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The map label for this gene is mprA [H]

Identifier: 222525072

GI number: 222525072

Start: 2287793

End: 2288152

Strand: Direct

Name: mprA [H]

Synonym: Chy400_1809

Alternate gene names: 222525072

Gene position: 2287793-2288152 (Clockwise)

Preceding gene: 222525071

Following gene: 222525073

Centisome position: 43.42

GC content: 52.5

Gene sequence:

>360_bases
ATGCCAACCATTCTGGTCGTTGATGATAGCCGTCTCGTTACCGACATCGTCAAGATGCGACTCGAGATGTATGGCTATAC
TGTTCGTCTCGCCCATAGTGGTGAGGAGGCGCTGGCCGCGATTGCTGCCGAACCGCCTGATCTGCTGGTGCTCGATGTGC
AGATGCCTGGTATCGATGGCTACGAGGTGTGCCGTCGTATTCGTGAAGATCCGGCGCTCGATGATCTGCGTATCATTATG
CTAACCTCATCTGATGACAAGCGCGCAGCGTTTGAAGCCGGGGTTGATGATTATCTCAACAAAGACATTGATCTCCTCAA
CCTGCCTAATCGGGTGCGACTGGTACTGGATATGGAATAA

Upstream 100 bases:

>100_bases
GGTTGGAAGTGGGAGCACAGGCCTACATCGTGAAGAGTCAGTTTAACCAGGACAGTTTGCTGAACGTGATTCAGCAACTG
CTCGGCCACGAGGAGTAGCT

Downstream 100 bases:

>100_bases
CAGGTTACCTTCGCTTAGCGGCGCAATGATGGGGTAGGGGTGTATGACAAACCCTCTGCGCGTCCTTGTTGTCGATGACT
CGGCGCTGATGCGTCGGTTG

Product: response regulator receiver protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 119; Mature: 118

Protein sequence:

>119_residues
MPTILVVDDSRLVTDIVKMRLEMYGYTVRLAHSGEEALAAIAAEPPDLLVLDVQMPGIDGYEVCRRIREDPALDDLRIIM
LTSSDDKRAAFEAGVDDYLNKDIDLLNLPNRVRLVLDME

Sequences:

>Translated_119_residues
MPTILVVDDSRLVTDIVKMRLEMYGYTVRLAHSGEEALAAIAAEPPDLLVLDVQMPGIDGYEVCRRIREDPALDDLRIIM
LTSSDDKRAAFEAGVDDYLNKDIDLLNLPNRVRLVLDME
>Mature_118_residues
PTILVVDDSRLVTDIVKMRLEMYGYTVRLAHSGEEALAAIAAEPPDLLVLDVQMPGIDGYEVCRRIREDPALDDLRIIML
TSSDDKRAAFEAGVDDYLNKDIDLLNLPNRVRLVLDME

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786911, Length=116, Percent_Identity=32.7586206896552, Blast_Score=63, Evalue=7e-12,
Organism=Escherichia coli, GI1788394, Length=118, Percent_Identity=32.2033898305085, Blast_Score=61, Evalue=2e-11,
Organism=Escherichia coli, GI1789809, Length=117, Percent_Identity=34.1880341880342, Blast_Score=59, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 13388; Mature: 13256

Theoretical pI: Translated: 4.13; Mature: 4.13

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTILVVDDSRLVTDIVKMRLEMYGYTVRLAHSGEEALAAIAAEPPDLLVLDVQMPGIDG
CCEEEEEECCHHHHHHHHHHHHHCCEEEEEEECCCHHHHEECCCCCCEEEEEEECCCCCH
YEVCRRIREDPALDDLRIIMLTSSDDKRAAFEAGVDDYLNKDIDLLNLPNRVRLVLDME
HHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHCCCHHHHCCCCEEEECCCEEEEEEECC
>Mature Secondary Structure 
PTILVVDDSRLVTDIVKMRLEMYGYTVRLAHSGEEALAAIAAEPPDLLVLDVQMPGIDG
CEEEEEECCHHHHHHHHHHHHHCCEEEEEEECCCHHHHEECCCCCCEEEEEEECCCCCH
YEVCRRIREDPALDDLRIIMLTSSDDKRAAFEAGVDDYLNKDIDLLNLPNRVRLVLDME
HHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHCCCHHHHCCCCEEEECCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA