Click here to switch to the map view.

The map label for this gene is ppiD [H]

Identifier: 222110395

GI number: 222110395

Start: 1246343

End: 1248265

Strand: Direct

Name: ppiD [H]

Synonym: Dtpsy_1188

Alternate gene names: 222110395

Gene position: 1246343-1248265 (Clockwise)

Preceding gene: 222110394

Following gene: 222110400

Centisome position: 32.83

GC content: 61.47

Gene sequence:

>1923_bases
ATGTTCGAATCCATCCGCAAGCACTCCAAGATCGTCATGTTCTTGTTGTTCTTGCTGATCATCCCGTCGTTCATCCTCGT
GGGTATCGACAGCAACTATTTCAGCGGAGGAAGCCCGGTGGTAGCGCGGGTCGATGGCAAGGACATCACCCAAGCCGACT
GGGACAACGCTCACCGTATGGAGAGTGATCGAATCCGCGCTCAGTCGCCAGGTATCGACGCCAAGCTGCTGGATTCACCG
CAGGCACGCTATGCCACGTTGGAGCGGCTGGTGCGTGACCGCGTGCTGCAAGTCGCGGCGCAGGACATGCACATGCTGAC
CAGCGATGCGCGGTTGGCACGCGAGCTGCAGAGCATTCCGCAGATAGCGGCGTTGAAACGAGCTGACGGCACGCTGGATG
CCGAAGCCTATCGCGCTCTGGCTGGTGCGCAGGGACTCACCCCTGAGGGGCTTGAAGCACGCATCCGCCAGGACCTGTCG
GTCAACCAGGTCATGGGCGGTGTCATGGGGTCGGCGTTCAGCGGCCCGGCAGAAGCACGTTTGGCACTGGATGCACTGTT
CCAGCGCCGTGAAATCCAGATCGCCCGTTTCAATGCTTCGGCGTTTGTGTCCAAGGTCGTGGTGACGGATGCCGACCTGG
AGGCCTATTACACCGCCCATCCTGCGAAATTCCAGCAGGCTGAACAAGCGTCAGTGGAGTATGTGGTGCTTGACCTTGAT
GCCGTGAAAGCGGGAATCACGCTCAGCGAAGATGACCTGCGCACCTATTACAAGGAAAACCTGAATCGCCTCGCGGGCAA
GGAGGAGCGCCGGGCAAGTCACATACTGATCAACGCCAGCAAGGACGCCCCTGCGGATGCGCGCACCCAGGCCAAGGCCA
AGGCGGAGGAACTGCTCGCGCAGGTACGCAAAGCGCCGGGCAGCTTCGCGGAGATTGCCAAAAAGGAGTCGCAGGACCCG
GGCTCAGCACCGTCCGGCGGTGACCTCGGTTTTTTTGGCCGGGGAGCCATGGTCAAACCCTTTGAAGACGCCGTTTTTTC
CATGAAGAAGGGGGAGATCAGCGACGTAGTGGAAACCGATTTCGGCTTCCACATCATCCTGCTTTCCGATATCAAGACTC
CGCGCCAGCCCAGTTTCGAGGAGCTGCGCCCCTCGCTCGAGGCAGAACTCAAGCAGCAGCAGGCCCAACGCAAGTTCGCA
GAAGTGGCCGAGGCGTTTGCCAATGGTGTGTATGAACAGGCGGACAGCCTGCAACCCGTCGCCGACAAGCTTAAGCTCAA
GATTCAGACGGCCGACGGGGTTACCCGTACTCCGGCTGCCGGTGGCGCGGGGCCGCTTGCCAACGCACGCTTCCTGGAGG
CGCTGTTCCAGTCGGACTCGCTGCAGAACAAGCGCAATACCGAGGCCATCGAGATCGGTACAAGTGTGCTGGCAGCCGGC
CGCGTTACGGCATACCAGCCCGCCATGACGCTGCCGCTGGACAAGGCGCGCGACCAGGTGCGCGCGATCTATATCGCCGA
GAAGTCCGCTGAACTTGCGCGGCAGGAAGGCCAAGCCAAACTGACCGCTTGGAAGGCCGCGCCGGATGCAGCCTCCGGGT
TGACTGCTGCGTTGACGGTGTCGCGGGACCGGCTGCAGGATCAGCCTCGTTCCGTGGTGGATGCCGCCTTGCGTGCCAAT
GTGGACCAACTCCCGGCCTGGACAGGTGTGGACCTTGGTGCGCAGGGCTATGCCGTGGTGAAAATCAACCGCGTCGTTCC
CCGGGACGGTGTGGACGACGCTCGTGCGCGTATGGAGCGAGAGCAATACTTGCAATCGTGGGCGTCGGCCGAGGCGCTAG
CGTATTACGATTTGCTCAAGCAGCGTTTCAAGGTCCAGATCAAGGCCCCCCGACCGGTGGCCCAGGCAGAGCTACAAAAC
TAA

Upstream 100 bases:

>100_bases
CAAGGCGTAGGTCAGCGGTTCGACCCCGTTAGCACCCACCACCCCATTCAAAGGCGAACGCAAGTTCGCCTTTTCTTTTG
CAGCTGTTGAAAGATTGACC

Downstream 100 bases:

>100_bases
GCCGGTTACCTCAGAGGGTAGATTTATCAGGCTATAATTCAAGGCTACGGTGGCTGTAGCTCAGTTGGTAGAGTCCAGGA
TTGTGATTCCTGTCGTCGTG

Product: ppic-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 640; Mature: 640

Protein sequence:

>640_residues
MFESIRKHSKIVMFLLFLLIIPSFILVGIDSNYFSGGSPVVARVDGKDITQADWDNAHRMESDRIRAQSPGIDAKLLDSP
QARYATLERLVRDRVLQVAAQDMHMLTSDARLARELQSIPQIAALKRADGTLDAEAYRALAGAQGLTPEGLEARIRQDLS
VNQVMGGVMGSAFSGPAEARLALDALFQRREIQIARFNASAFVSKVVVTDADLEAYYTAHPAKFQQAEQASVEYVVLDLD
AVKAGITLSEDDLRTYYKENLNRLAGKEERRASHILINASKDAPADARTQAKAKAEELLAQVRKAPGSFAEIAKKESQDP
GSAPSGGDLGFFGRGAMVKPFEDAVFSMKKGEISDVVETDFGFHIILLSDIKTPRQPSFEELRPSLEAELKQQQAQRKFA
EVAEAFANGVYEQADSLQPVADKLKLKIQTADGVTRTPAAGGAGPLANARFLEALFQSDSLQNKRNTEAIEIGTSVLAAG
RVTAYQPAMTLPLDKARDQVRAIYIAEKSAELARQEGQAKLTAWKAAPDAASGLTAALTVSRDRLQDQPRSVVDAALRAN
VDQLPAWTGVDLGAQGYAVVKINRVVPRDGVDDARARMEREQYLQSWASAEALAYYDLLKQRFKVQIKAPRPVAQAELQN

Sequences:

>Translated_640_residues
MFESIRKHSKIVMFLLFLLIIPSFILVGIDSNYFSGGSPVVARVDGKDITQADWDNAHRMESDRIRAQSPGIDAKLLDSP
QARYATLERLVRDRVLQVAAQDMHMLTSDARLARELQSIPQIAALKRADGTLDAEAYRALAGAQGLTPEGLEARIRQDLS
VNQVMGGVMGSAFSGPAEARLALDALFQRREIQIARFNASAFVSKVVVTDADLEAYYTAHPAKFQQAEQASVEYVVLDLD
AVKAGITLSEDDLRTYYKENLNRLAGKEERRASHILINASKDAPADARTQAKAKAEELLAQVRKAPGSFAEIAKKESQDP
GSAPSGGDLGFFGRGAMVKPFEDAVFSMKKGEISDVVETDFGFHIILLSDIKTPRQPSFEELRPSLEAELKQQQAQRKFA
EVAEAFANGVYEQADSLQPVADKLKLKIQTADGVTRTPAAGGAGPLANARFLEALFQSDSLQNKRNTEAIEIGTSVLAAG
RVTAYQPAMTLPLDKARDQVRAIYIAEKSAELARQEGQAKLTAWKAAPDAASGLTAALTVSRDRLQDQPRSVVDAALRAN
VDQLPAWTGVDLGAQGYAVVKINRVVPRDGVDDARARMEREQYLQSWASAEALAYYDLLKQRFKVQIKAPRPVAQAELQN
>Mature_640_residues
MFESIRKHSKIVMFLLFLLIIPSFILVGIDSNYFSGGSPVVARVDGKDITQADWDNAHRMESDRIRAQSPGIDAKLLDSP
QARYATLERLVRDRVLQVAAQDMHMLTSDARLARELQSIPQIAALKRADGTLDAEAYRALAGAQGLTPEGLEARIRQDLS
VNQVMGGVMGSAFSGPAEARLALDALFQRREIQIARFNASAFVSKVVVTDADLEAYYTAHPAKFQQAEQASVEYVVLDLD
AVKAGITLSEDDLRTYYKENLNRLAGKEERRASHILINASKDAPADARTQAKAKAEELLAQVRKAPGSFAEIAKKESQDP
GSAPSGGDLGFFGRGAMVKPFEDAVFSMKKGEISDVVETDFGFHIILLSDIKTPRQPSFEELRPSLEAELKQQQAQRKFA
EVAEAFANGVYEQADSLQPVADKLKLKIQTADGVTRTPAAGGAGPLANARFLEALFQSDSLQNKRNTEAIEIGTSVLAAG
RVTAYQPAMTLPLDKARDQVRAIYIAEKSAELARQEGQAKLTAWKAAPDAASGLTAALTVSRDRLQDQPRSVVDAALRAN
VDQLPAWTGVDLGAQGYAVVKINRVVPRDGVDDARARMEREQYLQSWASAEALAYYDLLKQRFKVQIKAPRPVAQAELQN

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein; Periplasmic side (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=545, Percent_Identity=23.8532110091743, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1786238, Length=344, Percent_Identity=25.8720930232558, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322478, Length=108, Percent_Identity=41.6666666666667, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 69893; Mature: 69893

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFESIRKHSKIVMFLLFLLIIPSFILVGIDSNYFSGGSPVVARVDGKDITQADWDNAHRM
CCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEECCCCCCCCCCCCHHHC
ESDRIRAQSPGIDAKLLDSPQARYATLERLVRDRVLQVAAQDMHMLTSDARLARELQSIP
CHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIAALKRADGTLDAEAYRALAGAQGLTPEGLEARIRQDLSVNQVMGGVMGSAFSGPAEAR
HHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHH
LALDALFQRREIQIARFNASAFVSKVVVTDADLEAYYTAHPAKFQQAEQASVEYVVLDLD
HHHHHHHHHHHEEEEEECHHHHHHHHHEECCCCHHHEECCCHHHHHHHHCCEEEEEEEHH
AVKAGITLSEDDLRTYYKENLNRLAGKEERRASHILINASKDAPADARTQAKAKAEELLA
HHHCCCEECHHHHHHHHHHHHHHHCCCHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
QVRKAPGSFAEIAKKESQDPGSAPSGGDLGFFGRGAMVKPFEDAVFSMKKGEISDVVETD
HHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHCC
FGFHIILLSDIKTPRQPSFEELRPSLEAELKQQQAQRKFAEVAEAFANGVYEQADSLQPV
CCEEEEEEECCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ADKLKLKIQTADGVTRTPAAGGAGPLANARFLEALFQSDSLQNKRNTEAIEIGTSVLAAG
HHHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
RVTAYQPAMTLPLDKARDQVRAIYIAEKSAELARQEGQAKLTAWKAAPDAASGLTAALTV
CCEEECCCCCCCHHHHHHHEEEEEEECHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEE
SRDRLQDQPRSVVDAALRANVDQLPAWTGVDLGAQGYAVVKINRVVPRDGVDDARARMER
CHHHHHCCHHHHHHHHHHCCHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHH
EQYLQSWASAEALAYYDLLKQRFKVQIKAPRPVAQAELQN
HHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHCCCC
>Mature Secondary Structure
MFESIRKHSKIVMFLLFLLIIPSFILVGIDSNYFSGGSPVVARVDGKDITQADWDNAHRM
CCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEECCCCCCCCCCCCHHHC
ESDRIRAQSPGIDAKLLDSPQARYATLERLVRDRVLQVAAQDMHMLTSDARLARELQSIP
CHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIAALKRADGTLDAEAYRALAGAQGLTPEGLEARIRQDLSVNQVMGGVMGSAFSGPAEAR
HHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHH
LALDALFQRREIQIARFNASAFVSKVVVTDADLEAYYTAHPAKFQQAEQASVEYVVLDLD
HHHHHHHHHHHEEEEEECHHHHHHHHHEECCCCHHHEECCCHHHHHHHHCCEEEEEEEHH
AVKAGITLSEDDLRTYYKENLNRLAGKEERRASHILINASKDAPADARTQAKAKAEELLA
HHHCCCEECHHHHHHHHHHHHHHHCCCHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
QVRKAPGSFAEIAKKESQDPGSAPSGGDLGFFGRGAMVKPFEDAVFSMKKGEISDVVETD
HHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHCC
FGFHIILLSDIKTPRQPSFEELRPSLEAELKQQQAQRKFAEVAEAFANGVYEQADSLQPV
CCEEEEEEECCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ADKLKLKIQTADGVTRTPAAGGAGPLANARFLEALFQSDSLQNKRNTEAIEIGTSVLAAG
HHHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
RVTAYQPAMTLPLDKARDQVRAIYIAEKSAELARQEGQAKLTAWKAAPDAASGLTAALTV
CCEEECCCCCCCHHHHHHHEEEEEEECHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEE
SRDRLQDQPRSVVDAALRANVDQLPAWTGVDLGAQGYAVVKINRVVPRDGVDDARARMER
CHHHHHCCHHHHHHHHHHCCHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHH
EQYLQSWASAEALAYYDLLKQRFKVQIKAPRPVAQAELQN
HHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]