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The map label for this gene is hisC [H]

Identifier: 222525341

GI number: 222525341

Start: 2658096

End: 2659202

Strand: Direct

Name: hisC [H]

Synonym: Chy400_2086

Alternate gene names: 222525341

Gene position: 2658096-2659202 (Clockwise)

Preceding gene: 222525337

Following gene: 222525342

Centisome position: 50.45

GC content: 58.36

Gene sequence:

>1107_bases
ATGATGTCGGTTCTGTCCGGTCTGATACGTCCTGAGATTGCCGATTTGGAAGCATATACCCCGATTGTACCGCTAGAAGT
GCTGGCTGATCGCCTTGGCCTGCCGGTGGCGCAGATTGTCAAGCTCGATGCGAATGAAAACCCCTACGGCCCAGCACCGG
CAGCGCTGGCCGCACTTCAGGCGACTGCGACCTACCATATATATCCCGACCCAGAGCAGACGGCGCTGCGGAAGGCGCTG
GCCGATTACACCGGTCGGTCAGCGGAGGAAATCCTCTGCGGAGCCGGTGCCGATGAATTGATCGACCTGGTTTTACGCCT
GATTATCAGTCCCGGCGATGCGATCATCGATTGTCCACCTACCTTCGGCATGTACCGGTTTGATGCCGGTATCTGTGGTG
GGCGGGTGATCAGTATCCCGCGCCGTGCCGATTTCAGTCTTGATCTACCGGCCATTGCCCGGGCAGCAGCGCAGGGTGCC
AAAGCCATCTTCCTCACCTCGCCTAACAACCCAACCGGCAACCCACTGCCACGCAGCGAACTACTCCAGATTCTTGAATT
GCCACTGCTGGTGGTTGTTGATGAGGCGTACATTGAGTTTGCTGAGCCAGAACACGCACCGGTCGGTGCGAGTGATCTGC
TCGACCGGTATCCAAATCTGGCCATTCTCCGCACATTCAGCAAATGGGCCGGTCTGGCCGGGCTGCGCGTAGGCTATGGC
CTGTTCCCGCGTTGGCTGAGTGAGCAACTCTGGAAGATCAAGCAACCGTACAATGTCTCGGTTGCTGCTCAGGCCGCCGC
TGTGGCATCACTCGCCGTCGCCGACGAATTGCGGGCGCGGGTGCAGGCTATCGTCGCCGAACGTGAGCGTCTGTTTCAGC
ATCTCAATACGTTCCCGTTTCTAACCCCTTTTCCAAGTGTGGCGAATTTCATCCTCTGTCGGGTCGAAGGGCGTGATGCC
CGCGAACTCAAACTGGCGCTCGAACGACGCGGTGTGTTAGTGCGCCATTATCAGACGCCGCTGCTTAATGGCTATATTCG
GATCAGCGTCGGTACTCCTGCCCAGACAGATGCGCTGATCGCGATGCTTGCTGAGGTGACCCGATGA

Upstream 100 bases:

>100_bases
CCTCAATTCAACTATTCAAGGCTTGAATTATACCACGTAGCTGTTGTGTCTGTGGTATCATACTCGCTGGTATGCGCTCC
CTCGTCACTATGGAGTTACT

Downstream 100 bases:

>100_bases
GCATATCACTTGCCCACACGCTTGACTTTGCCCGCCAGATCGCTTACGAGGCCGGCCAGATCACGCTGCGCTATTTTCAG
CGTGGTATCACTGTTGAACA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MMSVLSGLIRPEIADLEAYTPIVPLEVLADRLGLPVAQIVKLDANENPYGPAPAALAALQATATYHIYPDPEQTALRKAL
ADYTGRSAEEILCGAGADELIDLVLRLIISPGDAIIDCPPTFGMYRFDAGICGGRVISIPRRADFSLDLPAIARAAAQGA
KAIFLTSPNNPTGNPLPRSELLQILELPLLVVVDEAYIEFAEPEHAPVGASDLLDRYPNLAILRTFSKWAGLAGLRVGYG
LFPRWLSEQLWKIKQPYNVSVAAQAAAVASLAVADELRARVQAIVAERERLFQHLNTFPFLTPFPSVANFILCRVEGRDA
RELKLALERRGVLVRHYQTPLLNGYIRISVGTPAQTDALIAMLAEVTR

Sequences:

>Translated_368_residues
MMSVLSGLIRPEIADLEAYTPIVPLEVLADRLGLPVAQIVKLDANENPYGPAPAALAALQATATYHIYPDPEQTALRKAL
ADYTGRSAEEILCGAGADELIDLVLRLIISPGDAIIDCPPTFGMYRFDAGICGGRVISIPRRADFSLDLPAIARAAAQGA
KAIFLTSPNNPTGNPLPRSELLQILELPLLVVVDEAYIEFAEPEHAPVGASDLLDRYPNLAILRTFSKWAGLAGLRVGYG
LFPRWLSEQLWKIKQPYNVSVAAQAAAVASLAVADELRARVQAIVAERERLFQHLNTFPFLTPFPSVANFILCRVEGRDA
RELKLALERRGVLVRHYQTPLLNGYIRISVGTPAQTDALIAMLAEVTR
>Mature_368_residues
MMSVLSGLIRPEIADLEAYTPIVPLEVLADRLGLPVAQIVKLDANENPYGPAPAALAALQATATYHIYPDPEQTALRKAL
ADYTGRSAEEILCGAGADELIDLVLRLIISPGDAIIDCPPTFGMYRFDAGICGGRVISIPRRADFSLDLPAIARAAAQGA
KAIFLTSPNNPTGNPLPRSELLQILELPLLVVVDEAYIEFAEPEHAPVGASDLLDRYPNLAILRTFSKWAGLAGLRVGYG
LFPRWLSEQLWKIKQPYNVSVAAQAAAVASLAVADELRARVQAIVAERERLFQHLNTFPFLTPFPSVANFILCRVEGRDA
RELKLALERRGVLVRHYQTPLLNGYIRISVGTPAQTDALIAMLAEVTR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=335, Percent_Identity=37.0149253731343, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1786816, Length=226, Percent_Identity=26.9911504424779, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=397, Percent_Identity=31.7380352644836, Blast_Score=160, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40020; Mature: 40020

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSVLSGLIRPEIADLEAYTPIVPLEVLADRLGLPVAQIVKLDANENPYGPAPAALAALQ
CHHHHHHHHCCCHHCHHHCCCCCCHHHHHHHHCCCHHHHEEECCCCCCCCCCHHHHHHHH
ATATYHIYPDPEQTALRKALADYTGRSAEEILCGAGADELIDLVLRLIISPGDAIIDCPP
HHEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCC
TFGMYRFDAGICGGRVISIPRRADFSLDLPAIARAAAQGAKAIFLTSPNNPTGNPLPRSE
CCCCEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHH
LLQILELPLLVVVDEAYIEFAEPEHAPVGASDLLDRYPNLAILRTFSKWAGLAGLRVGYG
HHHHHHCCHHEEEEHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHH
LFPRWLSEQLWKIKQPYNVSVAAQAAAVASLAVADELRARVQAIVAERERLFQHLNTFPF
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LTPFPSVANFILCRVEGRDARELKLALERRGVLVRHYQTPLLNGYIRISVGTPAQTDALI
CCCCHHHHCEEEEEECCCCHHHHHHHHHHCCEEEEECCCHHHCCEEEEEECCCCHHHHHH
AMLAEVTR
HHHHHHCC
>Mature Secondary Structure
MMSVLSGLIRPEIADLEAYTPIVPLEVLADRLGLPVAQIVKLDANENPYGPAPAALAALQ
CHHHHHHHHCCCHHCHHHCCCCCCHHHHHHHHCCCHHHHEEECCCCCCCCCCHHHHHHHH
ATATYHIYPDPEQTALRKALADYTGRSAEEILCGAGADELIDLVLRLIISPGDAIIDCPP
HHEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCC
TFGMYRFDAGICGGRVISIPRRADFSLDLPAIARAAAQGAKAIFLTSPNNPTGNPLPRSE
CCCCEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHH
LLQILELPLLVVVDEAYIEFAEPEHAPVGASDLLDRYPNLAILRTFSKWAGLAGLRVGYG
HHHHHHCCHHEEEEHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHH
LFPRWLSEQLWKIKQPYNVSVAAQAAAVASLAVADELRARVQAIVAERERLFQHLNTFPF
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LTPFPSVANFILCRVEGRDARELKLALERRGVLVRHYQTPLLNGYIRISVGTPAQTDALI
CCCCHHHHCEEEEEECCCCHHHHHHHHHHCCEEEEECCCHHHCCEEEEEECCCCHHHHHH
AMLAEVTR
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA