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The map label for this gene is guaD [H]

Identifier: 222111201

GI number: 222111201

Start: 2146474

End: 2146941

Strand: Direct

Name: guaD [H]

Synonym: Dtpsy_2009

Alternate gene names: 222111201

Gene position: 2146474-2146941 (Clockwise)

Preceding gene: 222111194

Following gene: 222111202

Centisome position: 56.54

GC content: 74.36

Gene sequence:

>468_bases
ATGTCCACCGATACCGCCCTGCTGCGCCGGGCCGTGCACCTGGCCCATGACAACCGGGCCCGCGGGGGCCGGCCCTTCGG
CGCGGTGATCGCGCGCGGCGGCGAGGTGATCGCCACCGGCGTGAACGACATCGTGCACAGCCACGACCCCAGTACCCACG
CCGAGATGCAGGCCCTGCGCGCCGCAACACGCCAGCGGGCGAACCCCAGCCTGGCGGGCTGCACGGTCTACGCCAGCGGC
CACCCCTGCCCCATGTGCCTGGCGGCGCTGGTCATGGCCGGCGCGGACAGGGTGTTCTACGCCTTCGACAACCGCGACGC
CGCGCCCTACGGCCTGTCCAGCGAAGGCGCCTACCAGCGCCTGCGGCTGCCGCTGGACCCGCCGCCCCTGCCGCTGCAAC
GCCTGGCCACGGGCATTGGCGTGGAGCAACTCTACGGCGACGCGCCCTGGCCCACGGACGGCCCCTGA

Upstream 100 bases:

>100_bases
TCACATGCGTGATTCATCGGCAGGGTTTTTGTGTTCAAAGGACAATCCGGGCGCGGAGCCCGCGGGGAAAGCGGGGGCCG
CTCATTTTTCAGGAGTTCCC

Downstream 100 bases:

>100_bases
CACCCCTGACCACAGCGCCGCAGGGGCCGGTGCCGGCCCCTGCGTATAGGAATGTCTGGCGACGGTGGCGCTGGCCACGC
TGAACCGGGGCCCCCTTCCC

Product: zinc-binding CMP/dCMP deaminase

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 155; Mature: 154

Protein sequence:

>155_residues
MSTDTALLRRAVHLAHDNRARGGRPFGAVIARGGEVIATGVNDIVHSHDPSTHAEMQALRAATRQRANPSLAGCTVYASG
HPCPMCLAALVMAGADRVFYAFDNRDAAPYGLSSEGAYQRLRLPLDPPPLPLQRLATGIGVEQLYGDAPWPTDGP

Sequences:

>Translated_155_residues
MSTDTALLRRAVHLAHDNRARGGRPFGAVIARGGEVIATGVNDIVHSHDPSTHAEMQALRAATRQRANPSLAGCTVYASG
HPCPMCLAALVMAGADRVFYAFDNRDAAPYGLSSEGAYQRLRLPLDPPPLPLQRLATGIGVEQLYGDAPWPTDGP
>Mature_154_residues
STDTALLRRAVHLAHDNRARGGRPFGAVIARGGEVIATGVNDIVHSHDPSTHAEMQALRAATRQRANPSLAGCTVYASGH
PCPMCLAALVMAGADRVFYAFDNRDAAPYGLSSEGAYQRLRLPLDPPPLPLQRLATGIGVEQLYGDAPWPTDGP

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17554608, Length=132, Percent_Identity=32.5757575757576, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17555996, Length=115, Percent_Identity=33.9130434782609, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 16452; Mature: 16321

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDTALLRRAVHLAHDNRARGGRPFGAVIARGGEVIATGVNDIVHSHDPSTHAEMQALR
CCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEECHHHHHHCCCCCHHHHHHHHH
AATRQRANPSLAGCTVYASGHPCPMCLAALVMAGADRVFYAFDNRDAAPYGLSSEGAYQR
HHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHE
LRLPLDPPPLPLQRLATGIGVEQLYGDAPWPTDGP
ECCCCCCCCCCHHHHHHHCCHHHHHCCCCCCCCCC
>Mature Secondary Structure 
STDTALLRRAVHLAHDNRARGGRPFGAVIARGGEVIATGVNDIVHSHDPSTHAEMQALR
CCHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCEEEEECHHHHHHCCCCCHHHHHHHHH
AATRQRANPSLAGCTVYASGHPCPMCLAALVMAGADRVFYAFDNRDAAPYGLSSEGAYQR
HHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHE
LRLPLDPPPLPLQRLATGIGVEQLYGDAPWPTDGP
ECCCCCCCCCCHHHHHHHCCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]