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The map label for this gene is uvrC [H]

Identifier: 222525445

GI number: 222525445

Start: 2777377

End: 2779332

Strand: Direct

Name: uvrC [H]

Synonym: Chy400_2193

Alternate gene names: 222525445

Gene position: 2777377-2779332 (Clockwise)

Preceding gene: 222525443

Following gene: 222525446

Centisome position: 52.71

GC content: 56.95

Gene sequence:

>1956_bases
ATGGATCTTAGTCATACTGCCATCCGCGATCACACGGCCTTTCTCGAACGGCTGCGATTGGTACCCGACCAGCCCGGCGT
CTATCTCTGGAAAGACGCCAATGGCCGTCTGCTCTACGTGGGCAAGAGTAAACGGCTGCGCGACCGCATGCGTTCGTATT
TCGGTTCACCGCGCAGCCTGAGCGGCAAAACCCGGCGGCTGGTTAGCCATATTGCCGATTTTGACATTATCGTCACTCAA
AGTGAATTAGAGGCGTTGCTGCTCGAGATGAACCTGATTAAACAGCATCGCCCTCCGTATAATATTTTGCTCAAAGACGA
TAAGACCTATCCCTACATCAAGGTAACGGTCAACGAAGATTGGCCGCGTGTCTTCGCTACCCGTCAGGTGCTCAACGATG
GCGCACGCTATTTTGGCCCCTACGCCAGTCCCGGTTCCGTCTATCAGGCGCTCGATGTTCTCAATCGGCTCTTTGCCTTT
CGCCCGCCCTACGAGTGTAAAGACGACAAATTCAACCGTCACCGTAAACTGGGCAAGCCCTGCCTCTACTACCAGATGCG
GCGCTGTCTAGGCCCATGTGTGCCCGGTCTGGTGACAAAAGAAGCCTATCGGCAGGCGATTGACGCCGTCTGTCGCTTCC
TCGAAGGCAAGAGCGATCAAATCGTGCGCGAGTTACGTGCCCAGATGGAGCAGGCCGCTGAACAGCTTGAGTTCGAGCGT
GCCGCATACCTGCGTGATCGCATTCAGGCTATCGAGAAGATTTCCGAACGCCAGCAGGTTTTACGCACGGTTGACACTGA
TCAAGATGTGATCGCGTTTGCCCGCGAAGAGGGCAGTGCGGTGGTGCAGGTGCTCTTCATCCGGGGCGGTAAACTTATCA
ATGCCGAACCGTTTACCCTCCAGGGCACCGAAGGCGAGAGTGATGAAGCGTTGCTGACCTCATTTCTCACTCAGTTTTAC
CAGGATGCCCCCAACATTCCACCCAACCTGTTACTGGCCGATCATGTTGAGGAGCCAATGATAATCGCGTCGTGGCTCCA
ACAGAAAAGCGGCCATCGGGTCGAAATTACGGTGCCCCGCCGGGGTGAGAAGCGACAACTGGTTGAGCTGGCTGCCAACA
ACGCACGTCAGAAGCTGCGCGAAATTCGCGAACAGTGGCTCAATTCCGAGCAACGTGCTGTTGCTGCGCTCAGCGAGTTG
CGCGATCTGCTTGAGCTGCCCGCCCTGCCCCACCGCATTGAGTGCTACGATGTGTCGAATATTCAGGGACAACACTCAGT
TGCCAGTATGGTGGTGTTCGAGCGCGGATCACCCCGTCCGGCCCATTACCGTCGCTTCAAGATCAAGACGGTGAGTGGCG
CCAATGACGTTGCTTCGTTGCACGAAGTGATCAGCCGTCGTTTCCGGCGGGCGGCTGAGGCACTTGGCGAGACCCAAACC
GTCACCGGGATGGTTGCCGATGACGACAATAAGACCTCTGAGACGGGCAATACCGATCAACAGGCCCTGGAGAGTTGGGC
TGAGTTGCCCGATCTGCTGTTGGTTGACGGTGGGCAGGCGCAGGTTGCCGCTGCGTCGGCGGCCCTCCGCGACCTGGGAT
TTACCCAGATTCCGGTGGTTGGGGTTGCCAAAGGCCCTGATCGCAATCGTTTCGATCTGATTCGGCTCGATTGCGAGCCG
CTAGTGCTGGCCCGTGATAGCAAAGCCCTGGCCCTGATCCAGCGGATTGATGAAGAGGCTCATCGTTTTGCCATAACCTA
TCACCGCAAGCTACGTAGCAAAGCGACCCTTCGTTCATCCCTGGAAGATATTCCCGGTATCGGCCCCAAACGGAAGCGTG
CCCTGCTGAAGGCTTTTGGCTCTCTTGACGCCATTCGTCAGGCCAGTATCGATGAGCTTGCTGCCGTGCCGGGCATGACG
CGCAAGGCTGCCGAAGAGCTGAAGAGTTTGCTGTAG

Upstream 100 bases:

>100_bases
TACCATCACCGGTATGATATGATTGAGATACCTGTCAAAATCATGGTAAAGATACACAACATGCCGACCTTCAACGATGA
TGAGGTAACATCCGGGCGCT

Downstream 100 bases:

>100_bases
TTGTCGGAGAAGAGCAATGTCAATTATCCATTCGCATATCCAACCCAACAGCCCCGATTTTCAGGCCAACTTTGCCTATC
ATCAGTCACTGGCTGCCGAT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 651; Mature: 651

Protein sequence:

>651_residues
MDLSHTAIRDHTAFLERLRLVPDQPGVYLWKDANGRLLYVGKSKRLRDRMRSYFGSPRSLSGKTRRLVSHIADFDIIVTQ
SELEALLLEMNLIKQHRPPYNILLKDDKTYPYIKVTVNEDWPRVFATRQVLNDGARYFGPYASPGSVYQALDVLNRLFAF
RPPYECKDDKFNRHRKLGKPCLYYQMRRCLGPCVPGLVTKEAYRQAIDAVCRFLEGKSDQIVRELRAQMEQAAEQLEFER
AAYLRDRIQAIEKISERQQVLRTVDTDQDVIAFAREEGSAVVQVLFIRGGKLINAEPFTLQGTEGESDEALLTSFLTQFY
QDAPNIPPNLLLADHVEEPMIIASWLQQKSGHRVEITVPRRGEKRQLVELAANNARQKLREIREQWLNSEQRAVAALSEL
RDLLELPALPHRIECYDVSNIQGQHSVASMVVFERGSPRPAHYRRFKIKTVSGANDVASLHEVISRRFRRAAEALGETQT
VTGMVADDDNKTSETGNTDQQALESWAELPDLLLVDGGQAQVAAASAALRDLGFTQIPVVGVAKGPDRNRFDLIRLDCEP
LVLARDSKALALIQRIDEEAHRFAITYHRKLRSKATLRSSLEDIPGIGPKRKRALLKAFGSLDAIRQASIDELAAVPGMT
RKAAEELKSLL

Sequences:

>Translated_651_residues
MDLSHTAIRDHTAFLERLRLVPDQPGVYLWKDANGRLLYVGKSKRLRDRMRSYFGSPRSLSGKTRRLVSHIADFDIIVTQ
SELEALLLEMNLIKQHRPPYNILLKDDKTYPYIKVTVNEDWPRVFATRQVLNDGARYFGPYASPGSVYQALDVLNRLFAF
RPPYECKDDKFNRHRKLGKPCLYYQMRRCLGPCVPGLVTKEAYRQAIDAVCRFLEGKSDQIVRELRAQMEQAAEQLEFER
AAYLRDRIQAIEKISERQQVLRTVDTDQDVIAFAREEGSAVVQVLFIRGGKLINAEPFTLQGTEGESDEALLTSFLTQFY
QDAPNIPPNLLLADHVEEPMIIASWLQQKSGHRVEITVPRRGEKRQLVELAANNARQKLREIREQWLNSEQRAVAALSEL
RDLLELPALPHRIECYDVSNIQGQHSVASMVVFERGSPRPAHYRRFKIKTVSGANDVASLHEVISRRFRRAAEALGETQT
VTGMVADDDNKTSETGNTDQQALESWAELPDLLLVDGGQAQVAAASAALRDLGFTQIPVVGVAKGPDRNRFDLIRLDCEP
LVLARDSKALALIQRIDEEAHRFAITYHRKLRSKATLRSSLEDIPGIGPKRKRALLKAFGSLDAIRQASIDELAAVPGMT
RKAAEELKSLL
>Mature_651_residues
MDLSHTAIRDHTAFLERLRLVPDQPGVYLWKDANGRLLYVGKSKRLRDRMRSYFGSPRSLSGKTRRLVSHIADFDIIVTQ
SELEALLLEMNLIKQHRPPYNILLKDDKTYPYIKVTVNEDWPRVFATRQVLNDGARYFGPYASPGSVYQALDVLNRLFAF
RPPYECKDDKFNRHRKLGKPCLYYQMRRCLGPCVPGLVTKEAYRQAIDAVCRFLEGKSDQIVRELRAQMEQAAEQLEFER
AAYLRDRIQAIEKISERQQVLRTVDTDQDVIAFAREEGSAVVQVLFIRGGKLINAEPFTLQGTEGESDEALLTSFLTQFY
QDAPNIPPNLLLADHVEEPMIIASWLQQKSGHRVEITVPRRGEKRQLVELAANNARQKLREIREQWLNSEQRAVAALSEL
RDLLELPALPHRIECYDVSNIQGQHSVASMVVFERGSPRPAHYRRFKIKTVSGANDVASLHEVISRRFRRAAEALGETQT
VTGMVADDDNKTSETGNTDQQALESWAELPDLLLVDGGQAQVAAASAALRDLGFTQIPVVGVAKGPDRNRFDLIRLDCEP
LVLARDSKALALIQRIDEEAHRFAITYHRKLRSKATLRSSLEDIPGIGPKRKRALLKAFGSLDAIRQASIDELAAVPGMT
RKAAEELKSLL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=649, Percent_Identity=37.5963020030817, Blast_Score=400, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 73695; Mature: 73695

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSHTAIRDHTAFLERLRLVPDQPGVYLWKDANGRLLYVGKSKRLRDRMRSYFGSPRSL
CCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCCCCCCC
SGKTRRLVSHIADFDIIVTQSELEALLLEMNLIKQHRPPYNILLKDDKTYPYIKVTVNED
CHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCC
WPRVFATRQVLNDGARYFGPYASPGSVYQALDVLNRLFAFRPPYECKDDKFNRHRKLGKP
CHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCH
CLYYQMRRCLGPCVPGLVTKEAYRQAIDAVCRFLEGKSDQIVRELRAQMEQAAEQLEFER
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AAYLRDRIQAIEKISERQQVLRTVDTDQDVIAFAREEGSAVVQVLFIRGGKLINAEPFTL
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEHEECCCEEECCCCCEE
QGTEGESDEALLTSFLTQFYQDAPNIPPNLLLADHVEEPMIIASWLQQKSGHRVEITVPR
ECCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEHHCCCCCHHHHHHHHHCCCCEEEEEECC
RGEKRQLVELAANNARQKLREIREQWLNSEQRAVAALSELRDLLELPALPHRIECYDVSN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
IQGQHSVASMVVFERGSPRPAHYRRFKIKTVSGANDVASLHEVISRRFRRAAEALGETQT
CCCHHHHHHHHEEECCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCE
VTGMVADDDNKTSETGNTDQQALESWAELPDLLLVDGGQAQVAAASAALRDLGFTQIPVV
EEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEE
GVAKGPDRNRFDLIRLDCEPLVLARDSKALALIQRIDEEAHRFAITYHRKLRSKATLRSS
EECCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEDIPGIGPKRKRALLKAFGSLDAIRQASIDELAAVPGMTRKAAEELKSLL
HHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MDLSHTAIRDHTAFLERLRLVPDQPGVYLWKDANGRLLYVGKSKRLRDRMRSYFGSPRSL
CCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCCCCCCC
SGKTRRLVSHIADFDIIVTQSELEALLLEMNLIKQHRPPYNILLKDDKTYPYIKVTVNED
CHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCC
WPRVFATRQVLNDGARYFGPYASPGSVYQALDVLNRLFAFRPPYECKDDKFNRHRKLGKP
CHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCH
CLYYQMRRCLGPCVPGLVTKEAYRQAIDAVCRFLEGKSDQIVRELRAQMEQAAEQLEFER
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AAYLRDRIQAIEKISERQQVLRTVDTDQDVIAFAREEGSAVVQVLFIRGGKLINAEPFTL
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEHEECCCEEECCCCCEE
QGTEGESDEALLTSFLTQFYQDAPNIPPNLLLADHVEEPMIIASWLQQKSGHRVEITVPR
ECCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEHHCCCCCHHHHHHHHHCCCCEEEEEECC
RGEKRQLVELAANNARQKLREIREQWLNSEQRAVAALSELRDLLELPALPHRIECYDVSN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
IQGQHSVASMVVFERGSPRPAHYRRFKIKTVSGANDVASLHEVISRRFRRAAEALGETQT
CCCHHHHHHHHEEECCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCE
VTGMVADDDNKTSETGNTDQQALESWAELPDLLLVDGGQAQVAAASAALRDLGFTQIPVV
EEEEEECCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEE
GVAKGPDRNRFDLIRLDCEPLVLARDSKALALIQRIDEEAHRFAITYHRKLRSKATLRSS
EECCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEDIPGIGPKRKRALLKAFGSLDAIRQASIDELAAVPGMTRKAAEELKSLL
HHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA