Click here to switch to the map view.

The map label for this gene is guaB [H]

Identifier: 222110463

GI number: 222110463

Start: 1321740

End: 1323215

Strand: Direct

Name: guaB [H]

Synonym: Dtpsy_1260

Alternate gene names: 222110463

Gene position: 1321740-1323215 (Clockwise)

Preceding gene: 222110461

Following gene: 222110464

Centisome position: 34.81

GC content: 65.24

Gene sequence:

>1476_bases
ATGCGCCTTCTTGGAAAAGCGCTCACCTTCGACGATGTGTTGTTGGTGCCGGCGTACTCCCAGGTCCTGCCCAAGGACAC
CTCCCTCGTCACGCGCTTTACGCGCAACATCACCCTGAACCTCCCGCTCGTGTCCGCCGCCATGGACACCGTGACCGAAG
CGCGTCTGGCCATCGCCATCGCGCAAGAAGGGGGGATTGGCGTCATCCACAAGAACATGACGGCCGAGCAGCAGGCGGCC
GAGGTGTCAAAGGTCAAGCGGCATGAGTCCGGCGTGGTGCACGATCCCGTGGTCATCACGCCCGAACACACGGTGCTGCA
GGTGCTGGAACTGTCCGAGAACCTGGGCATCTCGGGCTTCCCGGTCTGTGATGGTGGCAAGGTGGTGGGCATCGTCACCA
GCCGCGACGTGCGCTTCGAGACGCGCTACGACGTCAAGGTGCGTGAGATCATGACGCCGCGCGAGAAGCTGATCACCGTC
AACGAAAAAGACGGCACCACCCCAGCCCAGGCCAAGGCGCTGCTCAACCGCCACAAGCTGGAGCGCCTGCTGGTGGTGAA
CGACGCCTTTGAGCTCAAGGGCCTCATCACGGTCAAGGACATCAACAAGCAGACCACGTTCCCCAACGCCGCGCGCGATG
CGGCAGGCCGCCTGCGCGTGGCCGCTGCCGTGGGCGTCGGCGCGGGCACCGAAGAGCGCGTGGCGTTGCTGGTCAAGGCC
GGTGTGGATGCCATCGTGGTGGATACAGCCCACGGCCACAGCAAAGGTGTGATCGACCGCGTGCGCTGGGTCAAACAGAA
CTACCCGCAGGTGGACGTGATCGGCGGCAACATCGCCACCGGCGCTGCCGCGCTGGCCCTGGCCGAGGCAGGCGCCGATG
CGGTCAAGGTCGGCATCGGTCCCGGCTCCATCTGCACCACACGCATCGTGGCTGGCGTGGGTGTACCCCAGATCATGGCC
ATCGACAGCGTCGCCACCGCGCTTCAGGGCACAGGGGTGCCGCTGATCGCCGATGGCGGCATCCGCTTCTCGGGGGATAT
TGCCAAGGCGCTGGCCGCGGGCGCGTCGACCATCATGATGGGCGGCATGTTTGCTGGCACCGAAGAAGCGCCCGGCGAAG
TCATCCTGTACCAGGGCCGCTCCTACAAAAGCTACCGTGGCATGGGCTCGATCGGCGCCATGCAGCAGGGCTCGGCCGAC
CGCTACTTCCAGGAAGCCACCACGGGCAATCCCAACGCCGACAAGCTGGTGCCCGAAGGCATCGAAGGCCGCGTGCCCTA
CAAGGGCTCCATGGTGTCCATCGTGTTCCAGATGGCCGGCGGCGTGCGTGCGGCCATGGGCTACTGTGGTTGCGCAACCA
TCGAAGAGATGAACAACAAGGCCGAATTCGTGGAGATCACGGCGGCTGGCATCCGCGAGTCGCACGTGCACGACGTGCAG
ATCACCAAGGAAGCCCCCAACTACCGGGCGGACTGA

Upstream 100 bases:

>100_bases
CGAGTGTAGCGGTGAGCGGCTGCACCCACCAAGGGGCGTTCACTCGGGGTGTGTGCGATTTGTCGCGCGGCGGGTACAAT
CCTTTTTTTGGAGCTTTCAC

Downstream 100 bases:

>100_bases
GTTTTCGCCATTCCGCAGGCCCGAACCCGTCTCCAGGTGTTCGGGCCTTTTGTCTTTTACCGACCCTGTCGCTCTCCATG
CAACACGACAAGATCCTCAT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MRLLGKALTFDDVLLVPAYSQVLPKDTSLVTRFTRNITLNLPLVSAAMDTVTEARLAIAIAQEGGIGVIHKNMTAEQQAA
EVSKVKRHESGVVHDPVVITPEHTVLQVLELSENLGISGFPVCDGGKVVGIVTSRDVRFETRYDVKVREIMTPREKLITV
NEKDGTTPAQAKALLNRHKLERLLVVNDAFELKGLITVKDINKQTTFPNAARDAAGRLRVAAAVGVGAGTEERVALLVKA
GVDAIVVDTAHGHSKGVIDRVRWVKQNYPQVDVIGGNIATGAAALALAEAGADAVKVGIGPGSICTTRIVAGVGVPQIMA
IDSVATALQGTGVPLIADGGIRFSGDIAKALAAGASTIMMGGMFAGTEEAPGEVILYQGRSYKSYRGMGSIGAMQQGSAD
RYFQEATTGNPNADKLVPEGIEGRVPYKGSMVSIVFQMAGGVRAAMGYCGCATIEEMNNKAEFVEITAAGIRESHVHDVQ
ITKEAPNYRAD

Sequences:

>Translated_491_residues
MRLLGKALTFDDVLLVPAYSQVLPKDTSLVTRFTRNITLNLPLVSAAMDTVTEARLAIAIAQEGGIGVIHKNMTAEQQAA
EVSKVKRHESGVVHDPVVITPEHTVLQVLELSENLGISGFPVCDGGKVVGIVTSRDVRFETRYDVKVREIMTPREKLITV
NEKDGTTPAQAKALLNRHKLERLLVVNDAFELKGLITVKDINKQTTFPNAARDAAGRLRVAAAVGVGAGTEERVALLVKA
GVDAIVVDTAHGHSKGVIDRVRWVKQNYPQVDVIGGNIATGAAALALAEAGADAVKVGIGPGSICTTRIVAGVGVPQIMA
IDSVATALQGTGVPLIADGGIRFSGDIAKALAAGASTIMMGGMFAGTEEAPGEVILYQGRSYKSYRGMGSIGAMQQGSAD
RYFQEATTGNPNADKLVPEGIEGRVPYKGSMVSIVFQMAGGVRAAMGYCGCATIEEMNNKAEFVEITAAGIRESHVHDVQ
ITKEAPNYRAD
>Mature_491_residues
MRLLGKALTFDDVLLVPAYSQVLPKDTSLVTRFTRNITLNLPLVSAAMDTVTEARLAIAIAQEGGIGVIHKNMTAEQQAA
EVSKVKRHESGVVHDPVVITPEHTVLQVLELSENLGISGFPVCDGGKVVGIVTSRDVRFETRYDVKVREIMTPREKLITV
NEKDGTTPAQAKALLNRHKLERLLVVNDAFELKGLITVKDINKQTTFPNAARDAAGRLRVAAAVGVGAGTEERVALLVKA
GVDAIVVDTAHGHSKGVIDRVRWVKQNYPQVDVIGGNIATGAAALALAEAGADAVKVGIGPGSICTTRIVAGVGVPQIMA
IDSVATALQGTGVPLIADGGIRFSGDIAKALAAGASTIMMGGMFAGTEEAPGEVILYQGRSYKSYRGMGSIGAMQQGSAD
RYFQEATTGNPNADKLVPEGIEGRVPYKGSMVSIVFQMAGGVRAAMGYCGCATIEEMNNKAEFVEITAAGIRESHVHDVQ
ITKEAPNYRAD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=456, Percent_Identity=43.640350877193, Blast_Score=344, Evalue=9e-95,
Organism=Homo sapiens, GI66933016, Length=490, Percent_Identity=41.0204081632653, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI156616279, Length=456, Percent_Identity=43.640350877193, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI34328930, Length=456, Percent_Identity=43.640350877193, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI34328928, Length=456, Percent_Identity=43.640350877193, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI217035152, Length=452, Percent_Identity=43.5840707964602, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI217035148, Length=456, Percent_Identity=42.7631578947368, Blast_Score=332, Evalue=5e-91,
Organism=Homo sapiens, GI217035150, Length=456, Percent_Identity=40.1315789473684, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI156104880, Length=250, Percent_Identity=36, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI50541956, Length=251, Percent_Identity=36.2549800796813, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI50541954, Length=251, Percent_Identity=36.2549800796813, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI50541952, Length=251, Percent_Identity=36.2549800796813, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI50541948, Length=251, Percent_Identity=36.2549800796813, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1788855, Length=490, Percent_Identity=61.4285714285714, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1786293, Length=265, Percent_Identity=30.5660377358491, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=482, Percent_Identity=36.3070539419087, Blast_Score=274, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=39.0995260663507, Blast_Score=268, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI17560440, Length=280, Percent_Identity=32.8571428571429, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322012, Length=489, Percent_Identity=38.8548057259714, Blast_Score=336, Evalue=6e-93,
Organism=Saccharomyces cerevisiae, GI6323585, Length=489, Percent_Identity=39.0593047034765, Blast_Score=331, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6323464, Length=489, Percent_Identity=38.6503067484663, Blast_Score=322, Evalue=7e-89,
Organism=Saccharomyces cerevisiae, GI6319352, Length=340, Percent_Identity=37.9411764705882, Blast_Score=243, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6319353, Length=114, Percent_Identity=42.1052631578947, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24641071, Length=489, Percent_Identity=40.081799591002, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24641073, Length=489, Percent_Identity=40.081799591002, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI28571163, Length=446, Percent_Identity=40.5829596412556, Blast_Score=310, Evalue=2e-84,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51792; Mature: 51792

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLGKALTFDDVLLVPAYSQVLPKDTSLVTRFTRNITLNLPLVSAAMDTVTEARLAIAI
CCCCCCCCCCCCEEEECCHHHHCCCCHHHHHHHCCCEEEECCHHHHHHHHHHHCEEEEEE
AQEGGIGVIHKNMTAEQQAAEVSKVKRHESGVVHDPVVITPEHTVLQVLELSENLGISGF
ECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEECCEEECCCHHHHHHHHHHHCCCCCCC
PVCDGGKVVGIVTSRDVRFETRYDVKVREIMTPREKLITVNEKDGTTPAQAKALLNRHKL
EECCCCEEEEEEECCCEEEEEECCEEHHHHCCCCHHEEEEECCCCCCHHHHHHHHHHHHH
ERLLVVNDAFELKGLITVKDINKQTTFPNAARDAAGRLRVAAAVGVGAGTEERVALLVKA
HEEEEEECCCHHCEEEEEEECCCCCCCCCHHHHHCCCEEEEEEEECCCCCHHHEEEEEEC
GVDAIVVDTAHGHSKGVIDRVRWVKQNYPQVDVIGGNIATGAAALALAEAGADAVKVGIG
CCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECC
PGSICTTRIVAGVGVPQIMAIDSVATALQGTGVPLIADGGIRFSGDIAKALAAGASTIMM
CCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEECCHHHHHHHCCCHHEEE
GGMFAGTEEAPGEVILYQGRSYKSYRGMGSIGAMQQGSADRYFQEATTGNPNADKLVPEG
CCEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
IEGRVPYKGSMVSIVFQMAGGVRAAMGYCGCATIEEMNNKAEFVEITAAGIRESHVHDVQ
CCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCHHHHHCCCCCEEEEEEECCCCCCCCEEEE
ITKEAPNYRAD
EEECCCCCCCC
>Mature Secondary Structure
MRLLGKALTFDDVLLVPAYSQVLPKDTSLVTRFTRNITLNLPLVSAAMDTVTEARLAIAI
CCCCCCCCCCCCEEEECCHHHHCCCCHHHHHHHCCCEEEECCHHHHHHHHHHHCEEEEEE
AQEGGIGVIHKNMTAEQQAAEVSKVKRHESGVVHDPVVITPEHTVLQVLELSENLGISGF
ECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEECCEEECCCHHHHHHHHHHHCCCCCCC
PVCDGGKVVGIVTSRDVRFETRYDVKVREIMTPREKLITVNEKDGTTPAQAKALLNRHKL
EECCCCEEEEEEECCCEEEEEECCEEHHHHCCCCHHEEEEECCCCCCHHHHHHHHHHHHH
ERLLVVNDAFELKGLITVKDINKQTTFPNAARDAAGRLRVAAAVGVGAGTEERVALLVKA
HEEEEEECCCHHCEEEEEEECCCCCCCCCHHHHHCCCEEEEEEEECCCCCHHHEEEEEEC
GVDAIVVDTAHGHSKGVIDRVRWVKQNYPQVDVIGGNIATGAAALALAEAGADAVKVGIG
CCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECC
PGSICTTRIVAGVGVPQIMAIDSVATALQGTGVPLIADGGIRFSGDIAKALAAGASTIMM
CCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEECCHHHHHHHCCCHHEEE
GGMFAGTEEAPGEVILYQGRSYKSYRGMGSIGAMQQGSADRYFQEATTGNPNADKLVPEG
CCEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
IEGRVPYKGSMVSIVFQMAGGVRAAMGYCGCATIEEMNNKAEFVEITAAGIRESHVHDVQ
CCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCHHHHHCCCCCEEEEEEECCCCCCCCEEEE
ITKEAPNYRAD
EEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA