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The map label for this gene is walR [H]

Identifier: 222150271

GI number: 222150271

Start: 26181

End: 26882

Strand: Direct

Name: walR [H]

Synonym: MCCL_0021

Alternate gene names: 222150271

Gene position: 26181-26882 (Clockwise)

Preceding gene: 222150269

Following gene: 222150272

Centisome position: 1.25

GC content: 37.89

Gene sequence:

>702_bases
ATGTCGAGAAAAATCGTTGTTGTAGATGATGAAAAACCGATTGCAGATATATTAGAATTTAACTTGAAAAAAGAAGGTTA
TGAAGTTCATGTCGCCTATGATGGCGATGATGCTGTAGAGCTAATCTATGATATTCAACCAGATATCGTATTACTAGATA
TTATGCTTCCAGGTCGTGATGGTATGGAAGTCTGTCGTGAAGTGCGTAAGAAGTACGATATGCCGATTATTATGCTGACA
GCTAAAGATTCTGAAATTGATAAAGTATTAGGTCTGGAACTTGGTGCGGATGATTATGTGACAAAGCCATTCTCTACACG
TGAACTGATTGCGCGAGTTAAAGCCAATTTACGTCGTCATTACTCACAAACACAGTCTGAAGAGAAGGAAGAATCCACAA
ATATTGTCATTAAAGATATTGTAGTCTACCCTGAAGCTTATTCAATAAAGAAACGTGGTATAGATATCGAACTGACACAC
CGTGAATTTGAACTTTTTCATTATCTAGCAAAGCATATTGGGCAGGTCATGACACGCGAACATCTACTACAAACAGTATG
GGGCTACGATTATTTCGGAGATGTAAGAACTGTAGATGTGACAATTAGACGTTTAAGAGAAAAGATTGAAGATGATGCAA
GTCATCCAGAATATATTGTGACACGCCGTGGTGTAGGATATTTCTTGCAGACGCAGGAGTAA

Upstream 100 bases:

>100_bases
CTTCTTTTTTGTACTTGTCAGTAGTATAGAAAAAGATATTAAACAGTGGTAAATTATAAGTTAGATACTTATAAAAATTT
TATGAGATGAGGGGAAATAT

Downstream 100 bases:

>100_bases
TAGAATGAAAGTGATCTTTAAAAAACTTCAGTCGTTACATATAAAGCTCGTTGTTATTTACGTATTATTAATTATTATTG
GCATGCAAATTATCGGACTT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MSRKIVVVDDEKPIADILEFNLKKEGYEVHVAYDGDDAVELIYDIQPDIVLLDIMLPGRDGMEVCREVRKKYDMPIIMLT
AKDSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHYSQTQSEEKEESTNIVIKDIVVYPEAYSIKKRGIDIELTH
REFELFHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTIRRLREKIEDDASHPEYIVTRRGVGYFLQTQE

Sequences:

>Translated_233_residues
MSRKIVVVDDEKPIADILEFNLKKEGYEVHVAYDGDDAVELIYDIQPDIVLLDIMLPGRDGMEVCREVRKKYDMPIIMLT
AKDSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHYSQTQSEEKEESTNIVIKDIVVYPEAYSIKKRGIDIELTH
REFELFHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTIRRLREKIEDDASHPEYIVTRRGVGYFLQTQE
>Mature_232_residues
SRKIVVVDDEKPIADILEFNLKKEGYEVHVAYDGDDAVELIYDIQPDIVLLDIMLPGRDGMEVCREVRKKYDMPIIMLTA
KDSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRHYSQTQSEEKEESTNIVIKDIVVYPEAYSIKKRGIDIELTHR
EFELFHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTIRRLREKIEDDASHPEYIVTRRGVGYFLQTQE

Specific function: Member of the two-component regulatory system walK/walR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=235, Percent_Identity=40, Blast_Score=167, Evalue=4e-43,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=41.8502202643172, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=36.4444444444444, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=38.2222222222222, Blast_Score=156, Evalue=9e-40,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=37.3333333333333, Blast_Score=154, Evalue=5e-39,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=38.2608695652174, Blast_Score=143, Evalue=8e-36,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=35.9649122807018, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=35.5555555555556, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=35.2173913043478, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1790860, Length=237, Percent_Identity=37.5527426160338, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=32.5892857142857, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=31.7180616740088, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790552, Length=231, Percent_Identity=32.034632034632, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787375, Length=234, Percent_Identity=31.1965811965812, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1788550, Length=128, Percent_Identity=38.28125, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1790299, Length=143, Percent_Identity=32.8671328671329, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1787487, Length=104, Percent_Identity=28.8461538461538, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27198; Mature: 27067

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKIVVVDDEKPIADILEFNLKKEGYEVHVAYDGDDAVELIYDIQPDIVLLDIMLPGRD
CCCEEEEEECCCCHHHHHHHCCCCCCEEEEEEECCCCCEEEEEECCCCEEEEEEEECCCC
GMEVCREVRKKYDMPIIMLTAKDSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRH
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCEECCCCCCCCCCCHHHHHHHHHHHHHHH
YSQTQSEEKEESTNIVIKDIVVYPEAYSIKKRGIDIELTHREFELFHYLAKHIGQVMTRE
HHHHHHHHHHHHCCEEEEEEEECCCCHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
HLLQTVWGYDYFGDVRTVDVTIRRLREKIEDDASHPEYIVTRRGVGYFLQTQE
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEECC
>Mature Secondary Structure 
SRKIVVVDDEKPIADILEFNLKKEGYEVHVAYDGDDAVELIYDIQPDIVLLDIMLPGRD
CCEEEEEECCCCHHHHHHHCCCCCCEEEEEEECCCCCEEEEEECCCCEEEEEEEECCCC
GMEVCREVRKKYDMPIIMLTAKDSEIDKVLGLELGADDYVTKPFSTRELIARVKANLRRH
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCEECCCCCCCCCCCHHHHHHHHHHHHHHH
YSQTQSEEKEESTNIVIKDIVVYPEAYSIKKRGIDIELTHREFELFHYLAKHIGQVMTRE
HHHHHHHHHHHHCCEEEEEEEECCCCHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
HLLQTVWGYDYFGDVRTVDVTIRRLREKIEDDASHPEYIVTRRGVGYFLQTQE
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA