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The map label for this gene is frzE [H]

Identifier: 222525071

GI number: 222525071

Start: 2285571

End: 2287790

Strand: Direct

Name: frzE [H]

Synonym: Chy400_1808

Alternate gene names: 222525071

Gene position: 2285571-2287790 (Clockwise)

Preceding gene: 222525070

Following gene: 222525072

Centisome position: 43.38

GC content: 55.9

Gene sequence:

>2220_bases
ATGGATTTGACCAGCTTCTACGATCAGTTTCGTGATGAGACAGCCGAAAATGTACGGGTGTTGAACGATGCCCTCTTGAA
CCTGGAGGCGCAGGTTGATGATGGTCAGCGGCGGGCAGCCCTGGATCGGGCTTTTCGCGCAGTCCATACGATTAAGGGGT
CGGCGCGCATGCTGGGTTTTGATCCGATTGCTCAGTTGGCGCATGCACTGGAACATGTCTTAGGTGATCTGCGAGAAGGT
CGGTGTATACCTGAACGAACACTGATCGATCTGCTGCTGCAAGGTGGCGATCTGGTTACCCGGCTGACCGCTGAGATTCC
TCAGTTGTCGGCAGCAACTCTCGCCCATCTGCCAGATTTTTTGCAAGCGCTAAGGGCAATCTCTCCGGCAATCCCTTCCG
TTTCGCCACCCACTCCACAACCTGCTTCGCCAGAGCCGTCGTCGCCAATCGACACACCACTGCGTACCACACGCCAGACA
GTGCGAGTGCGTGTTGATCGCCTCGACCGACTGTTTAATCTGGCCGGTGAACTTACCATCGAGCAACAATCGCTTGCCGA
ACTCGGTACGGAATTAGAACAGTTATACGCACTGGTCTCGCGCCAGCAACGTGCACTGCTGGCCCTTGAACAAGAGCTGG
CCCGTCTCCGTTTCTCGTCAACTCAGCGCCAGGCGCTTGATGCGCGTCTGTCCACCTTGCGTGATGTGCAAGTGATGCTC
GTTGATCGTGTCCAGAACCAGCGCGAGAACCTTGATCGTTACCTGTCGCGTCAGCATCTACTGGTCAAAGATCTGGAGCA
AGAGGTCATGGCGGTGCGCCTGTTACCGATTGCTACCATCTTTAACTCACTCCCCCGTCTGGTGCGTGATCTGGCAACGG
CGACCGGTAAACAGGCAGTGTTGGAGATCCGTGGTGAAACGACCGAGCTTGATCGTAAAGTGCTGGAGTTGATTAGCGAT
CCGCTGGTTCATCTGATACGGAATGCAGTTGATCACGGTCTCGAACCACCGGATGAACGCATTGCGCAGGGCAAACCACC
AACAGGTTTGATTCAGGTCAGTGCCGAGTCCTCGGGCAATGAGGTGCGGATCAGCATTCAGGATGATGGTCGGGGAATTG
ATCCAGCTCGCATCCGCACCCGGGCGATAGAACTCGGTCTGTTAACTGCCGGTCGAGCCGATCAGCTCGATACGCAAGAG
ACGCTCGATCTCATTTTCCAACCCGGCTTCTCGACGGCAACGAACGTTACCGAAATTTCCGGGCGTGGAGTCGGTATGGA
CATCGTGCGCGCCAATCTGCTTGAATTGGGCGGGCAGGTGCGCATCGATTCGACCATCGGCCAGGGTACGACCATCACGC
TCACGATCCCGCTCACTTTAATCACCAGCCGGGTTGTGGTTGTGCAGGTCGGCCAACACCATCTGGCGCTGCCGGCAGTG
ACTGTTCGGAGTATCTTGTGGGTACAGCGCGATCAGATTCAGTTCATTGATGGTCAGCCGACATTCGCGCATCAGCAACG
CACGATCAGTCTGCTCGCTTTGGCCGAACTACTGGCTATTCCCGCGGAGTCGCCACTCACGCGCTACCGTCGTGTACCGG
CTGTATTACTCAAGACGCGACAACATCGCGTTGCCTTGTTGGTTGACGACGTGATCGATGAGCGCGAGGCTGTGATTAAG
CCACTCGGCCCTCTGTTTGCTCGCCGCCCGGCCTTGAGTGGCGCGGTCCAATCGGGAGATGGTCGTCTCGTGTTGTTAAT
CAATCCGCTCTACCTGGTCGAAAGGAATGGCTATCGGCCAAAGCCTGCTGCTACCGCAATCAAGCCGGTAGCGGAACCAA
CCCGAACGGCACGCCTGCTGGTTGTTGATGACTCGTTTACAACACGCGAATTATTGCGCAGCATTCTCCAATCGGCTGGT
TACGATGTTACGGTGGCTATTGATGGGGCAGATGCTCTTGACAGGCTCCGTTCGACGCCATACGATCTGGTAGTAAGCGA
TATCGAGATGCCTCGTGTCGATGGCTTTACCCTCACGACTCGCATCCGAAATGAACTGGCCCTCGTTGATCTGCCGGTCA
TTTTAATTACCAGCCTTGCTTCCGAAGAACATCGTCGTCGCGGGTTGGAAGTGGGAGCACAGGCCTACATCGTGAAGAGT
CAGTTTAACCAGGACAGTTTGCTGAACGTGATTCAGCAACTGCTCGGCCACGAGGAGTAG

