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The map label for this gene is uppS [H]

Identifier: 222151093

GI number: 222151093

Start: 920241

End: 920990

Strand: Direct

Name: uppS [H]

Synonym: MCCL_0844

Alternate gene names: 222151093

Gene position: 920241-920990 (Clockwise)

Preceding gene: 222151092

Following gene: 222151094

Centisome position: 43.77

GC content: 36.27

Gene sequence:

>750_bases
ATGTTCCCATTTAAAAAAAGGAAAGTGACAGAAAACATTCAATTGAATAAGGCGCATATTCCGAAACACATTGCTATTAT
AATGGATGGTAATGGGAGATGGGCGAAAGCTAAGAAGATGCCGCGCATCAAAGGGCACTACGAAGGCATGCAGACAGTAA
AAAAGATAACAGGACATGCAAGTGATCTAGGTGTAGAATATTTAACATTGTATGCATTTTCTACTGAAAACTGGTCGCGA
CCTAAAGATGAAGTAAATTATTTAATGAAGTTACCAGGAGATTTCTTAAATACCTTTCTTCCGGAATTAGTTGCAAAGAA
CGTGAAGGTAGAGACGATCGGATTTATTGATGATCTGCCAGAGCACACAAAGCATGCTGTACTAGAGGCGAAAGAAAGAA
CAAAGGATAATACAGGATTGAAGTTAGTATTTGCATTGAACTACGGTGGCAGAAAAGAAATTATCTCTGCGGTACAGTTA
ATTGCAGAACAATATAAATCTGGAGAAATTTCATTAGATGAAATCAATGAATCTCAGTTTAATGAATTTTTATTTACAAA
AGGCATGCCAGATCCAGAACTTCTCATTCGTACATCTGGCGAAGAGCGCTTAAGTAACTTTCTAATCTGGCAATGTTCAT
ATAGTGAGTTTGTGTTTGTAGATGAATACTGGCCAGACTTTACAGTACAAAGTTTAGATAAATGTATTTCAATATACCAG
AATCGACATAGACGATTCGGTGGACTATAA

Upstream 100 bases:

>100_bases
AGCCAAATCATTTTTTGGCTCGACCTTTTTTTGTGATTTTCATGAATATACATATATCTTATGTTAAAATAAATGAATAA
GTTGAATTACGGAGGCCGCT

Downstream 100 bases:

>100_bases
GGAGTAAATCATGAAAACGAGAACGATTACTGCGATAATCGCAATGGCAGTTTTTTTGCCTGTAGTTGTATATGGAAAGC
TGCCACTATTAATTATGGCA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MFPFKKRKVTENIQLNKAHIPKHIAIIMDGNGRWAKAKKMPRIKGHYEGMQTVKKITGHASDLGVEYLTLYAFSTENWSR
PKDEVNYLMKLPGDFLNTFLPELVAKNVKVETIGFIDDLPEHTKHAVLEAKERTKDNTGLKLVFALNYGGRKEIISAVQL
IAEQYKSGEISLDEINESQFNEFLFTKGMPDPELLIRTSGEERLSNFLIWQCSYSEFVFVDEYWPDFTVQSLDKCISIYQ
NRHRRFGGL

Sequences:

>Translated_249_residues
MFPFKKRKVTENIQLNKAHIPKHIAIIMDGNGRWAKAKKMPRIKGHYEGMQTVKKITGHASDLGVEYLTLYAFSTENWSR
PKDEVNYLMKLPGDFLNTFLPELVAKNVKVETIGFIDDLPEHTKHAVLEAKERTKDNTGLKLVFALNYGGRKEIISAVQL
IAEQYKSGEISLDEINESQFNEFLFTKGMPDPELLIRTSGEERLSNFLIWQCSYSEFVFVDEYWPDFTVQSLDKCISIYQ
NRHRRFGGL
>Mature_249_residues
MFPFKKRKVTENIQLNKAHIPKHIAIIMDGNGRWAKAKKMPRIKGHYEGMQTVKKITGHASDLGVEYLTLYAFSTENWSR
PKDEVNYLMKLPGDFLNTFLPELVAKNVKVETIGFIDDLPEHTKHAVLEAKERTKDNTGLKLVFALNYGGRKEIISAVQL
IAEQYKSGEISLDEINESQFNEFLFTKGMPDPELLIRTSGEERLSNFLIWQCSYSEFVFVDEYWPDFTVQSLDKCISIYQ
NRHRRFGGL

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=227, Percent_Identity=36.5638766519824, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI45580742, Length=227, Percent_Identity=36.5638766519824, Blast_Score=143, Evalue=1e-34,
Organism=Escherichia coli, GI1786371, Length=231, Percent_Identity=41.5584415584416, Blast_Score=198, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=36.7256637168142, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=37.5586854460094, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=220, Percent_Identity=31.8181818181818, Blast_Score=105, Evalue=7e-24,
Organism=Drosophila melanogaster, GI18857969, Length=225, Percent_Identity=35.1111111111111, Blast_Score=138, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28771; Mature: 28771

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPFKKRKVTENIQLNKAHIPKHIAIIMDGNGRWAKAKKMPRIKGHYEGMQTVKKITGHA
CCCCCCCHHCCCCEECCCCCCEEEEEEECCCCCEEHHHCCCCCCHHHHHHHHHHHHHCCC
SDLGVEYLTLYAFSTENWSRPKDEVNYLMKLPGDFLNTFLPELVAKNVKVETIGFIDDLP
HHCCEEEEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCHHCCH
EHTKHAVLEAKERTKDNTGLKLVFALNYGGRKEIISAVQLIAEQYKSGEISLDEINESQF
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEHHHCCHHHH
NEFLFTKGMPDPELLIRTSGEERLSNFLIWQCSYSEFVFVDEYWPDFTVQSLDKCISIYQ
HHHHHHCCCCCHHEEEECCCHHHHCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHH
NRHRRFGGL
HHHHHCCCC
>Mature Secondary Structure
MFPFKKRKVTENIQLNKAHIPKHIAIIMDGNGRWAKAKKMPRIKGHYEGMQTVKKITGHA
CCCCCCCHHCCCCEECCCCCCEEEEEEECCCCCEEHHHCCCCCCHHHHHHHHHHHHHCCC
SDLGVEYLTLYAFSTENWSRPKDEVNYLMKLPGDFLNTFLPELVAKNVKVETIGFIDDLP
HHCCEEEEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCHHCCH
EHTKHAVLEAKERTKDNTGLKLVFALNYGGRKEIISAVQLIAEQYKSGEISLDEINESQF
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEHHHCCHHHH
NEFLFTKGMPDPELLIRTSGEERLSNFLIWQCSYSEFVFVDEYWPDFTVQSLDKCISIYQ
HHHHHHCCCCCHHEEEECCCHHHHCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHH
NRHRRFGGL
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9677368; 3182755; 11098133; 11346651; 12680756; 10489461; 11287651 [H]