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The map label for this gene is fabA [H]

Identifier: 222109757

GI number: 222109757

Start: 560207

End: 560731

Strand: Direct

Name: fabA [H]

Synonym: Dtpsy_0541

Alternate gene names: 222109757

Gene position: 560207-560731 (Clockwise)

Preceding gene: 222109756

Following gene: 222109758

Centisome position: 14.76

GC content: 64.95

Gene sequence:

>525_bases
ATGGCTGATTCCTTCTCGTACGAACAACTCATCGCCTCGGGCGAGGGCCGGTTGTTCGGTCCGGACAGCGGGCGCCTGCC
CCTGCCCCCCATGCTGATGTTCGATCGCATCACGCACATCGACACCGACGGCGGCGCGCATGGCCTGGGAAAGATCGTGG
CCGAACTCGACGTCAAGCCCGACCTGTGGTTCTTCGCCTGCCATTTCCAGGGTGACCCGGTCATGCCCGGCTGCCTGGGG
TTGGATGCCATGTGGCAGCTCATCGGCTTCTATCTCACCTGGCTGCGCCTGCCGGGCCGTGGCCGCGCGCTGGGCGCGGG
CGAGGTCAAGTTCACCGGCGAGGTGGGCCCGGACGTGAAGCTCGTGACCTACGAAATCGACATCAAGCGCGTCATCAAGC
GCAAACTCAACATGGCCATCGGCGATGCACGCCTGCTGGCCGACGGCAAGGAAATCTACGTGGCCAACGACCTGCGCGTG
GGTCTGTTCCTGCGCGAAGGCGACGCACAGGGAAGCGCAGCATGA

Upstream 100 bases:

>100_bases
GGGCCTTCGCCGCCCGTGGCCGCGGGCCGCGCGCTGATTTTTTTGCATCAACGACAACCACCTACCGCGACGGCACGGGC
CGTCTGGAGCACGATTGACA

Downstream 100 bases:

>100_bases
CCAAGAAACGGGTGGTGATCACGGGCGCGGGCATCGTCTCGTGCATTGGCAACGATCTGCAGACCGTGGAGGAGGCGCTG
CGCGCCAGCCGCTCCGGCAT

Product: 3-hydroxydecanoyl-(acyl carrier protein) dehydratase

Products: NA

Alternate protein names: Beta-hydroxydecanoyl thioester dehydrase [H]

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MADSFSYEQLIASGEGRLFGPDSGRLPLPPMLMFDRITHIDTDGGAHGLGKIVAELDVKPDLWFFACHFQGDPVMPGCLG
LDAMWQLIGFYLTWLRLPGRGRALGAGEVKFTGEVGPDVKLVTYEIDIKRVIKRKLNMAIGDARLLADGKEIYVANDLRV
GLFLREGDAQGSAA

Sequences:

>Translated_174_residues
MADSFSYEQLIASGEGRLFGPDSGRLPLPPMLMFDRITHIDTDGGAHGLGKIVAELDVKPDLWFFACHFQGDPVMPGCLG
LDAMWQLIGFYLTWLRLPGRGRALGAGEVKFTGEVGPDVKLVTYEIDIKRVIKRKLNMAIGDARLLADGKEIYVANDLRV
GLFLREGDAQGSAA
>Mature_173_residues
ADSFSYEQLIASGEGRLFGPDSGRLPLPPMLMFDRITHIDTDGGAHGLGKIVAELDVKPDLWFFACHFQGDPVMPGCLGL
DAMWQLIGFYLTWLRLPGRGRALGAGEVKFTGEVGPDVKLVTYEIDIKRVIKRKLNMAIGDARLLADGKEIYVANDLRVG
LFLREGDAQGSAA

Specific function: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzed the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP [H]

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787187, Length=161, Percent_Identity=59.0062111801242, Blast_Score=199, Evalue=6e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR010083
- InterPro:   IPR013114 [H]

Pfam domain/function: PF07977 FabA [H]

EC number: =4.2.1.60 [H]

Molecular weight: Translated: 19008; Mature: 18877

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSFSYEQLIASGEGRLFGPDSGRLPLPPMLMFDRITHIDTDGGAHGLGKIVAELDVKP
CCCCCCHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCC
DLWFFACHFQGDPVMPGCLGLDAMWQLIGFYLTWLRLPGRGRALGAGEVKFTGEVGPDVK
CEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCEEECCCCCCCEE
LVTYEIDIKRVIKRKLNMAIGDARLLADGKEIYVANDLRVGLFLREGDAQGSAA
EEEEEECHHHHHHHHHHHHCCCEEEEECCCEEEEECCCEEEEEEEECCCCCCCC
>Mature Secondary Structure 
ADSFSYEQLIASGEGRLFGPDSGRLPLPPMLMFDRITHIDTDGGAHGLGKIVAELDVKP
CCCCCHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCC
DLWFFACHFQGDPVMPGCLGLDAMWQLIGFYLTWLRLPGRGRALGAGEVKFTGEVGPDVK
CEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCEEECCCCCCCEE
LVTYEIDIKRVIKRKLNMAIGDARLLADGKEIYVANDLRVGLFLREGDAQGSAA
EEEEEECHHHHHHHHHHHHCCCEEEEECCCEEEEECCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]