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The map label for this gene is pyrD [H]

Identifier: 222151024

GI number: 222151024

Start: 836451

End: 837368

Strand: Direct

Name: pyrD [H]

Synonym: MCCL_0775

Alternate gene names: 222151024

Gene position: 836451-837368 (Clockwise)

Preceding gene: 222151023

Following gene: 222151025

Centisome position: 39.79

GC content: 41.83

Gene sequence:

>918_bases
ATGAGATTAAATGTTGAATTGCCAGGTTTAAAATTAAAAAATCCAGTAATGCCTGCAAGTGGTTGTTTTGCTTTCGGTAA
GGAGTATGCCCAGTTTATGGACTTAAATGAACTCGGTGCAATAATGATTAAAGCTGCGACACCTGAACGCAGATTCGGTA
ATCCGACGCCGCGTGTTGCAGAAACATCAAGTGGTATGATCAATGCGATAGGATTGCAGAATCCGGGTGTCGATCATATT
ATTCAGCATGAATTGAAATGGCTGGAACAATTTGAAACACCCATCATCGCAAATGTTGCAGGCTCTAAAGTTGAAGATTA
CGTTGAAGTTGCAGAGAAGATTTCAAATGCTCCGAATGTGTGTGCACTGGAACTTAATATTTCATGTCCGAACGTTAAGG
AAGGCGGTATTCAGTTTGGAACAGACCCTGACACTGCGAAGGAATTAACGCGTAAAGTTAAAGCAGTCTCAAGTGTCCCT
GTATACGTCAAGCTTTCTCCTAACGTGACTAATATTGTAGATATGGCGAAAGCAGTTGCTGAATATGCAGATGGTATTAC
GATGATTAACACGTTGGTTGGACTAAGGGTTAATGAAAAAACAGGGACTCCGATTATCTCAAACATTATCGGTGGGTTAA
GTGGGCCTGCTGTGAAGCCTGTTGCGATGCGTATGGTTTATGAAGTGCGTCGCGCATTGCCGAATATTCCGATTATTGCT
ATGGGTGGCGTTACAGAAGCACAGGACGTTATCGACTATATTTCAGTTGGTGCAGATGCTGTTGCCGTAGGTACGGCTAA
CTTTCAGAATCCTACAGTTTGTAAAGATATCATTGATGCATTACCAGGCTTTCTGGATAAATTAGGCGTTCATCATATTC
ATGAATTAAAAGGTCGCACACAGGAGGCAGTTAAATGA

Upstream 100 bases:

>100_bases
TCGGGGCATGTTATGCATGTGTATGTGAAGCGGATAATGAAGATGGCTACGTGAAGATTTGTACGGATGGCCCAGTATTT
GAGAAAGGGGCGCTGGCACT

Downstream 100 bases:

>100_bases
GTAAACCGATTATCGCATTAGATTTTAAAGATATGGATGCTGTCAGAAACTTTTTAAGTCCTTTTGAAGAATCGTTATTT
GTTAAAGTAGGGATGGAACT

Product: dihydroorotate dehydrogenase

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MRLNVELPGLKLKNPVMPASGCFAFGKEYAQFMDLNELGAIMIKAATPERRFGNPTPRVAETSSGMINAIGLQNPGVDHI
IQHELKWLEQFETPIIANVAGSKVEDYVEVAEKISNAPNVCALELNISCPNVKEGGIQFGTDPDTAKELTRKVKAVSSVP
VYVKLSPNVTNIVDMAKAVAEYADGITMINTLVGLRVNEKTGTPIISNIIGGLSGPAVKPVAMRMVYEVRRALPNIPIIA
MGGVTEAQDVIDYISVGADAVAVGTANFQNPTVCKDIIDALPGFLDKLGVHHIHELKGRTQEAVK

Sequences:

>Translated_305_residues
MRLNVELPGLKLKNPVMPASGCFAFGKEYAQFMDLNELGAIMIKAATPERRFGNPTPRVAETSSGMINAIGLQNPGVDHI
IQHELKWLEQFETPIIANVAGSKVEDYVEVAEKISNAPNVCALELNISCPNVKEGGIQFGTDPDTAKELTRKVKAVSSVP
VYVKLSPNVTNIVDMAKAVAEYADGITMINTLVGLRVNEKTGTPIISNIIGGLSGPAVKPVAMRMVYEVRRALPNIPIIA
MGGVTEAQDVIDYISVGADAVAVGTANFQNPTVCKDIIDALPGFLDKLGVHHIHELKGRTQEAVK
>Mature_305_residues
MRLNVELPGLKLKNPVMPASGCFAFGKEYAQFMDLNELGAIMIKAATPERRFGNPTPRVAETSSGMINAIGLQNPGVDHI
IQHELKWLEQFETPIIANVAGSKVEDYVEVAEKISNAPNVCALELNISCPNVKEGGIQFGTDPDTAKELTRKVKAVSSVP
VYVKLSPNVTNIVDMAKAVAEYADGITMINTLVGLRVNEKTGTPIISNIIGGLSGPAVKPVAMRMVYEVRRALPNIPIIA
MGGVTEAQDVIDYISVGADAVAVGTANFQNPTVCKDIIDALPGFLDKLGVHHIHELKGRTQEAVK

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=331, Percent_Identity=29.607250755287, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI45006951, Length=318, Percent_Identity=28.3018867924528, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI87082059, Length=215, Percent_Identity=29.7674418604651, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787177, Length=300, Percent_Identity=26, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71984108, Length=206, Percent_Identity=31.5533980582524, Blast_Score=98, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6322633, Length=299, Percent_Identity=29.7658862876254, Blast_Score=112, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24640763, Length=207, Percent_Identity=32.3671497584541, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI18858217, Length=207, Percent_Identity=32.3671497584541, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281361352, Length=319, Percent_Identity=27.8996865203762, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17137316, Length=319, Percent_Identity=27.8996865203762, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32694; Mature: 32694

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00911 DHODEHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLNVELPGLKLKNPVMPASGCFAFGKEYAQFMDLNELGAIMIKAATPERRFGNPTPRVA
CEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHCEEEEEECCCHHHCCCCCCCCC
ETSSGMINAIGLQNPGVDHIIQHELKWLEQFETPIIANVAGSKVEDYVEVAEKISNAPNV
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCCCCE
CALELNISCPNVKEGGIQFGTDPDTAKELTRKVKAVSSVPVYVKLSPNVTNIVDMAKAVA
EEEEEECCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHH
EYADGITMINTLVGLRVNEKTGTPIISNIIGGLSGPAVKPVAMRMVYEVRRALPNIPIIA
HHHCCHHHHHHHHHCEECCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEE
MGGVTEAQDVIDYISVGADAVAVGTANFQNPTVCKDIIDALPGFLDKLGVHHIHELKGRT
ECCCCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QEAVK
HHHCC
>Mature Secondary Structure
MRLNVELPGLKLKNPVMPASGCFAFGKEYAQFMDLNELGAIMIKAATPERRFGNPTPRVA
CEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHCEEEEEECCCHHHCCCCCCCCC
ETSSGMINAIGLQNPGVDHIIQHELKWLEQFETPIIANVAGSKVEDYVEVAEKISNAPNV
CCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCCCCE
CALELNISCPNVKEGGIQFGTDPDTAKELTRKVKAVSSVPVYVKLSPNVTNIVDMAKAVA
EEEEEECCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHH
EYADGITMINTLVGLRVNEKTGTPIISNIIGGLSGPAVKPVAMRMVYEVRRALPNIPIIA
HHHCCHHHHHHHHHCEECCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEE
MGGVTEAQDVIDYISVGADAVAVGTANFQNPTVCKDIIDALPGFLDKLGVHHIHELKGRT
ECCCCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QEAVK
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA