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The map label for this gene is comA [H]

Identifier: 222110147

GI number: 222110147

Start: 956886

End: 959471

Strand: Direct

Name: comA [H]

Synonym: Dtpsy_0933

Alternate gene names: 222110147

Gene position: 956886-959471 (Clockwise)

Preceding gene: 222110145

Following gene: 222110148

Centisome position: 25.2

GC content: 72.78

Gene sequence:

>2586_bases
ATGGACCAGTGGGCGCCCGAAGGGCCACAGCACCAGCAGGGAGGGAGCACCGCCGCGCGGGTGGCGACGGCGTCCGCTCG
CGTGCCGATCGCTTGCGTGCCTGTGGTGCGGTCCTGGCATCTGCCCATGGCGCTGGCTGCGGGGGTGCTGGGCGTGGCGC
TGCAACTGCAGCAGCCTTCGCTGTGGCCCTGGCCGTCCTATGCGGGGTTGATGGTTGGCGCGCTGCTGGCGGCCGGGGCG
CTCGCCTGGTGGGCCGGTGTGCGCGGCACGCGCCGCTGGCACGGCAGCGGCGTGGCGATTCTGGCCGCGGTGCTGATGTA
CGGGCTGTGCGGCATGCGCGCTGCGGTCTTCCTGGAGCAGTCTCTGGCGCCGGCGCTGGAGGGGCGTGATCTGCGCGTGA
CGGGCGTGGTTGCCGCCATGCCGCAGCCGCGCGAGACCGGATTGCGCCTGCGGCTGGAGGTGGAGGCGGCGCAACTGGAC
GGTGCGCCCGTGCGCGTGCCGCCGCTCATCGACCTGACCTGGTATGCCGGCGGGCTGGGTGATGAGGCAGGCGCGGACAG
TCCTCCGCCCGCTGTGCGCGCCGGTGAACGCTGGCGCCTGACCGTGCGCCTGAAGGCGCCGCACGGCGGGCGCAATCCGC
ACGGCTTCGATTACGAGCTGTGGCTGTGGGAGCAAGGGGTGCAGGCCACGGGCTACGTGCGTACCAGCGCGCGGCTGGAT
GCGCTGCACGGCCCGCCTGAGCGGCTGGGCGCCACCTGGCGCCACCCCGTGGAGCAACTGCGCCAGCGGGTGCGCGACGC
CATCGTGCGCACGCTGGTGGACCCTGCGCAGGATGCAGCCCGCCAGCGTGCGGCCGGGGTGGTGGCGGCGCTGGTCACGG
GCGACCAGCGCGCCATCGAGCGGGCAGACTGGGATGTGTTCCGCGCCACGGGCGTGGCCCACCTCATGAGCATCTCGGGG
CTGCACATCACGCTGTTTGCCTGGCTTGCGGCCGCACTGCTGGACCGGGCCTGGCGCCGCTCGCAACGCCTGTGCCTGGC
CGTGCCCGCGCCCACGGCGGCGTTGGTGGGCGGTGTGCTGCTGGCCGCTGCCTATGCGCTCTTCAGTGGATGGGGCGTGC
CCGCGCAGCGCACGGTGTGCATGTTGGCCACGGTGGCGCTGCTGCGCCTGTCGGGGCGGCGCTGGCCCTGGCCGCAGGTG
TGGCTGCTGGCCTGCGCGGTGGTGCTGGCGGTCGATCCGTGGGCGCTACTGCAGCCGGGCTTCTGGCTGAGCTTTGTGGC
CGTGGCCGTGCTGTTTGCTACCGATTTGGGAGCTGCTAGCGCTTATCCAGTGGGTATTACAGGCCGTTTTTATGCATTGC
TTCGAGAACAGTGGGTGGTGACGCTGGCGCTCACGCCCCTCACGCTATTGCTGTTCGGGCAGGTTGCGCTGGTGGGGCTG
CTGGCCAATTTGGTGGCGATTCCGTGGACCACGCTGGTGGTCACGCCGCTGGCGCTGCTGGGGGTGCTGTGGGCGCCGCT
GTGGCAGGCGGCGGCGTGGTGCGTGCAGGCGTTGTCGGTGTTGCTGCAGTGGCTGGCAGCCTGGCCCTGGGCGCAGGTCG
CTCTGCCCATGGCCCCGCAGTGGGCCGGCGCGGCAGCCGTGACCGGCGGCGTATTGCTGGCGCTGCGCCTGCCGTGGGGC
GTACGTGCCCTGGGCCTTGCGCTGCTGCTGCCGGCGCTGTGGTGGCAGCCCGCGCGCCCGCAGCCGGGGCAGTTCGAGCT
GCTGGCCGCCGACGTGGGCCAGGGCCAGGCCGTGCTGGTGCGCACGGCGCGCCATGCGCTGCTGTACGACGCCGGCCCGC
GCTACCACCAGGACAGCGACGCGGGCGAGCGCGTGCTGGTGCCCCTGCTGCGCGCGCTGGGCGAACGGCTGGACCTGCTG
GTGTTGAGCCACCGCGATACCGACCACACCGGCGGCGCCGCGGCAGTGCTGGCGCAACAGCCGCAGGCACGCCTGCTGGG
GTCGATTGAGGCCGACCATGCACTGCAGGCCCTGCGGCCCGCCGAGCCTTGCCTGGCAGGCCAGCACTGGAACTGGGACG
GCGTGCTTTTCGAAGTGCTGCACCCGCCGCGCGATGCGGGCGATGGGCCGGGCGCCCGTGCGCCGACGTCCAATGCCACG
AGCTGTGTGCTGCGCATCGCAGCCGCGGGGACCAGTGACAAGACCGGCGGTGCGGTGGCCCTGCTGGTGGGCGACATCGA
GCGCGCGCAGGAACAGGCGCTGGTAGATGGCGGTGCAGCGCTGGCGGCAGACCTGCTGCTGGTGCCGCACCATGGCAGCA
AGAGCTCGTCCAGCGCGCCATTCCTGGATGCCGTGCAGCCGCGCACCGCGCTGGTGCAGGCCGGCTACCGCAACCGCTTC
GGCCACCCCGCGCCCGACGTGGTGGCGCGCTACCGGCAGCGCGGCGTCTTGCTCGTGCAGTCGCCGCCCTGCGGTGCGGC
GCGTTGGGTATCCGATGCGCCGCTGGCCGTGCACTGTGAACGAGAGGCCACGCGGCGCTACTGGCACCACCGCGTGTCCG
AGGCGTCACTTTTGCCGCAGCCGTAG

Upstream 100 bases:

>100_bases
AACGCGCCCACGGCCGCTGATGCGGCGTGGGACCGGGCGAGTGTTGCACATCGCCACGCCGGCGGAGCGCCCATCGCGTG
CGTTCGCATAGCATGCGGCC

Downstream 100 bases:

>100_bases
CGTTGCCGGGCCTGCAACTTGCTATCCTGGGTGCAGGAGGCACGCCGCATGCAGCAGTTCGACGAGATGTACACCGTGCT
GCCCTTCGGGGGCAGCGACG

Product: DNA internalization-like competence protein comec/rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 861; Mature: 861

Protein sequence:

>861_residues
MDQWAPEGPQHQQGGSTAARVATASARVPIACVPVVRSWHLPMALAAGVLGVALQLQQPSLWPWPSYAGLMVGALLAAGA
LAWWAGVRGTRRWHGSGVAILAAVLMYGLCGMRAAVFLEQSLAPALEGRDLRVTGVVAAMPQPRETGLRLRLEVEAAQLD
GAPVRVPPLIDLTWYAGGLGDEAGADSPPPAVRAGERWRLTVRLKAPHGGRNPHGFDYELWLWEQGVQATGYVRTSARLD
ALHGPPERLGATWRHPVEQLRQRVRDAIVRTLVDPAQDAARQRAAGVVAALVTGDQRAIERADWDVFRATGVAHLMSISG
LHITLFAWLAAALLDRAWRRSQRLCLAVPAPTAALVGGVLLAAAYALFSGWGVPAQRTVCMLATVALLRLSGRRWPWPQV
WLLACAVVLAVDPWALLQPGFWLSFVAVAVLFATDLGAASAYPVGITGRFYALLREQWVVTLALTPLTLLLFGQVALVGL
LANLVAIPWTTLVVTPLALLGVLWAPLWQAAAWCVQALSVLLQWLAAWPWAQVALPMAPQWAGAAAVTGGVLLALRLPWG
VRALGLALLLPALWWQPARPQPGQFELLAADVGQGQAVLVRTARHALLYDAGPRYHQDSDAGERVLVPLLRALGERLDLL
VLSHRDTDHTGGAAAVLAQQPQARLLGSIEADHALQALRPAEPCLAGQHWNWDGVLFEVLHPPRDAGDGPGARAPTSNAT
SCVLRIAAAGTSDKTGGAVALLVGDIERAQEQALVDGGAALAADLLLVPHHGSKSSSSAPFLDAVQPRTALVQAGYRNRF
GHPAPDVVARYRQRGVLLVQSPPCGAARWVSDAPLAVHCEREATRRYWHHRVSEASLLPQP

Sequences:

>Translated_861_residues
MDQWAPEGPQHQQGGSTAARVATASARVPIACVPVVRSWHLPMALAAGVLGVALQLQQPSLWPWPSYAGLMVGALLAAGA
LAWWAGVRGTRRWHGSGVAILAAVLMYGLCGMRAAVFLEQSLAPALEGRDLRVTGVVAAMPQPRETGLRLRLEVEAAQLD
GAPVRVPPLIDLTWYAGGLGDEAGADSPPPAVRAGERWRLTVRLKAPHGGRNPHGFDYELWLWEQGVQATGYVRTSARLD
ALHGPPERLGATWRHPVEQLRQRVRDAIVRTLVDPAQDAARQRAAGVVAALVTGDQRAIERADWDVFRATGVAHLMSISG
LHITLFAWLAAALLDRAWRRSQRLCLAVPAPTAALVGGVLLAAAYALFSGWGVPAQRTVCMLATVALLRLSGRRWPWPQV
WLLACAVVLAVDPWALLQPGFWLSFVAVAVLFATDLGAASAYPVGITGRFYALLREQWVVTLALTPLTLLLFGQVALVGL
LANLVAIPWTTLVVTPLALLGVLWAPLWQAAAWCVQALSVLLQWLAAWPWAQVALPMAPQWAGAAAVTGGVLLALRLPWG
VRALGLALLLPALWWQPARPQPGQFELLAADVGQGQAVLVRTARHALLYDAGPRYHQDSDAGERVLVPLLRALGERLDLL
VLSHRDTDHTGGAAAVLAQQPQARLLGSIEADHALQALRPAEPCLAGQHWNWDGVLFEVLHPPRDAGDGPGARAPTSNAT
SCVLRIAAAGTSDKTGGAVALLVGDIERAQEQALVDGGAALAADLLLVPHHGSKSSSSAPFLDAVQPRTALVQAGYRNRF
GHPAPDVVARYRQRGVLLVQSPPCGAARWVSDAPLAVHCEREATRRYWHHRVSEASLLPQP
>Mature_861_residues
MDQWAPEGPQHQQGGSTAARVATASARVPIACVPVVRSWHLPMALAAGVLGVALQLQQPSLWPWPSYAGLMVGALLAAGA
LAWWAGVRGTRRWHGSGVAILAAVLMYGLCGMRAAVFLEQSLAPALEGRDLRVTGVVAAMPQPRETGLRLRLEVEAAQLD
GAPVRVPPLIDLTWYAGGLGDEAGADSPPPAVRAGERWRLTVRLKAPHGGRNPHGFDYELWLWEQGVQATGYVRTSARLD
ALHGPPERLGATWRHPVEQLRQRVRDAIVRTLVDPAQDAARQRAAGVVAALVTGDQRAIERADWDVFRATGVAHLMSISG
LHITLFAWLAAALLDRAWRRSQRLCLAVPAPTAALVGGVLLAAAYALFSGWGVPAQRTVCMLATVALLRLSGRRWPWPQV
WLLACAVVLAVDPWALLQPGFWLSFVAVAVLFATDLGAASAYPVGITGRFYALLREQWVVTLALTPLTLLLFGQVALVGL
LANLVAIPWTTLVVTPLALLGVLWAPLWQAAAWCVQALSVLLQWLAAWPWAQVALPMAPQWAGAAAVTGGVLLALRLPWG
VRALGLALLLPALWWQPARPQPGQFELLAADVGQGQAVLVRTARHALLYDAGPRYHQDSDAGERVLVPLLRALGERLDLL
VLSHRDTDHTGGAAAVLAQQPQARLLGSIEADHALQALRPAEPCLAGQHWNWDGVLFEVLHPPRDAGDGPGARAPTSNAT
SCVLRIAAAGTSDKTGGAVALLVGDIERAQEQALVDGGAALAADLLLVPHHGSKSSSSAPFLDAVQPRTALVQAGYRNRF
GHPAPDVVARYRQRGVLLVQSPPCGAARWVSDAPLAVHCEREATRRYWHHRVSEASLLPQP

Specific function: Essential for natural transformation. Could be a transporter involved in DNA uptake [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis ComEC, H.influenzae REC2, and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=687, Percent_Identity=29.5487627365357, Blast_Score=213, Evalue=4e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 92106; Mature: 92106

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQWAPEGPQHQQGGSTAARVATASARVPIACVPVVRSWHLPMALAAGVLGVALQLQQPS
CCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEHHHHHCCCHHHHHHHHHHHHEEECCCC
LWPWPSYAGLMVGALLAAGALAWWAGVRGTRRWHGSGVAILAAVLMYGLCGMRAAVFLEQ
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHH
SLAPALEGRDLRVTGVVAAMPQPRETGLRLRLEVEAAQLDGAPVRVPPLIDLTWYAGGLG
HHHHHHCCCCEEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCEECCCEEEEEEECCCCC
DEAGADSPPPAVRAGERWRLTVRLKAPHGGRNPHGFDYELWLWEQGVQATGYVRTSARLD
CCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEECCHHH
ALHGPPERLGATWRHPVEQLRQRVRDAIVRTLVDPAQDAARQRAAGVVAALVTGDQRAIE
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEECCCHHHHH
RADWDVFRATGVAHLMSISGLHITLFAWLAAALLDRAWRRSQRLCLAVPAPTAALVGGVL
HHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
LAAAYALFSGWGVPAQRTVCMLATVALLRLSGRRWPWPQVWLLACAVVLAVDPWALLQPG
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHCCC
FWLSFVAVAVLFATDLGAASAYPVGITGRFYALLREQWVVTLALTPLTLLLFGQVALVGL
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHH
LANLVAIPWTTLVVTPLALLGVLWAPLWQAAAWCVQALSVLLQWLAAWPWAQVALPMAPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCC
WAGAAAVTGGVLLALRLPWGVRALGLALLLPALWWQPARPQPGQFELLAADVGQGQAVLV
CCCHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEE
RTARHALLYDAGPRYHQDSDAGERVLVPLLRALGERLDLLVLSHRDTDHTGGAAAVLAQQ
EHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHCC
PQARLLGSIEADHALQALRPAEPCLAGQHWNWDGVLFEVLHPPRDAGDGPGARAPTSNAT
CHHHHHHCCCHHHHHHHHCCCCCHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHH
SCVLRIAAAGTSDKTGGAVALLVGDIERAQEQALVDGGAALAADLLLVPHHGSKSSSSAP
HHHHEEEECCCCCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHEEEEEECCCCCCCCCCCC
FLDAVQPRTALVQAGYRNRFGHPAPDVVARYRQRGVLLVQSPPCGAARWVSDAPLAVHCE
CHHHCCCHHHHHHCCHHCCCCCCCHHHHHHHHHCCEEEEECCCCCHHHHCCCCCEEEEEC
REATRRYWHHRVSEASLLPQP
HHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDQWAPEGPQHQQGGSTAARVATASARVPIACVPVVRSWHLPMALAAGVLGVALQLQQPS
CCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEHHHHHCCCHHHHHHHHHHHHEEECCCC
LWPWPSYAGLMVGALLAAGALAWWAGVRGTRRWHGSGVAILAAVLMYGLCGMRAAVFLEQ
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHH
SLAPALEGRDLRVTGVVAAMPQPRETGLRLRLEVEAAQLDGAPVRVPPLIDLTWYAGGLG
HHHHHHCCCCEEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCEECCCEEEEEEECCCCC
DEAGADSPPPAVRAGERWRLTVRLKAPHGGRNPHGFDYELWLWEQGVQATGYVRTSARLD
CCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEECCHHH
ALHGPPERLGATWRHPVEQLRQRVRDAIVRTLVDPAQDAARQRAAGVVAALVTGDQRAIE
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHEEECCCHHHHH
RADWDVFRATGVAHLMSISGLHITLFAWLAAALLDRAWRRSQRLCLAVPAPTAALVGGVL
HHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHH
LAAAYALFSGWGVPAQRTVCMLATVALLRLSGRRWPWPQVWLLACAVVLAVDPWALLQPG
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHCCC
FWLSFVAVAVLFATDLGAASAYPVGITGRFYALLREQWVVTLALTPLTLLLFGQVALVGL
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHH
LANLVAIPWTTLVVTPLALLGVLWAPLWQAAAWCVQALSVLLQWLAAWPWAQVALPMAPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCC
WAGAAAVTGGVLLALRLPWGVRALGLALLLPALWWQPARPQPGQFELLAADVGQGQAVLV
CCCHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEE
RTARHALLYDAGPRYHQDSDAGERVLVPLLRALGERLDLLVLSHRDTDHTGGAAAVLAQQ
EHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHCC
PQARLLGSIEADHALQALRPAEPCLAGQHWNWDGVLFEVLHPPRDAGDGPGARAPTSNAT
CHHHHHHCCCHHHHHHHHCCCCCHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHH
SCVLRIAAAGTSDKTGGAVALLVGDIERAQEQALVDGGAALAADLLLVPHHGSKSSSSAP
HHHHEEEECCCCCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHEEEEEECCCCCCCCCCCC
FLDAVQPRTALVQAGYRNRFGHPAPDVVARYRQRGVLLVQSPPCGAARWVSDAPLAVHCE
CHHHCCCHHHHHHCCHHCCCCCCCHHHHHHHHHCCEEEEECCCCCHHHHCCCCCEEEEEC
REATRRYWHHRVSEASLLPQP
HHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934834; 8830266 [H]