Click here to switch to the map view.

The map label for this gene is guaA [H]

Identifier: 222110464

GI number: 222110464

Start: 1323293

End: 1324909

Strand: Direct

Name: guaA [H]

Synonym: Dtpsy_1261

Alternate gene names: 222110464

Gene position: 1323293-1324909 (Clockwise)

Preceding gene: 222110463

Following gene: 222110465

Centisome position: 34.85

GC content: 65.18

Gene sequence:

>1617_bases
ATGCAACACGACAAGATCCTCATCCTCGACTTCGGCTCCCAGGTCACCCAACTCATCGCGCGCCGCGTGCGCGAGACGCA
TGTCTACTGCGAGGTCCACCCCTGCGACGTGAGCAGCGACTGGGTGCGCCAGTTCGCCGCAGACGGCAAGCTCAAGGGTG
TGATCCTGTCGGGCAGCCACGCCAGCGTCTACGAAGTGGACGACCGCGCCCCTGACGCCGTGTTCGAGTTGGGCGTGCCC
GTGCTGGGCATCTGCTACGGCATGCAGACCATGGCCGCGCAGCTGGGCGGCAAGGTCGAGGGCTCGCACAGCCGCGAGTT
CGGCTATGCCGAAGTCCGCGCCCATGGCCATACCGCGCTGCTCAAGGGCATCGAGGATTTCTCCACGCCCGAGGGCCACG
GCATGCTGAAGGTGTGGATGAGCCACGGCGACAAGGTCACCGAGCTGCCTCCCGGTTTCAAGCTGATGTGCTCCACCGGC
AACTGCCCCATCGCCGGCATGGCGGACGAAATGCGGCGCTTCTACGCCGTGCAATTCCACCCCGAGGTCACGCACACGGT
GCAGGGCGCGGCGCTGCTAAACCGCTTTGTGCGCGAGATCTGTGGCGCCCAGGCGGACTGGATCATGCGCGACCACATCG
AGGAAGCCGTGCAGAAGATCCGCGAGCAGGTGGGCGGCGAGGAAGTGATCCTAGGCCTGTCTGGCGGCGTGGATTCGTCG
GTGGCTGCGGCCCTGATCCACCGTGCGATTGGCGACCAGCTCACTTGCGTGTTCGTGGACCACGGCCTGCTGCGCCTCAA
CGAAGGCGATATGGTCATGGACATGTTCGCAGGCAAGCTGCACGCGAAGGTGGTGCGCGTGGATGCCTCGGACCTGTTCC
TGGGTGAGCTGGCCGGTGTGTCGGAGCCCGAGCAAAAGCGCAAGATCATCGGCCGATTGTTCGTGGACGTGTTCAAGGCC
GAAGCCGAAAAGCTCAAGGCCAGCGGCCAGGGCCACAAGGGCGCGACCTTCCTGGCGCAAGGCACCATCTACCCCGACGT
GATCGAGTCCGGCGGTGCCAAGAGCAAGAAGGCTGTCACCATCAAGAGCCACCACAACGTGGGCGGGCTGCCCGAGCAAC
TCGGCCTCAAACTGCTGGAGCCGCTGCGCGACCTGTTCAAGGACGAGGTGCGCGAGCTCGGCGTGGCCCTGGGGCTGCCG
CGCGAAATGGTCTACCGCCATCCGTTCCCCGGCCCGGGCCTGGGCGTGCGCATTCTGGGCGAGGTGAAGAAGGAATACGC
CGACCTGCTGCGCCGCGCCGATGCCATCTTCATCGAAGAGCTGCGCAACTTCACCGACGAAGCCACGGGCAAGACCTGGT
ACGACCTCACCAGCCAGGCCTTCACCGTGTTCCTGCCCGTCAAGAGCGTGGGCGTGATGGGCGATGGCCGCACCTACGAC
TATGTGGTGGCACTGCGCGCGGTGCAGACCAGCGACTTCATGACAGCCGACTGGGCGGAGTTGCCCTACGCGCTGTTGAA
GAAGGTCTCCAGCCGCATCATCAATGAGGTGCGCGGCATCAACCGCGTGACCTACGACGTGTCGAGCAAGCCGCCTGCCA
CCATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
CCCCCAACTACCGGGCGGACTGAGTTTTCGCCATTCCGCAGGCCCGAACCCGTCTCCAGGTGTTCGGGCCTTTTGTCTTT
TACCGACCCTGTCGCTCTCC

Downstream 100 bases:

>100_bases
AATCAGGTCCTTCGGGGACTATCGCTACTTATCGAAAATCCGCCGTAACGTGTTGATTTCAAAGAAAATACGTCACCACA
GCTATCGGTGACTATCGCCG

Product: gmp synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MQHDKILILDFGSQVTQLIARRVRETHVYCEVHPCDVSSDWVRQFAADGKLKGVILSGSHASVYEVDDRAPDAVFELGVP
VLGICYGMQTMAAQLGGKVEGSHSREFGYAEVRAHGHTALLKGIEDFSTPEGHGMLKVWMSHGDKVTELPPGFKLMCSTG
NCPIAGMADEMRRFYAVQFHPEVTHTVQGAALLNRFVREICGAQADWIMRDHIEEAVQKIREQVGGEEVILGLSGGVDSS
VAAALIHRAIGDQLTCVFVDHGLLRLNEGDMVMDMFAGKLHAKVVRVDASDLFLGELAGVSEPEQKRKIIGRLFVDVFKA
EAEKLKASGQGHKGATFLAQGTIYPDVIESGGAKSKKAVTIKSHHNVGGLPEQLGLKLLEPLRDLFKDEVRELGVALGLP
REMVYRHPFPGPGLGVRILGEVKKEYADLLRRADAIFIEELRNFTDEATGKTWYDLTSQAFTVFLPVKSVGVMGDGRTYD
YVVALRAVQTSDFMTADWAELPYALLKKVSSRIINEVRGINRVTYDVSSKPPATIEWE

Sequences:

>Translated_538_residues
MQHDKILILDFGSQVTQLIARRVRETHVYCEVHPCDVSSDWVRQFAADGKLKGVILSGSHASVYEVDDRAPDAVFELGVP
VLGICYGMQTMAAQLGGKVEGSHSREFGYAEVRAHGHTALLKGIEDFSTPEGHGMLKVWMSHGDKVTELPPGFKLMCSTG
NCPIAGMADEMRRFYAVQFHPEVTHTVQGAALLNRFVREICGAQADWIMRDHIEEAVQKIREQVGGEEVILGLSGGVDSS
VAAALIHRAIGDQLTCVFVDHGLLRLNEGDMVMDMFAGKLHAKVVRVDASDLFLGELAGVSEPEQKRKIIGRLFVDVFKA
EAEKLKASGQGHKGATFLAQGTIYPDVIESGGAKSKKAVTIKSHHNVGGLPEQLGLKLLEPLRDLFKDEVRELGVALGLP
REMVYRHPFPGPGLGVRILGEVKKEYADLLRRADAIFIEELRNFTDEATGKTWYDLTSQAFTVFLPVKSVGVMGDGRTYD
YVVALRAVQTSDFMTADWAELPYALLKKVSSRIINEVRGINRVTYDVSSKPPATIEWE
>Mature_538_residues
MQHDKILILDFGSQVTQLIARRVRETHVYCEVHPCDVSSDWVRQFAADGKLKGVILSGSHASVYEVDDRAPDAVFELGVP
VLGICYGMQTMAAQLGGKVEGSHSREFGYAEVRAHGHTALLKGIEDFSTPEGHGMLKVWMSHGDKVTELPPGFKLMCSTG
NCPIAGMADEMRRFYAVQFHPEVTHTVQGAALLNRFVREICGAQADWIMRDHIEEAVQKIREQVGGEEVILGLSGGVDSS
VAAALIHRAIGDQLTCVFVDHGLLRLNEGDMVMDMFAGKLHAKVVRVDASDLFLGELAGVSEPEQKRKIIGRLFVDVFKA
EAEKLKASGQGHKGATFLAQGTIYPDVIESGGAKSKKAVTIKSHHNVGGLPEQLGLKLLEPLRDLFKDEVRELGVALGLP
REMVYRHPFPGPGLGVRILGEVKKEYADLLRRADAIFIEELRNFTDEATGKTWYDLTSQAFTVFLPVKSVGVMGDGRTYD
YVVALRAVQTSDFMTADWAELPYALLKKVSSRIINEVRGINRVTYDVSSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=565, Percent_Identity=34.3362831858407, Blast_Score=280, Evalue=3e-75,
Organism=Escherichia coli, GI1788854, Length=535, Percent_Identity=62.803738317757, Blast_Score=660, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992717, Length=583, Percent_Identity=35.8490566037736, Blast_Score=300, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI71992710, Length=583, Percent_Identity=35.8490566037736, Blast_Score=300, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI133901714, Length=583, Percent_Identity=36.0205831903945, Blast_Score=299, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6323873, Length=539, Percent_Identity=50.278293135436, Blast_Score=517, Evalue=1e-147,
Organism=Drosophila melanogaster, GI281365319, Length=564, Percent_Identity=35.4609929078014, Blast_Score=294, Evalue=1e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 59183; Mature: 59183

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHDKILILDFGSQVTQLIARRVRETHVYCEVHPCDVSSDWVRQFAADGKLKGVILSGSH
CCCCCEEEEECCHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHCCCCEEEEEEECCC
ASVYEVDDRAPDAVFELGVPVLGICYGMQTMAAQLGGKVEGSHSREFGYAEVRAHGHTAL
CEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHHH
LKGIEDFSTPEGHGMLKVWMSHGDKVTELPPGFKLMCSTGNCPIAGMADEMRRFYAVQFH
HHHHHHCCCCCCCCEEEEEECCCCEECCCCCCCEEEEECCCCCCCCCHHHHHHHEEEEEC
PEVTHTVQGAALLNRFVREICGAQADWIMRDHIEEAVQKIREQVGGEEVILGLSGGVDSS
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHH
VAAALIHRAIGDQLTCVFVDHGLLRLNEGDMVMDMFAGKLHAKVVRVDASDLFLGELAGV
HHHHHHHHHHCCCEEEEEEECCEEEECCCCEEHHHHHHHHEEEEEEECCHHHHHHHHCCC
SEPEQKRKIIGRLFVDVFKAEAEKLKASGQGHKGATFLAQGTIYPDVIESGGAKSKKAVT
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHCCCCCCCEEEE
IKSHHNVGGLPEQLGLKLLEPLRDLFKDEVRELGVALGLPREMVYRHPFPGPGLGVRILG
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHH
EVKKEYADLLRRADAIFIEELRNFTDEATGKTWYDLTSQAFTVFLPVKSVGVMGDGRTYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEEEEHHHEEECCCCCCEE
YVVALRAVQTSDFMTADWAELPYALLKKVSSRIINEVRGINRVTYDVSSKPPATIEWE
EEEEEHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEECC
>Mature Secondary Structure
MQHDKILILDFGSQVTQLIARRVRETHVYCEVHPCDVSSDWVRQFAADGKLKGVILSGSH
CCCCCEEEEECCHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHCCCCEEEEEEECCC
ASVYEVDDRAPDAVFELGVPVLGICYGMQTMAAQLGGKVEGSHSREFGYAEVRAHGHTAL
CEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHHH
LKGIEDFSTPEGHGMLKVWMSHGDKVTELPPGFKLMCSTGNCPIAGMADEMRRFYAVQFH
HHHHHHCCCCCCCCEEEEEECCCCEECCCCCCCEEEEECCCCCCCCCHHHHHHHEEEEEC
PEVTHTVQGAALLNRFVREICGAQADWIMRDHIEEAVQKIREQVGGEEVILGLSGGVDSS
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHH
VAAALIHRAIGDQLTCVFVDHGLLRLNEGDMVMDMFAGKLHAKVVRVDASDLFLGELAGV
HHHHHHHHHHCCCEEEEEEECCEEEECCCCEEHHHHHHHHEEEEEEECCHHHHHHHHCCC
SEPEQKRKIIGRLFVDVFKAEAEKLKASGQGHKGATFLAQGTIYPDVIESGGAKSKKAVT
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHCCCCCCCEEEE
IKSHHNVGGLPEQLGLKLLEPLRDLFKDEVRELGVALGLPREMVYRHPFPGPGLGVRILG
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHH
EVKKEYADLLRRADAIFIEELRNFTDEATGKTWYDLTSQAFTVFLPVKSVGVMGDGRTYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEEEEEEEHHHEEECCCCCCEE
YVVALRAVQTSDFMTADWAELPYALLKKVSSRIINEVRGINRVTYDVSSKPPATIEWE
EEEEEHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA