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The map label for this gene is aceE [H]

Identifier: 222110851

GI number: 222110851

Start: 1748718

End: 1751414

Strand: Direct

Name: aceE [H]

Synonym: Dtpsy_1657

Alternate gene names: 222110851

Gene position: 1748718-1751414 (Clockwise)

Preceding gene: 222110845

Following gene: 222110852

Centisome position: 46.06

GC content: 64.48

Gene sequence:

>2697_bases
ATGTCTGATCCGACCAAAGTCCTGACCGCTACCGACATCGACCAACAGGAAACCCGCGAATGGCTGGACGCGCTGTCGGC
AGTGATCGACAAGGAGGGGCCGGAGCGTGCCCACTTCCTGCTGGAGCAATTGCTGGAGCAGGCCCGCCAGAGCAGTATTG
ACCTGCCGTTCTCCGCCAATACGGGATACGTGAACACCATCGAGCCGGACCAGGAGGCCCGCTGCCCGGGCAATATCGCC
ATCGAGAAGCGCCTGCGCGCCTACATGCGCTGGAATGCCATGGCCATGGTGGTGCGCGCCAACCGCCTGCATCCGCATGA
CGGCGGCGACCTGGGCGGCCACATCGGCTCCTTCGCTTCGCTGGCCTCCATGTGGGGCGCGGGCTTCAACCACTTCTGGC
ACGCCGAGAGCGAGAGCCACGGCGGCGACTGCATCTATTTCCAGGGCCACAGTGCGCCCGGCATCTACGCCCGTGCCTAC
CTGGAAGGCCGCATCACCGAGGACCAGCTCGAAAACTTCCGCCAGGAAGTAGGCGGCAAAGGCCTGTCCAGCTACCCGCA
CCCCAAGCTGATGCCGGGCTTCTGGCAGTTCCCCACGGTGTCCATGGGCCTGGGGCCGATGATGGCCATCTACCAGGCGC
GCTTTCTCAAGTACCTGCATGCCCGCGGTATCGCCAATACCGAGAACCGCAAGGTCTGGATCTTCCTGGGCGACGGCGAG
ATGGATGAGCCCGAGAGCAAGGGCGCGATCAGCCTGGCCGCACGTGAAAACCTGGACAACCTGATCTTCGTTATCAACTG
CAACCTGCAGCGCCTGGACGGCCCGGTGCGCGGCAACGGCAAGATCATCCAGGAGCTGGAGGGTGACTTCCGCGGTGCGG
GCTGGCATGTCATCAAGCTGCTGTGGGGCAAGGGCTGGGACGAGCTGCTGGCACGCGACAAGAGCGGCAAGCTCAAGCAG
CTGATGATGGAGACGCTGGACGGCGACTACCAGACCTACCGCGCCATGGACGGCGCGTATATCCGCAAGCATTTCTTTGG
CAGGTACCCCGAGACGGCCAAGCTCGTGGAGCACCTGAGCGACGACGAAATCTGGGAACTGCGCCGCGGTGGTCACGAGC
CCGAGAAGGTGTATGCCGCCTTCCATGCGGCCAATGAACACCAGGGCCAGCCCACGGTGTTGCTGGTCAAGACCGTCAAG
GGCTATGGCATGGGCAAGGCCGGTGAGGGCAAGAACACCGTGCACCAGACCAAGAAGCTGTCGGACGAGGACATCAAGTA
CATCCGCGACCGCTTCAACATCCCGATCCCCGACAGCGAGCTGGACAAGCTGCCCTACTACAAGCCGGCCGACGACACGC
CGGAAATGAAGTACCTGCACGAGCGCCGCAAGGCCCTGGGCGGCTACCTGCCGCAGCGTCGCACGCACGCCGACGAGAGT
TTCACCGTGCCGGCGCTGGAGACGTTCAAGGCCGTGCTGGAGCCCACCGCTGAGGGCCGCGAGATCTCCACCACCCAGGC
CTACGTGCGCTTTCTCACGCAGCTGCTGCGCGACAAGGCCCTGGGTCCGCGCGTGGTGCCCATCCTGGTGGATGAGGCGC
GTACCTTCGGCATGGAGGGATTGTTCCGCCAGATTGGCATCTACAACCCCAAGGGCCAGCTCTACACCCCGGTCGACCGC
GACCAGGTGATGTACTACAAGGAAGACAAGGCCGGTCAGATTCTTCAGGAGGGCATCAACGAGGCGGGCGGCATGTGCTC
GTGGATCGCTGCGGCGACGTCGTATTCGACGAACAACCGCATCATGATCCCGTTCTACGTGTACTACTCGATGTTCGGCT
TCCAGCGCTTTGGCGACTTCGCCTGGGCCGCGGGCGACATGCAGGCGCGCGGCTTCATCCTGGGAGGCACGTCGGGCCGC
ACCACGCTCAACGGCGAAGGCCTGCAGCACGAGGACGGCCACAGCCATATCCTGGCCAACACCATTCCCAACTGCGTGAG
CTACGACCCGACCTTCGCGCACGAGGTGGCGGTCATCATGCAGAATGGCCTGAAGCGCATGGTGGAGAAGCAGGAAAACG
TCTACTACTACATCACGCTGCTCAACGAGAACTACGCCATGCCGGGCCTGCAGCCGGGCACGGAAGAGCAGATCATCAAG
GGCATGTACCTGTGCAAGGCCGGTGCCGAGGGTGACAAGCGCGTGCAGCTGCTGGGCTCGGGCTCGATCCTGCGCGAGTC
GATCGAGGCGCAGAAGCTGCTCGCCGCCGACTGGGGCGTGCAGGCCGACGTGTGGAGCTGCACCAGCTTCAACGAGCTGA
CCCGCGAGGGCCAAGACGTGGCGCGCTGGAACCTGCTGCACCCGCTGGAGACACCGCGCGTGTCCTTCGTGGCGCAGCAG
CTGGGCGGCCGCCCGGGCCCCGTGGTGGCGTCCACCGACTACATGAAGAACTACGCCGAGCAGATCCGCGCCTTCGTCCC
CGCAGGGCGCTCCTACACCGTGTTGGGTACCGACGGCTTTGGCCGCAGCGACTTCCGCTACCGCCTGCGCGAGCACTTCG
AGGTCAACCGCCACTACATCACCGTGGCCGCGCTGAGCGCACTGGCCGACGAGGGTAAGCTGCCCAAGGCGAAGGTGGCC
GAGGCGATTGCCAAGTACGGCATCCAGACCGAGAAGATCAACCCCTTGCACGCCTGA

Upstream 100 bases:

>100_bases
TTCATATTAAGAGATGAAAAAGCATCATTTGAAATGATGAAAATTTGTGCGAAACTCGCGCCCGTATTACCGTTATTGCC
ACTGAATCAAGGAGACAGGT

Downstream 100 bases:

>100_bases
TGGCCCGGGAGACACGACATGGCATTGGTAAACATCCAGGTTCCCGACATCGGCGACTTCGACGAAGTCGGCGTGATCGA
GCTGCTGGTCAAGGTGGGCG

Product: pyruvate dehydrogenase subunit e1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 898; Mature: 897

Protein sequence:

>898_residues
MSDPTKVLTATDIDQQETREWLDALSAVIDKEGPERAHFLLEQLLEQARQSSIDLPFSANTGYVNTIEPDQEARCPGNIA
IEKRLRAYMRWNAMAMVVRANRLHPHDGGDLGGHIGSFASLASMWGAGFNHFWHAESESHGGDCIYFQGHSAPGIYARAY
LEGRITEDQLENFRQEVGGKGLSSYPHPKLMPGFWQFPTVSMGLGPMMAIYQARFLKYLHARGIANTENRKVWIFLGDGE
MDEPESKGAISLAARENLDNLIFVINCNLQRLDGPVRGNGKIIQELEGDFRGAGWHVIKLLWGKGWDELLARDKSGKLKQ
LMMETLDGDYQTYRAMDGAYIRKHFFGRYPETAKLVEHLSDDEIWELRRGGHEPEKVYAAFHAANEHQGQPTVLLVKTVK
GYGMGKAGEGKNTVHQTKKLSDEDIKYIRDRFNIPIPDSELDKLPYYKPADDTPEMKYLHERRKALGGYLPQRRTHADES
FTVPALETFKAVLEPTAEGREISTTQAYVRFLTQLLRDKALGPRVVPILVDEARTFGMEGLFRQIGIYNPKGQLYTPVDR
DQVMYYKEDKAGQILQEGINEAGGMCSWIAAATSYSTNNRIMIPFYVYYSMFGFQRFGDFAWAAGDMQARGFILGGTSGR
TTLNGEGLQHEDGHSHILANTIPNCVSYDPTFAHEVAVIMQNGLKRMVEKQENVYYYITLLNENYAMPGLQPGTEEQIIK
GMYLCKAGAEGDKRVQLLGSGSILRESIEAQKLLAADWGVQADVWSCTSFNELTREGQDVARWNLLHPLETPRVSFVAQQ
LGGRPGPVVASTDYMKNYAEQIRAFVPAGRSYTVLGTDGFGRSDFRYRLREHFEVNRHYITVAALSALADEGKLPKAKVA
EAIAKYGIQTEKINPLHA

Sequences:

>Translated_898_residues
MSDPTKVLTATDIDQQETREWLDALSAVIDKEGPERAHFLLEQLLEQARQSSIDLPFSANTGYVNTIEPDQEARCPGNIA
IEKRLRAYMRWNAMAMVVRANRLHPHDGGDLGGHIGSFASLASMWGAGFNHFWHAESESHGGDCIYFQGHSAPGIYARAY
LEGRITEDQLENFRQEVGGKGLSSYPHPKLMPGFWQFPTVSMGLGPMMAIYQARFLKYLHARGIANTENRKVWIFLGDGE
MDEPESKGAISLAARENLDNLIFVINCNLQRLDGPVRGNGKIIQELEGDFRGAGWHVIKLLWGKGWDELLARDKSGKLKQ
LMMETLDGDYQTYRAMDGAYIRKHFFGRYPETAKLVEHLSDDEIWELRRGGHEPEKVYAAFHAANEHQGQPTVLLVKTVK
GYGMGKAGEGKNTVHQTKKLSDEDIKYIRDRFNIPIPDSELDKLPYYKPADDTPEMKYLHERRKALGGYLPQRRTHADES
FTVPALETFKAVLEPTAEGREISTTQAYVRFLTQLLRDKALGPRVVPILVDEARTFGMEGLFRQIGIYNPKGQLYTPVDR
DQVMYYKEDKAGQILQEGINEAGGMCSWIAAATSYSTNNRIMIPFYVYYSMFGFQRFGDFAWAAGDMQARGFILGGTSGR
TTLNGEGLQHEDGHSHILANTIPNCVSYDPTFAHEVAVIMQNGLKRMVEKQENVYYYITLLNENYAMPGLQPGTEEQIIK
GMYLCKAGAEGDKRVQLLGSGSILRESIEAQKLLAADWGVQADVWSCTSFNELTREGQDVARWNLLHPLETPRVSFVAQQ
LGGRPGPVVASTDYMKNYAEQIRAFVPAGRSYTVLGTDGFGRSDFRYRLREHFEVNRHYITVAALSALADEGKLPKAKVA
EAIAKYGIQTEKINPLHA
>Mature_897_residues
SDPTKVLTATDIDQQETREWLDALSAVIDKEGPERAHFLLEQLLEQARQSSIDLPFSANTGYVNTIEPDQEARCPGNIAI
EKRLRAYMRWNAMAMVVRANRLHPHDGGDLGGHIGSFASLASMWGAGFNHFWHAESESHGGDCIYFQGHSAPGIYARAYL
EGRITEDQLENFRQEVGGKGLSSYPHPKLMPGFWQFPTVSMGLGPMMAIYQARFLKYLHARGIANTENRKVWIFLGDGEM
DEPESKGAISLAARENLDNLIFVINCNLQRLDGPVRGNGKIIQELEGDFRGAGWHVIKLLWGKGWDELLARDKSGKLKQL
MMETLDGDYQTYRAMDGAYIRKHFFGRYPETAKLVEHLSDDEIWELRRGGHEPEKVYAAFHAANEHQGQPTVLLVKTVKG
YGMGKAGEGKNTVHQTKKLSDEDIKYIRDRFNIPIPDSELDKLPYYKPADDTPEMKYLHERRKALGGYLPQRRTHADESF
TVPALETFKAVLEPTAEGREISTTQAYVRFLTQLLRDKALGPRVVPILVDEARTFGMEGLFRQIGIYNPKGQLYTPVDRD
QVMYYKEDKAGQILQEGINEAGGMCSWIAAATSYSTNNRIMIPFYVYYSMFGFQRFGDFAWAAGDMQARGFILGGTSGRT
TLNGEGLQHEDGHSHILANTIPNCVSYDPTFAHEVAVIMQNGLKRMVEKQENVYYYITLLNENYAMPGLQPGTEEQIIKG
MYLCKAGAEGDKRVQLLGSGSILRESIEAQKLLAADWGVQADVWSCTSFNELTREGQDVARWNLLHPLETPRVSFVAQQL
GGRPGPVVASTDYMKNYAEQIRAFVPAGRSYTVLGTDGFGRSDFRYRLREHFEVNRHYITVAALSALADEGKLPKAKVAE
AIAKYGIQTEKINPLHA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=890, Percent_Identity=61.685393258427, Blast_Score=1142, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 100886; Mature: 100754

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS50003 PH_DOMAIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPTKVLTATDIDQQETREWLDALSAVIDKEGPERAHFLLEQLLEQARQSSIDLPFSAN
CCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
TGYVNTIEPDQEARCPGNIAIEKRLRAYMRWNAMAMVVRANRLHPHDGGDLGGHIGSFAS
CCEEECCCCCHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHHHH
LASMWGAGFNHFWHAESESHGGDCIYFQGHSAPGIYARAYLEGRITEDQLENFRQEVGGK
HHHHHCCCCCCEECCCCCCCCCCEEEECCCCCCCCEEEEHHHCCCCHHHHHHHHHHHCCC
GLSSYPHPKLMPGFWQFPTVSMGLGPMMAIYQARFLKYLHARGIANTENRKVWIFLGDGE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
MDEPESKGAISLAARENLDNLIFVINCNLQRLDGPVRGNGKIIQELEGDFRGAGWHVIKL
CCCCCCCCCEEEHHHCCCCCEEEEEECCHHHCCCCCCCCCCCHHHHCCCCCCCCHHEEHH
LWGKGWDELLARDKSGKLKQLMMETLDGDYQTYRAMDGAYIRKHFFGRYPETAKLVEHLS
HHCCCHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
DDEIWELRRGGHEPEKVYAAFHAANEHQGQPTVLLVKTVKGYGMGKAGEGKNTVHQTKKL
CCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHCC
SDEDIKYIRDRFNIPIPDSELDKLPYYKPADDTPEMKYLHERRKALGGYLPQRRTHADES
CHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCC
FTVPALETFKAVLEPTAEGREISTTQAYVRFLTQLLRDKALGPRVVPILVDEARTFGMEG
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHCHHH
LFRQIGIYNPKGQLYTPVDRDQVMYYKEDKAGQILQEGINEAGGMCSWIAAATSYSTNNR
HHHHHCCCCCCCCEECCCCCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCE
IMIPFYVYYSMFGFQRFGDFAWAAGDMQARGFILGGTSGRTTLNGEGLQHEDGHSHILAN
EEEHHHHHHHHHHHHHHCCHHEECCCCCCCEEEEECCCCCCEECCCCCCCCCCCCEEHHH
TIPNCVSYDPTFAHEVAVIMQNGLKRMVEKQENVYYYITLLNENYAMPGLQPGTEEQIIK
HCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCHHHHHH
GMYLCKAGAEGDKRVQLLGSGSILRESIEAQKLLAADWGVQADVWSCTSFNELTREGQDV
HHHHEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHCCCHH
ARWNLLHPLETPRVSFVAQQLGGRPGPVVASTDYMKNYAEQIRAFVPAGRSYTVLGTDGF
HHHHCCCCCCCCHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHCCCCEEEEEECCCC
GRSDFRYRLREHFEVNRHYITVAALSALADEGKLPKAKVAEAIAKYGIQTEKINPLHA
CCHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SDPTKVLTATDIDQQETREWLDALSAVIDKEGPERAHFLLEQLLEQARQSSIDLPFSAN
CCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
TGYVNTIEPDQEARCPGNIAIEKRLRAYMRWNAMAMVVRANRLHPHDGGDLGGHIGSFAS
CCEEECCCCCHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHHHH
LASMWGAGFNHFWHAESESHGGDCIYFQGHSAPGIYARAYLEGRITEDQLENFRQEVGGK
HHHHHCCCCCCEECCCCCCCCCCEEEECCCCCCCCEEEEHHHCCCCHHHHHHHHHHHCCC
GLSSYPHPKLMPGFWQFPTVSMGLGPMMAIYQARFLKYLHARGIANTENRKVWIFLGDGE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
MDEPESKGAISLAARENLDNLIFVINCNLQRLDGPVRGNGKIIQELEGDFRGAGWHVIKL
CCCCCCCCCEEEHHHCCCCCEEEEEECCHHHCCCCCCCCCCCHHHHCCCCCCCCHHEEHH
LWGKGWDELLARDKSGKLKQLMMETLDGDYQTYRAMDGAYIRKHFFGRYPETAKLVEHLS
HHCCCHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
DDEIWELRRGGHEPEKVYAAFHAANEHQGQPTVLLVKTVKGYGMGKAGEGKNTVHQTKKL
CCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHCC
SDEDIKYIRDRFNIPIPDSELDKLPYYKPADDTPEMKYLHERRKALGGYLPQRRTHADES
CHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCC
FTVPALETFKAVLEPTAEGREISTTQAYVRFLTQLLRDKALGPRVVPILVDEARTFGMEG
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHCHHH
LFRQIGIYNPKGQLYTPVDRDQVMYYKEDKAGQILQEGINEAGGMCSWIAAATSYSTNNR
HHHHHCCCCCCCCEECCCCCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCE
IMIPFYVYYSMFGFQRFGDFAWAAGDMQARGFILGGTSGRTTLNGEGLQHEDGHSHILAN
EEEHHHHHHHHHHHHHHCCHHEECCCCCCCEEEEECCCCCCEECCCCCCCCCCCCEEHHH
TIPNCVSYDPTFAHEVAVIMQNGLKRMVEKQENVYYYITLLNENYAMPGLQPGTEEQIIK
HCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCHHHHHH
GMYLCKAGAEGDKRVQLLGSGSILRESIEAQKLLAADWGVQADVWSCTSFNELTREGQDV
HHHHEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHCCCHH
ARWNLLHPLETPRVSFVAQQLGGRPGPVVASTDYMKNYAEQIRAFVPAGRSYTVLGTDGF
HHHHCCCCCCCCHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHCCCCEEEEEECCCC
GRSDFRYRLREHFEVNRHYITVAALSALADEGKLPKAKVAEAIAKYGIQTEKINPLHA
CCHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8021225 [H]