLRERLAQIRQGGGAEQRRRHEERGKLFVRDRI
CCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEHH
DTLIDPDSSFLEIGALAAYNVYDEEVPAAGIVCGIGRVAGRPVMIIANDATVKGGTYFPL
HHHCCCCCCHHHHCCEEEECCCCCCCCCCHHEEEHHHHCCCEEEEEECCCEECCCEEEEE
TVKKHLRAQEIARENRLPCIYLVDSGGAYLPLQSEVFPDRDHFGRIFYNQAQMSAEGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCHHHCCEEEEEHHHHCCCCCCE
IACVMGSCTAGGAYVPAMSDEVVIVKGNGTIFLGGPPLVKAATGEEVTAEELGGADVHTR
EEHEEECCCCCCEECCCCCCCEEEEECCCEEEECCCCEEEECCCCCCCHHHCCCCCHHHH
ISGVADYFANDDREALAIVRDIVAHLGPRQRANWELRDPEPPRYDPREIYGILPRDFRQS
HHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHC
YDVREVIARIVDGSRLHEFKTRYGTTLVCGFAHIEGFPVGILANNGILFSESALKGAHFI
CCHHHHHHHHHCCHHHHHHHHHCCCEEEEEEHHCCCCEEEEEECCCEEEECHHCCCHHHH
ELCCARNIPLVFLQNITGFMVGKQYENGGIAKDGAKLVTAVSCANVPKFTVIIGGSFGAG
HHHHHCCCCEEEECCCCCEEEECEECCCCCCCCCHHHEEEEHHCCCCEEEEEEECCCCCC
NYGMCGRAYQPRQLWMWPNARISVMGGTQAANVLLTIRRDNLRARGQDMTPEEQERFMAP
CCCCCCCCCCCCEEEECCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHH
ILAKYEQEGHPYYASARLWDDGVIDPVETRRVLALGLAAAAEAPVQPTRFGVFRM
HHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]