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The map label for this gene is hisN [H]

Identifier: 222525342

GI number: 222525342

Start: 2659199

End: 2659984

Strand: Direct

Name: hisN [H]

Synonym: Chy400_2087

Alternate gene names: 222525342

Gene position: 2659199-2659984 (Clockwise)

Preceding gene: 222525341

Following gene: 222525343

Centisome position: 50.47

GC content: 58.4

Gene sequence:

>786_bases
ATGAGCATATCACTTGCCCACACGCTTGACTTTGCCCGCCAGATCGCTTACGAGGCCGGCCAGATCACGCTGCGCTATTT
TCAGCGTGGTATCACTGTTGAACACAAAGCCGATGAGTCGCCGGTGACGATTGCTGATCGGGAGGCCGAGCGTCATCTGC
GCGCCGCTATTCAGGCGGCCTACCCTGATCACGCCGTCCTTGGTGAAGAAGATGGTCTGACCGGGAGTGAACACGCTACC
TACCGCTGGGTGCTTGATCCGATTGACGGTACGAAAAGTTTTGTGCGGGGCGTGCCACTCTACGGAGTGCTGATTGGATT
GTTGCGGGAAGGTGAACCTGTGCTTGGTGTCATCCATATCCCGGCGCTGGCCGAAACTGTGGCAGCCGCGCAGGGTTTGG
GTTGTTACTGGAACAATCAACCCTGTCGGGTGTCGTCTGTCTCCAGCCTACGCGAGAGTCTGGTCGTCGGGACGGTGGCT
CACGGCTACGAACGCTACAACCGATCAGAAGCTTTTCAGCGTATTCTGAAGCGTGCCGGCCTGTTCCGCACCTGGGGCGA
TTGCTACGGCTACGTTCTGGTAGCCACCGGTCGCGCCGAAGTTGCGCTCGATCCGGCAATGAACGTCTGGGATGCCGCAG
CCCTGCTGCCGATTTTGAGCGAAGCTGGTGGTGCCTACACCGACTGGCAGGGTGTGCCGACCATTTACCACAACGAAGGC
ATTGGCAGCAATCGCCATGTCTTACCCGAACTGTTAAGCCTCATTGCTGGCGAGGAGTCGTCATGA

Upstream 100 bases:

>100_bases
GCCATTATCAGACGCCGCTGCTTAATGGCTATATTCGGATCAGCGTCGGTACTCCTGCCCAGACAGATGCGCTGATCGCG
ATGCTTGCTGAGGTGACCCG

Downstream 100 bases:

>100_bases
ACGCCGATAACTATCAAGAACTGGCAATGCGCACGCTGGCTGCCGGTCTGACACCGCGTGAGCGTCTGACCAATGCGGCG
CTTGGCCTGAGTGGCGAGGC

Product: inositol monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MSISLAHTLDFARQIAYEAGQITLRYFQRGITVEHKADESPVTIADREAERHLRAAIQAAYPDHAVLGEEDGLTGSEHAT
YRWVLDPIDGTKSFVRGVPLYGVLIGLLREGEPVLGVIHIPALAETVAAAQGLGCYWNNQPCRVSSVSSLRESLVVGTVA
HGYERYNRSEAFQRILKRAGLFRTWGDCYGYVLVATGRAEVALDPAMNVWDAAALLPILSEAGGAYTDWQGVPTIYHNEG
IGSNRHVLPELLSLIAGEESS

Sequences:

>Translated_261_residues
MSISLAHTLDFARQIAYEAGQITLRYFQRGITVEHKADESPVTIADREAERHLRAAIQAAYPDHAVLGEEDGLTGSEHAT
YRWVLDPIDGTKSFVRGVPLYGVLIGLLREGEPVLGVIHIPALAETVAAAQGLGCYWNNQPCRVSSVSSLRESLVVGTVA
HGYERYNRSEAFQRILKRAGLFRTWGDCYGYVLVATGRAEVALDPAMNVWDAAALLPILSEAGGAYTDWQGVPTIYHNEG
IGSNRHVLPELLSLIAGEESS
>Mature_260_residues
SISLAHTLDFARQIAYEAGQITLRYFQRGITVEHKADESPVTIADREAERHLRAAIQAAYPDHAVLGEEDGLTGSEHATY
RWVLDPIDGTKSFVRGVPLYGVLIGLLREGEPVLGVIHIPALAETVAAAQGLGCYWNNQPCRVSSVSSLRESLVVGTVAH
GYERYNRSEAFQRILKRAGLFRTWGDCYGYVLVATGRAEVALDPAMNVWDAAALLPILSEAGGAYTDWQGVPTIYHNEGI
GSNRHVLPELLSLIAGEESS

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Localized On The Inner Face Of The Cytoplasm Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=263, Percent_Identity=28.8973384030418, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI221625487, Length=259, Percent_Identity=27.4131274131274, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI7657236, Length=231, Percent_Identity=27.7056277056277, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI221625507, Length=145, Percent_Identity=30.3448275862069, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1790659, Length=239, Percent_Identity=32.6359832635983, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788882, Length=228, Percent_Identity=26.3157894736842, Blast_Score=86, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193202572, Length=239, Percent_Identity=26.3598326359833, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193202570, Length=242, Percent_Identity=26.8595041322314, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320493, Length=203, Percent_Identity=31.0344827586207, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6321836, Length=199, Percent_Identity=29.1457286432161, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24664918, Length=238, Percent_Identity=32.7731092436975, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24664922, Length=239, Percent_Identity=28.4518828451883, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21357329, Length=239, Percent_Identity=29.2887029288703, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21357957, Length=236, Percent_Identity=30.9322033898305, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24664926, Length=208, Percent_Identity=30.7692307692308, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357303, Length=227, Percent_Identity=30.3964757709251, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28443; Mature: 28312

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISLAHTLDFARQIAYEAGQITLRYFQRGITVEHKADESPVTIADREAERHLRAAIQAA
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEECCCCCCCEEECHHHHHHHHHHHHHC
YPDHAVLGEEDGLTGSEHATYRWVLDPIDGTKSFVRGVPLYGVLIGLLREGEPVLGVIHI
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCHHHHHHHHHHCCCCEEEEEEH
PALAETVAAAQGLGCYWNNQPCRVSSVSSLRESLVVGTVAHGYERYNRSEAFQRILKRAG
HHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LFRTWGDCYGYVLVATGRAEVALDPAMNVWDAAALLPILSEAGGAYTDWQGVPTIYHNEG
CCHHHHHHCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCC
IGSNRHVLPELLSLIAGEESS
CCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SISLAHTLDFARQIAYEAGQITLRYFQRGITVEHKADESPVTIADREAERHLRAAIQAA
CCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEECCCCCCCEEECHHHHHHHHHHHHHC
YPDHAVLGEEDGLTGSEHATYRWVLDPIDGTKSFVRGVPLYGVLIGLLREGEPVLGVIHI
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCHHHHHHHHHHCCCCEEEEEEH
PALAETVAAAQGLGCYWNNQPCRVSSVSSLRESLVVGTVAHGYERYNRSEAFQRILKRAG
HHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LFRTWGDCYGYVLVATGRAEVALDPAMNVWDAAALLPILSEAGGAYTDWQGVPTIYHNEG
CCHHHHHHCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCC
IGSNRHVLPELLSLIAGEESS
CCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]