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The map label for this gene is lysC [H]

Identifier: 222151295

GI number: 222151295

Start: 1156770

End: 1157993

Strand: Direct

Name: lysC [H]

Synonym: MCCL_1048

Alternate gene names: 222151295

Gene position: 1156770-1157993 (Clockwise)

Preceding gene: 222151294

Following gene: 222151296

Centisome position: 55.02

GC content: 37.75

Gene sequence:

>1224_bases
TTGCATAATCAATTAACTCAATCAAATATTCGGATACTAAAGTTTGGAGGTACGTCAGTTAGTGATTTCGATAAGATTAG
CACAGTCGCTAATTACTTAAAGGAACGCACAGAAAATAATGAAAAACTAGTTGTCGTCGTTTCTGCAATGGGAAAAACTA
CAGATGACCTCATGAGAAATGTCAGTTCAATCTCTCGTACACCGAAAGAAAGTGCATTAGCGATGCTGCTTACTACTGGA
GAACAGCAGACCATCTCATACTTATCGATCATATTGCATGATCTCCACGTTGCATCTATTGCAATGACCGGTAGTCAGGC
GGGTATTCGCACGAAAGGACATTATCTTAAAAGTAAGATTACTGAAATTAATGATCAGAAGCTCATTGAAAATTTCAAAT
CATATGACGTTATCATTATCGCAGGGTTTCAAGGTATAAATGAACAGGATGAAATCACCACGCTCGGCCGTGGCGGTAGT
GATACTACAGCGGTAGCACTGGCAGCAGCGTTAAGCGCTCCTTGTGAAATTTATACAGACGTTACAGGTGTCTTTGGAAC
AGACCCACGTATCTATCCTGAGACAAGACATATAGATGAGTTAAGCTTTGAAGAGATGATGGAACTCTCCTCTCTCGGAG
CTGGGGTGCTTGAGACAAGAAGTGTTGAAATTGCTAAAAATCATAATATTCCGATCTATCTCGGAAAAACTTTATCAGAT
GAGAGAGGAACCTGGATTATGCCAAAAGACCAAATACTCGAGAAAAAAGCAGTGACTGGTGTCGCTCTAGATAATGATAT
GGAGTATGTGACGCTAAGTTACCCTATGAATGACACAAAATTATTAAATCAATTATTTGATGAGTTAGAACAAGAAGAAG
TCAATATCGATATGATATCTCAAATCGTAAACTTAGATGGCCTTCAAATTTCATTCACAATGAAAGACACAGATAAGTTA
CAGATTGAGCGTATTTTTAATAGATTAAGTACAAACTACCCGGCTATCAGCCATCAGTCGCGTTCAACGTATGCGAAGCT
TTCTGTCATCGGTTCAGGTATGAGAGATATGAGCGGAGTGGCATCAAAGGTATTTAAATCATTGATTCATAATGAAATCC
CCTTCTATCAGGTAACAACAAGTGAAATATCGATTTCATATGTTATAGATAAAGAAAACGGTGAACATGCAGTACAGTCA
TTATGTAAAGTATTTAATATATAA

Upstream 100 bases:

>100_bases
TATTACTATAATGGAGTGCATCGCTTGTATATAAACGTTAACAAGTCCGGAGCATATCCGGGCTTGTTTTTTTGTTGCAG
ATGCCATAGGAGGATTTTAA

Downstream 100 bases:

>100_bases
AATTAAGGAGAGTCAATTATGTATAAAATTGCAGTTGTAGGTGCTACAGGTTTAGTCGGACAAAAAATGCTTGAAGTTTT
AGAAAGAAAACAGATTCCGT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase 2; Aspartokinase II [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MHNQLTQSNIRILKFGGTSVSDFDKISTVANYLKERTENNEKLVVVVSAMGKTTDDLMRNVSSISRTPKESALAMLLTTG
EQQTISYLSIILHDLHVASIAMTGSQAGIRTKGHYLKSKITEINDQKLIENFKSYDVIIIAGFQGINEQDEITTLGRGGS
DTTAVALAAALSAPCEIYTDVTGVFGTDPRIYPETRHIDELSFEEMMELSSLGAGVLETRSVEIAKNHNIPIYLGKTLSD
ERGTWIMPKDQILEKKAVTGVALDNDMEYVTLSYPMNDTKLLNQLFDELEQEEVNIDMISQIVNLDGLQISFTMKDTDKL
QIERIFNRLSTNYPAISHQSRSTYAKLSVIGSGMRDMSGVASKVFKSLIHNEIPFYQVTTSEISISYVIDKENGEHAVQS
LCKVFNI

Sequences:

>Translated_407_residues
MHNQLTQSNIRILKFGGTSVSDFDKISTVANYLKERTENNEKLVVVVSAMGKTTDDLMRNVSSISRTPKESALAMLLTTG
EQQTISYLSIILHDLHVASIAMTGSQAGIRTKGHYLKSKITEINDQKLIENFKSYDVIIIAGFQGINEQDEITTLGRGGS
DTTAVALAAALSAPCEIYTDVTGVFGTDPRIYPETRHIDELSFEEMMELSSLGAGVLETRSVEIAKNHNIPIYLGKTLSD
ERGTWIMPKDQILEKKAVTGVALDNDMEYVTLSYPMNDTKLLNQLFDELEQEEVNIDMISQIVNLDGLQISFTMKDTDKL
QIERIFNRLSTNYPAISHQSRSTYAKLSVIGSGMRDMSGVASKVFKSLIHNEIPFYQVTTSEISISYVIDKENGEHAVQS
LCKVFNI
>Mature_407_residues
MHNQLTQSNIRILKFGGTSVSDFDKISTVANYLKERTENNEKLVVVVSAMGKTTDDLMRNVSSISRTPKESALAMLLTTG
EQQTISYLSIILHDLHVASIAMTGSQAGIRTKGHYLKSKITEINDQKLIENFKSYDVIIIAGFQGINEQDEITTLGRGGS
DTTAVALAAALSAPCEIYTDVTGVFGTDPRIYPETRHIDELSFEEMMELSSLGAGVLETRSVEIAKNHNIPIYLGKTLSD
ERGTWIMPKDQILEKKAVTGVALDNDMEYVTLSYPMNDTKLLNQLFDELEQEEVNIDMISQIVNLDGLQISFTMKDTDKL
QIERIFNRLSTNYPAISHQSRSTYAKLSVIGSGMRDMSGVASKVFKSLIHNEIPFYQVTTSEISISYVIDKENGEHAVQS
LCKVFNI

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=456, Percent_Identity=26.5350877192982, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790455, Length=270, Percent_Identity=27.037037037037, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320893, Length=302, Percent_Identity=24.8344370860927, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 45230; Mature: 45230

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNQLTQSNIRILKFGGTSVSDFDKISTVANYLKERTENNEKLVVVVSAMGKTTDDLMRN
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHH
VSSISRTPKESALAMLLTTGEQQTISYLSIILHDLHVASIAMTGSQAGIRTKGHYLKSKI
HHHHHCCCHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHH
TEINDQKLIENFKSYDVIIIAGFQGINEQDEITTLGRGGSDTTAVALAAALSAPCEIYTD
HCCCHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCEEECC
VTGVFGTDPRIYPETRHIDELSFEEMMELSSLGAGVLETRSVEIAKNHNIPIYLGKTLSD
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCEEEEEECCCCEEEECCCCCC
ERGTWIMPKDQILEKKAVTGVALDNDMEYVTLSYPMNDTKLLNQLFDELEQEEVNIDMIS
CCCCEECCHHHHHHHHHHEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHH
QIVNLDGLQISFTMKDTDKLQIERIFNRLSTNYPAISHQSRSTYAKLSVIGSGMRDMSGV
HHHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
ASKVFKSLIHNEIPFYQVTTSEISISYVIDKENGEHAVQSLCKVFNI
HHHHHHHHHHCCCCEEEEEECCEEEEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MHNQLTQSNIRILKFGGTSVSDFDKISTVANYLKERTENNEKLVVVVSAMGKTTDDLMRN
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHH
VSSISRTPKESALAMLLTTGEQQTISYLSIILHDLHVASIAMTGSQAGIRTKGHYLKSKI
HHHHHCCCHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHH
TEINDQKLIENFKSYDVIIIAGFQGINEQDEITTLGRGGSDTTAVALAAALSAPCEIYTD
HCCCHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCEEECC
VTGVFGTDPRIYPETRHIDELSFEEMMELSSLGAGVLETRSVEIAKNHNIPIYLGKTLSD
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCEEEEEECCCCEEEECCCCCC
ERGTWIMPKDQILEKKAVTGVALDNDMEYVTLSYPMNDTKLLNQLFDELEQEEVNIDMIS
CCCCEECCHHHHHHHHHHEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHH
QIVNLDGLQISFTMKDTDKLQIERIFNRLSTNYPAISHQSRSTYAKLSVIGSGMRDMSGV
HHHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
ASKVFKSLIHNEIPFYQVTTSEISISYVIDKENGEHAVQSLCKVFNI
HHHHHHHHHHCCCCEEEEEECCEEEEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1444390 [H]