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The map label for this gene is thrS [H]

Identifier: 222110646

GI number: 222110646

Start: 1515427

End: 1517346

Strand: Direct

Name: thrS [H]

Synonym: Dtpsy_1448

Alternate gene names: 222110646

Gene position: 1515427-1517346 (Clockwise)

Preceding gene: 222110645

Following gene: 222110647

Centisome position: 39.92

GC content: 61.25

Gene sequence:

>1920_bases
ATGATTCACATTACGCTTCCCGACGGTTCCCAGCGAGAGTTTGCTGGTCCCGTGACTGTGGCGGAGGTGGCTGCCTCCAT
CGGTTCGGGCCTGGCCAAAGCGGCGCTCGCCGGCAAGATCGGGGACAAGGTGGTGGATACCAGCTACCAGATTACGCAAG
ACAGCCCGCTGTCCATCGTGACGGCCAAGGATGCCGACGGCCTGGAGGTGATCCGCCACTCTACGGCCCACCTGCTGGCC
TATGCGGTCAAGGAACTGTTTCCCGATGCGCAGGTGACCATCGGGCCGGTGATCGAGAACGGCTTCTACTACGACTTCTC
GTACAAGCGTCCGTTTACGCCGGAAGACTTGGCCGCCATTGAAAAGCGCATGGCGGAACTGGCTGCGAAGGATGAACCAG
TGGTGCGCCGTGTATTGCCTCGGGACGAGGCGGTGGCGTACTTCAAGGGCCTGGGCGAACACTACAAGGCCGAGATCATT
GCCAGCATCCCGACGAATGAGGACGTGAGCCTGTACCGCGAGGGCGGCTTTGAAGACCTGTGCCGTGGCCCCCACGTACC
CAGCACCGGCAAGCTCAAGTTCTTCAAACTCATGAAGGTGGCGGGCGCCTATTGGCGCGGCGACCACCGCAACGAGATGC
TCCAGCGCGTCTATGGCACGGCATGGGCCACGAAGGAAGAACTGCAGCAGTACCTGCACATGCTGGAAGAGGCCGAGAAG
CGCGACCACCGCAAGCTGGGCCGTGAGCTTGACCTGTTCCACATCGACGAGCATTCGCCCGGCACGGTGTTCTGGCACCC
CAAGGGCTGGACGCTGTGGCAGGAGGTGGAGCAGTACATGCGCCGCGTATACCGCGACAACGGCTACCAGGAGGTCAAGG
GCCCGCAGATCCTAGACAAGACGCTGTGGGAGAAAACGGGACACTGGGACAAGTACCGCGACAACATGTTCACCACTGAG
AGCGAGAAGCGCGACTACGCTCTCAAGCCGATGAACTGCCCGGGCCATATCCTGATCTTCAAGCAGGGCATCAAGAGCTA
CCGCGACCTGCCGCTACGCTACGGCGAGTTCGGCCAGTGCCACCGCAACGAGCCCACGGGTGGCCTGCACGGCATCATGC
GCGTGCGCGGTTTCACGCAGGACGATGGTCACATCTTCTGCACGGAAGACCACATCCTGGCCGAATGCACAGCTTACACA
GCGTTGCTGCAAAAGGTCTACAAGAACTTCGGCTTCCACAACATCATCTACAAGGTGGCCACGCGCCCCGAGGCACGCAT
CGGTTCCGACGAGAGCTGGGACAAGGCCGAGCATGCGCTGATGGAAAGCCTGCGCGCGTCGGGTTGCGAATTCGAGATCG
CTCCCGGCGATGGCGCCTTCTATGGCCCGAAGATCGAGTACACGCTCAAGGACGCGATCGGACGGCAGTGGCAGTGCGGC
ACCATGCAGGTGGACTTCTCGATGCCCGAGCGGCTGGATGCAGAGTACGTGGGCGAGGATGGCGGGCGCCATCGGCCGGT
GATGCTGCACCGCGCCATCGTGGGCAGCCTGGAGCGCTTCATCGGCATCCTGATCGAAGAACACGCCGGGGCCTTGCCCG
TATGGCTTGCGCCCGTACAGGTGGCGGTGCTCAATATCACCGACGCGCAGCAGGATTACTGTCGTGAAATCGCCGCAAAG
CTGCAAAAAGCGTTGCCGAATCAAGGCCTTAGGGTGGTGACTGATCTGCGTAACGAGAAGATTACGTATAAAATACGGGA
GCATTCGCTGCAAAAGCTGCCCTACATCCTCGTCGCCGGCGACAAGGAAAAGGCTGCAGGGGCTGTGGCAGTGCGTGCCC
GGGGTAACAAAGACCTCGGCGTGATGTCCCTCGACGCATTCGTCGATCTGATCGCGCAGGACATTGCCTCCAAAGTCTGA

Upstream 100 bases:

>100_bases
TCTCGCCCCCATAAAAGCGCGGACCTGTACCGCGCTTTTTGCTTTCTGAACCCCAGTCAAGCGCGGCTCACCTACCGAAA
AAGACTCGATAAGGATTTCC

Downstream 100 bases:

>100_bases
ATCATCGCTTGAAGCGCATCCCTGGTGCGTAAGCTGCTACGCTTTTCGTAGCTTTTTAATTGAAGGTGAGAGCCATCGCT
ACCGAATTTCGTGACCGTCG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 639; Mature: 639

Protein sequence:

>639_residues
MIHITLPDGSQREFAGPVTVAEVAASIGSGLAKAALAGKIGDKVVDTSYQITQDSPLSIVTAKDADGLEVIRHSTAHLLA
YAVKELFPDAQVTIGPVIENGFYYDFSYKRPFTPEDLAAIEKRMAELAAKDEPVVRRVLPRDEAVAYFKGLGEHYKAEII
ASIPTNEDVSLYREGGFEDLCRGPHVPSTGKLKFFKLMKVAGAYWRGDHRNEMLQRVYGTAWATKEELQQYLHMLEEAEK
RDHRKLGRELDLFHIDEHSPGTVFWHPKGWTLWQEVEQYMRRVYRDNGYQEVKGPQILDKTLWEKTGHWDKYRDNMFTTE
SEKRDYALKPMNCPGHILIFKQGIKSYRDLPLRYGEFGQCHRNEPTGGLHGIMRVRGFTQDDGHIFCTEDHILAECTAYT
ALLQKVYKNFGFHNIIYKVATRPEARIGSDESWDKAEHALMESLRASGCEFEIAPGDGAFYGPKIEYTLKDAIGRQWQCG
TMQVDFSMPERLDAEYVGEDGGRHRPVMLHRAIVGSLERFIGILIEEHAGALPVWLAPVQVAVLNITDAQQDYCREIAAK
LQKALPNQGLRVVTDLRNEKITYKIREHSLQKLPYILVAGDKEKAAGAVAVRARGNKDLGVMSLDAFVDLIAQDIASKV

Sequences:

>Translated_639_residues
MIHITLPDGSQREFAGPVTVAEVAASIGSGLAKAALAGKIGDKVVDTSYQITQDSPLSIVTAKDADGLEVIRHSTAHLLA
YAVKELFPDAQVTIGPVIENGFYYDFSYKRPFTPEDLAAIEKRMAELAAKDEPVVRRVLPRDEAVAYFKGLGEHYKAEII
ASIPTNEDVSLYREGGFEDLCRGPHVPSTGKLKFFKLMKVAGAYWRGDHRNEMLQRVYGTAWATKEELQQYLHMLEEAEK
RDHRKLGRELDLFHIDEHSPGTVFWHPKGWTLWQEVEQYMRRVYRDNGYQEVKGPQILDKTLWEKTGHWDKYRDNMFTTE
SEKRDYALKPMNCPGHILIFKQGIKSYRDLPLRYGEFGQCHRNEPTGGLHGIMRVRGFTQDDGHIFCTEDHILAECTAYT
ALLQKVYKNFGFHNIIYKVATRPEARIGSDESWDKAEHALMESLRASGCEFEIAPGDGAFYGPKIEYTLKDAIGRQWQCG
TMQVDFSMPERLDAEYVGEDGGRHRPVMLHRAIVGSLERFIGILIEEHAGALPVWLAPVQVAVLNITDAQQDYCREIAAK
LQKALPNQGLRVVTDLRNEKITYKIREHSLQKLPYILVAGDKEKAAGAVAVRARGNKDLGVMSLDAFVDLIAQDIASKV
>Mature_639_residues
MIHITLPDGSQREFAGPVTVAEVAASIGSGLAKAALAGKIGDKVVDTSYQITQDSPLSIVTAKDADGLEVIRHSTAHLLA
YAVKELFPDAQVTIGPVIENGFYYDFSYKRPFTPEDLAAIEKRMAELAAKDEPVVRRVLPRDEAVAYFKGLGEHYKAEII
ASIPTNEDVSLYREGGFEDLCRGPHVPSTGKLKFFKLMKVAGAYWRGDHRNEMLQRVYGTAWATKEELQQYLHMLEEAEK
RDHRKLGRELDLFHIDEHSPGTVFWHPKGWTLWQEVEQYMRRVYRDNGYQEVKGPQILDKTLWEKTGHWDKYRDNMFTTE
SEKRDYALKPMNCPGHILIFKQGIKSYRDLPLRYGEFGQCHRNEPTGGLHGIMRVRGFTQDDGHIFCTEDHILAECTAYT
ALLQKVYKNFGFHNIIYKVATRPEARIGSDESWDKAEHALMESLRASGCEFEIAPGDGAFYGPKIEYTLKDAIGRQWQCG
TMQVDFSMPERLDAEYVGEDGGRHRPVMLHRAIVGSLERFIGILIEEHAGALPVWLAPVQVAVLNITDAQQDYCREIAAK
LQKALPNQGLRVVTDLRNEKITYKIREHSLQKLPYILVAGDKEKAAGAVAVRARGNKDLGVMSLDAFVDLIAQDIASKV

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=636, Percent_Identity=38.8364779874214, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI38570111, Length=615, Percent_Identity=39.1869918699187, Blast_Score=457, Evalue=1e-128,
Organism=Homo sapiens, GI20070344, Length=661, Percent_Identity=36.6111951588502, Blast_Score=409, Evalue=1e-114,
Organism=Escherichia coli, GI1788013, Length=636, Percent_Identity=56.6037735849057, Blast_Score=765, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=632, Percent_Identity=39.2405063291139, Blast_Score=474, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI71984192, Length=632, Percent_Identity=39.2405063291139, Blast_Score=473, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322112, Length=633, Percent_Identity=36.9668246445498, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6322654, Length=393, Percent_Identity=39.6946564885496, Blast_Score=305, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24583842, Length=630, Percent_Identity=39.5238095238095, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI28574141, Length=630, Percent_Identity=39.5238095238095, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24583839, Length=630, Percent_Identity=39.5238095238095, Blast_Score=471, Evalue=1e-133,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 72141; Mature: 72141

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHITLPDGSQREFAGPVTVAEVAASIGSGLAKAALAGKIGDKVVDTSYQITQDSPLSIV
CEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEECCCCCEEEE
TAKDADGLEVIRHSTAHLLAYAVKELFPDAQVTIGPVIENGFYYDFSYKRPFTPEDLAAI
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCHHHHHHH
EKRMAELAAKDEPVVRRVLPRDEAVAYFKGLGEHYKAEIIASIPTNEDVSLYREGGFEDL
HHHHHHHHCCCCHHHHHHCCCHHHHHHHHHCCHHHEEEEEEECCCCCCCHHEECCCHHHH
CRGPHVPSTGKLKFFKLMKVAGAYWRGDHRNEMLQRVYGTAWATKEELQQYLHMLEEAEK
HCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RDHRKLGRELDLFHIDEHSPGTVFWHPKGWTLWQEVEQYMRRVYRDNGYQEVKGPQILDK
HHHHHHCCCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
TLWEKTGHWDKYRDNMFTTESEKRDYALKPMNCPGHILIFKQGIKSYRDLPLRYGEFGQC
HHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCC
HRNEPTGGLHGIMRVRGFTQDDGHIFCTEDHILAECTAYTALLQKVYKNFGFHNIIYKVA
CCCCCCCHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TRPEARIGSDESWDKAEHALMESLRASGCEFEIAPGDGAFYGPKIEYTLKDAIGRQWQCG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEHHHCCCCEECC
TMQVDFSMPERLDAEYVGEDGGRHRPVMLHRAIVGSLERFIGILIEEHAGALPVWLAPVQ
EEEECCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEE
VAVLNITDAQQDYCREIAAKLQKALPNQGLRVVTDLRNEKITYKIREHSLQKLPYILVAG
EEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEHHHHHHHCCEEEEEC
DKEKAAGAVAVRARGNKDLGVMSLDAFVDLIAQDIASKV
CCCCCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIHITLPDGSQREFAGPVTVAEVAASIGSGLAKAALAGKIGDKVVDTSYQITQDSPLSIV
CEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEECCCCCEEEE
TAKDADGLEVIRHSTAHLLAYAVKELFPDAQVTIGPVIENGFYYDFSYKRPFTPEDLAAI
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCHHHHHHH
EKRMAELAAKDEPVVRRVLPRDEAVAYFKGLGEHYKAEIIASIPTNEDVSLYREGGFEDL
HHHHHHHHCCCCHHHHHHCCCHHHHHHHHHCCHHHEEEEEEECCCCCCCHHEECCCHHHH
CRGPHVPSTGKLKFFKLMKVAGAYWRGDHRNEMLQRVYGTAWATKEELQQYLHMLEEAEK
HCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RDHRKLGRELDLFHIDEHSPGTVFWHPKGWTLWQEVEQYMRRVYRDNGYQEVKGPQILDK
HHHHHHCCCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
TLWEKTGHWDKYRDNMFTTESEKRDYALKPMNCPGHILIFKQGIKSYRDLPLRYGEFGQC
HHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCC
HRNEPTGGLHGIMRVRGFTQDDGHIFCTEDHILAECTAYTALLQKVYKNFGFHNIIYKVA
CCCCCCCHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TRPEARIGSDESWDKAEHALMESLRASGCEFEIAPGDGAFYGPKIEYTLKDAIGRQWQCG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEHHHCCCCEECC
TMQVDFSMPERLDAEYVGEDGGRHRPVMLHRAIVGSLERFIGILIEEHAGALPVWLAPVQ
EEEECCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEE
VAVLNITDAQQDYCREIAAKLQKALPNQGLRVVTDLRNEKITYKIREHSLQKLPYILVAG
EEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEEHHHHHHHCCEEEEEC
DKEKAAGAVAVRARGNKDLGVMSLDAFVDLIAQDIASKV
CCCCCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA