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The map label for this gene is fabB [H]

Identifier: 222109758

GI number: 222109758

Start: 560728

End: 561951

Strand: Direct

Name: fabB [H]

Synonym: Dtpsy_0542

Alternate gene names: 222109758

Gene position: 560728-561951 (Clockwise)

Preceding gene: 222109757

Following gene: 222109759

Centisome position: 14.77

GC content: 68.14

Gene sequence:

>1224_bases
ATGACCAAGAAACGGGTGGTGATCACGGGCGCGGGCATCGTCTCGTGCATTGGCAACGATCTGCAGACCGTGGAGGAGGC
GCTGCGCGCCAGCCGCTCCGGCATCAAGGCCGTGCCCCAGTTCACCGAGCTGGGCCTGCGCAGCCAGGTGGCGGGCGTGC
CTGAGATCGACGTCGAGGCGCGCATCGACCGCAAGCAGCTGCGCTTCATGGGCGACGCCGCGGCCTATGCGCAGATTGCC
CTGGAAGACGCCATCCAGCAGGCCGGCCTCACCCCCGAACAGGTCAGCCACCCGCGCACCGGCCTCATCATGGGCTCGGG
CGGCGGCTCTCCCGCCAACCAGATCGAGGCGGCCGACACGCTGCGCGAAAAAGGCATCCGCCGCGTGGGACCCTACCAGG
TCACGCGCTGCATGAGCTCCACCGTCTCGGCGTGCCTCGCGACCAACTTCAAGGTCAAGGGCATCAACTATTCCATTACC
TCGGCCTGCTCCACGTCGGCGCACTGCATCGGCGCCGCTGCGCAGCAGATCGCCTGGGGCCTGCAAGACGTGATGTTCGC
CGGCGGCGGCGAAGAGCTGTCCTGGGGCATGTCGCTGCTGTTCGACGGCATGGGCGCCATGTCCAGCAAGTACAACGCCA
CGCCCGAGAAGGCCTCGCGCGCCTATGACGCCAACCGCGACGGCTTCGTGATCGCCGGCGGCGGCGGTGCCGTGGTGCTG
GAAAGCCTGGAGCATGCACTGGCGCGCGGCGCCACCATCCTGGGTGAGGTCGTGGGCTTTGGCGCTACGAGCGACGGTGA
GGACATGGTGGCCCCGTCGGGCGACGGCGCCATCGCCTGCATGCAGCAGGCCATGGAAGGACTGGGCGCGCCCATCGACT
ACATCAACACCCACGGCACCTCCACGCCTGTGGGCGACATGCAGGAAGTGCGTGCGATGCAGGCGGTGTTCGGCGAGGCC
GTGCCGCCGTTCTCCAGCACCAAGTCGCTCACCGGCCATTCGCTGGGCGCCACCGGCGTGCAGGAAGCGATCTACTGCCT
GATCATGCTGAACAAGGGCTTCATCGCCGGTTCGGCCAACGTGGAGACGCCGGACCCGCTGCTCGGCTCCATGCCGCTGG
TGACCCAGACGCGCGACGCGCAGTTGACCCACGTGCTGTCCAACAGCTTCGGCTTTGGCGGCACCAACGCCAGCCTGGTG
CTGCGCCGCTGGCAAGGCCAGTGA

Upstream 100 bases:

>100_bases
GCGATGCACGCCTGCTGGCCGACGGCAAGGAAATCTACGTGGCCAACGACCTGCGCGTGGGTCTGTTCCTGCGCGAAGGC
GACGCACAGGGAAGCGCAGC

Downstream 100 bases:

>100_bases
CGGCCTCGGGCCAGGTACGACGGGGGCTGCGGCCCCCGTTTTGCTTGGACGCCTAAAATTGCCGGTTCGCGCGTGCGAGC
GCGCCCGCTCTCTCAGACAC

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MTKKRVVITGAGIVSCIGNDLQTVEEALRASRSGIKAVPQFTELGLRSQVAGVPEIDVEARIDRKQLRFMGDAAAYAQIA
LEDAIQQAGLTPEQVSHPRTGLIMGSGGGSPANQIEAADTLREKGIRRVGPYQVTRCMSSTVSACLATNFKVKGINYSIT
SACSTSAHCIGAAAQQIAWGLQDVMFAGGGEELSWGMSLLFDGMGAMSSKYNATPEKASRAYDANRDGFVIAGGGGAVVL
ESLEHALARGATILGEVVGFGATSDGEDMVAPSGDGAIACMQQAMEGLGAPIDYINTHGTSTPVGDMQEVRAMQAVFGEA
VPPFSSTKSLTGHSLGATGVQEAIYCLIMLNKGFIAGSANVETPDPLLGSMPLVTQTRDAQLTHVLSNSFGFGGTNASLV
LRRWQGQ

Sequences:

>Translated_407_residues
MTKKRVVITGAGIVSCIGNDLQTVEEALRASRSGIKAVPQFTELGLRSQVAGVPEIDVEARIDRKQLRFMGDAAAYAQIA
LEDAIQQAGLTPEQVSHPRTGLIMGSGGGSPANQIEAADTLREKGIRRVGPYQVTRCMSSTVSACLATNFKVKGINYSIT
SACSTSAHCIGAAAQQIAWGLQDVMFAGGGEELSWGMSLLFDGMGAMSSKYNATPEKASRAYDANRDGFVIAGGGGAVVL
ESLEHALARGATILGEVVGFGATSDGEDMVAPSGDGAIACMQQAMEGLGAPIDYINTHGTSTPVGDMQEVRAMQAVFGEA
VPPFSSTKSLTGHSLGATGVQEAIYCLIMLNKGFIAGSANVETPDPLLGSMPLVTQTRDAQLTHVLSNSFGFGGTNASLV
LRRWQGQ
>Mature_406_residues
TKKRVVITGAGIVSCIGNDLQTVEEALRASRSGIKAVPQFTELGLRSQVAGVPEIDVEARIDRKQLRFMGDAAAYAQIAL
EDAIQQAGLTPEQVSHPRTGLIMGSGGGSPANQIEAADTLREKGIRRVGPYQVTRCMSSTVSACLATNFKVKGINYSITS
ACSTSAHCIGAAAQQIAWGLQDVMFAGGGEELSWGMSLLFDGMGAMSSKYNATPEKASRAYDANRDGFVIAGGGGAVVLE
SLEHALARGATILGEVVGFGATSDGEDMVAPSGDGAIACMQQAMEGLGAPIDYINTHGTSTPVGDMQEVRAMQAVFGEAV
PPFSSTKSLTGHSLGATGVQEAIYCLIMLNKGFIAGSANVETPDPLLGSMPLVTQTRDAQLTHVLSNSFGFGGTNASLVL
RRWQGQ

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=33.0935251798561, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI41872631, Length=336, Percent_Identity=29.1666666666667, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI223972627, Length=166, Percent_Identity=36.7469879518072, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1788663, Length=404, Percent_Identity=60.8910891089109, Blast_Score=497, Evalue=1e-142,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=37.8640776699029, Blast_Score=232, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI71983541, Length=411, Percent_Identity=35.5231143552311, Blast_Score=188, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71983535, Length=258, Percent_Identity=37.5968992248062, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI212642053, Length=403, Percent_Identity=26.0545905707196, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=357, Percent_Identity=25.2100840336134, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=29.8440979955457, Blast_Score=170, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24644341, Length=415, Percent_Identity=36.144578313253, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI19920632, Length=337, Percent_Identity=29.3768545994065, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI221330659, Length=337, Percent_Identity=29.3768545994065, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24581345, Length=380, Percent_Identity=26.0526315789474, Blast_Score=92, Evalue=8e-19,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42326; Mature: 42194

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKRVVITGAGIVSCIGNDLQTVEEALRASRSGIKAVPQFTELGLRSQVAGVPEIDVEA
CCCCEEEEECCHHHHHHCCHHHHHHHHHHHHHCCCHHCCHHHHHCHHHHHCCCCCCCHHH
RIDRKQLRFMGDAAAYAQIALEDAIQQAGLTPEQVSHPRTGLIMGSGGGSPANQIEAADT
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEECCCCCCHHHHHHHHH
LREKGIRRVGPYQVTRCMSSTVSACLATNFKVKGINYSITSACSTSAHCIGAAAQQIAWG
HHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCEEHHHHCCCCHHHHHHHHHHHHHH
LQDVMFAGGGEELSWGMSLLFDGMGAMSSKYNATPEKASRAYDANRDGFVIAGGGGAVVL
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEECCCHHHHH
ESLEHALARGATILGEVVGFGATSDGEDMVAPSGDGAIACMQQAMEGLGAPIDYINTHGT
HHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCC
STPVGDMQEVRAMQAVFGEAVPPFSSTKSLTGHSLGATGVQEAIYCLIMLNKGFIAGSAN
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHEEHHEECCCEEECCCC
VETPDPLLGSMPLVTQTRDAQLTHVLSNSFGFGGTNASLVLRRWQGQ
CCCCCCCCCCCCCEECCCCHHHHHHHHCCCCCCCCCHHHHEEECCCC
>Mature Secondary Structure 
TKKRVVITGAGIVSCIGNDLQTVEEALRASRSGIKAVPQFTELGLRSQVAGVPEIDVEA
CCCEEEEECCHHHHHHCCHHHHHHHHHHHHHCCCHHCCHHHHHCHHHHHCCCCCCCHHH
RIDRKQLRFMGDAAAYAQIALEDAIQQAGLTPEQVSHPRTGLIMGSGGGSPANQIEAADT
HCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEECCCCCCHHHHHHHHH
LREKGIRRVGPYQVTRCMSSTVSACLATNFKVKGINYSITSACSTSAHCIGAAAQQIAWG
HHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCEEHHHHCCCCHHHHHHHHHHHHHH
LQDVMFAGGGEELSWGMSLLFDGMGAMSSKYNATPEKASRAYDANRDGFVIAGGGGAVVL
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEECCCHHHHH
ESLEHALARGATILGEVVGFGATSDGEDMVAPSGDGAIACMQQAMEGLGAPIDYINTHGT
HHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCC
STPVGDMQEVRAMQAVFGEAVPPFSSTKSLTGHSLGATGVQEAIYCLIMLNKGFIAGSAN
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHEEHHEECCCEEECCCC
VETPDPLLGSMPLVTQTRDAQLTHVLSNSFGFGGTNASLVLRRWQGQ
CCCCCCCCCCCCCEECCCCHHHHHHHHCCCCCCCCCHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]