Upstream 100 bases:

>100_bases
TGGATGGGAGAGACATTTGCGGAGCGACCTACGCTGTCATTGAACAGGCCAGTATTGCCCAGACTCTCAGTGAGCGCCGT
GTTGAGAACAGTTGTACCGT

Downstream 100 bases:

>100_bases
CTATGCCAACCATTCTGGTCGTTGATGATAGCCGTCTCGTTACCGACATCGTCAAGATGCGACTCGAGATGTATGGCTAT
ACTGTTCGTCTCGCCCATAG

Product: CheA signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 739; Mature: 739

Protein sequence:

>739_residues
MDLTSFYDQFRDETAENVRVLNDALLNLEAQVDDGQRRAALDRAFRAVHTIKGSARMLGFDPIAQLAHALEHVLGDLREG
RCIPERTLIDLLLQGGDLVTRLTAEIPQLSAATLAHLPDFLQALRAISPAIPSVSPPTPQPASPEPSSPIDTPLRTTRQT
VRVRVDRLDRLFNLAGELTIEQQSLAELGTELEQLYALVSRQQRALLALEQELARLRFSSTQRQALDARLSTLRDVQVML
VDRVQNQRENLDRYLSRQHLLVKDLEQEVMAVRLLPIATIFNSLPRLVRDLATATGKQAVLEIRGETTELDRKVLELISD
PLVHLIRNAVDHGLEPPDERIAQGKPPTGLIQVSAESSGNEVRISIQDDGRGIDPARIRTRAIELGLLTAGRADQLDTQE
TLDLIFQPGFSTATNVTEISGRGVGMDIVRANLLELGGQVRIDSTIGQGTTITLTIPLTLITSRVVVVQVGQHHLALPAV
TVRSILWVQRDQIQFIDGQPTFAHQQRTISLLALAELLAIPAESPLTRYRRVPAVLLKTRQHRVALLVDDVIDEREAVIK
PLGPLFARRPALSGAVQSGDGRLVLLINPLYLVERNGYRPKPAATAIKPVAEPTRTARLLVVDDSFTTRELLRSILQSAG
YDVTVAIDGADALDRLRSTPYDLVVSDIEMPRVDGFTLTTRIRNELALVDLPVILITSLASEEHRRRGLEVGAQAYIVKS
QFNQDSLLNVIQQLLGHEE

Sequences:

>Translated_739_residues
MDLTSFYDQFRDETAENVRVLNDALLNLEAQVDDGQRRAALDRAFRAVHTIKGSARMLGFDPIAQLAHALEHVLGDLREG
RCIPERTLIDLLLQGGDLVTRLTAEIPQLSAATLAHLPDFLQALRAISPAIPSVSPPTPQPASPEPSSPIDTPLRTTRQT
VRVRVDRLDRLFNLAGELTIEQQSLAELGTELEQLYALVSRQQRALLALEQELARLRFSSTQRQALDARLSTLRDVQVML
VDRVQNQRENLDRYLSRQHLLVKDLEQEVMAVRLLPIATIFNSLPRLVRDLATATGKQAVLEIRGETTELDRKVLELISD
PLVHLIRNAVDHGLEPPDERIAQGKPPTGLIQVSAESSGNEVRISIQDDGRGIDPARIRTRAIELGLLTAGRADQLDTQE
TLDLIFQPGFSTATNVTEISGRGVGMDIVRANLLELGGQVRIDSTIGQGTTITLTIPLTLITSRVVVVQVGQHHLALPAV
TVRSILWVQRDQIQFIDGQPTFAHQQRTISLLALAELLAIPAESPLTRYRRVPAVLLKTRQHRVALLVDDVIDEREAVIK
PLGPLFARRPALSGAVQSGDGRLVLLINPLYLVERNGYRPKPAATAIKPVAEPTRTARLLVVDDSFTTRELLRSILQSAG
YDVTVAIDGADALDRLRSTPYDLVVSDIEMPRVDGFTLTTRIRNELALVDLPVILITSLASEEHRRRGLEVGAQAYIVKS
QFNQDSLLNVIQQLLGHEE
>Mature_739_residues
MDLTSFYDQFRDETAENVRVLNDALLNLEAQVDDGQRRAALDRAFRAVHTIKGSARMLGFDPIAQLAHALEHVLGDLREG
RCIPERTLIDLLLQGGDLVTRLTAEIPQLSAATLAHLPDFLQALRAISPAIPSVSPPTPQPASPEPSSPIDTPLRTTRQT
VRVRVDRLDRLFNLAGELTIEQQSLAELGTELEQLYALVSRQQRALLALEQELARLRFSSTQRQALDARLSTLRDVQVML
VDRVQNQRENLDRYLSRQHLLVKDLEQEVMAVRLLPIATIFNSLPRLVRDLATATGKQAVLEIRGETTELDRKVLELISD
PLVHLIRNAVDHGLEPPDERIAQGKPPTGLIQVSAESSGNEVRISIQDDGRGIDPARIRTRAIELGLLTAGRADQLDTQE
TLDLIFQPGFSTATNVTEISGRGVGMDIVRANLLELGGQVRIDSTIGQGTTITLTIPLTLITSRVVVVQVGQHHLALPAV
TVRSILWVQRDQIQFIDGQPTFAHQQRTISLLALAELLAIPAESPLTRYRRVPAVLLKTRQHRVALLVDDVIDEREAVIK
PLGPLFARRPALSGAVQSGDGRLVLLINPLYLVERNGYRPKPAATAIKPVAEPTRTARLLVVDDSFTTRELLRSILQSAG
YDVTVAIDGADALDRLRSTPYDLVVSDIEMPRVDGFTLTTRIRNELALVDLPVILITSLASEEHRRRGLEVGAQAYIVKS
QFNQDSLLNVIQQLLGHEE

Specific function: FrzE is involved in a sensory transduction pathway that controls the frequency at which cells reverse their gliding direction. FrzE seems to be capable of autophosphorylating itself on an histidine residue and then to transfer that group to an aspartate r

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=327, Percent_Identity=37.0030581039755, Blast_Score=213, Evalue=4e-56,
Organism=Escherichia coli, GI145693157, Length=401, Percent_Identity=25.4364089775561, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1788191, Length=123, Percent_Identity=39.0243902439024, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788713, Length=116, Percent_Identity=36.2068965517241, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1786784, Length=102, Percent_Identity=37.2549019607843, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1788394, Length=104, Percent_Identity=37.5, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1790863, Length=109, Percent_Identity=34.8623853211009, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786599, Length=118, Percent_Identity=32.2033898305085, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790437, Length=120, Percent_Identity=32.5, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR005467
- InterPro:   IPR001789 [H]

Pfam domain/function: PF01584 CheW; PF02518 HATPase_c; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 81710; Mature: 81710

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLTSFYDQFRDETAENVRVLNDALLNLEAQVDDGQRRAALDRAFRAVHTIKGSARMLGF
CCHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECC
DPIAQLAHALEHVLGDLREGRCIPERTLIDLLLQGGDLVTRLTAEIPQLSAATLAHLPDF
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHH
LQALRAISPAIPSVSPPTPQPASPEPSSPIDTPLRTTRQTVRVRVDRLDRLFNLAGELTI
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
EQQSLAELGTELEQLYALVSRQQRALLALEQELARLRFSSTQRQALDARLSTLRDVQVML
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDRVQNQRENLDRYLSRQHLLVKDLEQEVMAVRLLPIATIFNSLPRLVRDLATATGKQAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LEIRGETTELDRKVLELISDPLVHLIRNAVDHGLEPPDERIAQGKPPTGLIQVSAESSGN
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCEEEEEECCCCC
EVRISIQDDGRGIDPARIRTRAIELGLLTAGRADQLDTQETLDLIFQPGFSTATNVTEIS
EEEEEEECCCCCCCHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCEEEC
GRGVGMDIVRANLLELGGQVRIDSTIGQGTTITLTIPLTLITSRVVVVQVGQHHLALPAV
CCCCCHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEHHHHHCCEEEEEECCCHHHHHHH
TVRSILWVQRDQIQFIDGQPTFAHQQRTISLLALAELLAIPAESPLTRYRRVPAVLLKTR
HHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
QHRVALLVDDVIDEREAVIKPLGPLFARRPALSGAVQSGDGRLVLLINPLYLVERNGYRP
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCEEEEECCCCCC
KPAATAIKPVAEPTRTARLLVVDDSFTTRELLRSILQSAGYDVTVAIDGADALDRLRSTP
CCHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCC
YDLVVSDIEMPRVDGFTLTTRIRNELALVDLPVILITSLASEEHRRRGLEVGAQAYIVKS
HHEEEECCCCCCCCCEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEECC
QFNQDSLLNVIQQLLGHEE
CCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDLTSFYDQFRDETAENVRVLNDALLNLEAQVDDGQRRAALDRAFRAVHTIKGSARMLGF
CCHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECC
DPIAQLAHALEHVLGDLREGRCIPERTLIDLLLQGGDLVTRLTAEIPQLSAATLAHLPDF
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHH
LQALRAISPAIPSVSPPTPQPASPEPSSPIDTPLRTTRQTVRVRVDRLDRLFNLAGELTI
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
EQQSLAELGTELEQLYALVSRQQRALLALEQELARLRFSSTQRQALDARLSTLRDVQVML
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDRVQNQRENLDRYLSRQHLLVKDLEQEVMAVRLLPIATIFNSLPRLVRDLATATGKQAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LEIRGETTELDRKVLELISDPLVHLIRNAVDHGLEPPDERIAQGKPPTGLIQVSAESSGN
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCEEEEEECCCCC
EVRISIQDDGRGIDPARIRTRAIELGLLTAGRADQLDTQETLDLIFQPGFSTATNVTEIS
EEEEEEECCCCCCCHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCEEEC
GRGVGMDIVRANLLELGGQVRIDSTIGQGTTITLTIPLTLITSRVVVVQVGQHHLALPAV
CCCCCHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEHHHHHCCEEEEEECCCHHHHHHH
TVRSILWVQRDQIQFIDGQPTFAHQQRTISLLALAELLAIPAESPLTRYRRVPAVLLKTR
HHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
QHRVALLVDDVIDEREAVIKPLGPLFARRPALSGAVQSGDGRLVLLINPLYLVERNGYRP
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCEEEEECCCCCC
KPAATAIKPVAEPTRTARLLVVDDSFTTRELLRSILQSAGYDVTVAIDGADALDRLRSTP
CCHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCC
YDLVVSDIEMPRVDGFTLTTRIRNELALVDLPVILITSLASEEHRRRGLEVGAQAYIVKS
HHEEEECCCCCCCCCEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEECC
QFNQDSLLNVIQQLLGHEE
CCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2165608; 2123853 [H]